Anus neoplasms are anomalies or growths that arise in the anal canal, which is the last segment of the digestive system. Anal squamous cell carcinoma is the most prevalent kind of cancer, but these growths can also be benign (like warts or polyps) or malignant. Chronic HPV infection, anal intercourse, smoking, immunosuppression, and some precancerous diseases such as anal intraepithelial neoplasia are risk factors. Bleeding, pain, itching, or a palpable mass in the anal region are common symptoms. A physical examination, anoscopy, imaging, and biopsy are all used in the diagnosis process. Chemotherapy, radiation, immunotherapy, and surgery are possible forms of treatment. Moreover, the rising prevalence of the disease is anticipated to positively impact the landscape for anus neoplasms emerging drugs.
Report Coverage
The Anus Neoplasms Drug Pipeline Insight Report by Expert Market Research gives comprehensive insights into anus neoplasms therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for anus neoplasms. The anus neoplasms report assessment includes the analysis of over 25 pipeline drugs and 10+ companies. The anus neoplasms pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials including their adverse effects on patients suffering from the condition, and alignment with anus neoplasms treatment guidelines to ensure optimal care practices.
The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to anus neoplasms.
Anus Neoplasms Drug Pipeline Outlook
Anus neoplasms are caused by aberrant and unchecked cell proliferation in the anal area, which frequently starts in the squamous epithelium lining the anus. Persistent exposure to high-risk HPV, especially HPV-16 and HPV-18, is often the cause of these alterations. By integrating into the host's DNA, the virus interferes with tumor-suppressor genes including p53 and Rb and causes unregulated cell division and genomic instability. Carcinogenesis in this area is also influenced by immunosuppression, chronic inflammation, and lifestyle choices like smoking.
Due to its capacity to direct the body's immune system against cancer cells, immunotherapies are frequently chosen for the treatment of anus neoplasms. These treatments are especially successful against HPV-related cancers and include immune checkpoint inhibitors and therapeutic vaccinations. Particularly for advanced or recurrent instances, they provide encouraging results, decreased systemic toxicity, and enhanced specificity, improving quality of life and survival rates. Further, the rising focus on the development of anus neoplasms emerging drugs and the advances in the understanding of the molecular pathogenesis of the disease are expected to support the pipeline expansion in the coming years.
Anus Neoplasms Epidemiology
Anal neoplasms, especially squamous cell carcinoma (SCCA), are becoming more common. Their incidence rate is between 1 to 2 per 100,000 people worldwide. According to recent studies, SCCA is on the rise, especially among people 50 and older, with annual rises of roughly 2.7% in the United States. Notably, almost 90% of occurrences of anal cancer are associated with HPV infection, making it a substantial risk factor. About 1 in 500 people will get anal cancer in their lifetime. The risks are higher in women than in males and among certain racial groupings, especially black men and white women born after the 1960s.
Anus Neoplasms – Drug Pipeline Therapeutic Assessment
This section of the report covers the analysis of anus neoplasms drug candidates based on several segmentations including:
By Phase
- Late-Stage Products (Phase 3 and Phase 4)
- Mid-Stage Products (Phase 2)
- Early-Stage Products (Phase I)
- Preclinical and Discovery Stage Products
- Small Molecules
- Biologics
- Peptides
- Immunotherapies
- Others
- Oral
- Parenteral
- Others
The report covers phase I, phase II, phase III, phase IV, and early phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis , phase II covers a major share of the total clinical trials, with a substantial number of anus neoplasm drugs undergoing clinical development.
Anus Neoplasms – Pipeline Assessment Segmentation, By Drug Classes
The drug molecule categories covered under the anus neoplasms pipeline analysis include small molecules, biologics, peptides, and immunotherapies, among others. The anus neoplasms report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for anus neoplasms.
Anus Neoplasms Clinical Trials Therapeutic Assessment – Competitive Dynamics
The EMR report for the anus neoplasms drug pipeline covers the profile of key companies involved in clinical trials and their drugs under development. It provides a detailed anus neoplasms therapeutic assessment, analyzing the competitive dynamics of the clinical trial landscape. Below is the list of a few players involved in anus neoplasms clinical trials:
- Merck Sharp & Dohme LLC
- Endeavor Biomedicines, Inc.
- MacroGenics
- Sumitomo Pharma America, Inc.
- Beijing Health Guard Biotechnology, Inc
- Transgene
- Incyte Corporation
- Frantz Viral Therapeutics, LLC
- Shanghai Bovax Biotechnology Co., Ltd.
Major drugs currently in the drug pipeline are as follows:
Drug: V503
Sponsored by Merck Sharp & Dohme LLC, the objective of this multicenter clinical trial is to investigate the efficacy and safety of the anus neoplasms drug candidate V503 in the affected patients. The study is under Phase III clinical development.
Drug: ENV- 101
Endeavor Biomedicines is conducting a study aimed at examining the efficacy of the investigational drug ENV- 101 for the treatment of anus neoplasms. The study is under Phase II clinical development.
Reasons To Buy This Report
The Anus Neoplasms Drug Report provides a strategic overview of the latest and future landscape of treatments for anus neoplasms. it provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into market trends, regulatory environments, and potential growth opportunities within anus neoplasms pipeline insights.
Key Questions Answered in the Anus Neoplasms – Pipeline Insight Report
- What is the current landscape of anus neoplasms disease pipeline drugs?
- Which companies/institutions are developing anus neoplasms disease emerging drugs?
- How many phase II drugs are currently present in anus neoplasms disease pipeline drugs?
- Which company is leading the anus neoplasms disease pipeline development activities?
- What is the current anus neoplasms disease therapeutic assessment?
- What are the opportunities and challenges present in the anus neoplasms disease drug pipeline landscape?
- What is the efficacy and safety profile of anus neoplasms disease pipeline drugs?
- Which companies/institutions are involved in anus neoplasms disease collaborations aimed at providing enhanced therapeutic alternatives for patients?
- What are the geographies covered for clinical trials in anus neoplasms disease?
Global Cancer Therapeutics Market
Global Clinical Trials Market
- 1 Preface
- 1.1 Introduction
- 1.2 Objectives of the Study
- 1.3 Research Methodology & Assumptions
- 2 Executive Summary
- 3 Overview of Anus Neoplasms
- 3.1 Signs and Symptoms
- 3.2 Causes
- 3.3 Risk Factors
- 3.4 Types of Anus Neoplasms
- 3.5 Diagnosis
- 3.6 Treatment
- 4 Patient Profile: Anus Neoplasms
- 4.1 Patient Profile Overview
- 4.2 Patient Psychology and Emotional Impact Factors
- 4.3 Risk Assessment and Treatment Success Rate
- 5 Anus Neoplasms: Epidemiology Snapshot
- 5.1 Anus Neoplasms Incidence by Key Markets
- 5.2 Anus Neoplasms – Patients Seeking Treatment in Key Markets
- 6 Anus Neoplasms: Market Dynamics
- 6.1 Market Drivers and Constraints
- 6.2 SWOT Analysis
- 7 Anus Neoplasms: Key Facts Covered
- 7.1 Top Countries Contributing to Clinical Trials in Asia-Pacific
- 7.2 Top Countries Contributing to Clinical Trials in Europe
- 7.3 Top Countries Contributing to Clinical Trials in North America
- 7.4 Top Countries Contributing to Clinical Trials in Other Regions
- 8 Anus Neoplasms, Drug Pipeline Assessment
- 8.1 Assessment by Treatment Type
- 8.2 Assessment by Route of Administration
- 8.3 Assessment by Drug Class
- 9 EMR Drug Pipeline Comparative Analysis
- 9.1 List of Anus Neoplasms Pipeline Drugs
- 9.1.1 By Company
- 9.1.2 By Phase
- 9.1.3 By Indication
- 9.1.4 By Trial Status
- 9.1.5 By Funder Type
- 9.2 EMR Attribute Scoring Analysis of Pipeline Drugs (Top Drugs)
- 10 Anus Neoplasms Drug Pipeline - Late-Stage Products (Phase III and IV) (Top Drugs)
- 10.1 Comparative Analysis for Late-Stage Drugs
- 10.1.1 Study Type
- 10.1.2 Recruitment Status
- 10.1.3 Company
- 10.1.4 Funder Type
- 10.2 Product Level Analysis*
- 10.2.1 Drug: V503
- 10.2.1.1 Product Description
- 10.2.1.2 Trial ID
- 10.2.1.3 Sponsor Name
- 10.2.1.4 Study Type
- 10.2.1.5 Drug Class
- 10.2.1.6 Eligibility Criteria
- 10.2.1.7 Study Record Dates
- 10.2.1.7.1 First Submitted
- 10.2.1.7.2 First Posted
- 10.2.1.7.3 Last Update Posted
- 10.2.1.7.4 Last Verified
- 10.2.1.8 Indication
- 10.2.1.9 Study Design
- 10.2.1.10 Recruitment Status
- 10.2.1.11 Enrollment (Estimated)
- 10.2.1.12 Location Countries
- 10.2.1.13 Recent Results
- 10.2.2 Drug: 9-HPV-3004
- 10.2.3 Other Drugs
- 11 Anus Neoplasms Drug Pipeline - Mid-Stage Products (Phase II) (Top Drugs)
- 11.1 Comparative Analysis for Mid-Stage Drugs
- 11.1.1 Study Type
- 11.1.2 Recruitment Status
- 11.1.3 Company
- 11.1.4 Funder Type
- 11.2 Product Level Analysis*
- 11.2.1 Drug: ENV-101
- 11.2.1.1 Product Description
- 11.2.1.2 Trial ID
- 11.2.1.3 Sponsor Name
- 11.2.1.4 Study Type
- 11.2.1.5 Drug Class
- 11.2.1.6 Eligibility Criteria
- 11.2.1.7 Study Record Dates
- 11.2.1.7.1 First Submitted
- 11.2.1.7.2 First Posted
- 11.2.1.7.3 Last Update Posted
- 11.2.1.7.4 Last Verified
- 11.2.1.8 Indication
- 11.2.1.9 Study Design
- 11.2.1.10 Recruitment Status
- 11.2.1.11 Enrollment (Estimated)
- 11.2.1.12 Location Countries
- 11.2.1.13 Recent Results
- 11.2.2 Drug: CP-MGC018-03
- 11.2.3 Other Drugs
- 12 Anus Neoplasms Drug Pipeline - Early-Stage Products (Phase I) (Top Drugs)
- 12.1 Comparative Analysis for Early-Stage Drugs
- 12.1.1 Study Type
- 12.1.2 Recruitment Status
- 12.1.3 Company
- 12.1.4 Funder Type
- 12.2 Product Level Analysis*
- 12.2.1 Drug: TP-1454
- 12.2.1.1 Product Description
- 12.2.1.2 Trial ID
- 12.2.1.3 Sponsor Name
- 12.2.1.4 Study Type
- 12.2.1.5 Drug Class
- 12.2.1.6 Eligibility Criteria
- 12.2.1.7 Study Record Dates
- 12.2.1.7.1 First Submitted
- 12.2.1.7.2 First Posted
- 12.2.1.7.3 Last Update Posted
- 12.2.1.7.4 Last Verified
- 12.2.1.8 Indication
- 12.2.1.9 Study Design
- 12.2.1.10 Recruitment Status
- 12.2.1.11 Enrollment (Estimated)
- 12.2.1.12 Location Countries
- 12.2.2 Drugs: INCA 0186
- 12.2.3 Other Drugs
- 13 Anus Neoplasms, Key Drug Pipeline Companies
- 13.1 Merck Sharp & Dohme LLC
- 13.1.1 Company Snapshot
- 13.1.2 Pipeline Product Portfolio
- 13.1.3 Financial Analysis
- 13.1.4 Recent News and Developments
- 13.2 Endeavor Biomedicines, Inc.
- 13.2.1 Company Snapshot
- 13.2.2 Pipeline Product Portfolio
- 13.2.3 Financial Analysis
- 13.2.4 Recent News and Developments
- 13.3 MacroGenics
- 13.3.1 Company Snapshot
- 13.3.2 Pipeline Product Portfolio
- 13.3.3 Financial Analysis
- 13.3.4 Recent News and Developments
- 13.4 Beijing Health Guard Biotechnology, Inc
- 13.4.1 Company Snapshot
- 13.4.2 Pipeline Product Portfolio
- 13.4.3 Financial Analysis
- 13.4.4 Recent News and Developments
- 13.5 Transgene
- 13.5.1 Company Snapshot
- 13.5.2 Pipeline Product Portfolio
- 13.5.3 Financial Analysis
- 13.5.4 Recent News and Developments
- 13.6 Incyte Corporation
- 13.6.1 Company Snapshot
- 13.6.2 Pipeline Product Portfolio
- 13.6.3 Financial Analysis
- 13.6.4 Recent News and Developments
- 13.7 Frantz Viral Therapeutics, LLC
- 13.7.1 Company Snapshot
- 13.7.2 Pipeline Product Portfolio
- 13.7.3 Financial Analysis
- 13.7.4 Recent News and Developments
- 13.8 Shanghai Bovax Biotechnology Co., Ltd.
- 13.8.1 Company Snapshot
- 13.8.2 Pipeline Product Portfolio
- 13.8.3 Financial Analysis
- 13.8.4 Recent News and Developments
- 14 Regulatory Framework for Drug Approval, By Region
- 15 Terminated or Suspended Pipeline Products
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