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Prion Disease

Publisher Reach Market Research
Published Aug 21, 2024
Length 32 Pages
SKU # RMR19265327

Description

Prion Disease


MarketVue®: Prion Disease

The MarketVue®: Prion Disease market landscape report combines primary (KOL interviews) and secondary market research to empower strategic decision-making and provide a complete view of the market.

Every MarketVue® includes a disease overview, epidemiology (US and EU5), current treatment, unmet needs, pipeline and access and reimbursement chapter.

Topics covered in this report
• Disease overview: Review the disease pathophysiology and potential druggable targets
• Epidemiology: Understand prevalence, diagnosed and drug-treated prevalence of the population and key market segments
• Current treatment: Understand the treatment decision tree and strengths and weaknesses of current on-label and off-label treatment
• Unmet needs: Identify opportunities to address treatment or disease management gaps
• Pipeline analysis: Compare current and emerging therapy clinical development strategy; their performance on efficacy, safety, and delivery metrics; and their potential to address unmet needs
• Value and access: Review the evidence needed to assess and communicate value to key stakeholders (e.g., providers, payers, regulators) and learn what competitors have done or are doing

Methodology
Research for the MarketVue®: Prion Disease report is supported by 8 qualitative interviews with key opinion leaders and secondary research.

Geographies covered:
United States plus epidemiology for EU5 (France, Germany, Italy, Spain, United Kingdom)

Key companies mentioned
• Ionis Pharmaceuticals
• Sangamo Therapeutics
• Gate Bioscience

Key drugs mentioned
• Antiepileptics (levetiracetam, sodium valproate)
• Long-acting benzodiazepines (clonazepam, diazepam)
• Antipsychotics (quetiapine, risperidone, olanzapine)
• Benzodiazepines (oxazepam, temazepam, alprazolam)
• Sedatives (trazadone, mirtazapine)
• ION717
• hSYN1-ZF-R

Please note: the online download version of this report is for a global site license.

Table of Contents

32 Pages
1. DISEASE OVERVIEW
Figure 1.1. Prion disease pathophysiology
Table 1.1. Human prion diseases
2. EPIDEMIOLOGY
Figure 2.1. Incident cases of prion disease by region (2023)
Table 2.1. Diagnosed symptomatic incident cases of prion diseases in the U.S. and EU5 (2023)
Figure 2.2. Distribution of types of prion disease
Figure 2.3. Average months from prion disease onset of symptoms to death
Figure 2.4. Trends in prion disease incidence
3. DIAGNOSIS & CURRENT TREATMENT
Figure 3.1. Diagnostic pathway for prion disease
Figure 3.2. Neurologist estimates of diagnosis in prion diseases (n=4)
Figure 3.3. Key recent advancements in prion disease diagnosis
Figure 3.4. Neurologist rates of genetic testing in prion disease patients (n=8)
Figure 3.5. Drivers and barriers of genetic testing in prion disease patients
Table 3.1. Prion disease symptoms
Figure 3.6. Defining disease severity in prion disease
Table 3.2. Treatment goals for prion disease
Table 3.3. Pharmacological and non-pharmacological symptom control approaches for prion disease
4. UNMET NEED
Figure 4.1. Top unmet needs in prion disease
Figure 4.2. Neurologist-reported level of unmet need for novel prion disease treatments (n=8)
5. PIPELINE ANALYSIS
Table 5.1. Comparison of ongoing trials of therapies for prion disease
Figure 5.1. Ionis ASO pre-clinical data
Figure 5.2. Comparison of target prion disease patient populations
6. VALUE & ACCESS
Table 6.1. Pricing analogues for prion disease
7. METHODOLOGY
Primary Market Research Approach
Epidemiology
Value and Access

Pricing

Currency Rates
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