
Neuromyelitis Optica Drug Industry Research Report 2025
Description
Summary
Neuromyelitis optica (NMO) is an uncommon disease syndrome of the central nervous system (CNS) that affects the optic nerves and spinal cord. Individuals with NMO develop optic neuritis, which causes pain in the eye and vision loss, and transverse myelitis, which causes weakness, numbness, and sometimes paralysis of the arms and legs, along with sensory disturbances and loss of bladder and bowel control. NMO leads to loss of myelin, which is a fatty substance that surrounds nerve fibers and helps nerve signals, move from cell to cell. The syndrome can also damage nerve fibers and leave areas of broken-down tissue. In the disease process of NMO, for reasons that aren't yet clear, immune system cells and antibodies attack and destroy myelin cells in the optic nerves and the spinal cord.
Neuromyelitis optica drug is drug used in the treatment of neuromyelitis optica, in this report we focused on Glucocorticoids such as Methylprednisolone and Immunoglobulin such as IVIg.
According to APO Research, The global Neuromyelitis Optica Drug market was valued at US$ million in 2024 and is anticipated to reach US$ million by 2031, witnessing a CAGR of xx% during the forecast period 2025-2031.
North American market for Neuromyelitis Optica Drug is estimated to increase from $ million in 2025 to reach $ million by 2031, at a CAGR of % during the forecast period of 2025 through 2031.
Asia-Pacific market for Neuromyelitis Optica Drug is estimated to increase from $ million in 2025 to reach $ million by 2031, at a CAGR of % during the forecast period of 2025 through 2031.
Europe market for Neuromyelitis Optica Drug is estimated to increase from $ million in 2025 to reach $ million by 2031, at a CAGR of % during the forecast period of 2025 through 2031.
The major global companies of Neuromyelitis Optica Drug include Pfizer, Fresenius, Teva, Sandoz, Intas, Gyjtrs, NANG KUANG, Tianjin Kingyork and Baxter, etc. In 2024, the world's top three vendors accounted for approximately % of the revenue.
Report Scope
This report aims to provide a comprehensive presentation of the global market for Neuromyelitis Optica Drug, with both quantitative and qualitative analysis, to help readers develop business/growth strategies, assess the market competitive situation, analyze their position in the current marketplace, and make informed business decisions regarding Neuromyelitis Optica Drug.
The Neuromyelitis Optica Drug market size, estimations, and forecasts are provided in terms of revenue ($ millions), considering 2024 as the base year, with history and forecast data for the period from 2020 to 2031. This report segments the global Neuromyelitis Optica Drug market comprehensively. Regional market sizes, concerning products by Type, by Application, and by players, are also provided. For a more in-depth understanding of the market, the report provides profiles of the competitive landscape, key competitors, and their respective market ranks. The report also discusses technological trends and new product developments.
Key Companies & Market Share Insights
In this section, the readers will gain an understanding of the key players competing. This report has studied the key growth strategies, such as innovative trends and developments, intensification of product portfolio, mergers and acquisitions, collaborations, new product innovation, and geographical expansion, undertaken by these participants to maintain their presence. Apart from business strategies, the study includes current developments and key financials. The readers will also get access to the data related to global revenue, price, and sales by manufacturers for the period 2020-2025. This all-inclusive report will certainly serve the clients to stay updated and make effective decisions in their businesses.
Neuromyelitis Optica Drug Segment by Company
Pfizer
Fresenius
Teva
Sandoz
Intas
Gyjtrs
NANG KUANG
Tianjin Kingyork
Baxter
CSL
Grifols
Octapharma
CBOP
Neuromyelitis Optica Drug Segment by Type
Glucocorticoids
Immunotherapies
Others
Neuromyelitis Optica Drug Segment by Application
Acute Attack
Remission Prophylactic Treatment
Neuromyelitis Optica Drug Segment by Application
Acute Attack
Remission Prophylactic Treatment
Neuromyelitis Optica Drug Segment by Region
North America
United States
Canada
Mexico
Europe
Germany
France
U.K.
Italy
Spain
Russia
Netherlands
Nordic Countries
Asia-Pacific
China
Japan
South Korea
India
Australia
Taiwan
Southeast Asia
South America
Brazil
Argentina
Chile
Middle East & Africa
Saudi Arabia
Israel
United Arab Emirates
Turkey
Iran
Egypt
Key Drivers & Barriers
High-impact rendering factors and drivers have been studied in this report to aid the readers to understand the general development. Moreover, the report includes restraints and challenges that may act as stumbling blocks on the way of the players. This will assist the users to be attentive and make informed decisions related to business. Specialists have also laid their focus on the upcoming business prospects.
Reasons to Buy This Report
1. This report will help the readers to understand the competition within the industries and strategies for the competitive environment to enhance the potential profit. The report also focuses on the competitive landscape of the global Neuromyelitis Optica Drug market, and introduces in detail the market share, industry ranking, competitor ecosystem, market performance, new product development, operation situation, expansion, and acquisition. etc. of the main players, which helps the readers to identify the main competitors and deeply understand the competition pattern of the market.
2. This report will help stakeholders to understand the global industry status and trends of Neuromyelitis Optica Drug and provides them with information on key market drivers, restraints, challenges, and opportunities.
3. This report will help stakeholders to understand competitors better and gain more insights to strengthen their position in their businesses. The competitive landscape section includes the market share and rank (in volume and value), competitor ecosystem, new product development, expansion, and acquisition.
4. This report stays updated with novel technology integration, features, and the latest developments in the market
5. This report helps stakeholders to gain insights into which regions to target globally
6. This report helps stakeholders to gain insights into the end-user perception concerning the adoption of Neuromyelitis Optica Drug.
7. This report helps stakeholders to identify some of the key players in the market and understand their valuable contribution.
Chapter Outline
Chapter 1: Research objectives, research methods, data sources, data cross-validation;
Chapter 2: Introduces the report scope of the report, executive summary of different market segments (product type, application, etc), including the market size of each market segment, future development potential, and so on. It offers a high-level view of the current state of the market and its likely evolution in the short to mid-term, and long term.
Chapter 3: Provides the analysis of various market segments product types, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different market segments.
Chapter 4: Provides the analysis of various market segments application, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.
Chapter 5: Introduces executive summary of global market size, regional market size, this section also introduces the market dynamics, latest developments of the market, the driving factors and restrictive factors of the market, the challenges and risks faced by companies in the industry, and the analysis of relevant policies in the industry.
Chapter 6: Detailed analysis of Neuromyelitis Optica Drug companies’ competitive landscape, revenue market share, latest development plan, merger, and acquisition information, etc.
Chapter 7, 8, 9, 10, 11: North America, Europe, Asia Pacific, South America, Middle East and Africa segment by country. It provides a quantitative analysis of the market size and development potential of each region and its main countries and introduces the market development, future development prospects, market space, and capacity of each country in the world.
Chapter 12: Provides profiles of key players, introducing the basic situation of the main companies in the market in detail, including revenue, gross margin, product introduction, recent development, etc.
Chapter 13: The main points and conclusions of the report.
Please Note: Single-User license will be delivered via PDF from the publisher without the rights to print or to edit.
Neuromyelitis optica (NMO) is an uncommon disease syndrome of the central nervous system (CNS) that affects the optic nerves and spinal cord. Individuals with NMO develop optic neuritis, which causes pain in the eye and vision loss, and transverse myelitis, which causes weakness, numbness, and sometimes paralysis of the arms and legs, along with sensory disturbances and loss of bladder and bowel control. NMO leads to loss of myelin, which is a fatty substance that surrounds nerve fibers and helps nerve signals, move from cell to cell. The syndrome can also damage nerve fibers and leave areas of broken-down tissue. In the disease process of NMO, for reasons that aren't yet clear, immune system cells and antibodies attack and destroy myelin cells in the optic nerves and the spinal cord.
Neuromyelitis optica drug is drug used in the treatment of neuromyelitis optica, in this report we focused on Glucocorticoids such as Methylprednisolone and Immunoglobulin such as IVIg.
According to APO Research, The global Neuromyelitis Optica Drug market was valued at US$ million in 2024 and is anticipated to reach US$ million by 2031, witnessing a CAGR of xx% during the forecast period 2025-2031.
North American market for Neuromyelitis Optica Drug is estimated to increase from $ million in 2025 to reach $ million by 2031, at a CAGR of % during the forecast period of 2025 through 2031.
Asia-Pacific market for Neuromyelitis Optica Drug is estimated to increase from $ million in 2025 to reach $ million by 2031, at a CAGR of % during the forecast period of 2025 through 2031.
Europe market for Neuromyelitis Optica Drug is estimated to increase from $ million in 2025 to reach $ million by 2031, at a CAGR of % during the forecast period of 2025 through 2031.
The major global companies of Neuromyelitis Optica Drug include Pfizer, Fresenius, Teva, Sandoz, Intas, Gyjtrs, NANG KUANG, Tianjin Kingyork and Baxter, etc. In 2024, the world's top three vendors accounted for approximately % of the revenue.
Report Scope
This report aims to provide a comprehensive presentation of the global market for Neuromyelitis Optica Drug, with both quantitative and qualitative analysis, to help readers develop business/growth strategies, assess the market competitive situation, analyze their position in the current marketplace, and make informed business decisions regarding Neuromyelitis Optica Drug.
The Neuromyelitis Optica Drug market size, estimations, and forecasts are provided in terms of revenue ($ millions), considering 2024 as the base year, with history and forecast data for the period from 2020 to 2031. This report segments the global Neuromyelitis Optica Drug market comprehensively. Regional market sizes, concerning products by Type, by Application, and by players, are also provided. For a more in-depth understanding of the market, the report provides profiles of the competitive landscape, key competitors, and their respective market ranks. The report also discusses technological trends and new product developments.
Key Companies & Market Share Insights
In this section, the readers will gain an understanding of the key players competing. This report has studied the key growth strategies, such as innovative trends and developments, intensification of product portfolio, mergers and acquisitions, collaborations, new product innovation, and geographical expansion, undertaken by these participants to maintain their presence. Apart from business strategies, the study includes current developments and key financials. The readers will also get access to the data related to global revenue, price, and sales by manufacturers for the period 2020-2025. This all-inclusive report will certainly serve the clients to stay updated and make effective decisions in their businesses.
Neuromyelitis Optica Drug Segment by Company
Pfizer
Fresenius
Teva
Sandoz
Intas
Gyjtrs
NANG KUANG
Tianjin Kingyork
Baxter
CSL
Grifols
Octapharma
CBOP
Neuromyelitis Optica Drug Segment by Type
Glucocorticoids
Immunotherapies
Others
Neuromyelitis Optica Drug Segment by Application
Acute Attack
Remission Prophylactic Treatment
Neuromyelitis Optica Drug Segment by Application
Acute Attack
Remission Prophylactic Treatment
Neuromyelitis Optica Drug Segment by Region
North America
United States
Canada
Mexico
Europe
Germany
France
U.K.
Italy
Spain
Russia
Netherlands
Nordic Countries
Asia-Pacific
China
Japan
South Korea
India
Australia
Taiwan
Southeast Asia
South America
Brazil
Argentina
Chile
Middle East & Africa
Saudi Arabia
Israel
United Arab Emirates
Turkey
Iran
Egypt
Key Drivers & Barriers
High-impact rendering factors and drivers have been studied in this report to aid the readers to understand the general development. Moreover, the report includes restraints and challenges that may act as stumbling blocks on the way of the players. This will assist the users to be attentive and make informed decisions related to business. Specialists have also laid their focus on the upcoming business prospects.
Reasons to Buy This Report
1. This report will help the readers to understand the competition within the industries and strategies for the competitive environment to enhance the potential profit. The report also focuses on the competitive landscape of the global Neuromyelitis Optica Drug market, and introduces in detail the market share, industry ranking, competitor ecosystem, market performance, new product development, operation situation, expansion, and acquisition. etc. of the main players, which helps the readers to identify the main competitors and deeply understand the competition pattern of the market.
2. This report will help stakeholders to understand the global industry status and trends of Neuromyelitis Optica Drug and provides them with information on key market drivers, restraints, challenges, and opportunities.
3. This report will help stakeholders to understand competitors better and gain more insights to strengthen their position in their businesses. The competitive landscape section includes the market share and rank (in volume and value), competitor ecosystem, new product development, expansion, and acquisition.
4. This report stays updated with novel technology integration, features, and the latest developments in the market
5. This report helps stakeholders to gain insights into which regions to target globally
6. This report helps stakeholders to gain insights into the end-user perception concerning the adoption of Neuromyelitis Optica Drug.
7. This report helps stakeholders to identify some of the key players in the market and understand their valuable contribution.
Chapter Outline
Chapter 1: Research objectives, research methods, data sources, data cross-validation;
Chapter 2: Introduces the report scope of the report, executive summary of different market segments (product type, application, etc), including the market size of each market segment, future development potential, and so on. It offers a high-level view of the current state of the market and its likely evolution in the short to mid-term, and long term.
Chapter 3: Provides the analysis of various market segments product types, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different market segments.
Chapter 4: Provides the analysis of various market segments application, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.
Chapter 5: Introduces executive summary of global market size, regional market size, this section also introduces the market dynamics, latest developments of the market, the driving factors and restrictive factors of the market, the challenges and risks faced by companies in the industry, and the analysis of relevant policies in the industry.
Chapter 6: Detailed analysis of Neuromyelitis Optica Drug companies’ competitive landscape, revenue market share, latest development plan, merger, and acquisition information, etc.
Chapter 7, 8, 9, 10, 11: North America, Europe, Asia Pacific, South America, Middle East and Africa segment by country. It provides a quantitative analysis of the market size and development potential of each region and its main countries and introduces the market development, future development prospects, market space, and capacity of each country in the world.
Chapter 12: Provides profiles of key players, introducing the basic situation of the main companies in the market in detail, including revenue, gross margin, product introduction, recent development, etc.
Chapter 13: The main points and conclusions of the report.
Please Note: Single-User license will be delivered via PDF from the publisher without the rights to print or to edit.
Table of Contents
146 Pages
- 1 Preface
- 1.1 Scope of Report
- 1.2 Reasons for Doing This Study
- 1.3 Research Methodology
- 1.4 Research Process
- 1.5 Data Source
- 1.5.1 Secondary Sources
- 1.5.2 Primary Sources
- 2 Market Overview
- 2.1 Product Definition
- 2.2 Neuromyelitis Optica Drug by Type
- 2.2.1 Market Value Comparison by Type (2020 VS 2024 VS 2031)
- 2.2.2 Glucocorticoids
- 2.2.3 Immunotherapies
- 2.2.4 Others
- 2.3 Neuromyelitis Optica Drug by Application
- 2.3.1 Market Value Comparison by Application (2020 VS 2024 VS 2031)
- 2.3.2 Acute Attack
- 2.3.3 Remission Prophylactic Treatment
- 2.4 Assumptions and Limitations
- 3 Neuromyelitis Optica Drug Breakdown Data by Type
- 3.1 Global Neuromyelitis Optica Drug Historic Market Size by Type (2020-2025)
- 3.2 Global Neuromyelitis Optica Drug Forecasted Market Size by Type (2026-2031)
- 4 Neuromyelitis Optica Drug Breakdown Data by Application
- 4.1 Global Neuromyelitis Optica Drug Historic Market Size by Application (2020-2025)
- 4.2 Global Neuromyelitis Optica Drug Forecasted Market Size by Application (2026-2031)
- 5 Global Growth Trends
- 5.1 Global Neuromyelitis Optica Drug Market Perspective (2020-2031)
- 5.2 Global Neuromyelitis Optica Drug Growth Trends by Region
- 5.2.1 Global Neuromyelitis Optica Drug Market Size by Region: 2020 VS 2024 VS 2031
- 5.2.2 Neuromyelitis Optica Drug Historic Market Size by Region (2020-2025)
- 5.2.3 Neuromyelitis Optica Drug Forecasted Market Size by Region (2026-2031)
- 5.3 Neuromyelitis Optica Drug Market Dynamics
- 5.3.1 Neuromyelitis Optica Drug Industry Trends
- 5.3.2 Neuromyelitis Optica Drug Market Drivers
- 5.3.3 Neuromyelitis Optica Drug Market Challenges
- 5.3.4 Neuromyelitis Optica Drug Market Restraints
- 6 Market Competitive Landscape by Players
- 6.1 Global Top Neuromyelitis Optica Drug Players by Revenue
- 6.1.1 Global Top Neuromyelitis Optica Drug Players by Revenue (2020-2025)
- 6.1.2 Global Neuromyelitis Optica Drug Revenue Market Share by Players (2020-2025)
- 6.2 Global Neuromyelitis Optica Drug Industry Players Ranking, 2023 VS 2024 VS 2025
- 6.3 Global Key Players of Neuromyelitis Optica Drug Head Office and Area Served
- 6.4 Global Neuromyelitis Optica Drug Players, Product Type & Application
- 6.5 Global Neuromyelitis Optica Drug Manufacturers Established Date
- 6.6 Global Neuromyelitis Optica Drug Market CR5 and HHI
- 6.7 Global Players Mergers & Acquisition
- 7 North America
- 7.1 North America Neuromyelitis Optica Drug Market Size (2020-2031)
- 7.2 North America Neuromyelitis Optica Drug Market Growth Rate by Country: 2020 VS 2024 VS 2031
- 7.3 North America Neuromyelitis Optica Drug Market Size by Country (2020-2025)
- 7.4 North America Neuromyelitis Optica Drug Market Size by Country (2026-2031)
- 7.5 United States
- 7.5 United States
- 7.6 Canada
- 7.7 Mexico
- 8 Europe
- 8.1 Europe Neuromyelitis Optica Drug Market Size (2020-2031)
- 8.2 Europe Neuromyelitis Optica Drug Market Growth Rate by Country: 2020 VS 2024 VS 2031
- 8.3 Europe Neuromyelitis Optica Drug Market Size by Country (2020-2025)
- 8.4 Europe Neuromyelitis Optica Drug Market Size by Country (2026-2031)
- 8.5 Germany
- 8.6 France
- 8.7 U.K.
- 8.8 Italy
- 8.9 Spain
- 8.10 Russia
- 8.11 Netherlands
- 8.12 Nordic Countries
- 9 Asia-Pacific
- 9.1 Asia-Pacific Neuromyelitis Optica Drug Market Size (2020-2031)
- 9.2 Asia-Pacific Neuromyelitis Optica Drug Market Growth Rate by Country: 2020 VS 2024 VS 2031
- 9.3 Asia-Pacific Neuromyelitis Optica Drug Market Size by Country (2020-2025)
- 9.4 Asia-Pacific Neuromyelitis Optica Drug Market Size by Country (2026-2031)
- 9.5 China
- 9.6 Japan
- 9.7 South Korea
- 9.8 India
- 9.9 Australia
- 9.10 China Taiwan
- 9.11 Southeast Asia
- 10 South America
- 10.1 South America Neuromyelitis Optica Drug Market Size (2020-2031)
- 10.2 South America Neuromyelitis Optica Drug Market Growth Rate by Country: 2020 VS 2024 VS 2031
- 10.3 South America Neuromyelitis Optica Drug Market Size by Country (2020-2025)
- 10.4 South America Neuromyelitis Optica Drug Market Size by Country (2026-2031)
- 10.5 Brazil
- 10.6 Argentina
- 10.7 Chile
- 10.8 Colombia
- 10.9 Peru
- 11 Middle East & Africa
- 11.1 Middle East & Africa Neuromyelitis Optica Drug Market Size (2020-2031)
- 11.2 Middle East & Africa Neuromyelitis Optica Drug Market Growth Rate by Country: 2020 VS 2024 VS 2031
- 11.3 Middle East & Africa Neuromyelitis Optica Drug Market Size by Country (2020-2025)
- 11.4 Middle East & Africa Neuromyelitis Optica Drug Market Size by Country (2026-2031)
- 11.5 Saudi Arabia
- 11.6 Israel
- 11.7 United Arab Emirates
- 11.8 Turkey
- 11.9 Iran
- 11.10 Egypt
- 12 Players Profiled
- 12.1 Pfizer
- 12.1.1 Pfizer Company Information
- 12.1.2 Pfizer Business Overview
- 12.1.3 Pfizer Revenue in Neuromyelitis Optica Drug Business (2020-2025)
- 12.1.4 Pfizer Neuromyelitis Optica Drug Product Portfolio
- 12.1.5 Pfizer Recent Developments
- 12.2 Fresenius
- 12.2.1 Fresenius Company Information
- 12.2.2 Fresenius Business Overview
- 12.2.3 Fresenius Revenue in Neuromyelitis Optica Drug Business (2020-2025)
- 12.2.4 Fresenius Neuromyelitis Optica Drug Product Portfolio
- 12.2.5 Fresenius Recent Developments
- 12.3 Teva
- 12.3.1 Teva Company Information
- 12.3.2 Teva Business Overview
- 12.3.3 Teva Revenue in Neuromyelitis Optica Drug Business (2020-2025)
- 12.3.4 Teva Neuromyelitis Optica Drug Product Portfolio
- 12.3.5 Teva Recent Developments
- 12.4 Sandoz
- 12.4.1 Sandoz Company Information
- 12.4.2 Sandoz Business Overview
- 12.4.3 Sandoz Revenue in Neuromyelitis Optica Drug Business (2020-2025)
- 12.4.4 Sandoz Neuromyelitis Optica Drug Product Portfolio
- 12.4.5 Sandoz Recent Developments
- 12.5 Intas
- 12.5.1 Intas Company Information
- 12.5.2 Intas Business Overview
- 12.5.3 Intas Revenue in Neuromyelitis Optica Drug Business (2020-2025)
- 12.5.4 Intas Neuromyelitis Optica Drug Product Portfolio
- 12.5.5 Intas Recent Developments
- 12.6 Gyjtrs
- 12.6.1 Gyjtrs Company Information
- 12.6.2 Gyjtrs Business Overview
- 12.6.3 Gyjtrs Revenue in Neuromyelitis Optica Drug Business (2020-2025)
- 12.6.4 Gyjtrs Neuromyelitis Optica Drug Product Portfolio
- 12.6.5 Gyjtrs Recent Developments
- 12.7 NANG KUANG
- 12.7.1 NANG KUANG Company Information
- 12.7.2 NANG KUANG Business Overview
- 12.7.3 NANG KUANG Revenue in Neuromyelitis Optica Drug Business (2020-2025)
- 12.7.4 NANG KUANG Neuromyelitis Optica Drug Product Portfolio
- 12.7.5 NANG KUANG Recent Developments
- 12.8 Tianjin Kingyork
- 12.8.1 Tianjin Kingyork Company Information
- 12.8.2 Tianjin Kingyork Business Overview
- 12.8.3 Tianjin Kingyork Revenue in Neuromyelitis Optica Drug Business (2020-2025)
- 12.8.4 Tianjin Kingyork Neuromyelitis Optica Drug Product Portfolio
- 12.8.5 Tianjin Kingyork Recent Developments
- 12.9 Baxter
- 12.9.1 Baxter Company Information
- 12.9.2 Baxter Business Overview
- 12.9.3 Baxter Revenue in Neuromyelitis Optica Drug Business (2020-2025)
- 12.9.4 Baxter Neuromyelitis Optica Drug Product Portfolio
- 12.9.5 Baxter Recent Developments
- 12.10 CSL
- 12.10.1 CSL Company Information
- 12.10.2 CSL Business Overview
- 12.10.3 CSL Revenue in Neuromyelitis Optica Drug Business (2020-2025)
- 12.10.4 CSL Neuromyelitis Optica Drug Product Portfolio
- 12.10.5 CSL Recent Developments
- 12.11 Grifols
- 12.11.1 Grifols Company Information
- 12.11.2 Grifols Business Overview
- 12.11.3 Grifols Revenue in Neuromyelitis Optica Drug Business (2020-2025)
- 12.11.4 Grifols Neuromyelitis Optica Drug Product Portfolio
- 12.11.5 Grifols Recent Developments
- 12.12 Octapharma
- 12.12.1 Octapharma Company Information
- 12.12.2 Octapharma Business Overview
- 12.12.3 Octapharma Revenue in Neuromyelitis Optica Drug Business (2020-2025)
- 12.12.4 Octapharma Neuromyelitis Optica Drug Product Portfolio
- 12.12.5 Octapharma Recent Developments
- 12.13 CBOP
- 12.13.1 CBOP Company Information
- 12.13.2 CBOP Business Overview
- 12.13.3 CBOP Revenue in Neuromyelitis Optica Drug Business (2020-2025)
- 12.13.4 CBOP Neuromyelitis Optica Drug Product Portfolio
- 12.13.5 CBOP Recent Developments
- 13 Report Conclusion
- 14 Disclaimer
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