Sickle cell disease (SCD) is a group of inherited red blood cell disorders, in which the red blood cells of the individuals become sticky and almost ‘C’ or curved in the shape and therefore the disease is known as sickle cell disease. The sickle cell diseases include sickle cell anemia, sickle cell beta- thalassemia, sickle Hemoglobin C Disease, and others. The various symptoms associated with the sickle cell diseases include anemia, episodes of pain, swelling of hands and feet, and others. Major side effects of hydroxyurea on the long-term treatment in patients suffering from sickle cell disease are gastrointestinal effects such as gastric distress, gastritis, mucositis, and oral mucosa ulcer, dermatological effects such as painful skin ulcers, aphthous ulcers, non-ulcerative toxicity with erythema, and skin infiltration, it can also decrease sperm count and sperm motility in males and can even cause severe interstitial pneumonia. The treatment of the sickle cell disease includes medications and blood transfusions. In some cases of the children and teenagers, a stem cell transplant might also cure the disease.
Market Dynamics
The increasing product approvals by key players for the treatment of sickle cell disease is expected to drive the growth of the North America sickle cell disease market over the forecast period. For instance, in May 2021, Chiesi Farmaceutici S.p.A., a pharmaceutical company, announced that the company had received the U.S. Food Drug and Administration approval for FERRIPROX (deferiprone) indicated for the treatment of transfusional iron overload due to sickle cell disease (SCD) and anemia in pediatric patients of three years old or older and adults.
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