Plaque Modification and Removal Devices

Global Plaque Modification and Removal Devices Market to Reach US$3.0 Billion by 2030

The global market for Plaque Modification and Removal Devices estimated at US$2.0 Billion in the year 2024, is expected to reach US$3.0 Billion by 2030, growing at a CAGR of 7.3% over the analysis period 2024-2030. Atherectomy Devices, one of the segments analyzed in the report, is expected to record a 8.8% CAGR and reach US$1.4 Billion by the end of the analysis period. Growth in the Thrombectomy Devices segment is estimated at 5.0% CAGR over the analysis period.

The U.S. Market is Estimated at US$532.9 Million While China is Forecast to Grow at 11.6% CAGR

The Plaque Modification and Removal Devices market in the U.S. is estimated at US$532.9 Million in the year 2024. China, the world`s second largest economy, is forecast to reach a projected market size of US$636.4 Million by the year 2030 trailing a CAGR of 11.6% over the analysis period 2024-2030. Among the other noteworthy geographic markets are Japan and Canada, each forecast to grow at a CAGR of 3.5% and 7.1% respectively over the analysis period. Within Europe, Germany is forecast to grow at approximately 4.8% CAGR.

Global Plaque Modification and Removal Devices Market – Key Trends & Drivers Summarized

The plaque modification and removal devices market is witnessing significant growth, driven by rising cases of cardiovascular diseases (CVDs), advancements in minimally invasive procedures, and increasing preference for catheter-based plaque removal techniques. As atherosclerosis and peripheral artery disease (PAD) become more prevalent, the need for effective and safe plaque removal technologies is growing, particularly among aging populations and individuals with diabetes, obesity, and hypertension.

One of the major trends shaping the market is the increasing adoption of minimally invasive plaque removal techniques, which offer faster recovery times, reduced procedural risks, and improved long-term outcomes compared to traditional surgical methods. Atherectomy devices, laser-based plaque removal systems, and mechanical thrombectomy tools are becoming more sophisticated, enabling precise targeting and safer plaque removal in coronary and peripheral arteries. These innovations are particularly beneficial for patients with complex calcified lesions, chronic total occlusions (CTOs), and high-risk cardiovascular conditions.

Another key driver of market growth is the integration of advanced imaging and navigation technologies in plaque modification devices. Intravascular ultrasound (IVUS), optical coherence tomography (OCT), and real-time angiography-assisted guidance systems are enhancing plaque characterization, lesion assessment, and procedural accuracy. These imaging techniques allow cardiologists and vascular surgeons to determine plaque composition, optimize device selection, and ensure complete lesion modification, reducing the risk of restenosis and complications.

Additionally, the rise of bioresorbable stents and drug-coated balloon technologies is complementing plaque removal strategies, providing sustained vessel patency and improved post-procedural outcomes. With regulatory approvals expanding and clinical trials demonstrating positive long-term efficacy, the demand for next-generation plaque removal and modification solutions is expected to rise in both hospital settings and ambulatory surgical centers (ASCs) worldwide.

How Are Technological Innovations Transforming Plaque Modification Devices?

The plaque modification industry is undergoing rapid technological advancements, with a strong focus on device precision, reduced procedural risks, and improved patient outcomes. Next-generation atherectomy devices, high-frequency laser systems, and mechanical aspiration thrombectomy tools are enhancing the effectiveness of plaque removal in complex and high-risk patients.

One of the most notable innovations in the field is the development of orbital and rotational atherectomy devices. These catheter-based systems use differential cutting technology to selectively remove calcified plaque while preserving the integrity of healthy arterial tissue. The use of diamond-coated burrs and rotational energy allows for precise modification of arterial plaques, improving blood flow and reducing the need for repeat interventions.

Another groundbreaking advancement is laser-based plaque removal systems, which utilize high-energy laser pulses to vaporize atherosclerotic plaques. These devices offer exceptional precision, reduced trauma to vessel walls, and enhanced efficacy in treating in-stent restenosis. Excimer laser catheters, in particular, are proving to be highly effective in complex coronary and peripheral interventions, allowing controlled ablation of calcified and fibrotic plaques without mechanical force.

In addition to mechanical and laser-based approaches, ultrasound-enhanced and shockwave lithotripsy technologies are emerging as promising alternatives for calcified plaque modification. Intravascular lithotripsy (IVL) delivers acoustic pressure waves to fracture hardened plaques, facilitating their removal with minimal vessel trauma. This technique is gaining widespread adoption in complex cardiovascular interventions, particularly in patients with diabetes and heavily calcified lesions that are resistant to traditional treatments.

Moreover, bioengineered plaque-targeting nanoparticles and drug-eluting plaque modification devices are in development to provide targeted plaque dissolution and vessel stabilization. These nanotechnology-based solutions are expected to reduce procedural risks, minimize inflammatory responses, and enhance the durability of plaque removal procedures, making them a key focus for future research and clinical applications.

How Are Clinical Applications and End-User Preferences Shaping Market Demand?

The demand for plaque modification and removal devices is heavily influenced by the increasing prevalence of peripheral artery disease (PAD), carotid artery disease, and coronary artery disease (CAD). As more patients seek non-surgical interventions for arterial blockages, hospitals, specialty cardiovascular clinics, and ambulatory surgical centers (ASCs) are adopting advanced plaque removal technologies to meet clinical demands.

One of the fastest-growing segments is peripheral vascular interventions, where atherectomy and laser plaque removal devices are widely used to treat femoropopliteal and infrapopliteal arterial blockages. PAD affects millions of people worldwide, leading to critical limb ischemia (CLI) and potential limb amputation if left untreated. The availability of catheter-based plaque removal tools has significantly improved limb salvage rates and long-term vessel patency, making these devices essential in modern vascular surgery.

The coronary intervention sector is also seeing increased adoption of plaque modification technologies, particularly in patients with calcified coronary lesions that are resistant to balloon angioplasty and stenting. Rotational atherectomy, intravascular lithotripsy, and laser-assisted plaque removal are now preferred options for high-risk percutaneous coronary interventions (PCIs), offering better lesion preparation and stent expansion outcomes.

Another emerging application is in the treatment of carotid artery disease, where plaque removal devices are helping to prevent stroke and cerebrovascular events. Hybrid plaque modification techniques, combining atherectomy with embolic protection filters and drug-coated balloons, are enhancing carotid revascularization outcomes, reducing the risk of distal embolization and restenosis.

Moreover, the rising adoption of outpatient cardiovascular procedures in ASCs and office-based labs (OBLs) is driving demand for compact, user-friendly plaque removal devices. Single-use, disposable catheter-based atherectomy systems and cost-effective laser platforms are enabling same-day discharge and reduced hospital stays, making plaque modification treatments more accessible and affordable for a broader patient population.

What Factors Are Driving the Growth of the Plaque Modification and Removal Devices Market?

The growth in the plaque modification and removal devices market is driven by several factors, including advancements in minimally invasive cardiovascular procedures, increasing prevalence of peripheral and coronary artery diseases, the integration of real-time imaging and AI-driven analytics, and the expansion of outpatient cardiovascular care settings.

The rising global burden of atherosclerosis and cardiovascular disease (CVD) is a primary market driver. As aging populations, sedentary lifestyles, and metabolic disorders (such as diabetes and obesity) continue to rise, the demand for effective, catheter-based plaque removal solutions is increasing. Physicians are seeking safer, faster, and more durable interventions, making high-precision atherectomy, laser ablation, and shockwave lithotripsy devices critical tools in modern cardiovascular medicine.

Another key factor is the rapid development of AI-assisted imaging and procedural navigation systems. AI-powered platforms are enhancing pre-procedural planning, intraoperative guidance, and post-procedural monitoring, allowing interventionalists to detect complex plaques, optimize device selection, and improve procedural safety. The integration of AI with IVUS, OCT, and angiography is significantly reducing complication rates, restenosis risks, and procedural failures, further driving market adoption.

The expansion of outpatient cardiovascular care and the rise of ambulatory surgical centers (ASCs) are also fueling market growth. With healthcare systems shifting toward cost-effective, same-day procedures, the demand for portable, easy-to-use plaque removal technologies is increasing. Companies are introducing disposable atherectomy devices, compact laser systems, and single-use lithotripsy catheters to support the transition from hospital-based interventions to office-based treatments.

Moreover, regulatory approvals and clinical trial success in next-generation plaque modification devices are accelerating commercialization. Leading companies are investing in research and development (R&D) for bioresorbable scaffolds, nanotechnology-based plaque-targeting therapies, and hybrid atherectomy-stent systems, ensuring long-term vessel patency and improved cardiovascular health outcomes.

As the demand for precision-based cardiovascular interventions continues to grow, the plaque modification and removal devices market is expected to expand significantly, with technological advancements, AI-driven diagnostics, and minimally invasive treatment innovations shaping the future of atherosclerosis management and vascular health care.

SCOPE OF STUDY:

The report analyzes the Plaque Modification and Removal Devices market in terms of units by the following Segments, and Geographic Regions/Countries:

Segments:
Product (Atherectomy Devices, Thrombectomy Devices, Chronic Occlusion Devices, Embolic Protection Devices); Application (Coronary Artery Disease, Peripheral Artery Disease); End-Use (Hospitals, Ambulatory Surgery Centers, Others)

Geographic Regions/Countries:
World; United States; Canada; Japan; China; Europe (France; Germany; Italy; United Kingdom; Spain; Russia; and Rest of Europe); Asia-Pacific (Australia; India; South Korea; and Rest of Asia-Pacific); Latin America (Argentina; Brazil; Mexico; and Rest of Latin America); Middle East (Iran; Israel; Saudi Arabia; United Arab Emirates; and Rest of Middle East); and Africa.

Select Competitors (Total 42 Featured) -

• Abbott Laboratories
• AngioDynamics, Inc.
• Asahi Intecc Co., Ltd.
• Avinger, Inc.
• B. Braun Melsungen AG
• Becton, Dickinson and Company (BD)
• Biotronik SE & Co. KG
• Boston Scientific Corporation
• Cardinal Health, Inc.
• Cardiovascular Systems, Inc.
• Edwards Lifesciences Corporation
• Johnson & Johnson
• Medtronic plc
• Merit Medical Systems, Inc.
• MicroPort Scientific Corporation
• Penumbra, Inc.
• Philips Healthcare
• Stryker Corporation
• Teleflex Incorporated
• Terumo Corporation

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