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Next-generation Sequencing: Emerging Clinical Applications and Global Markets

Next-generation Sequencing: Emerging Clinical Applications and Global Markets

Report Highlights
The global clinical next-generation sequencing (NGS) market reached $2.7 billion in 2016. This market is expected to grow at a compound annual growth rate (CAGR) of 27%, from nearly $3.2 billion in 2017 to $10.5 billion by 2022.

Report Includes
An overview of the global market for next-generation sequencing and its emerging clinical applications.
Analyses of global market trends, with data from 2016, estimates for 2017, and projections of compound annual growth rates (CAGRs) through 2022.
Examination of the sequencing industry structure for key market segments.
Discussion covering the strategies employed by the main companies in the market.
Comprehensive company profiles of major players in the field.

Report Scope
The scope of the report includes clinical NGS technologies, applications, industries, initiatives, patents and companies. The markets for NGS-based diagnostics are given for the years 2015, 2016, 2017 and 2022.

This report reviews the main sequencing technologies and explains why genetic variation is important in clinical testing. It then discusses some of the significant research initiatives that impact clinical NGS applications. The main market driving forces are also discussed.

The report examines the markets by test complexity, clinical indication and test purpose. Test complexity refers to the plex level (i.e., the number of genetic markers that can be analyzed within a sample) and coverage (e.g., the extent to which the genome is covered) of the test. Examining the market by test complexity provides valuable insight into which products (e.g., sample preparation, NGS instrument, informatics, etc.) will be in demand in the future.

The report provides market data and forecasts for NGS diagnostics by specific applications, including those for cancer, cardiovascular diseases, clinical microbiology and infectious diseases, Mendelian disorders, metabolic and immune disorders, neurological disorders, reproductive health, and transplant medicine.

Specific geographic markets are discussed, including North America, Europe, Asia-Pacific, and the rest of the world.

Industry sectors analyzed include sequencing instruments, target enrichment, informatics, clinical laboratory testing services, reproductive health diagnostics, liquid biopsy, immune sequencing, HLA typing, third generation sequencing, and direct to consumer.

More than 200 companies in the clinical NGS industry are profiled in this report.

BCC Research provides a summary of the main industry acquisitions and strategic alliances from 2015 through April 2017, including key alliance trends.


Chapter 1: Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Analyst's Credentials
Related BCC Research Reports
Chapter 2: Summary and Highlights
Chapter 3: Overview
Introduction
Clinical NGS Markets
Clinical NGS Growth Driving Forces
Technology Drivers
Market Drivers
Clinical NGS Applications
Clinical NGS Industry
Chapter 4: Technology Background
Importance of DNA
Genetic Variation and Analysis
Genetic Analysis Technologies
Sequencing in Clinical Applications
Sequencing Technologies
History of DNA Sequencing
Sanger Sequencing Technology
Next-Generation Sequencing Platforms
Benchtop Sequencers
Informatics Technologies
Base Calling
Mapping to a Reference Sequence
Variant Analysis
Clinical Sequencing Technology Challenges
Chapter 5: Clinical NGS Initiatives
Clinical Next-Generation Sequencing Projects
Actionable Genome Consortium
BabySeq
Cancer Moon Shoots Program
China Precision Medicine Initiative
ClinGen
France Genomic Medicine Plan
Lung-Map
Matchmaker Exchange
MedSeq
Metagenomics and Metadesign of Subways and Urban Biomes (MetaSub)
Microbiome Coalition
Million Veteran Program
National Microbiome Initiative
Precision Medicine
Prompt
Chapter 6: Clinical NGS Applications
Introduction
Cancer Applications
Mendelian Disorders Applications
Reproductive Health Applications
Microbiology and Infectious Disease Applications
Complex Disorders Applications
Chapter 7: Clinical NGS Industry
Introduction
NGS Instrument Industry
Target Enrichment and Amplification Industry
NGS Clinical Informatics Industry
NGS Testing Services Industry
Reproductive Health Diagnostics Industry
NonInvasive Prenatal Testing Industry
Fetal Cell NIPT Industry
Liquid Biopsy Industry
Immune Sequencing Industry
HLA Typing Industry
Third-Generation Sequencing Industry
Tier 1 Companies
Tier 2 Companies
Tier 3 Companies
Direct-to-Consumer Genetic Testing Industry
Chapter 8: Acquisitions and Strategic Alliances
Acquisitions
Strategic Alliances
2015 Alliances
2016 Alliances
2017 Alliances
Chapter 9: Clinical NGS Markets
Growth Driving Forces
Clinical Sequencing Market
Clinical NGS Cancer Market
NGS Cardiology Diagnostics Markets
NGS Mendelian Disorders Diagnostics Markets
NGS Metabolic/Immune Disorder Diagnostics Markets
NGS Neurology Diagnostics Markets
Reproductive Health Markets
NIPT Market
IVF Market
Newborn Screening Market
Carrier Screening Market
NGS Microbiology and Infectious Disease Diagnostic Market
Transplant Market
Geographical Market
Chapter 10: Patent Review
Clinical NGS Patents
Clinical NGS Patents by Indication
Cell-free DNA Patents
Sequencing-Related Patent Issues
Chapter 11: Company Profiles
About BCC Research
About BCC Research
BCC Membership
BCC Custom Research
List of Tables
Table 1 Summary Table: Global Clinical Next-Generation Sequencing Market, by Disease Class, Through 2022 ($ Millions)
Table 2 Report Scope
Table 3 Global Next-Generation Sequencing Diagnostic Market, by Disease Type, Through 2022 ($ Millions)
Table 4 Key Technology Drivers for Clinical Next-Generation Sequencing
Table 5 Clinical Next-Generation Sequencing Market Driving Forces
Table 6 Clinical Next-Generation Sequencing Application Status
Table 7 Key Diagnostic Next-Generation Industry Participants by Sector
Table 8 DNA Chemical Building Blocks
Table 9 DNA Translation and Transcription
Table 10 Long-range DNA Structure
Table 11 Genetic Variant Types
Table 12 Molecular Diagnostic Technology Platforms
Table 13 Genetic Testing Evolution
Table 14 Key Near- to Mid-term Segments for Next-Generation Sequencing Diagnostics
Table 15 DNA Sequencing Historical Timeline
Table 16 Sequencing Technology Development, 1990-2020
Table 17 Cost to Sequence a Single Human Genome, 2001-2017 ($)
Table 18 Sanger Sequencing Summary
Table 19 Sanger Sequencing Improvements
Table 20 Next-Generation Sequencing Technologies
Table 21 Roche Next-Generation Sequencing Workflow
Table 22 Illumina Next-Generation Sequencing Workflow
Table 23 Thermo Fisher Next-Generation Sequencing Workflow
Table 24 Benchtop and Handheld Sequencer Platforms
Table 25 Next-Generation Sequencing Bioinformatics Workflow
Table 26 Sequence Annotation Steps
Table 27 Future Challenges for Implementing Clinical Next-Generation Sequencing
Table 28 Clinical Next-Generation Sequencing Projects
Table 29 Clinical Next-Generation Sequencing Near- to Mid-term Applications
Table 30 Cancer Applications
Table 31 Mendelian Disorders Applications
Table 32 Reproductive Health Screening Applications
Table 33 Ethical Issues Associated with Prenatal and Newborn Screening
Table 34 Microbiology and Infectious Disease Applications
Table 35 Complex Disorder Applications
Table 36 Key Segments within the Next-Generation Sequencing Clinical Industry
Table 37 Next-Generation Sequencing Instrument Company Summary
Table 38 Target Enrichment Industry
Table 39 Next-Generation Sequencing Clinical Informatics Company Positioning
Table 40 Selected NGS Clinical Testing Laboratories
Table 41 NGS NIPT Industry
Table 42 Number of Tests and Market for NIPT, by Region and Company, 2015 (Number of Tests Performed)
Table 43 Germany NGS-based Non-invasive Prenatal Diagnostic Companies
Table 44 Fetal Cell NIPT Industry
Table 45 Liquid Biopsy Company Focus
Table 46 Example of NGS-based Liquid Biopsy Market Differentiation
Table 47 Immune System Profiling Industry
Table 48 NGS-based HLA Typing Industry Competitors
Table 49 Third-Generation Sequencing Industry
Table 50 Key Competitors in the Direct-to-Consumer Genetic Testing Industry
Table 51 Clinical Next-Generation Sequencing Industry Acquisitions, January 2015- April 2017
Table 52 Clinical Next-Generation Sequencing Strategic Alliances, January 2015- April 2017
Table 53 Clinical Next-Generation Sequencing Key Market Growth Driving Forces
Table 54 Global Clinical Sequencing Market, by Indication, Through 2022 ($ Millions)
Table 55 Global Clinical NGS Market, by Test Complexity, Through 2022 ($ Millions)
Table 56 Global Clinical NGS Market, by Test Purpose, Through 2022 ($ Millions)
Table 57 NGS-based Preventive Genetic Screening Tests
Table 58 Global Clinical NGS Cancer Market, by Indication, Through 2022 ($ Millions)
Table 59 Global Clinical NGS Cancer Market, by Test Purpose, Through 2022 ($ Millions)
Table 60 Early Cancer Detection
Table 61 NGS Instrument Company Companion Diagnostics Status
Table 62 Global Clinical NGS Cancer Market, by Test Complexity, Through 2022 ($ Millions)
Table 63 Global Clinical NGS Cardiology Diagnostic Market, by Test Purpose, Through 2022 ($ Millions)
Table 64 Dilated Cardiomyopathy Test Providers
Table 65 Global Clinical NGS Cardiology Diagnostic Market, by Test Complexity, Through 2022 ($ Millions)
Table 66 Global Clinical NGS Mendelian Disorder Diagnostic Market, by Test Purpose, Through 2022 ($ Millions)
Table 67 Global Clinical NGS Mendelian Disorder Diagnostic Market, by Test Complexity, Through 2022 ($ Millions)
Table 68 Global Clinical NGS Metabolic and Immune Disorder Diagnostic Market, by Test Purpose, Through 2022 ($ Millions)
Table 69 Multiple Sclerosis Diagnostic Technologies
Table 70 Global Clinical NGS Metabolic and Immune Disorder Diagnostic Market, by Test Complexity, Through 2022 ($ Millions)
Table 71 Global Clinical NGS Neurology Diagnostic Market, by Test Purpose, Through 2022 ($ Millions)
Table 72 Global Clinical NGS Neurology Diagnostic Market, by Test Complexity, Through 2022 ($ Millions)
Table 73 Global Reproductive Health Market, by Application, Through 2022 ($ Millions)
Table 74 Global NIPT Market, by Risk Type, Through 2022 ($ Millions)
Table 75 Global Clinical NGS Reproductive Health Market, by Test Complexity, Through 2022 ($ Millions)
Table 76 NGS-based Infectious Disease Landscape
Table 77 Global Clinical NGS Microbiology and Infectious Disease Diagnostic Market, by Test Purpose, Through 2022 ($ Millions)
Table 78 Global Clinical NGS Microbiology and Infectious Disease Diagnostic Market, by Test Complexity, Through 2022 ($ Millions)
Table 79 NGS in Infectious Disease Diagnostics
Table 80 Global Clinical NGS Transplant Market, by Analysis Purpose, Through 2022 ($ Millions)
Table 81 Global Clinical NGS Transplant Market, by Test Complexity, Through 2022 ($ Millions)
Table 82 Global Clinical NGS Transplant Monitoring Market, by Organ Type, Through 2022 ($ Millions)
Table 83 Transplant Procedures Performed in the United States, 2015 and 2016
Table 84 Global Clinical NGS Market, by Region, Through 2022 ($ Millions)
Table 85 Global Clinical NGS Cancer Market, by Region, Through 2022 ($ Millions)
Table 86 Global Reproductive Health Market, by Region, Through 2022 ($ Millions)
Table 87 Global Transplant Market, by Region, Through 2022 ($ Millions)
Table 88 Clinical Next-Generation Sequencing Patents, 2005-2015
Table 89 Clinical Next-Generation Sequencing Patents by Indication, 2005-2015
Table 90 Cell-free DNA Patents, 2005-2015
Table 91 Status of Sequencing-Related Patent Disputes
Table 92 Data Needs
Table 93 Companies in the Epigenetic Sequencing Industry
Table 94 Molecular Thyroid Nodule Classifier Test Company Positioning
Table 95 Sensitivity to Detect Drug Resistant Mutations in Viruses (%)
Table 96 WaferGen Strategic Alliances
List of Figures
Figure 1 Summary Figure: Global Clinical Next-Generation Sequencing Market, by Disease Class, 2015-2022 ($ Millions)

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