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Prurigo Nodularis (PN)

Publisher Reach Market Research
Published Mar 01, 2022
Length 24 Pages
SKU # RMR19136511

Description

MarketVue®: Prurigo Nodularis (PN)

The MarketVue®: Prurigo Nodularis (PN) market landscape report combines primary (KOL interviews and survey data) and secondary market research to empower strategic decision-making and provide a complete view of the market.
Every MarketVue® includes a disease overview, epidemiology (US and EU5), current treatment, unmet needs, pipeline and access and reimbursement chapter.

Topics covered in this report:
• Disease overview: Review the disease pathophysiology and potential druggable targets
• Epidemiology: Understand prevalence, diagnosed and drug-treated prevalence of the population and key market segments
• Current treatment: Understand the treatment decision tree and strengths and weaknesses of current on-label and off-label treatment
• Unmet needs: Identify opportunities to address treatment or disease management gaps
• Pipeline analysis: Compare current and emerging therapy clinical development strategy; their performance on efficacy, safety, and delivery metrics; and their potential to address unmet needs
• Value and access: Review the evidence needed to assess and communicate value to key stakeholders (e.g., providers, payers, regulators) and learn what competitors have done or are doing

Methodology:
Research for the MarketVue®: Prurigo Nodularis (PN) report is supported by 4 qualitative interviews with key opinion leaders, a quantitative survey with 20 U.S. physicians and secondary research.

Geographies covered:
United States plus epidemiology for EU5 (France, Germany, Italy, Spain, United Kingdom)

Key companies mentioned:
• Galderma
• Sanofi
• Menlo Therapeutics / Vyne Therapeutics
• Trevi Therapeutics
• Incyte
• Kiniksa
• Celldex Therapeutics

Key drugs mentioned:
• Methotrexate
• Gabapentin
• Dupilumab (Dupixent)
• Nemolizumab (Nemluvio)
• Nalbuphine HCl (Haduvio)
• INCB054707
• Vixarelimab
• CDX-0159
• Serlopitant
• INCB054707
• CDX-0159

Please note: the online download version of this report is for a global site license.

Table of Contents

24 Pages
1. DISEASE OVERVIEW
A rare and chronic inflammatory condition causing itchy nodules on the skin
Figure 1.1 – “Itch-and-scratch” cycle
PN is largely an idiopathic condition
Figure 1.2 – Percentage of PN patients with idiopathic disease
Table 1.1 – Comorbidities associated with PN
Quality of life and psychosocial impact of PN on patients
Figure 1.3 – Percentage of patients experiencing various negative impacts of PN
2. EPIDEMIOLOGY & PATIENT POPULATIONS
Disease definition
Figure 2.1 – G6 diagnosed prevalent cases of PN by region
Table 2.1 – Diagnosed prevalent and drug-treated populations of PN in the U.S. and EU5
PN diagnosis and drug-treatment rates are exceptionally high
Figure 2.2 – Dermatologist-reported segmentation of PN population by disease severity
3. DIAGNOSIS AND CURRENT TREATMENT
Diagnosis overview
Figure 3.1 – Diagnostic journey for PN patients
Lack of FDA-approved treatments for PN
Treatment overview
Table 3.1 – Treatment goals for PN
Figure 3.2 – Dermatologists rating the effectiveness of and satisfaction with current PN therapies
Current treatments for PN
Figure 3.3 – Patient share and physician use of current treatments in PN
Table 3.2 – Upsides and downsides of current treatments used for PN
Current treatments for PN
Figure 3.4 – Percentage of dermatologists who treat PN and their PN patient load
Figure 3.5 – Treatment decision tree for PN
Dermatologists’ opinions on current treatments
Off-label Dupixent use to treat PN
Figure 3.6 – Treatment dynamics of Dupixent use in PN
Key treatment dynamics that shape disease management and drug use in PN
Table 3.3 – Must-know PN treatment dynamics for now and the future
Figure 3.7 – Percentage of PN patients that are eligible for a biologic or advanced systemic
New therapies for PN likely to arrive to the market as label expansions of current therapies
Figure 3.8 – Important dynamics of PN market evolution
4. UNMET NEEDS
Overview
Figure 4.1 – Top unmet needs in PN
Figure 4.2 – Dermatologist-reported unmet needs in PN
Physician perspectives on unmet needs in PN
Figure 4.3 – U.S. dermatologists’ ranking of the need for new treatments in dermatology
5. PIPELINE ANALYSIS
Figure 5.1 – Number of clinical stage therapies addressing unmet needs in PN
Figure 5.2 – Percentage of dermatologists selecting attribute among their top three influencers of treatment selection in PN
Dermatologists are excited about biologics and other mechanisms of action for PN
Table 5.1 – Dermatologists’ rating of how “promising” emerging therapies are on a scale of 1-7
Table 5.2 – Emerging PN therapies, Phase 1 to Phase 3
Dupixent and nemolizumab are out front and poised to compete for first-line biologic use in PN
Figure 5.3 – Differentiation between Dupixent and nemolizumab in PN
Figure 5.4 – Comparison of reduction of itch (WI-NRS) of pipeline agents in moderate-to-severe PN
6. VALUE & ACCESS
Overview
Figure 6.1. Commercial insurance restrictions on Dupixent’s use in atopic dermatitis
Figure 6.2. Dupixent monthly copay payments of Medicare and commercially-insured patients
7. METHODOLOGY
Primary market research approach
Epidemiology methodology

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