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Cell-based Assays: Technologies and Global Markets

Cell-based Assays: Technologies and Global Markets

Report Scope:

This report is an update of an earlier report of the same title. It reviews global markets and new developments for cell-based assays and forecasts trends for the use of these assays for drug discovery, safety and toxicology through 2023. The report includes details of important assays, technologies and the latest developments and outlines market shares by assay type and company, with a special emphasis on the U.S. market. Statistical information on the prevalence of types of cancers worldwide is also included.

The report also details current issues and trends affecting the industry, as well as costs and factors that have an impact on demand. It covers products in development, new technologies, trends, and alliances and mergers. The report offers market data by segment and region and discusses market trends with respect to drivers, restraints and opportunities.

Report Includes:

- 23 data tables and 48 additional tables
- Detailed overview of the global market for cell-based assays within the industry
- Analyses of global market trends with data from 2017, estimates for 2018, and projections of compound annual growth rates (CAGRs) through 2023
- Details of important assays, technologies and the latest developments and outlines market shares by assay type and company, with a special emphasis on the U.S. market
- Regional dynamics of cell-based assays covering North America, Europe and other emerging economies
- Examination of the cell-based assays available and currently being used, new developments, spending trends, and revenue prospects for cell-based assays in the pharmaceutical industry
- Discussion of current issues and trends affecting the industry, as well as costs and factors that have an impact on demand
- Coverage of major issues involved in the research and development (R&D) of more effective cell-based approaches for drug discovery
- Company profiles of major players in the industry including Beckman Coulter, DiscoverX, PerkinElmer, Life Technologies and Promega Corp.


Chapter 1 Introduction
Study Goals and Objectives
Reasons for Doing This Study
Scope of the Report
Intended Audience
Methodology
Geographic Breakdown
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports
Chapter 2 Summary and Highlights
Chapter 3 Overview
Introduction
Drug Discovery
High-content Screening
Data Analysis
Overview: Cell-based Assay
Tools for Drug Discovery
High-content Screening
Cell-based Screening
Proliferation Assays
Proof of Concept for Cell-based Assays
Cell-based Assays and Technology Trends
Advancements in Cell-based Assays
Novel Cell-based Assay Using Organoids, Scaffolds/Hydrogels and Organs-on-a-Chip
Spheroids for Drug Development
Label-free Cell-based Assay Technology Using Biolayer Interferometry
Lineage Sequencing for Mutational Analysis and Cancer-based Studies
Evaluation of Hantavirus Replication Using In-cell Western Assay
Quantitative Cell-based Assay Using a High-content Analysis Platform
High-throughput Single-cell Transcriptome Sequencing
Ex Vivo Chemosensitivity Assays for Individualized Cancer Chemotherapy
G Protein-coupled Receptors
Luciferase-based High-throughput Screening Assay
Functionally Relevant Morphological Profiling for Mesenchymal Stromal Cells
Chapter 4 Assays for Drug Discovery
Cell-based Approaches for ADME/Tox Screening
Market Opportunities
ADME and Toxicity Screening
Multiplexed Cell-based Assays
High-throughput Imaging-based Platform for Cell-based Assays
Cell Assays in Today's Drug Discovery Process
Label-free Cellular Assays: The Relevant Future of Drug Discovery
Conclusion
Chapter 5 Cell-based Assays: Current Technologies
Factors in Cell-based Assay Development
Reporter Gene Technology
Cell-based Assays for Studying Protein-Protein Interactions
Cell-based Protein-fragment Complementation Assays
Measuring Calcium Signaling
Cell-based Label-free Approaches
Automation and Miniaturization
Cell Patterning
Cell-based Assays and Physiological Relevance
Cell-based Assays and Multiplexing
Developing Reporter Assays
Reporter Assays and Multiplexing
Ultrahigh-throughput Screening
Development of the PathHunter Assay
High-content Screening Technology
Imaging Cells for Cell-based Assays
Microscopic Visualization of Cells
Quantum Dots
Label-free Imaging
Investigational New Studies in Drug Development
Role of ADME in Drug Design
Prodrug Strategies
Molecular Modeling
Summary
Limitations of Cell-based Assays in the Risk Assessment Process
Bottlenecks in Cell-based Screening
Methods to Improve Throughput in Cell-based Assays
New Technologies
DataChip
BIND Technology
Miniaturization of Biological Assays
Microfluidic Cell Culture Systems for Drug Research
Conclusion
Chapter 6 Commercialization of Cell-based Assays
Role of Cell-based Assays
Drug Discovery and Cell-based Assays
Opportunities for Market Adoption
Measuring Cell Proliferation
Companies Offering Cell Proliferation Assays
Move Toward Therapies with Stem and Immune Cells
Cell-based Screening Assays
Orphan Receptors
Summary
Chapter 7 Global Cell-based Assay and Instrumentation Market
Current Market Overview
Cell-based Assays
Cell-based Assay Market
Market Dynamics
Market Drivers
Cell-based Assays for Preclinical Development
Cell Biology Reagents
High-throughput Screening
Advantages of HTS Assays
Major Drivers
Drug Discovery Technology Market
Market for Life Sciences Tools and Reagents
Cell Culture Market
Cell Culture Reagent Market
Global Market for Cell Culture Reagents
Three-dimensional Cell Culture Market
Cell-based Assay Market Growth
Market Demand
Cell-based Assays: Basic Research
Market for Cellular Assays in Basic Research
Cell Proliferation Fluorescence Assay
In Vitro Toxicity Testing
In Vitro Skin Irritation Testing
ADME and Toxicology Market
In Vitro Predictive Toxicology
Cell-based Assays for Drug Discovery
ADME Toxicology Testing Market
DiscoverX
ADME Tools and Technologies
ADME Studies for FDA Submissions
Market Players
New Developments
In Vitro Inflammation Models
Multiplex Assays for GPCR Signaling
Types of Cell-based Assays
HCS Market Drivers
High-Content Screening Kits
High-Content Screening Instrumentation Market
Flow Cytometers
Label-free Detection Market
Microplate Instrumentation and Supplies
Challenges of Cell-based Assays
Future of Cell-based Assays
Cell-based Assays for Research Purposes
G Protein-Coupled Receptors
GPCRs: A Potent Class of Drug Targets
GPCR Drugs
Developments
Cell-based Assays: Screening Ion Channels
Label-free Detection
Companies
Thermo Fisher
CellSensor
LanthaScreen
Molecular Devices
Conclusion
Chapter 8 Global Markets
Global Market Overview
Global Market for Cell-based Assays
Cell-based Assays in Leading Emerging Markets
Summary
North American Market
U.S. Market
European Market
Drug Discovery in Emerging Economies
Drug Discovery in India and China
Advances in Cell-based Assays
Contract Research Organizations and Cell-based Assays
Outlook
Chapter 9 Company Profiles
ACEA BIOSCIENCES
BD BIOSCIENCES
BECKMAN COULTER
CELLULAR DYNAMICS INTERNATIONAL
CALIPER LIFE SCIENCES
CELSIS IN VITRO TECHNOLOGIES (CELSIS IVT)
CISBIO BIOASSAYS
DISCOVERX CORP.
EMD MILLIPORE
ENZO LIFE SCIENCES
ENDONOVO THERAPEUTICS
EVOTEC AG
GE HEALTHCARE
HEMOGENIX
LIFE TECHNOLOGIES
LONZA
MOLECULAR DEVICES (DANAHER)
ONCOLMMUNIN
ORIGENE TECHNOLOGIES
PERKINELMER
PROMEGA CORP.
ROCHE GROUP
STEMCELLS INC.
THERMO FISHER SCIENTIFIC
TTP LABTECH
VIVO BIOSCIENCES
VITRO BIOPHARMA
Chapter 10 Legal Aspects of Cell-based Assays
Intellectual Property Landscape for Cell-based Assays
Recent News, Alliances and Mergers
Summary and Outlook
Chapter 11 Appendix: Bibliography
List of Tables
Summary Table : Global Market for Cell-based Assays, by Segment, Through 2023
Table 1 : Estimated U.S. Medical and Health Research Expenditures and Percentage of Total Spending at Academic and Research Institutions
Table 2 : Uses of Cell-based Assays by Area
Table 3 : Types of Cell-based Assays
Table 4 : Apoptotic Markers
Table 5 : Proof of Concept for Cell-based Assays
Table 6 : Global Market for Cell-based Assays, Through 2023
Table 7 : Materials and Manufacturers of Hydrogels, by Type
Table 8 : Minimum Requirements for Organ-on-a-Chip Units, by Type
Table 9 : HCS Instrumentation Available in the Market, by Company
Table 10 : HCS Informatics Tools Available in the Market, by Application
Table 11 : Selected High-throughput Instruments Available in the Market
Table 12 : Biological Assay Systems for the Evaluation of Cytochrome P450 Enzyme Isoforms
Table 13 : Types of Hepatocyte Assay Systems
Table 14 : Types of ADME Assays
Table 15 : Common Types of Toxicity Assays
Table 16 : Traditional Methods of ADME/Tox Testing
Table 17 : Conventional In vitro ADME/Tox Screening Methods
Table 18 : Applications of Label-free Assays
Table 19 : Factors for Cell-based Assay Development
Table 20 : Approaches to Cell-based Systems for Drug Screening
Table 21 : List of Current Confocal HCS Platforms
Table 22 : Widefield HCS Platforms, by Type
Table 23 : List of Studies for Filing an Investigational New Drug Application
Table 24 : List of Studies for Clinical Filings
Table 25 : List of Existing Cell-based Assay Technologies
Table 26 : Biological Applications for High-Content Analysis
Table 27 : Global Market for Cell Biology Reagents and Tools, Through 2023
Table 28 : Global Market for High-throughput Screening, Through 2023
Table 29 : Key Companies for High-throughput Screening Technologies
Table 30 : Global Market for Drug Discovery Technologies, Through 2023
Table 31 : Key Companies for Drug Discovery Technologies
Table 32 : Global Market for Tools and Reagents Used in Life Sciences Research, Through 2023
Table 33 : Global Market for Cell Culture, Through 2023
Table 34 : Cell Culture Reagent Types
Table 35 : Global Market for Cell Culture Reagents, Through 2023
Table 36 : U.S. Market for Cell Culture, Through 2023
Table 37 : Global Market for 3D Cell Culture, Through 2023
Table 38 : 3D Cell Culture Technologies
Table 39 : Key Companies in Cell-based Assays
Table 40 : Cell-based Assay Market Segments
Table 41 : Global Market for Cell-based Assays, Through 2023
Table 42 : Limitations of Cell-based Assays
Table 43 : Global Market for Cell-based Assays Used in Basic Research, Through 2023
Table 44 : Areas Using In Vitro Toxicology Testing
Table 45 : Global Market for 3D Cell Culture, Through 2023
Table 46 : Global Market for Specialized Cell-based Assays Used in Drug Discovery, Through 2023
Table 47 : In Vitro Predictive Toxicology Assays
Table 48 : 3D Microtissue and Spheroid Models
Table 49 : Global Market for ADME Assays, Through 2023
Table 50 : List of Key Companies in ADME Assays
Table 51 : Major Companies in the High-Content Screening Market
Table 52 : Products Offered by Molecular Devices
Table 53 : High-content Screening System Platforms
Table 54 : Millipore Product Applications
Table 55 : Global Market for High-Content Screening Instruments, Through 2023
Table 56 : Key Flow Cytometry Companies
Table 57 : Assay Methods Used to Study GPCRs
Table 58 : GPCR Primary Screening Assays
Table 59 : Key GPCR Targeting Drugs
Table 60 : Key Companies with GPCR Products
Table 61 : Omeros' GPCRs and Their Indications
Table 62 : Thermo Fisher's Products
Table 63 : Thermo Fisher's Cell-based Technologies
Table 64 : Key Growth Drivers of the Cell-based Assay Market
Table 65 : Global Market for Cell-based Assays, by Region, Through 2023
Table 66 : North American Market for Cell-based Assays, Through 2023
Table 67 : U.S. Market for Cell-based Assays, Through 2023
Table 68 : European Market for Cell-based Assays, Through 2023
Table 69 : Chinese Market for Drug Discovery Outsourcing, Through 2023
Table 70 : Indian Market for Drug Discovery Products, Through 2023
List of Figures
Summary Figure : Global Market for Cell-based Assays, by Segment, 2017-2023
Figure 1 : Projected Global Aging Population (60 Years and Above), 1990-2100
Figure 2 : Drug Discovery Process Steps
Figure 3 : Global Market for Cell-based Assays, 2017-2023
Figure 4 : Process Flow for Patient-derived Organoid Cell Assay
Figure 5 : Basic Architecture of Organ-on-a-Chip Systems
Figure 6 : Shares of Approved Drugs with Unique GPCRs, 2017
Figure 7 : Cell Viability and Kinase Assays Used to Measure Change in ATP Levels
Figure 8 : Shares of Common Diseases Registered for Mesenchymal Stromal Cell-based Therapy, 2016
Figure 9 : Global Market for Cell Biology Reagents and Tools, 2017-2023
Figure 10 : Global Market for Drug Discovery Technologies, 2017-2023
Figure 11 : Global Market for Tools and Reagents Used in Life Sciences Research, 2017-2023
Figure 12 : Global Market for Cell Culture, 2017-2023
Figure 13 : Global Market for Cell Culture Reagents, 2017-2023
Figure 14 : U.S. Market for Cell Culture, 2017-2023
Figure 15 : Global Market for 3D Cell Culture, 2017-2023
Figure 16 : Global Market for Cell-based Assays, 2017-2023
Figure 17 : Global Market for Cell-based Assays Used in Basic Research, 2017-2023
Figure 18 : Global Market for 3D Cell Culture, 2017-2023
Figure 19 : Global Market for Specialized Cell-based Assays Used in Drug Discovery, 2017-2023
Figure 20 : Phase Transition Success Rates and Likelihood of Approval from Phase I for all Diseases, all Modalities, 2005-2016
Figure 21 : Global Market for ADME Assays, 2017-2023
Figure 22 : Global Market for High-Content Screening Instruments, 2017-2023
Figure 23 : Global Market for Cell-based Assays, by Region, 2017-2023
Figure 24 : North American Market for Cell-based Assays, 2017-2023
Figure 25 : U.S. Market for Cell-based Assays, 2017-2023
Figure 26 : European Market for Cell-based Assays, 2017-2023
Figure 27 : Chinese Market for Drug Discovery Outsourcing, 2017-2023
Figure 28 : Indian Market for Drug Discovery Products, 2017-2023

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