Intraoperative Radiation Therapy Market Size, Share & Trends Analysis Report By Technology, (Electron IORT (E-IORT), X-ray / Low-Energy IORT), By Application (Breast Cancer, Brain Tumors, Head & Neck Cancer), By End-use, By Region, And Segment Forecasts,

Publisher Grand View Research

Published Sep 26, 2025

Length 150 Pages

SKU # GV20471157

Description

Intraoperative Radiation Therapy Market Summary

The global intraoperative radiation therapy market size was estimated at USD 121.74 million in 2024 and is projected to reach USD 247.14 million by 2033, growing at a CAGR of 8.2% from 2025 to 2033. The intraoperative radiation therapy (IORT) market is expanding in response to the rising cancer burden.

According to the World Health Organization’s report published in February 2024, there were 20 million new cases and 9.7 million deaths reported in 2022. IORT devices, including mobile linear accelerators, compact X-ray platforms, and brachytherapy systems, enable precise delivery of radiation directly to the tumor bed during surgery. This targeted approach reduces exposure to surrounding healthy tissues and minimizes local recurrence risks. With 53.5 million patients living within five years of a cancer diagnosis, hospitals, and specialty centers are increasingly adopting these devices to improve long-term outcomes. The lifetime cancer risk of 1 in 5 people further highlights the need for patient-centric devices that streamline treatment and improve adherence.

Breast and colorectal cancers are key drivers for IORT device adoption due to their high incidence rates. In 2022, breast cancer accounted for 2.3 million new cases (11.6%), while colorectal cancer contributed 1.9 million new cases (9.6%). Hospitals are deploying electron-based IORT systems, low-energy X-ray devices, and applicator-guided brachytherapy tools to deliver high-dose intraoperative radiation in a single session. This reduces the need for extended postoperative radiotherapy. These devices improve local tumor control, shorten treatment timelines, and reduce hospitalization costs. Patient convenience and workflow efficiency are critical advantages, encouraging wider integration of IORT systems in surgical oncology suites globally across hospitals and specialty centers.

The IORT device market is expected to grow as the global cancer burden rises, with over 35 million new cases predicted by 2050, representing a 77% increase from 2022. Population growth, aging, and lifestyle risk factors such as tobacco, alcohol, obesity, and environmental exposures drive this surge. High HDI countries are projected to see the most significant absolute increase, with 4.8 million additional cases, while low HDI countries could experience a 142% proportional increase and medium HDI countries 99%. The projected doubling of cancer mortality in these regions underscores the need for advanced devices capable of delivering precise, efficient treatment. The growing adoption of electron accelerators, X-ray IORT systems, and brachytherapy devices will be central to addressing rising clinical demand worldwide.

The 2022 global cancer incidence data reveals significant regional disparities, with Asia reporting the highest cases (≈9.8 million), followed by Europe (4.47M), North America (2.67M), Africa (1.55M), and Latin America/Caribbean (1.18M). This highlights the urgent need for region-specific cancer management and advanced therapies. Intraoperative Radiation Therapy (IORT), delivering targeted radiation during surgery, offers precise treatment while minimizing healthy tissue exposure, particularly valuable in high-incidence regions such as Asia and Europe. Rising cancer rates in North America and Africa also boost demand for advanced modalities. Adoption of IORT can shorten treatment duration, reduce hospitalization costs, and enhance patient outcomes. Expanding healthcare infrastructure, favorable reimbursement policies, and innovations in compact IORT systems are expected to drive global market growth.

Global Intraoperative Radiation Therapy Market Report Segmentation

This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends in each of the sub-segments from 2021 to 2033. For this study, Grand View Research has segmented the global intraoperative radiation therapy market report based on technology, application, end-use, and region:

Technology Outlook (Revenue, USD Million, 2021 - 2033)
Electron IORT (E-IORT)
Intraoperative Brachytherapy (HDR / LDR Afterloaders)
X-ray / Low-Energy IORT
Application Outlook (Revenue, USD Million, 2021 - 2033)
Breast Cancer
Brain Tumors
Gastrointestinal Cancers
Head & Neck Cancer
Others
End-use Outlook (Revenue, USD Million, 2021 - 2033)
Hospitals and Clinics
Specialty Cancer Centers
Ambulatory Centers
Regional Outlook (Revenue, USD Million, 2021 - 2033)
North America
U.S.
Canada
Mexico
Europe
UK
Germany
France
Italy
Spain
Denmark
Sweden
Norway
Asia Pacific
Japan
China
India
Australia
South Korea
Thailand
Latin America
Brazil
Argentina
Middle East & Africa
South Africa
Saudi Arabia
UAE
Kuwait

Please note The report will be delivered in 2-3 business days upon order notification.

Chapter 1. Methodology and Scope: 1.1. Market Segmentation & Scope; 1.2. Segment Definitions; 1.2.1. Technology; 1.2.2. Application; 1.2.3. End Use; 1.3. Estimates and Forecast Timeline; 1.4. Research Methodology; 1.5. Information Procurement; 1.5.1. Purchased Database; 1.5.2. GVR’s Internal Database; 1.5.3. Secondary Sources; 1.5.4. Primary Research; 1.6. Information Analysis; 1.6.1. Data Analysis Models; 1.7. Market Formulation & Data Visualization; 1.8. Model Details; 1.8.1. Commodity Flow Analysis; 1.9. List of Secondary Sources; 1.10. Objectives
Chapter 2. Executive Summary: 2.1. Market Snapshot; 2.2. Segment Snapshot; 2.3. Competitive Landscape Snapshot
Chapter 3. Intraoperative Radiation Therapy Market Variables, Trends, & Scope: 3.1. Market Lineage Outlook; 3.2. Market Dynamics; 3.2.1. Market Driver Analysis; 3.2.2. Market Restraint Analysis; 3.3. Business Environment Analysis; 3.3.1. Industry Analysis - Porter’s Five Forces Analysis; 3.3.1.1. Supplier Power; 3.3.1.2. Buyer Power; 3.3.1.3. Substitution Threat; 3.3.1.4. Threat of New Entrants; 3.3.1.5. Competitive Rivalry; 3.3.2. PESTLE Analysis
Chapter 4. Intraoperative Radiation Therapy Market: Technology Business Analysis: 4.1. Technology Market Share, 2024 & 2033; 4.2. Technology Segment Dashboard; 4.3. Market Size & Forecasts and Trend Analysis, by Technology, 2021 to 2033 (USD Million); 4.4. Electron IORT (E-IORT); 4.4.1. Electron IORT (E-IORT) Market, 2021 - 2033 (USD Million); 4.5. Intraoperative Brachytherapy (HDR / LDR Afterloaders); 4.5.1. Intraoperative Brachytherapy (HDR / LDR Afterloaders) Market, 2021 - 2033 (USD Million); 4.6. X-ray / Low-Energy IORT; 4.6.1. X-ray / Low-Energy IORT Market, 2021 - 2033 (USD Million)
Chapter 5. Intraoperative Radiation Therapy Market: Application Business Analysis: 5.1. Application Market Share, 2024 & 2033; 5.2. Application Segment Dashboard; 5.3. Market Size & Forecasts and Trend Analysis, by Application, 2021 to 2033 (USD Million); 5.4. Breast Cancer; 5.4.1. Breast Cancer Market, 2021 - 2033 (USD Million); 5.5. Brain Tumors; 5.5.1. Brain Tumors Market, 2021 - 2033 (USD Million); 5.6. Gastrointestinal Cancers; 5.6.1. Gastrointestinal Cancers Market, 2021 - 2033 (USD Million); 5.7. Head & Neck Cancer; 5.7.1. Head & Neck Cancer Market, 2021 - 2033 (USD Million); 5.8. Others; 5.8.1. Others Market, 2021 - 2033 (USD Million)
Chapter 6. Intraoperative Radiation Therapy Market: End Use Business Analysis: 6.1. End Use Market Share, 2024 & 2033; 6.2. End Use Segment Dashboard; 6.3. Market Size & Forecasts and Trend Analysis, by End use, 2021 to 2033 (USD Million); 6.4. Hospitals and Clinics; 6.4.1. Hospitals and Clinics Market, 2021 - 2033 (USD Million); 6.5. Specialty Cancer Centers; 6.5.1. Specialty Cancer Centers Market, 2021 - 2033 (USD Million); 6.6. Ambulatory Centers; 6.6.1. Ambulatory Centers Market, 2021 - 2033 (USD Million)
Chapter 7. Intraoperative Radiation Therapy Market: Countries Estimates & Trend Analysis: 7.1. Country Market Share Analysis, 2024 & 2033; 7.2. Country Market Dashboard; 7.3. Market Size & Forecasts Trend Analysis, 2021 to 2033:; 7.3.1. U.S.; 7.3.1.1. Key Country Dynamics; 7.3.1.2. Target Disease Prevalence; 7.3.1.3. Regulatory Framework; 7.3.1.4. Reimbursement Framework; 7.3.1.5. Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.3.2. Canada; 7.3.2.1. Key Country Dynamics; 7.3.2.2. Target Disease Prevalence; 7.3.2.3. Regulatory Framework; 7.3.2.4. Reimbursement Framework; 7.3.2.5. U.S. Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.3.3. Mexico; 7.3.3.1. Key Country Dynamics; 7.3.3.2. Target Disease Prevalence; 7.3.3.3. Regulatory Framework; 7.3.3.4. Reimbursement Framework; 7.3.3.5. Mexico Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.4. Europe; 7.4.1. Europe Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.4.2. UK; 7.4.2.1. Key Country Dynamics; 7.4.2.2. Target Disease Prevalence; 7.4.2.3. Regulatory Framework; 7.4.2.4. Reimbursement Framework; 7.4.2.5. Uk Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.4.3. Germany; 7.4.3.1. Key Country Dynamics; 7.4.3.2. Target Disease Prevalence; 7.4.3.3. Regulatory Framework; 7.4.3.4. Reimbursement Framework; 7.4.3.5. Germany Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.4.4. France; 7.4.4.1. Key Country Dynamics; 7.4.4.2. Target Disease Prevalence; 7.4.4.3. Regulatory Framework; 7.4.4.4. Reimbursement Framework; 7.4.4.5. France Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.4.5. Italy; 7.4.5.1. Key Country Dynamics; 7.4.5.2. Target Disease Prevalence; 7.4.5.3. Regulatory Framework; 7.4.5.4. Reimbursement Framework; 7.4.5.5. Italy Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.4.6. Spain; 7.4.6.1. Key Country Dynamics; 7.4.6.2. Target Disease Prevalence; 7.4.6.3. Regulatory Framework; 7.4.6.4. Reimbursement Framework; 7.4.6.5. Spain Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.4.7. Denmark; 7.4.7.1. Key Country Dynamics; 7.4.7.2. Target Disease Prevalence; 7.4.7.3. Regulatory Framework; 7.4.7.4. Reimbursement Framework; 7.4.7.5. Denmark Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.4.8. Sweden; 7.4.8.1. Key Country Dynamics; 7.4.8.2. Target Disease Prevalence; 7.4.8.3. Regulatory Framework; 7.4.8.4. Reimbursement Framework; 7.4.8.5. Sweden Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.4.9. Norway; 7.4.9.1. Key Country Dynamics; 7.4.9.2. Target Disease Prevalence; 7.4.9.3. Regulatory Framework; 7.4.9.4. Reimbursement Framework; 7.4.9.5. Norway Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.5. Asia Pacific; 7.5.1. Asia Pacific Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.5.2. Japan; 7.5.2.1. Key Country Dynamics; 7.5.2.2. Target Disease Prevalence; 7.5.2.3. Regulatory Framework; 7.5.2.4. Reimbursement Framework; 7.5.2.5. Japan Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.5.3. China; 7.5.3.1. Key Country Dynamics; 7.5.3.2. Target Disease Prevalence; 7.5.3.3. Regulatory Framework; 7.5.3.4. Reimbursement Framework; 7.5.3.5. China Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.5.4. India; 7.5.4.1. Key Country Dynamics; 7.5.4.2. Target Disease Prevalence; 7.5.4.3. Regulatory Framework; 7.5.4.4. Reimbursement Framework; 7.5.4.5. India Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.5.5. Australia; 7.5.5.1. Key Country Dynamics; 7.5.5.2. Target Disease Prevalence; 7.5.5.3. Regulatory Framework; 7.5.5.4. Reimbursement Framework; 7.5.5.5. Australia Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.5.6. South Korea; 7.5.6.1. Key Country Dynamics; 7.5.6.2. Target Disease Prevalence; 7.5.6.3. Regulatory Framework; 7.5.6.4. Reimbursement Framework; 7.5.6.5. South Korea Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.5.7. Thailand; 7.5.7.1. Key Country Dynamics; 7.5.7.2. Target Disease Prevalence; 7.5.7.3. Regulatory Framework; 7.5.7.4. Reimbursement Framework; 7.5.7.5. Thailand Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.6. Latin America; 7.6.1. Latin America Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.6.2. Brazil; 7.6.2.1. Key Country Dynamics; 7.6.2.2. Target Disease Prevalence; 7.6.2.3. Regulatory Framework; 7.6.2.4. Reimbursement Framework; 7.6.2.5. Japan Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.6.3. Argentina; 7.6.3.1. Key Country Dynamics; 7.6.3.2. Target Disease Prevalence; 7.6.3.3. Regulatory Framework; 7.6.3.4. Reimbursement Framework; 7.6.3.5. China Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.7. Middle East and Africa; 7.7.1. Middle East and Africa Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.7.2. South Africa; 7.7.2.1. Key Country Dynamics; 7.7.2.2. Target Disease Prevalence; 7.7.2.3. Regulatory Framework; 7.7.2.4. Reimbursement Framework; 7.7.2.5. South Africa Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.7.3. Saudi Arabia; 7.7.3.1. Key Country Dynamics; 7.7.3.2. Target Disease Prevalence; 7.7.3.3. Regulatory Framework; 7.7.3.4. Reimbursement Framework; 7.7.3.5. Saudi Arabia Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.7.4. UAE; 7.7.4.1. Key Country Dynamics; 7.7.4.2. Target Disease Prevalence; 7.7.4.3. Regulatory Framework; 7.7.4.4. Reimbursement Framework; 7.7.4.5. UAE Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million); 7.7.5. Kuwait; 7.7.5.1. Key Country Dynamics; 7.7.5.2. Target Disease Prevalence; 7.7.5.3. Regulatory Framework; 7.7.5.4. Reimbursement Framework; 7.7.5.5. Kuwait Intraoperative Radiation Therapy Market Estimates and Forecasts, 2021 - 2033 (USD Million)
Chapter 8. Competitive Landscape: 8.1. Participant Overview; 8.2. Company Market Position Analysis; 8.3. Company Categorization; 8.4. Strategy Mapping; 8.5. Company Profiles/Listing; 8.5.1. IntraOp Medical, Inc.; 8.5.1.1. Overview; 8.5.1.2. Financial Performance; 8.5.1.3. Product Benchmarking; 8.5.1.4. Strategic Initiatives; 8.5.2. Elekta; 8.5.2.1. Overview; 8.5.2.2. Financial Performance; 8.5.2.3. Product Benchmarking; 8.5.2.4. Strategic Initiatives; 8.5.3. S.I.T. Sordina IORT Technologies S.p.A.; 8.5.3.1. Overview; 8.5.3.2. Financial Performance; 8.5.3.3. Product Benchmarking; 8.5.3.4. Strategic Initiatives; 8.5.4. IBA Worldwide; 8.5.4.1. Overview; 8.5.4.2. Financial Performance; 8.5.4.3. Product Benchmarking; 8.5.4.4. Strategic Initiatives; 8.5.5. Carl Zeiss Meditec AG; 8.5.5.1. Overview; 8.5.5.2. Financial Performance; 8.5.5.3. Product Benchmarking; 8.5.5.4. Strategic Initiatives; 8.5.6. Eckert & Ziegler; 8.5.6.1. Overview; 8.5.6.2. Financial Performance; 8.5.6.3. Product Benchmarking; 8.5.6.4. Strategic Initiatives; 8.5.7. IsoRay, Inc.; 8.5.7.1. Overview; 8.5.7.2. Financial Performance; 8.5.7.3. Product Benchmarking; 8.5.7.4. Strategic Initiatives; 8.5.8. PTW‑Freiburg GmbH; 8.5.8.1. Overview; 8.5.8.2. Financial Performance; 8.5.8.3. Product Benchmarking; 8.5.8.4. Strategic Initiatives; 8.5.9. CIVCO Radiotherapy; 8.5.9.1. Overview; 8.5.9.2. Financial Performance; 8.5.9.3. Product Benchmarking; 8.5.9.4. Strategic Initiatives; 8.5.10. Radcore Systems; 8.5.10.1. Overview; 8.5.10.2. Financial Performance; 8.5.10.3. Product Benchmarking; 8.5.10.4. Strategic Initiatives; 8.5.11. Varian; 8.5.11.1. Overview; 8.5.11.2. Financial Performance; 8.5.11.3. Product Benchmarking; 8.5.11.4. Strategic Initiatives

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