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Current Trends in Targeted Therapies in Non-Small Cell Lung Cancer (NSCLC)

Publisher GlobalData
Published Apr 01, 2025
Length 15 Pages
SKU # GBDT19975470

Description

Current Trends in Targeted Therapies in Non-Small Cell Lung Cancer (NSCLC)

Summary

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for approximately 85% of all lung cancer cases

There are currently ten actionable genomic alterations (AGAs) that are addressed by targeted therapy agents across multiple lines of therapy. Patients who did not undergo genetic testing or tested negative for AGAs, receive immunotherapy agents depending on their PD-L1 status. Chemotherapy works as salvage therapy for late-line recurrent/relapsed patients.
  • Targeted therapy in NSCLC is a highly competitive and differentiated space covering ten different actionable biomarkers.
  • Treatment development for EGFR mutations shifts from label expansion and CNS activity to overcoming resistance mechanisms.
  • The relatively quiet ALK and ROS1 segments are to be reshaped by Nuvalent’s TKIs with better efficacy and safety.
  • Small molecule + anti-PD-1 combo therapy will unlock new first-line opportunity in the KRAS G12C segment.
Scope
  • This report includes ten actionable biomarkers in NSCLC that are addressed by targeted therapy agents across multiple lines of therapy. Current and future state of these market segments is included in the scope of the report.

Table of Contents

15 Pages
    • Targeted therapy in NSCLC is a highly competitive and differentiated space covering 10 different actionable biomarkers
    • Development focus shift away from label expansion and CNS activity to overcoming resistance mechanism in the busy EGFR segment
    • The relatively quiet ALK and ROS1 segments are to be reshaped by Nuvalent’s TKIs with better efficacy and safety
    • Small molecule + PD-1i combo therapy will unlock new 1L opportunity in the KRAS G12C segment
    • HER2 and NRG1+ segments are evolving NSCLC segments while BRAF and METex14 skipping remain static

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