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The Market for Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs)


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The Market for Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs)

Circulating tumor cells (CTCs) are believed to detach from primary or secondary tumors and enter the bloodstream, traveling to distant organs and forming new tumors. These cells that leave the primary tumor are able to colonize distant organs in the body and initiate the process of metastasis; however, their biology is still not entirely elucidated.
Circulating tumor cells have tremendous utility in cancer research, aiding scientists in deciphering the complex biology of cancer metastasis. Besides the applications in cancer research, the detection and analysis of circulating tumor cells has enormous potential in the diagnosis and management of cancer, as current tools, such as tumor tissue biopsy or imaging technologies, have numerous limitations. This report, The Market for Circulating Tumor Cells (CTCs) and Cancer Stem Cells, is Kalorama's detailed analysis of the potential opportunities for manufacturers of CTCs-based technologies. Analyst Adriana Rusu informs readers of the scientific basis of CTCs in an understandable fashion, and constructs models of revenue opportunity based on several dimensions - application area, cancer type and region - that can assist with business planning efforts.
Despite their potential, the detection and analysis of circulating tumor cells has been a challenging endeavor, and their significance in cancer not completely understood. Progress in the field of CTC-based cancer diagnostics and therapeutics has been thus far hampered by the rarity of these cells and the difficulty to isolate them from the patient’s blood. Nonetheless, in the past decade, numerous technological advances have contributed to a renewed interest in this field. The report considers these challenges and trends in the markets and provides data on the following:

  • Introduction and Overview of Biolgy Behind CTCs
  • Market and Forecast to 2017 For CTCs-based Technologies
  • Market Breakdown by Type of Cancer
  • Market Breakdown by Application Type (Research, Diagnostics)
  • Market Breakdown by Geographic Region
  • Current Isolation and Identification Methods
  • Uses in Prognosis, Diagnosis, Drug Development and Other Research
  • CTCs-based Products and Competitors
  • The Current State of Cancer Treatment, Incidence and Other Helpful Statistics
  • Collaboration and Partnerships
The global market for CTC detection, isolation and analysis devices is a heterogeneous and competitive market, constantly driven by technological innovation and demand for improved technologies. The market includes numerous competitors with different capabilities. These numerous specialized or research-based companies also develop and commercialize products for the detection, isolation and analysis of CTCs, and contribute considerably to the technological advancements in this field. As part of its extensive coverage, the report profiles several competitors in the market. The following companies are profiled:
  • AdnaGen AG
  • Advanced Cell Diagnostics, Inc.
  • ApoCell, Inc.
  • Aviva Biosciences Corporation
  • Biocept, Inc.
  • Biofluidica
  • BioView Ltd.
  • Celula, Inc.
  • Clearbridge Biomedics
  • Creatv MicroTech, Inc.
  • Cynvenio Biosystems
  • CytoTrack ApS
  • Epic Sciences
  • Fluidigm Corporation
  • Fluxion Biosciences, Inc.
  • Ikonisys, Inc.
  • Miltenyi Biotec GmbH
  • On-Q-ity
  • Parsortix/ANGLE
  • RareCells Diagnostics
  • ScreenCell
  • Silicon Biosystems
  • TeloVISION LLC
  • Veridex, LLC
  • Vitatex Inc.


  • Executive Summary
    • CANCER AND CIRCULATING TUMOR CELLS
    • CURRENT AND POTENTIAL CLINICAL APPLICATIONS OF CTCS
    • CTCS DETECTION, ISOLATION AND ANALYSIS TECHNOLOGIES
    • INDUSTRY AND MARKET STRUCTURE
  • Cancer Overview
    • DISEASE OVERVIEW
      • Table Top Ten Causes of Death in the World by Geographical Region, 2008
      • Table Top Ten Causes of Death in the World in High Income Countries, 2008
      • Table Top Ten Causes of Death in the World in High Income Countries, 2008
    • RISK FACTORS
    • INCIDENCE OF CANCER
      • Table Global Incidence of Cancer by Geographical Region, 2008
      • Table Global Incidence of Most Common Types of Cancer in Men, 2008
      • Table Projected Growth in Global Incidence of Cancer by Geographical Region, 2008-2030
  • Circulating Tumor Cells Overview
    • OVERVIEW
      • CTCs Applications
      • CTCs Isolation and Characterization Challenges
    • CHARACTERISTICS OF CTCS
      • Table Typical Human Blood Cellular Composition
    • BIOLOGY OF CIRCULATING TUMOR CELLS
      • Intravasation
      • Bloodstream circulation
      • Extravasation
      • Metastasis
    • CURRENT MARKERS FOR CTCS IDENTIFICATION AND ANALYSIS
      • Table Selected Markers for CTCs Identification and Analysis
      • Epithelial Cell Adhesion Molecule (EpCAM)
        • Table Selected EpCAM-based Methods
      • Ephrin Receptor B4 (EpB4)
      • Epidermal Growth Factor Receptor (EGFR)
      • Human Epidermal Growth Factor (HER2)
      • Mucin-1 (MUC-1)
      • Carcinoembryonic Antigen (CEA)
      • Cytokeratins
      • Conclusions
    • CURRENT AND POTENTIAL CLINICAL APPLICATIONS OF CTCS
      • Table Current and Potential Applications of CTCs in Clinical Practice
      • Non-invasive Early Cancer Diagnostic Method
      • Prognostic Tool for Survival
      • Therapy Monitoring/ Predictor of Response to Therapy and Selection of Therapy
      • Drug Development - Selection of Drug Targets/ Selection of Patients
  • CTCs Isolation and Detection Technologies
    • OVERVIEW
    • ENRICHMENT METHODS BASED ON PHYSICAL PROPERTIES
      • Table Selected Size and Density-Based CTCs Enrichment Methods
      • Conclusions
        • Table Selected CTCs Detection and Isolation Methods Based on Electro-physiological Properties
      • Immuno-magnetic Capture Methods
        • Table Selected CTCs Magnetic Platforms Based on Cell Surface Markers
        • Table Selected CTCs Microfluidics Platforms
      • Conclusion
      • Other CTCs Isolation Approaches
      • Automated Enumeration and Identification of CTCs
      • Other Automated Scanning/Imaging Methods
        • Table Selected CTCs Identification Methods Based on Automated Identification and Enumeration
      • Nucleic Acid-Based CTCs Identification Methods
        • Table Selected Nucleic Acid-Based CTCs Identification Methods
  • Industry and Market Landscape
    • INDUSTRY STRUCTURE
      • Table Industry Structure - Selected Competitors and Marketed Products, 2013
      • Competitive Factors
      • Market Challenges
      • Product Analysis - CellSearch
        • Table Significant Trends in the CTCs Market, 2013
    • NOTABLE RECENT INDUSTRY EVENTS
      • Veridex Launched CellSearch system in China
      • Total Market Revenues and Forecast
        • Table Global Market Revenues and Forecast for CTCs-based Technologies ($ Millions), 2011-2017
        • Table Global Market Revenues for CTCs-based Technologies by Geographical Region ($ Millions), 2011-2017
  • Company Profiles
    • ADNAGEN AG
    • ADVANCED CELL DIAGNOSTICS, INC.
    • APOCELL, INC.
    • AVIVA BIOSCIENCES CORPORATION
    • BIOCEPT, INC.
    • BIOFLUIDICA
    • BIOVIEW LTD.
    • CELULA, INC.
    • CLEARBRIDGE BIOMEDICS
    • CREATV MICROTECH, INC.
    • CYNVENIO BIOSYSTEMS
    • CYTOTRACK APS
    • EPIC SCIENCES
    • FLUIDIGM CORPORATION
    • FLUXION BIOSCIENCES, INC.
    • IKONISYS, INC.
    • MILTENYI BIOTEC GMBH
    • ON-Q-ITY
    • PARSORTIX/ANGLE plc
    • RARECELLS DIAGNOSTICS
    • SCREENCELL
    • SILICON BIOSYSTEMS
    • TELOVISION LLC
    • VERIDEX, LLC
    • VITATEX INC.
  • Selected Clinical Trials Investigating Circulating Tumor Cells in Cancer Patients
    • Breast Cancer
    • Prostate Cancer
    • Colorectal Cancer
    • Lung Cancer
    • Skin Cancer

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