
Moderate to Severe Atopic Dermatitis - Pipeline Insight, 2025
Description
DelveInsight’s, “Moderate to Severe Atopic Dermatitis - Pipeline Insight, 2025” report provides comprehensive insights about 45+ companies and 50+ pipeline drugs in Moderate to Severe Atopic Dermatitis pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
Moderate to Severe Atopic Dermatitis: Overview
Atopic dermatitis (AD) is the most common chronic inflammatory skin disorder, typically beginning in infancy, characterized by dry skin, eczematous lesions, and lichenification. This condition is often associated with other IgE-mediated disorders such as allergic rhinitis, asthma, and food allergies. The prevalence of AD has been increasing over the past few decades, and it carries a significant morbidity burden. Moderate to severe AD is marked by recurrent flare-ups, leading to symptoms like intense itching, rashes, thickened or discolored skin, and raised bumps. For those with severe AD, nocturnal scratching can disrupt sleep and impact daily functioning, further exacerbating the condition. The emotional and psychological impact of AD is also significant, as patients often experience anxiety, depression, and social stigma due to the visible nature of their symptoms. Effective management requires a combination of skincare routines, medications, and sometimes lifestyle modifications to control flare-ups and improve quality of life.
Moderate to severe atopic dermatitis (AD) has a complex etiology involving both genetic and environmental factors that lead to abnormalities in the skin barrier and immune system. It is part of the atopic triad, which includes allergic rhinoconjunctivitis and asthma, and often follows the ""atopic march,"" where symptoms develop sequentially. Genetic mutations, particularly in filaggrin, a protein crucial for skin hydration, are found in many AD patients and may also predispose them to other atopic conditions. Environmental triggers, such as food allergies (e.g., eggs, milk, peanuts) and smoking, can exacerbate symptoms, making management more challenging. These factors collectively contribute to the chronic and often debilitating nature of moderate to severe AD.
Moderate to severe atopic dermatitis is characterized by a range of distressing symptoms, including intense itching, redness (which may appear purple, brown, or ashen gray in people of color), and dry, flaky, or scaly skin. Affected skin may crack, swell, and become open or oozing, with crusting often forming on the surface. These symptoms can persist daily and are particularly severe in individuals with full-body eczema, where the entire body is affected. Additionally, people may experience flare-ups in specific areas such as the face, eyelids, lips, ears, neck, scalp, hands, arms, elbows, feet, legs, behind the knees, and ankles. The skin is often extremely sensitive, further exacerbating discomfort and impairing quality of life.
The treatment and management of moderate to severe atopic dermatitis involve a comprehensive approach, including trigger avoidance, daily skin care, anti-inflammatory therapy, and complementary modalities. Daily skin care focuses on applying emollients twice a day, ideally within three minutes of bathing, to prevent dryness. Topical steroids are the first-line treatment for acute flare-ups, while nonsteroidal agents like calcineurin inhibitors are used for sensitive areas. When topical treatments are insufficient, systemic therapies such as phototherapy or immunosuppressants like cyclosporine may be considered. A newly approved biologic therapy, dupilumab, offers targeted treatment by blocking IL-4 and IL-13 signaling. Complementary treatments like bleach baths may help reduce bacterial colonization, and probiotics during pregnancy and breastfeeding have shown promise in reducing the frequency of AD in children. Additionally, crisaborole, a topical PDE-4 inhibitor, has been approved for mild to moderate cases, further expanding treatment options.
""Moderate to Severe Atopic Dermatitis- Pipeline Insight, 2025"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Moderate to Severe Atopic Dermatitis pipeline landscape is provided which includes the disease overview and Moderate to Severe Atopic Dermatitis treatment guidelines. The assessment part of the report embraces, in depth Moderate to Severe Atopic Dermatitis commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Moderate to Severe Atopic Dermatitis collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
This segment of the Moderate to Severe Atopic Dermatitis report encloses its detailed analysis of various drugs in different stages of clinical development, including Phase III, II, I, Preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Moderate to Severe Atopic Dermatitis Emerging Drugs
Further product details are provided in the report……..
Moderate to Severe Atopic Dermatitis: Therapeutic Assessment
This segment of the report provides insights about the different Moderate to Severe Atopic Dermatitis drugs segregated based on following parameters that define the scope of the report, such as:
Moderate to Severe Atopic Dermatitis: Pipeline Development Activities
The report provides insights into different therapeutic candidates in Phase III, II, I, preclinical and discovery stage. It also analyses Moderate to Severe Atopic Dermatitis therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Moderate to Severe Atopic Dermatitis drugs.
Moderate to Severe Atopic Dermatitis Report Insights
Current Treatment Scenario and Emerging Therapies:
Geography Covered
- Global coverage
Moderate to Severe Atopic Dermatitis: Overview
Atopic dermatitis (AD) is the most common chronic inflammatory skin disorder, typically beginning in infancy, characterized by dry skin, eczematous lesions, and lichenification. This condition is often associated with other IgE-mediated disorders such as allergic rhinitis, asthma, and food allergies. The prevalence of AD has been increasing over the past few decades, and it carries a significant morbidity burden. Moderate to severe AD is marked by recurrent flare-ups, leading to symptoms like intense itching, rashes, thickened or discolored skin, and raised bumps. For those with severe AD, nocturnal scratching can disrupt sleep and impact daily functioning, further exacerbating the condition. The emotional and psychological impact of AD is also significant, as patients often experience anxiety, depression, and social stigma due to the visible nature of their symptoms. Effective management requires a combination of skincare routines, medications, and sometimes lifestyle modifications to control flare-ups and improve quality of life.
Moderate to severe atopic dermatitis (AD) has a complex etiology involving both genetic and environmental factors that lead to abnormalities in the skin barrier and immune system. It is part of the atopic triad, which includes allergic rhinoconjunctivitis and asthma, and often follows the ""atopic march,"" where symptoms develop sequentially. Genetic mutations, particularly in filaggrin, a protein crucial for skin hydration, are found in many AD patients and may also predispose them to other atopic conditions. Environmental triggers, such as food allergies (e.g., eggs, milk, peanuts) and smoking, can exacerbate symptoms, making management more challenging. These factors collectively contribute to the chronic and often debilitating nature of moderate to severe AD.
Moderate to severe atopic dermatitis is characterized by a range of distressing symptoms, including intense itching, redness (which may appear purple, brown, or ashen gray in people of color), and dry, flaky, or scaly skin. Affected skin may crack, swell, and become open or oozing, with crusting often forming on the surface. These symptoms can persist daily and are particularly severe in individuals with full-body eczema, where the entire body is affected. Additionally, people may experience flare-ups in specific areas such as the face, eyelids, lips, ears, neck, scalp, hands, arms, elbows, feet, legs, behind the knees, and ankles. The skin is often extremely sensitive, further exacerbating discomfort and impairing quality of life.
The treatment and management of moderate to severe atopic dermatitis involve a comprehensive approach, including trigger avoidance, daily skin care, anti-inflammatory therapy, and complementary modalities. Daily skin care focuses on applying emollients twice a day, ideally within three minutes of bathing, to prevent dryness. Topical steroids are the first-line treatment for acute flare-ups, while nonsteroidal agents like calcineurin inhibitors are used for sensitive areas. When topical treatments are insufficient, systemic therapies such as phototherapy or immunosuppressants like cyclosporine may be considered. A newly approved biologic therapy, dupilumab, offers targeted treatment by blocking IL-4 and IL-13 signaling. Complementary treatments like bleach baths may help reduce bacterial colonization, and probiotics during pregnancy and breastfeeding have shown promise in reducing the frequency of AD in children. Additionally, crisaborole, a topical PDE-4 inhibitor, has been approved for mild to moderate cases, further expanding treatment options.
""Moderate to Severe Atopic Dermatitis- Pipeline Insight, 2025"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Moderate to Severe Atopic Dermatitis pipeline landscape is provided which includes the disease overview and Moderate to Severe Atopic Dermatitis treatment guidelines. The assessment part of the report embraces, in depth Moderate to Severe Atopic Dermatitis commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Moderate to Severe Atopic Dermatitis collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Moderate to Severe Atopic Dermatitis R&D. The therapies under development are focused on novel approaches to treat/improve Moderate to Severe Atopic Dermatitis.
This segment of the Moderate to Severe Atopic Dermatitis report encloses its detailed analysis of various drugs in different stages of clinical development, including Phase III, II, I, Preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Moderate to Severe Atopic Dermatitis Emerging Drugs
- VC005: Jiangsu vcare pharmaceutical technology co., LTD
- TQH2722: Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.
- Rezpegaldesleukin: Nektar Therapeutics
- QY201: E-nitiate Biopharmaceuticals (Hangzhou) Co., Ltd.
- Soquelitinib: Corvus Pharmaceuticals, Inc.
Further product details are provided in the report……..
Moderate to Severe Atopic Dermatitis: Therapeutic Assessment
This segment of the report provides insights about the different Moderate to Severe Atopic Dermatitis drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in Moderate to Severe Atopic Dermatitis
- There are approx. 45+ key companies which are developing the therapies for Moderate to Severe Atopic Dermatitis. The companies which have their Moderate to Severe Atopic Dermatitis drug candidates in the most advanced stage, i.e. Phase III include, Jiangsu vcare pharmaceutical technology co., LTD.
- Phases
- Late stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage product (Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Oral
- Intravenous
- Subcutaneous
- Parenteral
- Topical
- Molecule Type
- Recombinant fusion proteins
- Small molecule
- Monoclonal antibody
- Peptide
- Polymer
- Gene therapy
- Product Type
Moderate to Severe Atopic Dermatitis: Pipeline Development Activities
The report provides insights into different therapeutic candidates in Phase III, II, I, preclinical and discovery stage. It also analyses Moderate to Severe Atopic Dermatitis therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Moderate to Severe Atopic Dermatitis drugs.
Moderate to Severe Atopic Dermatitis Report Insights
- Moderate to Severe Atopic Dermatitis Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Moderate to Severe Atopic Dermatitis drugs?
- How many Moderate to Severe Atopic Dermatitis drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Moderate to Severe Atopic Dermatitis?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Moderate to Severe Atopic Dermatitis therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Moderate to Severe Atopic Dermatitis and their status?
- What are the key designations that have been granted to the emerging drugs?
- Jiangsu vcare pharmaceutical technology co., LTD
- Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.
- Nektar Therapeutics
- E-nitiate Biopharmaceuticals (Hangzhou) Co., Ltd.
- Corvus Pharmaceuticals, Inc.
- UCB Biopharma SRL
- Tavotek Biotherapeutics
- Guangdong Hengrui Pharmaceutical Co., Ltd
- SCM Lifescience Co., LTD.
- Sanofi
- Amgen
- Qurient Co., Ltd.
- Sun Pharmaceutical Industries Limited
- Pfizer
- UNION therapeutics
- Bio-Thera Solutions
- medac GmbH
- Eli Lilly and Company
- AbbVie
- Lynk Pharmaceuticals Co., Ltd
- LEO Pharma
- Guangzhou JOYO Pharma Co., Ltd
- Beijing InnoCare Pharma Tech Co., Ltd.
- Oneness Biotech Co., Ltd.
- Evommune, Inc.
- VC005
- TQH2722
- Rezpegaldesleukin
- QY201
- Soquelitinib
- UCB9741
- TAVO101
- SHR-1819
- SCM-AGH
- SAR444656
- Rocatinlimab
- Q301
- SCD-044
- PF-07832837
- Orismilast
- BAT6026
- Methotrexate
- LY3454738
- Lutikizumab
- LNK01001
- LEO 138559
- JYP0061
- ICP-332
- FB825
- EVO301
Table of Contents
80 Pages
- Table of Contents
- Introduction
- Executive Summary
- Moderate to Severe Atopic Dermatitis: Overview
- Introduction
- Causes
- Pathophysiology
- Signs and Symptoms
- Diagnosis
- Treatment
- Pipeline Therapeutics
- Comparative Analysis
- Therapeutic Assessment
- Assessment by Product Type
- Assessment by Stage and Product Type
- Assessment by Route of Administration
- Assessment by Stage and Route of Administration
- Assessment by Molecule Type
- Assessment by Stage and Molecule Type
- Moderate to Severe Atopic Dermatitis– DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Comparative Analysis
- VC005: Jiangsu vcare pharmaceutical technology co., LTD
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- Comparative Analysis
- Rezpegaldesleukin: Nektar Therapeutics
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- Comparative Analysis
- Soquelitinib: Corvus Pharmaceuticals, Inc.
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Preclinical and Discovery Stage Products
- Comparative Analysis
- Drug Name: Company Name
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Inactive Products
- Comparative Analysis
- Moderate to Severe Atopic Dermatitis Key Companies
- Moderate to Severe Atopic Dermatitis Key Products
- Moderate to Severe Atopic Dermatitis- Unmet Needs
- Moderate to Severe Atopic Dermatitis- Market Drivers and Barriers
- Moderate to Severe Atopic Dermatitis- Future Perspectives and Conclusion
- Moderate to Severe Atopic Dermatitis Analyst Views
- Moderate to Severe Atopic Dermatitis Key Companies
- Appendix
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