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Global Bio-Detection HLS-HLD Technologies and Markets - 2010-2014

Published by: Homeland Security Research Corporation

Published: Nov. 1, 2009 - 325 Pages


Table of Contents


1 Introduction

1.1 Scope

1.2 Terms of Reference

1.3 Methodology

1.4 Who is This Report For?

2 Executive Summary

2.1 Main Findings

2.2 Main Conclusions

2.3 Global Bio-Detection Market Forecast - 2010-2014

2.3.1 Global Systems, Service & Upgrade Markets - 2010-2014

2.3.2 Markets by Countries & Regions - 2010-2014

2.3.3 Markets by Outdoor, Indoor, Hand-Held and Mobile Lab - 2010-2014

2.3.4 Systems Market by Technology Generation - 2010-2014

2.3.5 Service & Upgrade Market by Generation - 2010-2014

2.4 Business Opportunities

2.4.1 Bio-Surveillance, Detection & Bio-forensics Business Challenges -2010-2014

2.5 Technology Outlook

3 Bio-Terror

4 Forty Countries: Bio-Security Status Review

4.1 Background

4.1.1 Forty Countries Bio-Technology & Bio-Defense Performance Score

5 Market Drivers

6 Market Inhibitors

7 Bio-Detection Industry Competitive Analysis

8 Industry SWOT Analysis

8.1 Scope

8.2 SWOT Analysis

9 The Bio-Detection Process

9.1 Sampling the Environment

9.2 Bio-Detectors in a Multitude of Ambient Settings

9.3 Bio-Detection Triggering

9.4 Sample Collection

9.5 Bio-Particle Detectors

9.6 Bio-Agent Identification

10 Bio-Detection Technological Challenges

10.1 Challenge 1 - Detection of Small Particle Concentration

10.2 Challenge 2 - Bio-Background Suppression

10.3 Challenge 3 - Expensive Reagents

10.4 Challenge 4 - Expensive Equipment Maintenance

10.5 Challenge 5 - Adapting Equipment to Changing Environments

10.6 Challenge 6 - Dealing With Emerging Threats

11 Present and Pipeline Bio-Detection Technologies

11.1 Bio-Detection - Core Technologies Comparison

11.2 Collector/Concentrator Core Technologies

11.3 Cyclone Collectors

11.4 Variable Particle-Size Impactor

11.5 Virtual Impactors

11.6 Impingers

11.7 Reagent-less Trigger Core Technologies

11.7.1 Flow Cytometry

11.7.2 Particle Sizing

11.7.3 Gas Chromatography

11.7.4 Trigger Technologies - Drivers

11.7.5 Trigger Technologies - Inhibitors

11.8 DNA Based Diagnostic Core Technologies

11.8.1 Overview of DNA-Based Detection

11.8.2 Polymerase Chain Reaction (PCR)

11.8.3 DNA / RNA Microarrays

11.8.4 DNA Technology Drivers

11.8.5 DNA Technology Inhibitors

11.9 Antibody-Antigen Diagnostic Core Technologies

11.9.1 Overview of Antibody-Antigen Reaction

11.9.2 Hand-Held Immuno-Chromatographic Assays (HHA)

11.9.3 Magnetic Microbead-Base Assays

11.9.4 Microfluidic Devices - “Lab on a Chip”

11.9.5 Fluorescence Imaging

11.9.6 Electrochemical-Luminescence (ECL)

11.9.7 Antibody/Antigen Technology - Drivers

11.9.8 Antibody/Antigen Technology - Inhibitors

11.10 Signal Analysis Algorithms

11.10.1 Clustering / Classifier Algorithms

11.10.2 Image Analysis Algorithms

11.10.3 Decision Algorithms

11.10.4 Drivers

11.10.5 Inhibitors

11.11 Rapid Microbiological Technologies

12 Bio- Detection - Analysis by Application

12.1.1 Application 1 - Emergency Responder Hand-Held Detectors

12.1.2 Application 2 - Emergency Responder Mobile Labs

12.1.3 Application 3 - Indoor Standoff Detectors

12.1.4 Application 4 - Outdoor Standoff Detectors

13 Global Bio- Detection Market - 2010-2014

13.1 The Global Market Overview

13.2 Markets by Systems, Upgrade and Service Segments - 2010-2014

13.3 Global Market by Countries & Regions - 2010-2014

13.4 Global Systems Market by Technological Generation - 2010-2014

13.5 Global Systems Market by Indoor, Outdoor, Hand-Held and Mobile Labs Segments - 2010-2014

13.6 Global Service & Upgrade Market by Technological Generation - 2010-2014

13.6.1 Global Service and Upgrade Business by Technological Generation - 2010-2014

13.6.2 Global Service & Upgrade Market by Indoor, Outdoor, Hand-Held and Mobile Labs Segments - 2010-2014

14 US Bio-Detection Market - 2010-2014

14.1 Leading Bio-Security Projects

14.1.1 Project BioWatch

14.1.2 Project BioSense

14.1.3 Project BioShield

14.2 US Bio-Defense Background & Analysis

14.3 US Bio-Defense Funding

14.3.1 DHHS Bio-Defense Missions and Funding

14.3.2 DHS Bio-Defense Missions and Funding

14.3.3 DOD Bio-Defense Missions and Funding

14.3.4 DOA Bio-Defense Missions and Funding

14.3.5 EPA Bio-Defense Missions and Funding

14.3.6 Other Bio-Defense Missions and Funding

14.4 The Obama Administration Bio-Defense Strategy

14.5 Market Drivers

14.6 Market Inhibitors

14.7 US Bio-Detection Systems Market - 2010-2014

14.7.1 Sales by Generation Forecast

14.7.2 US Bio-Detection Systems Market by Modality Forecast

14.8 US Outdoor Standoff Bio-Detection Systems Market - 2010-2014

14.8.1 Sales Outlook

14.9 US Indoor Bio-Detection Systems Market - 2010-2014

14.9.1 Indoor Market Outlook

14.10 US Hand-Held Detection Systems Market - 2010-2014

14.10.1 Hand-Held Detection Systems Market Outlook

14.11 US Mobile Bio-Detection Labs Market - 2010-2014

14.11.1 Market Outlook

14.12 US Service Business - 2010-2014

14.12.1 Service & Upgrade Business by Modality - 2010-2014

14.12.2 Service Business by Generation - 2010-2014

15 The UK, Germany, France, Italy and Spain HLS-HLD Bio-Detection Market

15.1 The European Union

15.1.1 The European Union Bio-Defense Background

15.1.2 EU Program of Cooperation on Preparedness and Response to Biological and Chemical Agent Attacks (BICHAT)

15.1.3 EU Bio-Defense Research Programs

15.2 The UK

15.2.1 Bio-Defense Strategy

15.2.2 Main Bio-Defense Initiatives

15.3 Germany

15.3.1 Bio-Defense Strategy

15.3.2 Main Bio-Defense Initiatives

15.3.3 Bio- Detection R&D Projects

15.4 France

15.5 Italy

15.6 Spain

15.7 Market Drivers

15.8 Market Inhibitors

15.9 UK, Germany, France, Italy and Spain Bio-Detection Systems Market - 2010-2014

15.9.1 Sales by Technology Generations Forecast

15.9.2 Sales by Modality Forecast

15.10 UK, Germany, France, Italy and Spain Outdoor Standoff Bio-Detection Systems Market Forecast - 2010-2014

15.10.1 Systems Market Outlook

15.11 UK, Germany, France, Italy and Spain Indoor Bio-Detection Systems Market - 2010-2014

15.11.1 Systems Market Outlook

15.12 UK, Germany, France, Italy and Spain Hand-Held Detection Systems Market - 2010-2014

15.12.1 Systems Market Outlook

15.13 UK, Germany, France, Italy and Spain Mobile Bio-Detection Labs Market - 2010-2014

15.13.1 Market Outlook

15.14 UK, Germany, France, Italy and Spain Service Business - 2010-2014

15.14.1 Service & Upgrade Business by Modality - 2010-2014

15.14.2 Service Business by Generation - 2010-2014

16 China, Taiwan, Japan, India and Middle East HLS-HLD Bio-Detection Market

16.1 Asian Countries Bio- Defense Background

16.2 Japan

16.3 China

16.4 Taiwan

16.5 India

16.6 Singapore

16.7 Middle East

16.8 Market Drivers

16.9 Market Inhibitors

16.10 China, Taiwan, Japan, India and Middle East Bio-Detection Systems Market - 2010-2014

16.10.1 Sales by Technology Generation - 2010-2014

16.10.2 Market by Modality - 2010-2014

16.11 China, Taiwan, Japan, India and Middle East Bio-Detection Outdoor Systems Market - 2010-2014

16.11.1 Sales Outlook

16.12 China, Taiwan, Japan, India and Middle East Bio-Detection Indoor Systems Market - 2010-2014

16.12.1 Market Outlook

16.13 China, Taiwan, Japan, India and Middle East Hand-Held Detection Systems Market - 2010-2014

16.13.1 Market Outlook

16.14 China, Taiwan, Japan, India and Middle East Bio-Detection Mobile Labs Market - 2010-2014

16.14.1 Market Outlook

16.15 China, Taiwan, Japan, India and Middle East Service Business - 2010-2014

16.15.1 Service & Upgrade Business by Modality - 2010-2014

16.15.2 Service Business by Generation - 2008-2014

17 The Rest of the World HLS-HLD Bio-Detection Market

17.1 ROW: Bio-Defense Background

17.1.1 Russia and CIS

17.1.2 Russian Government Bio-Security Initiatives

17.1.3 International Science and Technology Center (ISTC)

17.1.4 Canada

17.1.5 Australia

17.2 Market Drivers

17.3 Market Inhibitors

17.4 ROW Bio-Detection Systems Market - 2010-2014

17.4.1 Sales Forecast by Generation

17.4.2 Market by Modality Forecast

17.5 ROW Outdoor Bio-Detection Systems Market - 2010-2014

17.5.1 Sales Outlook

17.6 ROW Indoor Bio-Detection Systems Market - 2010-2014

17.6.1 Market Outlook

17.7 ROW Hand-Held Detection Systems Market - 2010-2014

17.7.1 ROW Market Outlook

17.8 ROW Mobile Bio-Detection Labs Market - 2010-2014

17.8.1 Market Outlook

17.9 ROW Service Business - 2010-2014

17.9.1 ROW Service & Upgrade Business by Modality

17.9.2 Service Business by Generation - 2010-2014

18 Bio-Detection Business Opportunities - 2010-2014

18.1 Historical Perspective: A Market Waiting for Transition

18.1.1 The Current and Future HLS Bio-Defense Strategy for Detection

18.1.2 Factors Affecting Biological Detectors Deployment and Technologies - 2010-2014

18.1.3 Biological Detection Technology Timeline - 1992-2014

18.2 Business Opportunities for Next Generation HLS Bio-Detection Systems

18.2.1 Business Opportunity 1 - Emerging Threats

18.2.2 Business Opportunity 2 - Human Sentinel Surveillance System

18.2.3 Business Opportunity 3 - Animal Sentinel Surveillance System

18.2.4 Business Opportunity 4 - Biological IC3 - Biological Threat Assessment Intelligence Command, Control, and Communication Infrastructure

18.2.5 Business Opportunity 5 - Reducing False Alarms - Less False Positives and False Negatives

18.2.6 Business Opportunity 6 - Reducing Cost - Minimizing Use of Non-Reusable Reagents

18.3 Outdoor Standoff Biological Detectors

18.3.1 Business Opportunity 7 - Bio-agent Autonomous Networked Detectors (BAND)

18.3.2 Business Opportunity 8 - Rapid Automated Biological Identification System (RABIS)

18.3.3 Business Opportunity 9 - First Responder Portable Hand-Held Detector

18.3.4 Business Opportunity 10 - First-Responder Mobile Biological Detection Station

18.3.5 Business Opportunity 11 - Regional Automatic Detector - Outdoor Standoff Detectors

18.3.6 Business Opportunity 12 - Networked Automatic Detector - Indoor Standoff Detectors

18.3.7 Business Opportunity 13 - External Dissemination of Bio-Agent Detection

18.3.8 Business Opportunity 14 - Internal Dissemination of Bio-Agent

18.4 Other Bio-Detection Technologies - Business Opportunities

18.4.1 Business Opportunity 15 - “Lab on a Chip” - Miniature Detection Devices

18.4.2 Business Opportunity 16 - Reagent-less Specific Detection Assays

18.4.3 Business Opportunity 17 - Laser-Induced Breakdown Spectroscopy (LIBS)

18.4.4 Business Opportunity 18 - Raman Spectroscopy-based Reagent-less Detection

18.5 Future Technologies and Systems

19 Bio-Defense U.S. Federal R&D Funding - 2010-2014

19.1 Summary & Outlook

19.2 Bio-Defense Federal R&D Funding Forecast - 2010-2014

19.2.1 Department of Homeland Security Bio-Security R&D

19.2.2 Department of Defense Bio-Security R&D

19.2.3 Department of Health and Human Services Bio-Security R&D

19.2.4 Other Agencies Bio-Security R&D

19.3 HLS-HLD Bio-Detection R&D Funding - Drivers

19.4 HLS-HLD Bio-Detection R&D Funding - Inhibitors

19.5 Department of Homeland Security - Biological Detection HLS Technologies R&D Programs

19.5.1 Surveillance and Detection R&D

19.5.2 Rapid Development for Sensors for Novel Threat Agents

19.5.3 Cross Correlation of Environmental Biological Sensors

and Human Illness

19.5.4 Facility Airborne Biological Toxin Alarm System (FABTAS)

19.5.5 Field-Deployable Detection Technology for the Identification of Biological Toxins

19.5.6 Forensics

19.6 Defense Advanced Research Project Agency (DARPA) - Biological Detection HLS Technologies R&D Programs

19.6.1 Hand-held Isothermal Silver Standard Sensor (HISSS)

19.6.2 Triangulation Identification for Genetic Evaluation of Biological Risk (TIGER)

19.6.3 Spectral Sensing of Bio-Aerosols (SSBA)

19.6.4 Threat Agent Cloud Tactical Intercept Countermeasure (TACTIC)

19.6.5 Immune Buildings

19.7 Chemical Biological Defense Program (CBDP) - Biological Detection HLS Technologies R&D Programs

19.7.1 Project CB1 - Biological Defense (Basic Research) - Detection

19.7.2 Project CB2 - Biological Defense (Applied Research) - Detection

19.7.3 Project CB3 - Biological Defense (ATD) - Detection

19.7.4 Project CA5 Contamination Avoidance (SDD)

19.8 Technical Support Working Group (TSWG) - Biological Detection HLS Technologies R&D Programs

19.8.1 Real-Time Biological Aerosol Detection

20 Vendors

20.1 20/20 GeneSystems Inc.

20.2 Advnt Biotechnologies

20.3 Agilent Technologies

20.4 Alexeter Technologies

20.5 ANP Technologies, Inc.

20.6 BAS - Biological Alarm Systems Ltd. (Israel)

20.7 BD Biosciences Immunocytometry Systems

20.8 Bertin Technologies

20.9 BioDefense Corporation

20.10 BioDETECT AS

20.11 BioSentinel Pharmaceuticals LLC

20.12 3M Microbiology (Biotrace International, Ltd.)

20.13 BioTraces, Inc.

20.14 BioVeris Corporation

20.15 Biral

20.16 Cepheid

20.17 Commonwealth Biotechnologies, Inc.

20.18 Dycor Technologies Ltd.

20.19 Environics Oy

20.20 Evogen, Inc.

20.21 General Dynamics Canada

20.22 GenPrime, Inc.

20.23 Groton Biosystems

20.24 Haztech Systems, Inc.

20.25 Idaho Technology, Inc.

20.26 JMAR Technologies, Inc.

20.27 New Horizons Diagnostics

20.28 Proengin

20.29 QTL Biodetection

20.30 Research International

20.31 Response Biomedical

20.32 Roche Applied Science

20.33 Smiths Detection

20.34 Tetracore, Inc.

21 Prices of Bio-Detection Equipment

22 Pricing Outlook - 2010-2014

23 Bio-Detection - Economic Considerations

24 Bio-Detection - Personnel Considerations

25 Appendix A: The Threat of Bio-Terror

25.1 Biological Terror

25.2 Bio-Weapons - Historical Perspective

25.3 Biological Terror - Bacterial Agents

25.3.1 Anthrax

25.3.2 Cholera

25.3.3 Plague

25.3.4 Tularemia

25.4 Biological Terror - Viral Agents

25.4.1 Smallpox

25.4.2 Hemorrhagic Fever Viruses

25.4.3 Venezuelan Equine Encephalitis

25.5 Biological Terror - Rickettsiae Agents

25.5.1 Q Fever

25.5.2 Typhus

25.6 Biological Terror - Toxins

25.6.1 Botulinum Toxin

25.6.2 Ricin

25.6.3 Saxitoxin

25.6.4 Staphylococcal Enterotoxin B (SEB)

26 Appendix B: Bio-Detection - Patent Review

26.1 Scope

26.2 Bio-Detection Patents

27 Appendix C: Legal Issues

27.1 International / European Legislation / Agreements

27.1.1 The Biological and Toxin Weapons Convention (BTWC) 1972

27.2 U.S. Bioterrorism Legislation

27.3 The European Treaties & Legislation

27.3.1 EU Program of Cooperation on Preparedness and Response to Biological and Chemical Agent Attacks

(BICHAT)

List of Tables

2 Executive Summary

Table 1 - US Federal HLS-HLD Bio-Defense Funding [$Million] - 2001-2009

Table 2 - Global HLS Bio-Detection Systems, Service & Upgrade Market Forecast [$ Million] - 2008-2014

Table 3 - Global HLS Bio-Detection Systems, Service & Upgrade Market Forecast by Expenditure Share [%] - 2010-2014

Table 4 - Global HLS Bio-Detection (Systems, Service & Upgrade) Market Forecast [$ Million] by Countries & Regions - 2008-2014

Table 5 - Global HLS Bio-Detection Systems, Service & Upgrade Market Forecast by Modality [$ Million] - 2008-2014

Table 6 - Global HLS Bio-Detection Systems , Service & Upgrade Market Forecast by Modality Share [%] - 2008-2014

Table 7 - Bio-Detection Systems Market by Generation [$ Million] - 2008-2014

Table 8 - Bio-Detection Systems Market by Generation [%] - 2008-2014

Table 9 - Bio-Detection Service and Upgrade Business Forecast by Technology Generation [$ Million] - 2008-2014

Table 10 - Bio-Detection Service and Upgrade Business Forecast by Technology Generation Share [%] - 2008-2014

Table 11 - Bio Surveillance, Detection & Bio-forensics Challenges - 2010-2014

4 Forty Countries: Bio-Security Status Review

Table 12 - 40 Countries’ Bio-Defense & Bio-Detection Technologies Performance Rating

11 Present and Pipeline Bio-Detection Technologies

Table 13 - Cost, Speed & Accuracy Comparison of Bio-Detection Technologies

13 Global Bio- Detection Market - 2010-2014

Table 14 - Global Market by Systems, Upgrade and Service Segments [$Million] - 2008-2014

Table 15 - Global HLS Bio-Detection Systems , Service & Upgrade Market Forecast by Expenditure Share [%] - 2010-2014

Table 16 - Global HLS Bio-Detection (Systems, Service & Upgrade) Market Forecast [$ Million] by Countries & Regions - 2008-2014

Table 17 - Global HLS Bio-Detection (Systems, Service & Upgrade) Market Share [%] by Countries & Regions - 2009-2014

Table 18 - Global Bio-Detection Systems Market by Generation [$ Million] - 2010-2014

Table 19 - Global Bio-Detection Systems Market by Generation [%] - 2010-2014

Table 20 - Global Systems Market by Indoor, Outdoor, Hand-Held and Mobile Labs Segments - 2008-2014

Table 21 - Global Systems Market Share [%] by Indoor, Outdoor, Hand-Held and Mobile Labs Segments - 2008-2014

Table 22 - Global Bio-Detection Service and Upgrade Business by Generation [$ Million] - 2008-2014

Table 23 - Global Bio-Detection Service and Upgrade Business Forecast by Generation Share [%] - 2008-2014

Table 24 - Global Service & Upgrade Market by Indoor, Outdoor, Hand-Held and Mobile Labs Segments - 2008-2014

Table 25 - Global Service & Upgrade Market Share [%] by Indoor, Outdoor, Hand-Held and Mobile Labs Segments - 2009 & 2014

14 US Bio-Detection Market - 2010-2014

Table 26 - The CDC Biological Threat Agents Categorization

Table 27 - US Federal HLS-HLD Bio-Defense Funding [$ Millions], by Agency - FY2001-FY2009

Table 28 - US Bio-Detection Systems Market by Generation [$ Million] - 2008-2014

Table 29 - US Bio-Detection Systems Market by Generation Share [%] - 2008-2014

Table 30 - US Bio-Detection Market by Modality [$ Million] - 2008-2014

Table 31 - US Bio-Detection Systems Market by Modality Share [%] - 2008-2014

Table 32 - US Outdoor Standoff Detectors Systems Market by Generation [$Million] - 2008-2014

Table 33 - US Outdoor Standoff Detectors Systems Market by Generation Share [%] - 2008-2014

Table 34 - US Indoor Detectors Systems Market by Generation [$ Million] - 2008-2014

Table 35 - US Indoor Standoff Detectors Systems Market by Technological Generation Share [%] - 2008-2014

Table 36 - US Hand-Held Systems Market [$ Million] by Generation - 2008-2014

Table 37 - US Hand-Held Systems Market Share [%]by Generation - 2008-2014

Table 38 - US Mobile Labs Market by Technology Generation [$ Million] - 2008-2014

Table 39 - US Mobile Labs Market Share [%] by Generation - 2008-2014

Table 40 - US Service & Upgrade Business by Modality [$ Million] - 2008-2014

Table 41 - US Bio-Detection Service & Upgrade Business by Modality Share [%] - 2008-2014

Table 42 - US Service Business Forecast by Generation [$ Million] - 2008-2014

Table 43 - US Service Business by Generation Share [%] - 2008-2014

15 The UK, Germany, France, Italy and Spain HLS-HLD Bio-Detection Market

Table 44 - UK, Germany, France, Italy and Spain Bio-Detection Systems Market by Generation [$ Million] - 2008-2014

Table 45 - UK, Germany, France, Italy and Spain Bio-Detection Systems Market Share by Generation [%] - 2008-2014

Table 46 - UK, Germany, France, Italy and Spain Bio-Detection Market by Modality [$ Million] - 2008-2014

Table 47 - UK, Germany, France, Italy and Spain Bio-Detection Systems Market by Modality Share [%] - 2008-2014

Table 48 - UK, Germany, France, Italy and Spain Outdoor Detectors Market by Technology Generation [$ Million] - 2008-2014

Table 49 - UK, Germany, France, Italy and Spain Outdoor Detectors Market by Technology Generation Share [%] - 2008-2014

Table 50 - UK, Germany, France, Italy and Spain Indoor Standoff Detectors Market by Technology Generation [$ Million] - 2008-2014

Table 51 - UK, Germany, France, Italy and Spain Indoor Detectors Market by Generation Share [%] - 2008-2014

Table 52 - UK, Germany, France, Italy and Spain Hand-Held Systems Market [$Million] by Generation - 2008-2014

Table 53 - UK, Germany, France, Italy and Spain Hand-Held Detection Systems Market Share by Generation [%] - 2008-2014

Table 54 - UK, Germany, France, Italy and Spain Mobile Labs Market by Generation [$ Million] - 2008-2014

Table 55 - UK, Germany, France, Italy and Spain Mobile Labs Market Share [%] by Generation - 2008-2014

Table 56 - UK, Germany, France, Italy and Spain Service & Upgrade Business by Modality [$ Million] - 2008-2014

Table 57 - UK, Germany, France, Italy and Spain Bio-Detection Service & Upgrade Business Forecast by Modality Share [%] - 2008-2014

Table 58 - UK, Germany, France, Italy and Spain Service Business by Generation [$ Million] - 2008-2014

Table 59 - UK, Germany, France, Italy and Spain Service Business Forecast by Generation Share [%] - 2008-2014

16 China, Taiwan, Japan, India and Middle East HLS-HLD Bio-Detection Market

Table 60 - China, Taiwan, Japan, India and Middle East Bio-Detection Systems Market by Generation [$ Million] - 2008-2014

Table 61 - China, Taiwan, Japan, India and Middle East Bio-Detection Systems Market by Generation Share [%] - 2008-2014

Table 62 - China, Taiwan, Japan, India and Middle East Bio-Detection Market by Modality [$ Million] - 2008-2014

Table 63 - China, Taiwan, Japan, India and Middle East Bio-Detection Systems Market by Modality Share [%] - 2008-2014

Table 64 - China, Taiwan, Japan, India and Middle East Outdoor Detectors Market by Generation [$ Million] - 2008-2014

Table 65 - China, Taiwan, Japan, India and Middle East Outdoor Detectors Market by Generation Share [%] - 2008-2014

Table 66 - China, Taiwan, Japan, India and Middle East Indoor Detectors Market by Generation [$ Million] - 2008-2014

Table 67 - China, Taiwan, Japan, India and Middle East Indoor Detectors Market by Generation Share [%] - 2008-2014

Table 68 - China, Taiwan, Japan, India and Middle East Hand-Held Detection Systems Market [$ Million] by Generation - 2008-2014

Table 69 - China, Taiwan, Japan, India and Middle East 1st Responder Hand-Held Detection Systems Market by Generation Share [%] - 2008-2014

List of Figures

2 Executive Summary

Figure 1 - US Federal Cumulative HLS-HLD Bio-Defense Funding - 2001-2009 [$Million], by Agency

Figure 2 - Bio-Detection Strategy - Three Pillars

Figure 3 - Bio-Detection Modalities

Figure 4 - Global HLS Bio-Detection Systems, Service & Upgrade Market Forecast [$ Million] - 2010-2014

Figure 5 - Global HLS Bio-Detection Systems & Service Market Share [%] - 2008, 2011 & 2014

Figure 6 - Global Bio-Detection (Systems, Service & Upgrade) Market Forecast [$ Million] by Countries & Regions - 2008-2014

Figure 7 - Global HLS Bio-Detection (Systems, Service & Upgrade) Markets Forecast by Modality [$ Million] - 2010-2014

Figure 8 - Global HLS Bio-Detection Systems , Service & Upgrade Market Forecast by Modality Share [%] - 2008, 2011 & 2014

Figure 9 - Global Bio-Detection Systems Market by Generation [$ Million] - 2008-2014

Figure 10 - Bio-Detection Systems Market by Generation [%] - 2008, 2011 & 2014

Figure 11 - Bio-Detection Service Business Forecast by Technology [$ Million] - 2008-2014

Figure 12 - Bio-Detection Service and Upgrade Business Forecast by Technology Generation Share [%] - 2008, 2011 & 2014

7 Bio-Detection Industry Competitive Analysis

Figure 13 - Bio-Detection Industry Competitive Analysis

8 Industry SWOT Analysis

Figure 14 - Bio-Detection Industry SWOT Analysis

9 The Bio-Detection Process

Figure 15 - Airborne Bacterial Concentration Fluctuation in a Single Day

Figure 16 - Cross-Section of Cascade Impactor: PIXE International Corporation

Figure 17 - TSI's Model 3317 System with Concentrator, GPS Receiver & Wireless Data Radio

10 Bio-Detection Technological Challenges

Figure 18 - Comparison in Weight of Pathogens Between BW Agents and CW Agents [mg]

Figure 19 - Typical Point Detection Automated Architecture (With a Combined Trigger/Cue)

11 Present and Pipeline Bio-Detection Technologies

Figure 20 - Biological Detection Technologies - 2010-2014

Figure 21 - Flow Cytometry

Figure 22 - Gas Chromatography

Figure 23 - Polymerase Chain Reaction

Figure 24 - RT-PCR

Figure 25 - Principles of Real-Time PCR

Figure 26 - DNA Micro-arrays - Principles of Operation

Figure 27 - Schematic for Antibody Protein

12 Bio- Detection - Analysis by Application

Figure 28 - Hand Held Detectors: Alexeter Guardian Reader System and Tetracore Test Strips

Figure 29 - Roche Applied Science - Light CyclerTM Model 1.2

13 Global Bio- Detection Market - 2010-2014

Figure 30 - Global Market by Systems, Upgrade & Service Segments - 2008- 2014

Figure 31 - Global HLS Bio-Detection Systems & Service Market Share [%] - 2009 & 2014

Figure 32 - Global Bio-Detection (Systems, Service & Upgrade) Market Forecast [$ Million] by Countries & Regions - 2008-2014

Figure 33 - Global Bio-Detection (Systems, Service & Upgrade) Market Share [%] by Countries & Regions - 2009 & 2014

Figure 34 - Global Bio-Detection Systems Market by Generation [$ Million] - 2010-2014

Figure 35 - Global Bio-Detection Systems Market by Generation [%] - 2009 & 2014

Figure 36 - Global Systems Market [$ Million] by Indoor, Outdoor, Hand-Held and Mobile Labs Segments - 2008-2014

Figure 37 - Global Systems Market Share [%] by Indoor, Outdoor, Hand-Held and Mobile Labs Segments - 2009 & 2014

Figure 38 - Global Service & Upgrade Business by Generation [$ Million] - 2008-2014

Figure 39 - Global Bio-Detection Service and Upgrade Business by Generation Share [%] - 2009 & 2014

Figure 40 - Global Service & Upgrade Market by Indoor, Outdoor, Hand-Held and Mobile Labs Segments - 2008-2014

Figure 41 - Global Service & Upgrade Market Share [%] by Indoor, Outdoor, Hand-Held and Mobile Labs Segments - 2009 & 2014

14 US Bio-Detection Market - 2010-2014

Figure 42 - US Cumulative 2001-2009 HLS-HLD Bio-Defense Funding [$Million], by Agency

Figure 43 - Bio-Defense Funding Share [%], by Agency - 2001 & 2009

Figure 44 - US Bio-Detection Systems Market by Generation [$ Million] - 2008-2014

Figure 45 - US Bio-Detection Systems Market by Generation Share [%] - 2009 & 2014

Figure 46 - US Bio-Detection Systems Market by Modality [$ Million] - 2008-2014

Figure 47 - US Bio-Detection Systems Market by Modality Share [%] - 2009 & 2014

Figure 48 - US Outdoor Systems Standoff Detectors Market by Generation [$Million] - 2008-2014

Figure 49 - US Outdoor Standoff Detectors Systems Market by Generation Share [%] - 2009 & 2014

Figure 50 - US Indoor Standoff Detectors Systems Market by Generation [$Million] - 2008-2014

Figure 51 - US Indoor Standoff Detectors Systems Market by Generation Share [%] - 2009 & 2014

Figure 52 - US Hand-Held Systems Market [$ Million] by Generation - 2008-2014

Figure 53 - US Hand-Held Systems Market Share [%] by Generation - 2009 & 2014

Figure 54 - US Mobile Labs Market by Generation [$ Million] - 2008-2014

Figure 55 - US Mobile Labs Market by Generation Share [%] - 2009 & 2014

Figure 56 - US Bio-Detection Service & Upgrade Business Forecast by Modality [$ Million] - 2008-2014

Figure 57 - US Bio-Detection Service & Upgrade Business Forecast by Modality Share [%] - 2009 & 2014

Figure 58 - US Service & Upgrade Business Forecast by Generation [$ Million] - 2008-2014

Figure 59 - US Service & Upgrade Business by Generation [%] - 2009 & 2014

15 The UK, Germany, France, Italy and Spain HLS-HLD Bio-Detection Market

Figure 60 - The EU Counter-Terrorism Strategy

Figure 61 - Member States Primary Responsibility

Figure 62 - Credit Card-sized Portable Lab (lab-on-a-chip) For Ultra High Speed PCR

Figure 63 - UK, Germany, France, Italy and Spain Bio-Detection Systems Market by Generation [$ Million] - 2008-2014

Figure 64 - UK, Germany, France, Italy and Spain Bio-Detection Systems Market by Generation Share [%] - 2009 & 2014

Figure 65 - UK, Germany, France, Italy and Spain Bio-Detection Systems Market by Modality [$ Million] - 2008-2014

Figure 66 - UK, Germany, France, Italy and Spain Bio-Detection Systems Market by Modality Share [%] - 2009 & 2014

Figure 67 - UK, Germany, France, Italy and Spain Outdoor Detectors Market by Generation [$ Million] - 2008-2014

Figure 68 - UK, Germany, France, Italy and Spain Outdoor Detectors Systems Market by Generation Share [%] - 2009 & 2014

Figure 69 - UK, Germany, France, Italy and Spain Indoor Detectors Market by Generation [$ Million] - 2008-2014

Figure 70 - UK, Germany, France, Italy and Spain Indoor Detectors Market by Generation Share [%] - 2009 & 2014

Figure 71 - UK, Germany, France, Italy and Spain Hand-Held Detection Systems

Market [$ Million] by Generation - 2008-2014

Figure 72 - UK, Germany, France, Italy and Spain Hand-Held Systems Market Share [%] by Generation - 2009 & 2014

Figure 73 - UK, Germany, France, Italy and Spain Mobile Labs Market by Generation [$ Million] - 2008-2014

Figure 74 - UK, Germany, France, Italy and Spain Mobile Labs Market by Generation Share [%] - 2009 & 2014

Figure 75 - UK, Germany, France, Italy and Spain Bio-Detection Service & Upgrade Business Forecast by Modality [$ Million] - 2008-2014

Figure 76 - UK, Germany, France, Italy and Spain Bio-Detection Service & Upgrade Business Forecast by Modality Share [%] - 2009 & 2014

Figure 77 - UK, Germany, France, Italy and Spain Bio-Detection Service & Upgrade Business Forecast by Generation [$ Million] - 2008-2014

Figure 78 - UK, Germany, France, Italy and Spain Service & Upgrade Business by Generation [%] - 2009 & 2014

16 China, Taiwan, Japan, India and Middle East HLS-HLD Bio-Detection Market

Figure 79 - A Bio-attack Decontamination Drill In Japan

Figure 80 - China, Taiwan, Japan, India and Middle East Bio-Detection Systems Market by Generation [$ Million] - 2008-2014

Figure 81 - China, Taiwan, Japan, India and Middle East Bio-Detection Systems Market by Generation Share [%] - 2009 & 2014

Figure 82 - China, Taiwan, Japan, India and Middle East Bio-Detection Systems Market by Modality [$ Million] - 2008-2014

Figure 83 - China, Taiwan, Japan, India and Middle East Bio-Detection Systems Market by Modality Share [%] - 2009 & 2014

Figure 84 - China, Taiwan, Japan, India and Middle East Outdoor Detectors Market by Generation [$ Million] - 2008-2014

Figure 85 - China, Taiwan, Japan, India and Middle East Outdoor Detectors Systems Market by Generation Share [%] - 2009 & 2014

Figure 86 - China, Taiwan, Japan, India and Middle East Indoor Detectors Market by Generation [$ Million] - 2008-2014

Figure 87 - China, Taiwan, Japan, India and Middle East Indoor Standoff Detectors Market by Generation Share [%] - 2009 & 2014

Figure 88 - China, Taiwan, Japan, India and Middle East 1st Responder Hand-Held Detection Systems Market [$ Million] by Generation - 2008-2014

Figure 89 - China, Taiwan, Japan, India and Middle East Hand-Held Systems Market Share [%] by Generation - 2009 & 2014

Figure 90 - China, Taiwan, Japan, India and Middle East Mobile Labs Market by Generation [$ Million] - 2008-2014

Figure 91 - China, Taiwan, Japan, India and Middle East Mobile Labs Market by Generation Share [%] - 2009 & 2014

Figure 92 - China, Taiwan, Japan, India and Middle East Bio-Detection Service & Upgrade Business by Modality [$ Million] - 2008-2014

Figure 93 - China, Taiwan, Japan, India and Middle East Bio-Detection Service & Upgrade Business by Modality Share [%] - 2009 & 2014

Figure 94 - China, Taiwan, Japan, India and Middle East Service & Upgrade Business by Generation [$ Million] - 2008-2014

Figure 95 - China, Taiwan, Japan, India and Middle East Service & Upgrade Business by Generation [%] - 2009 & 2014

17 The Rest of the World HLS-HLD Bio-Detection Market

Figure 96 - ROW Bio-Detection Systems Market by Generation [$ Million] - 2008-2014

Figure 97 - ROW Bio-Detection Systems Market by Generation Share [%] - 2009 & 2014

Figure 98 - ROW Bio-Detection Systems Market by Modality [$ Million] - 2008-2014

Figure 99 - ROW Bio-Detection Systems Market by Modality Share [%] - 2009 & 2014

Figure 100 - ROW Outdoor Detectors Market by Generation [$ Million] - 2008-2014

Figure 101 - ROW Outdoor Detectors Market by Generation Share [%] - 2009 & 2014

Figure 102 - Indoor Detectors Market by Generation [$ Million] - 2008-2014

Figure 103 - ROW Indoor Detectors Market by Generation Share [%] - 2009 & 2014

Figure 104 - ROW Hand-Held Systems Market [$ Million] by Generation - 2008-2014

Figure 105 - ROW Hand-Held Systems Market Share [%] by Generation - 2009 & 2014

Figure 106 - ROW Mobile Labs Market by Generation [$ Million] - 2008-2014

Figure 107 - ROW First Responder Mobile Labs Market by Generation Share [%] - 2009 & 2014

Figure 108 - ROW Bio-Detection Service & Upgrade Business by Modality [$ Million] - 2008-2014

Figure 109 - ROW Bio-Detection Service & Upgrade Business Forecast by Modality Share [%] - 2009 & 2014

Figure 110 - ROW Bio-Detection Service & Upgrade Business Forecast by Generation [$ Million] - 2008-2014

Figure 111 - ROW Bio-Detection Service & Upgrade Business Forecast by Generation [%] - 2009 & 2014

18 Bio-Detection Business Opportunities - 2010-2014

Figure 112 - Factors Affecting Biological Detection Deployment and

Technologies - 2010-2014

Figure 113 - Past Bio-Detection Timeline

Figure 114 - Civilians in China During the SARS Epidemic

Figure 115 - A Typical Microfluidic Device

19 Bio-Defense U.S. Federal R&D Funding - 2010-2014

Figure 116 - Bio-Defense R&D Federal Funding by Agency [$ Million] - 2010-2014

Figure 117 - DHS Bio-Security R&D Budget Forecast [$ Million] -

2010-2014 (Without Bio-Shield Funding)

Figure 118 - DOD Bio-security R&D Budget Forecast [$ Million] -

2010-2014 (Without BioShield Funding)

Figure 119 - DHHS Bio-security R&D Budget Forecast [$ Million] -

2010-2014

Figure 120 - Other Agencies Bio-Security R&D Budget Forecast [$ Million] - 2010-2014

Figure 121 - BAS101 Scheme.

25 Appendix A: The Threat of Bio-Terror

Figure 122 - Categories of the Bio-threat Divides

Figure 123 - The Spraying of Anthrax from Aum Shinrikyo’s Headquarters June 1993

Figure 124 - Anthrax Spores and Disease

Figure 125 - Cholera Bacteria

Figure 126 - Pneumonic Plague - The Disease

Figure 127 - Tularemia - The Disease

Figure 128 - Smallpox Virus And Disease

Figure 129 - Ebola Virus - Electron Microscopy Image

Figure 130 - VEE - Venezuelan Equine Encephalitis Virus in the Olfactory Mucosa of a Mouse

Figure 131 - Q Fever

Figure 132 - Typhus Microbe - Electron Microscopy Image

Figure 133 - Castor Plant And Structure For The Ricin Toxin

Figure 134 - The Dinoflagellate Alexandrium Tamarense And Structure of Saxitoxin

Abstract

Despite eight years of research and development, and program implementation, at a cost of more than $49.7 million (in the US alone), virtually all significant targets are as vulnerable to biological warfare today as they were in September 2001.

In the words of President Obama: “Just as we must guard against the spread of nuclear terrorism, it’s time for a comprehensive effort to tackle bio-terror. ..we know that the successful deployment of a biological weapon - whether it is sprayed into our cities or spread through our food supply - could kill tens of thousands of Americans and deal a crushing blow to our economy.”

Homeland Security Research Corporation (HSRC) forecasts that, led by the US, Germany, France, China, Japan and India, the cumulative global bio-detection market (systems, service and upgrades and R&D) will grow from $2.3 billion in 2009 to $4.9 billion in 2014 at a CAGR of 16%.

Developed using HSRC’s tested methodology, the report delves into:
  • Global market by expenditure segments: systems, upgrade and service segments
  • Global market by technology generation: first, second and third
  • Global market by installation segments: indoor, outdoor, hand-held and mobile labs
  • Leading global bio-security projects
  • Current and pipeline technologies: e.g..advanced collectors-concentrators, reagent-less triggers, DNA-based diagnostics, antigen/anti-body methods, signal analysis algorithms
  • Competitive analysis: e.g. barriers to entry, barriers to substitution, competitive rivalry
  • Regional market Analysis : e.g. USA, UK, Germany, France, Italy, Singapore, Spain China, Taiwan, Japan, India, Middle East
  • Business opportunities: e.g. emerging threats, human and animal sentinel surveillance, reagent-less detection assays, IC3
  • Market drivers and inhibitors: i.e. government fears and government funds, inadequate detection technologies, strong public and media support for bio-defense


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