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Global Nucleic Acid Methylation Market Size Study, By Product & Services (Kits & Reagents, Enzymes, Services, Instruments & Software, Consumables), By Type (DNA Methylation, RNA Methylation), By Technology (Next-Generation Sequencing, PCR-Based Techniques

Publisher Factview Research
Published Oct 03, 2025
Length 285 Pages
SKU # FAVR20464191

Description

The global nucleic acid methylation market was valued at approximately USD 3.43 billion in 2024 and is projected to expand at a CAGR of 15.4% from 2024 to 2034. This rapid growth is attributed to the increasing role of DNA and RNA methylation in precision medicine, cancer research, and drug discovery, as well as advancements in sequencing technologies and AI-driven data analysis. The growing demand for epigenetics-based diagnostics and the rise in methylation marker-based disease detection are expected to accelerate market expansion.

Nucleic acid methylation plays a crucial role in epigenetics, influencing gene expression and disease progression. The rising demand for non-invasive diagnostic methods and targeted therapies has led to an increased focus on methylation-based biomarker research. For instance, according to the National Cancer Institute (NCI), nearly 1.9 million new cancer cases were reported in the U.S. in 2024, driving demand for methylation-based cancer diagnostics and liquid biopsy techniques. Additionally, research into m6A RNA methylation modifications is growing, particularly in neurological disorders and autoimmune diseases, further expanding market opportunities.

The integration of Artificial Intelligence (AI) in DNA methylation analysis is revolutionizing disease detection and drug development. AI-powered models can analyze large-scale methylation datasets, uncover epigenetic biomarkers, and improve early cancer detection. A 2024 study from Cambridge University and University College London demonstrated that an AI-based DNA methylation analysis system could classify 13 types of cancer with 98.2% accuracy, significantly enhancing early diagnosis capabilities.

Furthermore, the expanding research focus on epigenetics-based drug discovery is driving investments in methylation sequencing and mass spectrometry technologies. The increasing use of CRISPR-based epigenetic editing tools and advancements in next-generation sequencing (NGS) platforms are expected to enhance methylation profiling techniques, making them more cost-effective and scalable for clinical applications.

North America dominated the global nucleic acid methylation market in 2024, accounting for 40.46% of total revenue, owing to strong research funding, early adoption of sequencing technologies, and the presence of major biotech firms. The Asia Pacific market is expected to witness the fastest CAGR of 16.56% from 2025 to 2034, fueled by growing government investments in genomics research, increasing adoption of precision medicine, and expanding healthcare infrastructure. Europe remains a key epigenetics research hub, with major pharmaceutical companies investing in methylation-based drug discovery and biomarker research.

Major Market Players Included in This Report Are:
  • Thermo Fisher Scientific Inc.
  • Illumina Inc.
  • QIAGEN
  • New England Biolabs
  • Agilent Technologies Inc.
  • Bio-Rad Laboratories, Inc.
  • F. Hoffmann-La Roche Ltd
  • Exact Sciences Corporation
  • Diagenode Diagnostics S.A.
  • Abcam plc
  • Oxford Nanopore Technologies
  • Zymo Research
  • EpiGentek Group Inc.
  • Pacific Biosciences of California, Inc.
  • Epimorphy LLC
The Detailed Segments and Sub-Segment of the Market Are Explained Below:

By Product & Services
  • Kits & Reagents
  • Enzymes
  • Services
  • Instruments & Software
  • Consumables
By Type
  • DNA Methylation
  • RNA Methylation
By Technology
  • Next-Generation Sequencing (NGS)
  • Bisulfite Sequencing & PCR-based Techniques
  • Microarray-based Methylation Analysis
  • Mass Spectrometry
  • Hybridization-based & Antibody-based Detection
By Application
  • Drug Discovery & Personalized Medicines
  • Clinical Diagnostics
  • Others
By End-use
  • Pharmaceutical & Biotechnology Companies
  • Academic & Research Institutes
  • Hospitals & Diagnostic Laboratories
By Region:

North America
  • U.S.
  • Canada
  • Mexico
Europe
  • U.K.
  • Germany
  • France
  • Italy
  • Spain
  • Denmark
  • Sweden
  • Norway
Asia Pacific
  • China
  • Japan
  • India
  • South Korea
  • Australia
  • Thailand
Latin America
  • Brazil
  • Argentina
Middle East & Africa
  • Saudi Arabia
  • South Africa
  • UAE
  • Kuwait
Years Considered for the Study Are As Follows:
  • Historical Year – 2022
  • Base Year – 2024
  • Forecast Period – 2024 to 2034
Key Takeaways:
  • Market Estimates & Forecasts for 10 Years from 2022 to 2034
  • Annualized Revenue and Regional-Level Analysis for Each Market Segment
  • Detailed Analysis of Geographical Landscape with Country-Level Analysis of Major Regions
  • Competitive Landscape with Information on Major Players in the Market
  • Analysis of Key Business Strategies and Recommendations on Future Market Approach
  • Analysis of Competitive Structure of the Market
  • Demand Side and Supply Side Analysis of the Market

Table of Contents

285 Pages
Chapter 1. Global Nucleic Acid Methylation Market Executive Summary
1.1. Global Nucleic Acid Methylation Market Size & Forecast (2024-2034)
1.2. Regional Summary
1.3. Segmental Summary
1.3.1. By Product & Services
1.3.2. By Type
1.3.3. By Technology
1.3.4. By Application
1.3.5. By End-use
1.4. Key Trends
1.5. Recession Impact
1.6. Industry Metrics
1.7. Investment Analysis
1.8 .Investment Rationale
1.9. Analyst Recommendation & Conclusion
Chapter 2. Global Nucleic Acid Methylation Market Definition and Research Assumptions
2.1. Research Objective
2.2. Market Definition
2.3. Research Assumptions
2.3.1. Inclusion & Exclusion
2.3.2. Limitations
2.3.3. Supply Side Analysis
2.3.3.1. Availability
2.3.3.2. Infrastructure
2.3.3.3. Regulatory Environment
2.3.3.4. Market Competition
2.3.3.5. Economic Viability (Consumer’s Perspective)
2.3.4. Demand Side Analysis
2.3.4.1. Regulatory Frameworks
2.3.4.2. Technological Advancements
2.3.4.3. Environmental Considerations
2.3.4.4. Consumer Awareness & Acceptance
2.4. Estimation Methodology
2.5. Years Considered for the Study
2.6. Currency Conversion Rates
Chapter 3. Global Nucleic Acid Methylation Market Dynamics
3.1. Market Drivers
3.1.1. Rising demand for methylation-based disease detection
3.1.2. Advancements in sequencing technologies and AI-driven analysis
3.1.3. Increasing investments in precision medicine and oncology
3.2. Market Challenges
3.2.1. High costs associated with advanced methylation sequencing techniques
3.2.2. Regulatory and compliance barriers in clinical diagnostics
3.3. Market Opportunities
3.3.1. Emerging applications of RNA methylation in drug discovery
3.3.2. Expansion of epigenetics-based biomarkers in non-invasive diagnostics
3.3.3. AI-powered data analysis in methylation research
Chapter 4. Global Nucleic Acid Methylation Market Industry Analysis
4.1. Porter’s 5 Force Model
4.1.1. Bargaining Power of Suppliers
4.1.2. Bargaining Power of Buyers
4.1.3. Threat of New Entrants
4.1.4. Threat of Substitutes
4.1.5. Competitive Rivalry
4.1.6. Futuristic Approach to Porter’s 5 Force Model
4.1.7. Porter’s 5 Force Impact Analysis
4.2. PESTEL Analysis
4.2.1. Political
4.2.2. Economical
4.2.3. Social
4.2.4. Technological
4.2.5. Environmental
4.2.6. Legal
4.3. Top Investment Opportunity
4.4. Top Winning Strategies
4.5. Disruptive Trends
4.6. Industry Expert Perspective
4.7. Analyst Recommendation & Conclusion
Chapter 5. Global Nucleic Acid Methylation Market Size & Forecasts by Product & Services 2022-2032
5.1. Segment Dashboard
5.2. Global Nucleic Acid Methylation Market: Product & Services Revenue Trend Analysis, 2022 & 2032 (USD Million/Billion)
5.2.1. Kits & Reagents
5.2.2. Enzymes
5.2.3. Services
5.2.4. Instruments & Software
5.2.5. Consumables
Chapter 6. Global Nucleic Acid Methylation Market Size & Forecasts by Type 2022-2032
6.1. Segment Dashboard
6.2. Global Nucleic Acid Methylation Market: Type Revenue Trend Analysis, 2022 & 2032 (USD Million/Billion)
6.2.1. DNA Methylation
6.2.2. RNA Methylation
Chapter 7. Global Nucleic Acid Methylation Market Size & Forecasts by Technology 2022-2032
7.1. Segment Dashboard
7.2. Global Nucleic Acid Methylation Market: Technology Revenue Trend Analysis, 2022 & 2032 (USD Million/Billion)
7.2.1. Next-Generation Sequencing (NGS)
7.2.2. Bisulfite Sequencing & PCR-based Techniques
7.2.3. Microarray-based Methylation Analysis
7.2.4. Mass Spectrometry
7.2.5. Hybridization-based & Antibody-based Detection
Chapter 8. Global Nucleic Acid Methylation Market Size & Forecasts by Application 2022-2032
8.1. Segment Dashboard
8.2. Global Nucleic Acid Methylation Market: Application Revenue Trend Analysis, 2022 & 2032 (USD Million/Billion)
8.2.1. Drug Discovery & Personalized Medicines
8.2.2. Clinical Diagnostics
8.2.3. Others
Chapter 9. Global Nucleic Acid Methylation Market Size & Forecasts by End-use 2022-2032
9.1. Segment Dashboard
9.2. Global Nucleic Acid Methylation Market: End-use Revenue Trend Analysis, 2022 & 2032 (USD Million/Billion)
9.2.1. Pharmaceutical & Biotechnology Companies
9.2.2. Academic & Research Institutes
9.2.3. Hospitals & Diagnostic Laboratories
Chapter 10. Global Nucleic Acid Methylation Market Size & Forecasts by Region 2022-2032
10.1. North America
10.1.1. U.S.
10.1.2. Canada
10.1.3. Mexico
10.2. Europe
10.2.1. U.K.
10.2.2. Germany
10.2.3. France
10.2.4. Italy
10.2.5. Spain
10.2.6. Denmark
10.2.7. Sweden
10.2.8. Norway
10.3. Asia-Pacific
10.3.1. China
10.3.2. Japan
10.3.3. India
10.3.4. South Korea
10.3.5. Australia
10.3.6. Thailand
10.4. Latin America
10.4.1. Brazil
10.4.2. Argentina
10.5. Middle East & Africa
10.5.1. Saudi Arabia
10.5.2. South Africa
10.5.3. UAE
10.5.4. Kuwait
Chapter 11. Competitive Intelligence
11.1. Key Company SWOT Analysis
11.1.1. Thermo Fisher Scientific
11.1.2. Illumina Inc.
11.1.3. QIAGEN
11.2. Top Market Strategies
11.3. Company Profiles
11.3.1. New England Biolabs
11.3.2. Agilent Technologies
11.3.3. Bio-Rad Laboratories
11.3.4. Exact Sciences Corporation
11.3.5. Diagenode Diagnostics S.A.
Chapter 12. Research Process
12.1. Research Process
12.1.1. Data Mining
12.1.2. Analysis
12.1.3. Market Estimation
12.1.4. Validation
12.1.5. Publishing
12.2. Research Attributes

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