Traumatic Brain Injury Biomarkers Market Size, Share & Trends Analysis Report By Type (Protein Biomarkers, Genetic Biomarkers), By Sample Type, By Application, By End-use, By Region, And Segment Forecasts, 2025 - 2033

Traumatic Brain Injury Biomarkers Market Summary

The global traumatic brain injury biomarkers market size was estimated at USD 1.04 billion in 2024 and is projected to reach USD 4.73 billion by 2033, growing at a CAGR of 18.84% from 2025 to 2033. The market is facing significant growth driven by rising incidents of traumatic brain injuries, growing demand for rapid and point-of-care diagnostics, and a shift towards personalized medicine and telehealth.

Traumatic brain injury (TBI) remains a major global health concern, ranking among the leading causes of long-term disability and mortality. According to the Centers for Disease Control and Prevention, in 2024, 2.8 million people in America were diagnosed with brain injury every year, and more than 56,000 people died as a result of TBI. Although everyone is at risk of sustaining a traumatic brain injury (TBI), males are approximately 1.5 times more likely than females to experience a TBI and have a mortality rate that is three times higher.

Factors such as increasing road traffic accidents, sports-related injuries, falls among the elderly, and military combat injuries contribute significantly to this trend. Each year, traumatic brain injury (TBI) results in disability for six times more individuals than spinal cord injuries, multiple sclerosis, HIV/AIDS, and breast cancer combined. The pie chart below illustrates leading causes of TBI:

This surge in TBI cases fuels demand for reliable, early diagnostic tools like biomarkers that can aid in timely detection and treatment, ultimately driving market growth.

Individuals aged 65 and above are the most vulnerable to hospitalization and death caused by traumatic brain injury (TBI), with falls being the leading cause. Across all age groups, men experience higher rates of severe TBI compared to women, and they are not only more frequently hospitalized but also face nearly triple the risk of death from TBI.

Thus, there is a growing need for rapid, portable, and point-of-care diagnostic tools for TBI, particularly in pre-hospital environments such as accident scenes, sports fields, and military battlefields. Biomarker-based tests that provide quick and accurate results enable timely clinical decisions, improving patient outcomes and reducing healthcare costs.

Studies are being conducted to investigate whether biomarkers can be used in clinical trials to support the development of new treatments for traumatic brain injury (TBI). These biomarkers could improve the diagnosis and evaluation of TBI severity, facilitating the selection of suitable patients for participation in drug trials. One such study reported by the USFDA, conducted in September 2022, focused on identifying and validating diagnostic biomarkers that accurately detected traumatic brain injury (TBI) and assessed the severity to improve early diagnosis and patient management. The study successfully identified potential biomarkers that demonstrated a strong correlation with TBI presence and severity, laying the groundwork for improved diagnostic tools and enabling more precise patient selection in future clinical trials.

The increasing focus on personalized medicine is driving demand for biomarker-based diagnostics tailored to individual patient profiles and severity of injury. Biomarkers enable clinicians to customize treatment strategies, improving outcomes and reducing adverse effects. Innovations in biomarker identification tests are in development with a focus on personalized medicine.

For instance, in May 2024, bioMerieux received U.S. FDA 510(k) clearance for VIDAS TBI, a serum-based test designed to assist in evaluating patients with mild traumatic brain injury (mTBI), including concussions. This test assists in detecting patients who are unlikely to have acute intracranial lesions (ICL), which helps decrease the number of unnecessary head CT scans. VIDAS TBI also enables healthcare providers to make faster, better-informed decisions tailored to individual patient needs. Thus, inculcating such approaches promotes continuous monitoring and timely intervention, supporting market growth by integrating biomarker testing into personalized therapeutic approaches.

Global Traumatic Brain Injury Biomarkers Market Report Segmentation

This report forecasts revenue growth at the global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Grand View Research has segmented the global traumatic brain injury biomarkers market report based on type, sample type, application, end use, and region:

• Type Outlook (Revenue, USD Million, 2021 - 2033)
• Protein Biomarkers
• Genetic Biomarkers
• Metabolomic Biomarkers
• Sample Type Outlook (Revenue, USD Million, 2021 - 2033)
• Blood-based
• Cerebrospinal fluid (CSF)-based
• Urine-based
• Application Outlook (Revenue, USD Million, 2021 - 2033)
• Diagnosis
• Prognosis
• Monitoring treatment response
• End Use Outlook (Revenue, USD Million, 2021 - 2033)
• Hospitals & Clinics
• Diagnostic Laboratories
• Research Institutes
• Regional Outlook (Revenue in USD Million, 2021 - 2033)
• North America
• U.S.
• Canada
• Mexico
• Europe
• UK
• Germany
• France
• Italy
• Spain
• Sweden
• Denmark
• Norway
• Asia Pacific
• Japan
• China
• India
• Australia
• South Korea
• Thailand
• Latin America
• Brazil
• Argentina
• Middle East and Africa
• Saudi Arabia
• South Africa
• UAE
• Kuwait