Enzymatic DNA Synthesis Market Size, Share, By Services (Oligonucleotide Synthesis, and Gene Synthesis), Application (Synthetic Biology, Genetic Engineering, Vaccine Development, and Others), End Use (Biopharmaceutical Companies, Academic & Research Insti

Enzymatic DNA Synthesis Market Size, Share, By Services (Oligonucleotide Synthesis, and Gene Synthesis), Application (Synthetic Biology, Genetic Engineering, Vaccine Development, and Others), End Use (Biopharmaceutical Companies, Academic & Research Institutes, and Others), and Region - Trends, Analysis, and Forecast till 2035

The Enzymatic DNA Synthesis Market Report offers an in-depth exploration of emerging market trends, driving factors, challenges, and key segments that shape the industry. It includes a thorough examination of regulatory frameworks, company profiles, and the latest industry developments. The report delves into product development, positioning strategies, and the impact of new technologies on the market landscape. By identifying challenges and opportunities, the report provides a detailed roadmap for market growth.

Method of creating synthetic DNA that uses enzymes (biological catalysts) rather than more traditional chemical processes. Due to several factors, the market for enzymatic DNA synthesis has expanded dramatically. This need is heightened by the growing emphasis on personalized medicine, where unique DNA sequences are essential for developing tailored therapies. Furthermore, because of their speed and affordability, enzymatic approaches are an attractive alternative to conventional chemical synthesis in the expanding fields of genetic research and diagnostics, which require precise and rapid DNA synthesis. The growing prevalence of chronic illnesses and the need for innovative treatment alternatives, such as gene therapy, are driving the market's expansion.

Report Highlights:

Enzymatic DNA Synthesis Market size is valuated at USD 6.4 Billion in 2025.

Target Market size is estimated to be valuated at USD 16.0 Billion by 2035 and at a CAGR of 10.6%.

Oligonucleotide Synthesis has largest market share in the Enzymatic DNA Synthesis Market.

Among applications, synthetic biology has the highest share.

Biopharmaceutical companies are superior in target market growth.

North America held the largest market share in enzymatic DNA synthesis market size.

Asia Pacific is fastest growing region in the market.

Key Highlights:

• In May 2025, Telesis Bio announced that it has signed a convertible preferred stock purchase agreement to sell shares of a new series of convertible preferred stock in a private placement. With the company's recently released patented next-generation enzymatic synthesis platform, Gibson SOLA, customers can take full control of their nucleic acid supply chain, protect valuable intellectual property, and retain ownership of data and insights to feed future generations of AI drug discovery models. The Gibson SOLA reagent platform and comprehensive suite of tools enable customers to perform overnight synthesis of lengthy, complex complexes needed for biologics, vaccines, and cell treatments using standard automated liquid handling equipment.

Report Analysis:

Enzymatic DNA Synthesis Process:

• A DNA primer attached to solid support is exposed to the TdT-dNTP conjugate of the first desired base to add to the primer of the sequence.
• A conjugate extends the primer using its tethered dNTP and then remains covalently attached to the 3’ end, blocking other conjugates from further extending the primer. (1. Extend)
• Cleaving the linker releases TdT from the primer, enabling subsequent extension. (2. De-block)
• The process is repeated with a sequence of conjugates to synthesize the desired DNA sequence.

Segmentation:

By Services:

• Oligonucleotide Synthesis
• Gene Synthesis

By Application:

• Synthetic Biology
• Genetic Engineering
• Vaccine Development
• Others

By End Use:

• Biopharmaceutical Companies
• Academic & Research Institutes
• Others

By Region:

• North America

o U.S.

Canada

• Europe

o Germany

U.K.

France

Russia

Italy

Spain

Netherlands

Rest of Europe

• Asia Pacific

o China

India

Japan

Australia

Indonesia

Malaysia

South Korea

Rest of Asia Pacific

• Latin America

o Brazil

Mexico

Argentina

Rest of Latin America

• Middle East & Africa

o GCC

Israel

South Africa

Rest of Middle East & Africa

The report also includes a competitive analysis with a detailed SWOT review, examining the strengths, weaknesses, opportunities, and threats of each leading company, as well as their market share and product offerings.

Enzymatic DNA Synthesis Market Companies:

Telesis Bio Inc.

Evonetix

Ansa Biotechnologies

Camena Bioscience

GenScript

DNA Script

Eurofins Scientific

Synbio Technologies

DNA TwoPointO, Inc.

Twist Bioscience

Elegen Corporation

Yeasen

Molecular Assemblies

GenomeWeb

What Our Report Delivers:

• Regional & Country-Level Market Insights: Detailed market share analysis across key regions and countries to help you understand competitive positioning.
• Guidance for New Market Players: Actionable strategic recommendations for businesses entering the market, ensuring a strong foothold from the start.
• Comprehensive Market Forecasts: Reliable data projections for 2024, 2025, 2026, 2028, and 2032 to support long-term planning and investment decisions.
• In-Depth Market Dynamics: Analysis of drivers, restraints, opportunities, and emerging threats, along with challenges and high-potential investment areas.
• Data-Driven Business Strategies: Expert recommendations tailored to key market segments, backed by precise market evaluations.
• Competitive Intelligence: Mapping of prevailing industry trends and competitor strategies to identify growth opportunities.
• Detailed Company Profiles: In-depth analysis of major players, including their business strategies, financial performance, and recent developments.
• Supply Chain Innovations: Insights into the latest technological advancements and trends shaping supply chain efficiency

FAQs:

Key Questions Answered in the Report.

1. What was the Enzymatic DNA Synthesis Market size in 2025?

2. What is projected growth rate of the Enzymatic DNA Synthesis Market during 2025-2035?

3. What are the key factors driving the Enzymatic DNA Synthesis Market growth?

4. What are leading players in the Enzymatic DNA Synthesis Market ?

5. What are the key regions analyzed in the Enzymatic DNA Synthesis Market ?

6. Which region is dominating in the Enzymatic DNA Synthesis Market ?