
Idiopathic Inflammatory Myopathies
Description
MarketVue®: Idiopathic inflammatory myopathies (IIMs)
The MarketVue®: Idiopathic inflammatory myopathies market landscape report combines primary (KOL interviews and survey data) and secondary market research to empower strategic decision-making and provide a complete view of the market.Every MarketVue® includes a disease overview, epidemiology (US and EU5), current treatment, unmet needs, pipeline and access and reimbursement chapter.
Topics covered in this report:
• Disease overview: Review the disease pathophysiology and potential druggable targets
• Epidemiology: Understand prevalence, diagnosed and drug-treated prevalence of the population and key market segments
• Current treatment: Understand the treatment decision tree and strengths and weaknesses of current on-label and off-label treatment
• Unmet needs: Identify opportunities to address treatment or disease management gaps
• Pipeline analysis: Compare current and emerging therapy clinical development strategy; their performance on efficacy, safety, and delivery metrics; and their potential to address unmet needs
• Value and access: Review the evidence needed to assess and communicate value to key stakeholders (e.g., providers, payers, regulators) and learn what competitors have done or are doing
Methodology:
Research for the MarketVue®: Idiopathic inflammatory myopathies report is supported by 5 qualitative interviews with key opinion leaders, a quantitative survey with 26 U.S. physicians and secondary research.
Geographies covered:
United States plus epidemiology for EU5 (France, Germany, Italy, Spain, United Kingdom)
Key companies mentioned:
• Priovant
• CSL Behring
• Janssen
• argenx
• Alexion/AstraZeneca
• Pfizer
• Horizon Therapeutics
• Paean Biotechnology
• EMD Serono
Key drugs mentioned:
• IVIg (Octagam)
• Rituximab
• Azathioprine
• Methotrexate
• Mycophenolate mofetil
• Tofacitinib (Xeljanz)
• Etanercept (Enbrel)
• Adalimumab (Humira)
• Brepocitinib
• IgPro20
• Nipocalimab
• Efgartigimod (Vyvgart)
• Ravulizumab (Ultomiris)
• Zilucoplan (Zilbrysq)
• PF-06823859
• Daxdilimab
• PN-101
• M5049
Please note: the online download version of this report is for a global site license.
Table of Contents
27 Pages
- 1. DISEASE OVERVIEW
- A heterogenous group of chronic, autoimmune disorders marked by inflammation and weakness of the skeletal muscle
- Figure 1.1. Immune system involvement and druggable therapeutic targets in IIM
- There are no standardized classification criteria for IIMs
- Figure 1.2. Clinical manifestations in the IIM sub-types
- 2. EPIDEMIOLOGY & PATIENT POPULATIONS
- Disease definition
- Figure 2.1. Diagnosed prevalent cases of DM, ASyS, and IMNM by region
- Table 2.1. Diagnosed prevalent and drug-treated patients in the US and EU5
- 3. DIAGNOSIS & CURRENT TREATMENT
- Overview
- Figure 3.1. Referral and diagnostic pathway for IIM patients
- Autoantibody testing is useful in predicting the severity and disease course of IIM patients
- Table 3.1. Clinical presentation of IIM subtypes and associated antibodies
- All IIM patients need to be on drug therapy during the course of their disease
- Table 3.2. Treatment goals for DM, ASyS, and IMNM patients
- Figure 3.2. Physician-reported percentage of IIM patients receiving some form of drug therapy
- Treatment flow for DM, ASyS, and IMNM
- Immune suppression is the current backbone of IIM treatment
- Figure 3.3. Current treatment share for DM, IMNM, and ASyS patients
- Figure 3.4. Physician-reported rating of current therapy effectiveness in DM, IMNM, and ASyS
- Upsides and downsides of current IIM treatments
- Physicians’ perspectives on current treatment use in DM, ASyS, and IMNM
- Octagam 10% is the only FDA-approved treatment for DM; there are no approved therapies for other subtypes
- Table 3.3. Summary of the PRODERM trial results
- IIMs are characterized by frequent occurrences of remission and relapse
- Key treatment dynamics that will shape disease management and drug use in DM, ASyS, and IMNM
- Figure 3.5. Important dynamics of IIM market evolution
- 4. UNMET NEED
- Overview
- Figure 4.1. Top unmet needs in DM, IMNM, and ASyS
- Figure 4.2. Physician-reported unmet needs in DM, IMNM, and ASyS
- There is a high unmet need for FDA-approved treatments with fewer insurance barriers
- Figure 4.3. Neurologist-reported proportion of DM, IMNM, and ASyS who are not well-managed with current therapy options
- Figure 4.4. Physician-reported proportion of DM, IMNM, and ASyS patients who encounter these barriers to receiving drug therapy
- Physician perspectives on unmet needs in the diagnosis and treatment of IIM
- 5. PIPELINE ANALYSIS
- Overview
- Figure 5.1. Percentage of rheumatologists and neurologists (n=26) rating target as “promising” for DM, IMNM, and ASyS (score of 6 or 7)
- The pipeline for IIM is limited with three treatments in Phase 2/3 clinical development
- Table 5.1. Comparison of ongoing Phase 3 and Phase 2/3 trials of therapies for IIM
- The pipeline for DM is active; currently there are no industry-funded Phase 1 trials for IIM
- Table 5.2. Comparison of ongoing Phase 2 therapies for IIM
- Physician perspectives on novel, upcoming therapies are largely positive
- 6. VALUE & ACCESS
- Overview
- Table 6.1. Current IIM therapy pricing, U.S.
- Table 6.2. Typical U.S. commercial payer coverage of Octagam 10%
- Key market access dynamics that will continue to shape treatment use
- Table 6.1. IIM patients by insurance type
- 7. METHODOLOGY
- Primary market research approach
- Epidemiology methodology
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