Endoscopic Submucosal Dissection Market

Endoscopic Submucosal Dissection Market Summary

The global endoscopic submucosal dissection market size was estimated at USD 391.50 million in 2025 and is projected to reach USD 597.58 million by 2033, growing at a CAGR of 5.40% from 2026 to 2033. The increasing prevalence of gastrointestinal cancers and other related disorders, and advancements in endoscopic technology & instrumentation, drive the demand for diagnostic and therapeutic procedures such as ESD.

For instance, the American Cancer Society estimates that in January 2026, there will be 31,510 new cases of stomach cancer, with 13,610 cases in women and 17,900 cases in men. As esophageal, gastric, and colorectal cancer rates continue to rise globally, the need for advanced procedures, such as ESD, is increasing.

The endoscopic submucosal dissection (ESD) market encompasses an advanced endoscopic procedure used mainly for en bloc removal of superficial neoplastic lesions within the gastrointestinal (GI) tract, particularly in the esophagus, stomach, and colon. In contrast to endoscopic mucosal resection (EMR), which is generally suited for smaller lesions, ESD allows for the complete resection of larger and more complex lesions through precise dissection of the submucosal layer. The procedure relies on specialized tools, including ESD knives, submucosal injection solutions, hemostatic devices, and high-definition endoscopes. ESD plays a critical role in the management of early-stage GI cancers, offering higher curative resection rates, improved pathological evaluation, and preservation of organ integrity.

The aging population worldwide is boosting the demand for ESD. As the global population ages, age-related gastrointestinal conditions, including cancers, are expected to rise. According to the American Cancer Society in January 2026, gastric cancer predominantly affects older individuals, with an average age of 68 when diagnosed, and 6 out of 10 diagnosed annually are 65 or older. Many older patients also have other health conditions, which make traditional surgery riskier, further contributing to the rising demand for ESD procedures.

The growth of the endoscopic submucosal dissection (ESD) market is driven by the rising burden of gastrointestinal (GI) cancers. Key GI cancer types include colorectal, gastric, esophageal, and pancreatic cancers. Factors such as long-standing gastroesophageal reflux disease (GERD), hereditary conditions, gastric infections, chronic gastritis, and the presence of polyps increase the risk of stomach cancer. According to the American Cancer Society (ACS), 152,810 new colorectal cancer cases are expected in the U.S. in 2024, including 106,590 colon cancer cases and 46,220 rectal cancer cases. Colorectal cancer also remains the second leading cause of cancer-related deaths in the country, with an estimated 53,010 deaths projected in 2024. This growing prevalence of GI cancers is significantly driving the demand for advanced, minimally invasive treatments such as ESD, which offer higher curative resection rates and better patient outcomes.

The growing awareness and training programs for healthcare professionals in ESD techniques contribute to market growth. The proficiency of gastroenterologists and surgeons in ESD has been increasing, enhancing both the reach and feasibility of this advanced procedure, particularly in areas that previously had limited access to such treatments. Various medical organizations offer specialized training and certification programs, which are important in gaining knowledge and expertise in ESD. For instance, in April 2024, FUJIFILM Healthcare Europe GmbH introduced EndoGel, an innovative training model designed for performing Peroral Endoscopic Myotomy (POEM) and Endoscopic Submucosal Dissection (ESD) procedures. This simulator is available in two versions such as EndoGel for ESD/POEM and EndoGel for ESD. It is designed to be cost effective for endoscopy professionals and healthcare institutions, aiming to enhance proficiency and patient outcomes through realistic simulation training.

Artificial intelligence (AI) is expected to play an increasingly important role in the future of the ESD market by enhancing lesion detection, characterization, and procedural planning. AI-powered image analysis and real-time decision-support systems can assist endoscopists in accurately identifying lesion margins, assessing invasion depth, and optimizing resection strategies. Furthermore, AI integration with robotic and endoscopic platforms can improve procedural precision, consistency, and outcomes, while supporting training and reducing operator dependency. As AI-enabled endoscopy continues to mature, it is likely to improve clinical efficiency, reduce variability in outcomes, and further expand the adoption of advanced ESD procedures.

Global Endoscopic Submucosal Dissection Market Report Segmentation

This report forecasts revenue growth and provides an analysis on the latest trends in each of the sub-segments from 2021 to 2033. For the purpose of this report, Grand View Research has segmented the endoscopic submucosal dissection market on the basis of product, indication, end use, and regions.

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• Product Outlook (Revenue, USD Million, 2021 - 2033)
• Gastroscopes and Colonoscopes
• Knives
• Injection Agents
• Tissue Retractors
• Graspers/ Clips
• Other Products
• Indication Outlook (Revenue, USD Million, 2021 - 2033)
• Stomach Cancer
• Colon Cancer
• Esophageal Cancer
• End Use Outlook (Revenue, USD Million, 2021 - 2033)
• Hospitals {Including inpatient departments and hospital outpatient departments (HOPDs)}
• Outpatient Facilities {Including ambulatory surgical centers (ASCs), clinics, and other outpatient care settings}
• Regional Outlook (Revenue, USD Million, 2021 - 2033)
• North America
• U.S.
• Canada
• Mexico
• Europe
• UK
• Germany
• France
• Italy
• Spain
• Denmark
• Sweden
• Norway
• Asia Pacific
• Japan
• China
• India
• South Korea
• Australia
• Thailand
• Latin America
• Brazil
• Argentina
• Middle East & Africa
• South Africa
• Saudi Arabia
• UAE
• Kuwait

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