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Dihydroorotate dehydrogenase inhibitors - Pipeline Insight, 2025

Publisher DelveInsight
Published Apr 01, 2025
Length 60 Pages
SKU # DEL19993342

Description

DelveInsight’s, “Dihydroorotate Dehydrogenase (DHODH) Inhibitor - Pipeline Insight, 2025” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Dihydroorotate Dehydrogenase (DHODH) Inhibitor pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
  • Global coverage
Dihydroorotate Dehydrogenase (DHODH) Inhibitor Understanding

Dihydroorotate Dehydrogenase (DHODH) Inhibitor: Overview

Dihydroorotate dehydrogenase (DHODH), a novel enzyme, involved in the biosynthesis of uridine. Dihydroorotate dehydrogenases are grouped into Class 1 and Class 2, according to sequence similarity, subcellular location and substrate preference. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane (IMM). DHODH enzyme is proven to play an active role in cancer and immunological disorders such as acute myeloid leukemia, RA, multiple sclerosis. Inhibitors of DHODH block the synthesis of pyrimidine-based nucleotides and are known to potentially possess wide applications as chemotherapeutic agents. Suppression of the DHODH enzyme in humans is a proven treatment method for immune disorders, especially cancer, RA (Leflunomide) and multiple sclerosis (Teriflunomide). There are a number of clinical trials underway for COVID19 treatment using DHODH inhibitors.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence Dihydroorotate Dehydrogenase (DHODH) Inhibitor R&D. The therapies under development are focused on novel approaches for Dihydroorotate Dehydrogenase (DHODH) Inhibitor.
Dihydroorotate Dehydrogenase (DHODH) Inhibitor Emerging Drugs Chapters

This segment of the Dihydroorotate Dehydrogenase (DHODH) Inhibitor report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Dihydroorotate Dehydrogenase (DHODH) Inhibitor Emerging Drugs
  • IMU-838: Immunic
IMU-838 is a small molecule, oral tablet formulation based investigational drug that inhibits dihydroorotate dehydrogenase (DHODH) enzyme. IMU-838 is under clinical development for the treatment of relapsing-remitting multiple sclerosis, or RRMS, inflammatory bowel disease, or IBD, and other chronic inflammatory and autoimmune diseases. The drug is in Phase II/III clinical evaluation for the treatment of COVID 2019 infections.
  • PTC 299: PTC Therapeutics
Emvododstat (formerly PTC 299) is an oral, small molecule tablet that inhibits the cellular enzyme DHODH. The drug is in Phase II/III clinical studies for COVID 2019 infections and in Phase I for Acute myeloid leukaemia.

Further product details are provided in the report……..

Dihydroorotate Dehydrogenase (DHODH) Inhibitor: Therapeutic Assessment

This segment of the report provides insights about the different Dihydroorotate Dehydrogenase (DHODH) Inhibitor drugs segregated based on following parameters that define the scope of the report, such as:
  • Major Players working on Dihydroorotate Dehydrogenase (DHODH) Inhibitor
There are approx. 10+ key companies which are developing the Dihydroorotate Dehydrogenase (DHODH) Inhibitor. The companies which have their Dihydroorotate Dehydrogenase (DHODH) Inhibitor drug candidates in the most advanced stage, i.e. Phase II/III include, Immunic
  • Phases
DelveInsight’s report covers around 10+ products under different phases of clinical development like
  • Late-stage products (Phase III and
  • Mid-stage products (Phase II and
  • Early-stage products (Phase I/II and Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration
Dihydroorotate Dehydrogenase (DHODH) Inhibitor pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
  • Infusion
  • Intradermal
  • Intramuscular
  • Intranasal
  • Intravaginal
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical
  • Molecule Type
Products have been categorized under various Molecule types such as
  • Vaccines
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Product Type
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Dihydroorotate Dehydrogenase (DHODH) Inhibitor: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Dihydroorotate Dehydrogenase (DHODH) Inhibitor therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Dihydroorotate Dehydrogenase (DHODH) Inhibitor drugs.

Dihydroorotate Dehydrogenase (DHODH) Inhibitor Report Insights
  • Dihydroorotate Dehydrogenase (DHODH) Inhibitor Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs
Dihydroorotate Dehydrogenase (DHODH) Inhibitor Report Assessment
  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs
Key Questions

Current Scenario and Emerging Therapies:
  • How many companies are developing Dihydroorotate Dehydrogenase (DHODH) Inhibitor drugs?
  • How many Dihydroorotate Dehydrogenase (DHODH) Inhibitor drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for Dihydroorotate Dehydrogenase (DHODH) Inhibitor?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Dihydroorotate Dehydrogenase (DHODH) Inhibitor therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Dihydroorotate Dehydrogenase (DHODH) Inhibitor and their status?
  • What are the key designations that have been granted to the emerging drugs?
Key Players
  • Sanofi
  • Immunic
  • PTC Therapeutics
  • Clear Creek Bio
  • EyeGate Pharma
  • ASLAN Pharmaceuticals
  • Medicines for Malaria Venture
Key Products
  • Teriflunomide
  • IMU-838
  • Emvododstat
  • Olorofim
  • Brequinar
  • PP 001 EyeGate Pharma
  • ASLAN-003
  • MMV-1793609

Table of Contents

60 Pages
Introduction
Executive Summary
Dihydroorotate Dehydrogenase (DHODH) Inhibitor: Overview
Structure
Mechanism of Action
Pipeline Therapeutics
Comparative Analysis
Therapeutic Assessment
Assessment by Product Type
Assessment by Stage and Product Type
Assessment by Route of Administration
Assessment by Stage and Route of Administration
Dihydroorotate Dehydrogenase (DHODH) Inhibitor – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Dihydroorotate Dehydrogenase (DHODH) Inhibitor companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Dihydroorotate Dehydrogenase (DHODH) Inhibitor Collaboration Deals
Company-Company Collaborations (Licensing / Partnering) Analysis
Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
Comparative Analysis
Drug name: Company name
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Mid Stage Products (Phase II/III)
Comparative Analysis
IMU-838: Immunic
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Early Stage Products (Phase I/II)
Comparative Analysis
PP 001: EyeGate Pharma
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
Comparative Analysis
MMV-1793609: Medicines for Malaria Venture
Product Description
Research and Development
Product Development Activities
Drug profiles in the detailed report…..
Inactive Products
Comparative Analysis
Dihydroorotate Dehydrogenase (DHODH) Inhibitor Key Companies
Dihydroorotate Dehydrogenase (DHODH) Inhibitor Key Products
Dihydroorotate Dehydrogenase (DHODH) Inhibitor- Unmet Needs
Dihydroorotate Dehydrogenase (DHODH) Inhibitor- Market Drivers and Barriers
Dihydroorotate Dehydrogenase (DHODH) Inhibitor- Future Perspectives and Conclusion
Dihydroorotate Dehydrogenase (DHODH) Inhibitor Analyst Views
Dihydroorotate Dehydrogenase (DHODH) Inhibitor Key Companies
Appendix

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