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RNA Sequencing: Technologies and Global Markets

RNA Sequencing: Technologies and Global Markets

The global RNA-Sequencing market should reach nearly $2.1 billion in 2020, from over $1.0 billion in 2015 registering a compound annual growth rate (CAGR) of 14.9%.

This report provides:
An overview of the global markets for RNA sequencing and related technologies.
Analyses of global market trends, with data from 2015, estimates for 2016, and projections of CAGRs through 2020.
Analysis of RNA sequencing clinical application initiatives.
Evaluation of collaboration and merger and acquisition activity.
A look at the regulatory environment and its effect on the market.
Analyses of the market's dynamics, specifically growth drivers, restraints, and opportunities.
Identification of patents with the potential to make an impact in the RNA sequencing industry.
Profiles of major players in the industry.


SCOPE AND FORMAT

The geographic scope is global. The RNA-Seq market is complex, consisting of a number of different segments. The market segments are: RNA-Seq instruments; RNA-Seq tools and reagents; RNA-Seq data analysis and RNA-Seq services. Each segment is affected differently by technological and regulatory developments. This report identifies the main factors affecting each segment and forecasts market growth, future trends and product development in every major market segment. Market forecasts are given for the years 2015, 2016 and 2020.

The report is organized by presenting the core segment (sequencing instruments) first, followed by its derivative segments (tools and reagents, data analysis, services). The development of sequencing instruments is vital for RNA-Seq development; thus sequencing instruments segment is classified as the core segment. However, it does not suggest that the derivative segments are not important. In fact, the RNA-Seq instruments segment is neither the biggest nor the fastest growing among the four segments. The instruments segment, however, provides the infrastructure for the health and growth of the RNA-Seq market as a whole.

CHAPTER 1 INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
INTENDED AUDIENCE
SCOPE AND FORMAT
METHODOLOGY AND INFORMATION SOURCES
ANALYST'S CREDENTIALS
RELATED BCC RESEARCH REPORTS
BCC RESEARCH WEBSITE
DISCLAIMER
CHAPTER 2 SUMMARY
SUMMARY TABLE GLOBAL RNA-SEQ MARKET BY SEGMENT, THROUGH 2020 ($MILLIONS)
SUMMARY FIGURE GLOBAL RNA-SEQ MARKET TRENDS BY SEGMENT, 2014-2020 ($MILLIONS)
CHAPTER 3 INTRODUCTION ON RNA-SEQ
TRANSCRIPTOMICS
TABLE 1 TYPES OF RNAS IN CELLS
TABLE 2 TRANSCRIPTOMICS INSIGHTS
TECHNOLOGIES FOR TRANSCRIPTOMICS
FIGURE 1 COST OF SEQUENCING ONE RAW MEGABASE OF DNA
FIGURE 2 COST OF SEQUENCING ONE HUMAN GENOME
RNA-SEQ FOR TRANSCRIPTOMICS
TABLE 3 COMPARISON OF TRANSCRIPTOMICS METHODS
RNA-SEQ EXPERIMENT
FIGURE 3 GENERIC RNA-SEQ EXPERIMENT WORKFLOW
EXPERIMENTAL DESIGN
FIGURE 4 RNA-SEQ EXPERIMENTS FOR TRANSCRIPTOMICS
Establish the Primary Experimental Objective
TABLE 4 RNA-SEQ ANNOTATION/DGE OPTIONS
Replication, Depth and Complexity of the Experiment
RNA SAMPLE PREPARATION
LIBRARY PREPARATION
TABLE 5 FUNCTIONAL ELEMENTS IN SEQUENCING ADAPTERS
HIGH-THROUGHPUT SEQUENCING
Choosing a Sequencing Platform
DATA ANALYSIS
CHALLENGES FOR RNA-SEQ
LIBRARY CONSTRUCTION CHALLENGES
TABLE 6 FRAGMENTATION METHODS AND BIAS
BIOINFORMATIC CHALLENGES
COST VERSUS COVERAGE CHALLENGES
RNA-SEQ INSIGHTS AND APPLICATIONS
MAPPING GENE AND EXON BOUNDARIES
EXTENSIVE TRANSCRIPT COMPLEXITY
NOVEL TRANSCRIPTION
DEFINING TRANSCRIPTION LEVEL
FUTURE DIRECTION
CHAPTER 4 RNA-SEQUENCING INSTRUMENTS
OVERVIEW
SEQUENCING TECHNOLOGIES FOR RNA-SEQ
NOTABLE RNA-SEQ PLATFORMS
TABLE 7 ILLUMINA SEQUENCING INSTRUMENTS
TABLE 8 THERMO FISHER SEQUENCING INSTRUMENTS
TABLE 9 ROCHE SEQUENCING INSTRUMENTS
TABLE 10 PACBIO SEQUENCING INSTRUMENTS
SEQUENCING PLATFORMS TO WATCH
TABLE 11 SIGNIFICANT PLAYERS IN SEQUENCING MARKET
TECHNOLOGY AND RNA-SEQ ON ILLUMINA PLATFORMS
SBS SEQUENCING TECHNOLOGY
Cluster Generation
Sequencing by Synthesis
SEQUENCING WORKFLOW
TABLE 12 WORKFLOW STEPS FOR SEQUENCING SYSTEM
RNA-SEQ APPLICATIONS ON ILLUMINA SEQUENCING PLATFORMS
TABLE 13 RNA-SEQ APPLICATIONS ON ILLUMINA PLATFORMS
mRNA-Seq on Illumina Instruments
TABLE 14 MRNA-SEQ ON ILLUMINA PLATFORMS
Total RNA-Seq on Illumina Platforms
TABLE 15 TOTAL RNA-SEQ ON ILLUMINA PLATFORMS
Targeted RNA-Seq
TABLE 16 RECOMMENDED SETUP FOR TARGETED RNA-SEQ ON MISEQ PLATFORMS
Small RNA Sequencing
TABLE 17 SMALL RNA-SEQ ON ILLUMINA PLATFORMS
Ribosome Profiling
TABLE 18 RIBOSOMAL PROFILING ON ILLUMINA PLATFORMS
Ultra-Low-Input and Single-Cell RNA-Seq
Low-Quality and FFPE RNA-Seq
TECHNOLOGIES AND RNA-SEQ ON THERMO FISHER PLATFORMS
SANGER SEQUENCING
ION TORRENT TECHNOLOGY
Library Construction
Template Prep or Amplification
Sequencing
Data Analysis
RNA-SEQ ON ION TORRENT PLATFORMS
TABLE 19 RNA-SEQ APPLICATIONS ON ION SYSTEMS
SOLID SEQUENCING PLATFORM
TABLE 20 SOLID 5500 SEQUENCING PLATFORM PERFORMANCES
SOLiD Total RNA-Seq, Small RNA-Seq and miRNA Profiling
FIGURE 5 SOLID RNA-SEQ WORKFLOW
TECHNOLOGIES AND RNA-SEQ ON PACBIO PLATFORMS
SMRT TECHNOLOGY
RNA-SEQ APPLICATIONS ON PACBIO PLATFORMS
TABLE 21 PACBIO RNA-SEQ APPLICATIONS
Human/Plant/Animal RNA-Seq
TABLE 22 PACBIO RNA-SEQ WORKFLOW
RNA-SEQ APPLICATIONS ON 454 PLATFORMS
FIGURE 6 454'S DNA SEQUENCER MECHANISM
CDNA RAPID LIBRARY PREP
LOW-INPUT RNA SAMPLES
TABLE 23 WORKFLOW FOR 454 SEQUENCER
OTHER COMMERCIAL SEQUENCING PLATFORMS
BGI (COMPLETE GENOMICS)
GENEPSYS
OXFORD NANOPORE
QIAGEN (INTELLIGENT BIOSYSTEMS)
NEW SEQUENCING TECHNOLOGIES AND RNA-SEQ APPLICATIONS
GENIA
BASE4 AND HITACHI
GNUBIO/BIO-RAD
NABSYS
STRATOS GENOMICS
TWO PORE GUYS
MARKET SHARE OF EACH PLATFORM
TABLE 24 HIGH-THROUGHPUT INSTRUMENT COMPETITORS BY INSTALLED INSTRUMENT BASE, AS OF DECEMBER 2015 (NUMBER/%)
TABLE 25 BENCHTOP INSTRUMENT COMPETITORS BY INSTALLED INSTRUMENT BASE, AS OF DECEMBER 2015 (NUMBER/%)
RNA-SEQ INSTRUMENT MARKET PROJECTION
TABLE 26 GLOBAL MARKET FOR INSTRUMENTS USED IN DNA SEQUENCING AND RNA-SEQUENCING, THROUGH 2020 ($ MILLIONS)
MARKET TRENDS
TABLE 27 REQUIREMENTS FOR RNA-SEQ ON SEQUENCING PLATFORMS
CHAPTER 5 RNA-SEQ TOOLS AND REAGENTS
OVERVIEW
MARKET LANDSCAPE
RNA-SEQ AUTOMATION
TABLE 28 NOTABLE LIQUID HANDLING PLATFORMS FOR RNA-SEQ AUTOMATION
TABLE 29 RNA SAMPLE AND LIBRARY PREPARATION PLATFORMS
NEOPREP FROM ILLUMINA
REM E SYSTEM FROM ROCHE
ION TORRENT ION CHEF SYSTEM FROM THERMO FISHER
SOLID EZ BEAD SYSTEM FROM THERMO FISHER
C1 SYSTEM FROM FLUIDIGM
QIACUBE FROM QIAGEN
RNA-SEQ SAMPLE PREPARATION
RNA SAMPLE ISOLATION AND PURIFICATION
TABLE 30 LEADING PRODUCTS PRESERVING RNA EXPRESSION PROFILE
TABLE 31 LEADING COMMERCIAL EXTRACTION OR PURIFICATION KITS
RNA CONCENTRATION AND PURITY DETERMINATION
TABLE 32 RNA QUANTIFICATION INSTRUMENT
RNA SAMPLE QUALITY CONTROL
TABLE 33 RNA INTEGRITY MEASURING INSTRUMENT
Agilent 2100 Bioanalyzer
QIAxcel Advanced System
RNA DEPLETION OR ENRICHMENT
RRNA DEPLETION
TABLE 34 RRNA DELETION KITS
RiboMinus Technology from Thermo Fisher
NEBNext rRNA Depletion Kit (Human/Mouse/Rat) from NEB
GeneRead rRNA Depletion Kits from Qiagen
Ribo-Zero rRNA Removal Kit from Illumina
RiboGone from Clontech
MRNA ENRICHMENT
TABLE 35 MRNA ENRICHMENT KITS
MagJET mRNA Enrichment Kit from Thermo Fisher
Dynabeads from Thermo Fisher
Ambion Poly(A)Purist MAG Kit from Thermo Fisher
SideStep mRNA Enrichment Kit from Agilent
GeneRead Pure mRNA Kit from Qiagen
RNA-SEQ LIBRARY PREPARATION
RNA-SEQ LIBRARY PREP KITS FROM ILLUMINA
TABLE 36 RNA-SEQ KITS FOR ILLUMINA PLATFORM
RNA-SEQ LIBRARY PREP PRODUCTS FROM THERMO FISHER
TABLE 37 THERMO FISHER RNA-SEQ PRODUCTS FOR ION TORRENT
TABLE 38 THERMO FISHER’S RNA-SEQ LIBRARY PREP KITS FOR SOLID
RNA-SEQ LIBRARY PREP KITS FROM ROCHE 454
TABLE 39 RNA-SEQ LIBRARY PREP KITS FROM 454
RNA-SEQ LIBRARY PREP KITS FROM PACBIO PLATFORM
TABLE 40 PACBIO'S RNA-SEQ REAGENTS PRODUCTS
RNA-SEQ PRODUCTS FROM NEW ENGLAND BIOLABS
TABLE 41 RNA-SEQ PRODUCTS FROM NEW ENGLAND BIOLABS
RNA-SEQ LIBRARY PREPARATION PRODUCTS FROM KAPA BIOSYSTEMS
TABLE 42 RNA-SEQ KITS FROM KAPA BIOSYSTEMS
RNA-SEQ PRODUCTS FROM CLONTECH (TAKARA)
TABLE 43 RNA-SEQ PRODUCTS FROM CLONTECH
RNA-SEQ PRODUCTS FROM AGILENT
RNA-SEQ PRODUCTS FROM QIAGEN
RNA-SEQ REAGENTS FROM NIMBLEGEN (ROCHE)
TABLE 44 RNA-SEQ REAGENTS FROM NIMBLEGEN
MARKET ANALYSIS
TABLE 45 AVERAGE CONSUMABLE COST OF RUNNING SEQUENCING MACHINES
TABLE 46 GLOBAL MARKET FOR DNA-SEQ AND RNA-SEQ CONSUMABLES, THROUGH 2020 ($ MILLIONS)
CHAPTER 6 RNA-SEQ DATA ANALYSIS
OVERVIEW
FIGURE 7 NEXT-GENERATION SEQUENCING DATA ANALYSIS
RNA-SEQ DATA ANALYSIS CHALLENGES
DATA SOLUTION
ALIGNMENT AND ANNOTATION
DATA ANALYSIS FOR LONG-READ SEQUENCERS
RNA-SEQ DATA CLOUD SERVICES
TABLE 47 CLOUD COMPUTING PROVIDERS FOR GENOMICS/RNA-SEQ
STAND-ALONE TOOLS FOR RNA-SEQ DATA ANALYSIS
TABLE 48 STAND-ALONE RNA-SEQ DATA ANALYSIS TOOLS
RNA-SEQ DATA ANALYSIS ON ILLUMINA PLATFORMS
BASESPACE
TABLE 49 BASESPACE NOTABLE RNA-SEQ APPS
RNA-SEQ DATA ANALYSIS ON OTHER PLATFORMS
RNA-SEQ DATA ANALYSIS ON ION TORRENT PLATFORMS
RNA-SEQ DATA ANALYSIS ON SOLID PLATFORMS
RNA-SEQ DATA ANALYSIS ON 454 PLATFORMS
RNA-SEQ DATA ANALYSIS ON PACBIO PLATFORMS
RNA-SEQ DATA ANALYSIS MARKET ANALYSIS
TABLE 50 GLOBAL MARKET FOR RNA-SEQ DATA ANALYSIS, THROUGH 2020 ($MILLIONS)
CHAPTER 7 RNA-SEQ SERVICE MARKET
OVERVIEW
PLATFORM-SPECIFIC CERTIFIED SERVICE PROVIDERS
ILLUMINA CERTIFIED SERVICE PROVIDERS (CSPRO)
TABLE 51 ILLUMINA CERTIFIED SERVICE PROVIDERS (CSPRO) NORTH AMERICA, AS OF NOVEMBER 2015
TABLE 52 ILLUMINA CERTIFIED SERVICE PROVIDERS (CSPRO) EUROPE, AS OF NOVEMBER 2015
TABLE 53 ILLUMINA CERTIFIED SERVICE PROVIDERS (CSPRO) ASIA-PACIFIC, AS OF NOVEMBER 2015
ION TORRENT CERTIFIED SERVICE PROVIDER PROGRAM
TABLE 54 ION TORRENT CERTIFIED SERVICE PROVIDERS, AS OF NOVEMBER 2015
SOLID NEXT-GENERATION SEQUENCING ANALYSIS SERVICES
TABLE 55 SOLID SEQUENCING SERVICE PROVIDERS, AS OF NOVEMBER 2015
NIMBLEGEN CERTIFIED SERVICE PROVIDERS ON 454 PLATFORMS
TABLE 56 ROCHE SEQUENCING EFFORTS
TABLE 57 NIMBLEGEN CERTIFIED SERVICE PROVIDERS
PACIFIC BIOSCIENCES (PACBIO) CERTIFIED SERVICE PROVIDERS
TABLE 58 PACBIO CERTIFIED SERVICE PROVIDERS, AS OF NOVEMBER 2015
TABLE 59 ADDITIONAL SERVICE PROVIDERS ON PACBIO PLATFORMS, AS OF
NOVEMBER 2015
AGILENT'S CERTIFIED SERVICE PROVIDERS-TARGET ENRICHMENT
TABLE 60 AGILENT CERTIFIED SERVICE PROVIDERS, AS OF NOVEMBER 2015
NON-CERTIFIED SERVICE PROVIDERS
TABLE 61 NON-CERTIFIED RNA-SEQ PROVIDERS, AS OF NOVEMBER 2015
TABLE 62 NON-CERTIFIED, NON-PROFIT SEQUENCING SERVICE PROVIDERS, AS OF NOVEMBER 2015
TABLE 63 NON-CERTIFIED, COMMERCIAL SEQUENCING SERVICE PROVIDERS, AS OF NOVEMBER 2015
NOTABLE SERVICE PROVIDERS
TABLE 64 SEQUENCING SERVICE PROVIDERS CERTIFIED BY MULTIPLE PROGRAMS, AS OF NOVEMBER 2015
AMBRY GENETICS
BASECLEAR
BECKMAN COULTER GENOMICS
BGI
CEGAT
DNA LINK
DNAVISION
EXIQON A/S
EXPRESSION ANALYSIS (Q2 SOLUTIONS)
FASTERIS
GATC
GENEWIZ
INTEGRAGEN
PERKINELMER INC
SEQLL
SEQWRIGHT (NOW GE HEALTHCARE)
MARKET ANALYSIS
TABLE 65 GLOBAL MARKET FOR RNA-SEQ RESEARCH SERVICES, THROUGH 2020 ($ MILLIONS)
CHAPTER 8 COMPANY PROFILES
AGILENT TECHNOLOGIES INC.
AMAZON.COM INC.
BGI
BIO-RAD
DNANEXUS INC.
GENERAL ELECTRIC COMPANY
ILLUMINA INC.
NEW ENGLAND BIOLAB INC.
OXFORD NANOPORE TEHNOLOGIES LTD.
PACIFIC BIOSCIENCES OF CALIFORNIA INC.
QIAGEN NV
ROCHE HOLDING AG
TAKARA BIO INC.
THERMO FISHER SCIENTIFIC INC.
CHAPTER 9 COMPANIES MENTIONED IN THE REPORT
ACGT INC.
ADVANCED GENOMICS
AFFILIATED GENETICS INC.
AGRESEARCH LIMITED
AGYSIS BIOLABS
AITBIOTECH
ALACRIS
ALPHABIOLABS
ALTHEA DX
AMBRY GENETICS
AMPLICON EXPRESS
AMRESCO
APPLIED BIOLOGICAL MATERIAL INC.
AROS APPLIED BIOTECHNOLOGY A/S
ARRAYXPRESS INC.
ASURAGEN INC.
BIORELIANCE
CD GENOMICS
CEGAT GMBH
CENTOGENE AG
CHUNLAB INC.
CLARITAS GENOMICS
CLC BIO
CLINICAL GENOMICS
CLONTECH LABORATORIES INC.
COFACTOR GENOMICS
COGENTECH
CREATIVE GENOMICS
CUROVERSE
CYPHER GENOMICS
DECODE GENETICS
DELTAGENE MOLECULAR DIAGNOSTIC
DENA LIFE SCIENCE INC.
DNA ANALYSIS LLC.
DNA LINK INC.
DNANEXUS
DNAVISION
EAGLE GENOMICS
EDGEBIO
ELIM BIOPHARMACEUTICALS
ENSIGNA BIOSYSTEMS INC.
EPICENTRE
EPOCH LIFE SCIENCE
EPPENDORF
ERA7 BIOINFORMATICS
EUREKA GENOMICS
EUROFINS MWG OPERON
EXIQON
EXPRESSION ANALYSIS
FASTERIS SA
FAVORGEN BIOTECH COMPANY
FIRST BASE LABORATORIES
FLUIDIGM
FUNCTIONAL BIOSCIENCES
GATC BIOTECH AG
GE HEALTHCARE
GENAPSYS
GENE DX
GENEAID BIOTECH
GENEBLITZ
GENECHRON
GENERGY BIOTECHNOLOGY
GENES DIFFUSION
GENESEEK
GENESTACK
GENETIC VISIONS INC.
GENETICLAB CO. LTD.
GENEWIZ INC.
GENIA TECHNOLOGIES
GENOMA
GOOGLE GENOME CLOUD
GENOME INTERNATIONAL CORP.
GENOMED
GENOSPACE
GENOTECH CORP.
GEOSPIZA
GIRIHLET INC.
GLOBUS GENOMICS
GNUBIO
HAMILTON ROBOTICS
HOKKAIDO SYSTEM SCIENCE CO., LTD
IGA TECHNOLOGY SERVICES SRL
ILLUMINA
IMGM LABORATORIES GMBH
INGENUITY
INQABA BIOTEC
INTEGRAGEN
INTELLIGENT BIO-SYSTEM
KAPA BIOSYSTEMS
KEYGENE
LAB FELLOWS INC.
LABCORP CLINICAL TRIALS
LARAGEN
LC SCIENCES
LGC GENOMICS
LI-COR BIOSCIENCES
LIFESEQUENCING SL
LOFSTRAND LABS
LONE STAR LABS INC.
LUCIGEN CORP.
MACROGEN
MCLAB
MICROSYNTH AG
MOGENE, LC
NABSYS
NEW ENGLAND BIOLABS
NIMBLEGEN
NIMGENETICS
NORGEN BIOTEK CORP
OMEGA BIOSERVICES
OMICIA
ONECODEX
OTOGENETICS CORP.
OXFORD NANOPORE TECHNOLOGIES
PACIFIC BIOSCIENCES
PARTEK
PERSONALIS
PROMEGA
QIAGEN
RETROGEN
RIKENGENESIS CO. LTD.
RNASSIST
ROCHE SEQUENCING
SELAH GENOMICS
SEQLL INC.
SEQMATIC
SEQUENCEBASE
SEQUENSYS
SEQUETECH
SEQUISERVE
SEQXCEL
SERVICEXS B.V.
SEVEN BRIDGES GENOMICS
SHIMADZU
SIGMA-ALDRICH
SINOGENOMAX CO. LTD.
SISTEMAS GENOMICOS
SNP GENETICS INC.
SOLVEBIO
SOLVIAS
SORENSON GENOMICS
SOURCE BIOSCIENCE
SPIRAL GENETICS
STARSEQ
STRAND NGS
STRATOS GENOMICS
SYAPSE
SYNERGENE BIOTECH GMBH
SYNTHETIC GENOMICS
SYSTEM BIOSCIENCES
TAKARA BIO INC.
TAUERET LABORATORIES
TECAN
TEPNEL PHARMACEUTICAL SERVICES
THERMO FISHER SCIENTIFIC
TRAITGENETICSGMBH
TUTE GENOMICS
TWO PORE GUYS
VBC-BIOTECH
VIA GENETICS
WAFERGEN
WUXI APPTEC
WUXI NEXTCODE
YORKSHIRE BIOSCIENCE
YOURGENE BIOSCIENCE
ZOETIS GENETICS
ZS GENETICS
ZYMO RESEARCH

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