The Market for Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs)
Circulating tumor cells (CTCs) have tremendous utility in cancer research, aiding researchers in deciphering the complex processes leading to cancer metastasis and in developing more effective cancer therapeutics. Besides the research applications, the detection and analysis of CTCs has enormous potential in the diagnosis and management of cancer, as current tools, such as tumor tissue biopsy or imaging technologies, have numerous limitations. Although their biology and characteristics are still not entirely elucidated, CTCs are believed to detach from primary or secondary tumors, enter the bloodstream, and travel to distant organs.
In The Market for Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) analyst Adriana Rusu provides a detailed analysis of the potential opportunities for manufacturers of CTCs-based technologies, informing readers of the scientific basis of CTCs in an understandable fashion and constructing models of revenue opportunity based on several dimensions – application area, cancer type and region – that can assist with business planning efforts. The report provides data on the following:
- Industry Structure – Selected Competitors and Marketed Products, 2014
- CellSearch System (IVD Use) Analysis, 2015
- AdnaTest (IVD Use) Analysis, 2015
- Significant Trends in the CTCs Market, 2015
- Estimated Market Breakdown, 2014 (Research Segment, Diagnostics Segment)
- Estimated Market Breakdown by Type of Cancer, 2014
- Estimated Market Breakdown by Geographic Region, 2014
- Global Revenues and Forecast for the CTCs Market by Application, 2013-2015 and 2019
- Global Revenues for the CTCs Market by Geographic Region, 2013-2015 and 2019
- Increasing Incorporation of CTCs Technologies in Clinical Trials to Accelerate Market Growth
- The Quest for Personalized Medicine to Spur the Use of CTCs in Research & Development
- Increasing Development of CTC-based Diagnostics Tests to Augment Market Revenues
- Increasing Global Incidence of Cancer and Life Expectancy to Increase Testing Volumes
- The Impact of Clinical Utility on Adoption of CTCs Tests in Clinical Practice
- The Impact of New Technologies Approved by Regulatory Agencies on Market Growth
- The Impact of Insurance Coverage on Utilization and Market Revenues The report also covers notable industry events such as:
- CTCs Enumeration by CellSearch Demonstrating Potential as an Efficacy-Response Surrogate
- The Menarini Group Acquisition of Silicon Biosystems
- Cynvenio Biosystems’ Launch of the ClearID Breast Cancer Monitoring Test
- Vitatex’s Licensing of Cell Adhesion Matrix Technology to Noble Life Sciences
- Janssen Diagnostics and Asuragen’s Introduction of NGS technology for CellSearch
- Janssen Diagnostics
- AdnaGen AG (currently QIAGEN Hannover GmbH)
- Acousys Biodevices, Inc.
- Advanced Cell Diagnostics, Inc.
- ApoCell, Inc.
- BioCEP Ltd.
- Biocept, Inc.
- Biofluidica
- BioView Ltd.
- Clearbridge Biomedics Pte Ltd
- Creatv MicroTech, Inc.
- Cynvenio Biosystems
- CytoTrack ApS
- DeNovo Sciences Inc.
- Epic Sciences
- Fluidigm Corporation
- Fluxion Biosciences
- GILUPI GmbH
- iCellate Medical AB
- Ikonisys, Inc.
- IVDiagnostics, LLC
- Miltenyi Biotec GmbH
- On-chip Biotechnologies
- Oncolys Biopharma Inc.
- Parsortix/ANGLE plc
- QIAGEN N.V.
- RareCells Diagnostics
- RareCyte, Inc.
- ScreenCell
- Silicon Biosystems
- SRI Biosciences
- Vitatex Inc.
- Vortex Biosciences
- Executive Summary
- CIRCULATING TUMOR CELLS IN CANCER
- Current and Potential Clinical Applications of CTCs
- CTCS DETECTION, ISOLATION AND ANALYSIS TECHNOLOGIES
- INDUSTRY AND MARKET STRUCTURE
- CIRCULATING TUMOR CELLS IN CANCER
- Cancer Overview
- DISEASE OVERVIEW
- Table Top Ten Causes of Death in the World by Geographic Region, 2012
- Table Top Ten Causes of Death in the World, 2012
- Table Projected Top Ten Causes of Death in the World, 2015
- Table Projected Top Ten Causes of Death in the World in High Income Countries, 2015
- Table Projected Top Ten Causes of Death in the World in Upper Middle Income Countries, 2015
- RISK FACTORS
- PREVALENCE AND INCIDENCE OF CANCER
- Table Global Incidence of Cancer by Geographic Region, 2012
- Table Global Incidence of the Five Most Common Types of Cancer in Men, 2012
- Table Global Incidence of the Five Most Common Types of Cancer in Women, 2012
- Table Global Incidence of Most Common Types of Cancer in Both Genders, 2012
- Table Projected Growth in Global Incidence of Cancer by Geographic Region, 2012-2030
- DISEASE OVERVIEW
- Circulating Tumor Cells Overview
- OVERVIEW
- CTCS APPLICATIONS
- CHARACTERISTICS OF CTCS
- Table Typical Human Blood Cellular Composition
- CTCs Isolation and Characterization Challenges
- Table Challenges in the Detection and Isolation of CTCs, 2015
- CURRENT MARKERS FOR CTCS IDENTIFICATION AND ANALYSIS
- Table Selected Markers for CTCs Identification and Analysis
- Epithelial Cell Adhesion Molecule (EpCAM)
- Table Selected EpCAM-based Methods
- Epidermal Growth Factor Receptor (EGFR)
- Human Epidermal Growth Factor (HER2)
- Carcinoembryonic Antigen (CEA)
- OTHER CTCSMARKERS INVESTIGATED FOR CLINICAL APPLICATIONS
- Cyclophilins
- Plastin3 (PLS3)
- Vimentin
- Conclusions
- CURRENT AND POTENTIAL CLINICAL APPLICATIONS OF CTCS
- Prognostic Tool for Survival
- Non-Invasive Early Diagnosis of Cancer
- Predictors of Disease Evolution and Metastatic Potential
- Therapy Guidance and Monitoring/ Predictor of Response to Therapy
- Patient Stratification in Clinical Trials
- Surrogate Endpoint in Clinical Trials
- Drug Development - Selection of Drug Targets
- Table Current and Potential Clinical Uses of CTCs, 2015
- CTCs Isolation and Detection Technologies
- OVERVIEW
- ENRICHMENT METHODS BASED ON PHYSICAL PROPERTIES
- Size-based Methods
- Table Selected Size-Based CTCs Enrichment Methods
- Density-based Methods
- Table Selected Density-Based CTCs Enrichment Methods
- Electrophysiological-based Methods
- Table Selected CTCs Detection and Isolation Methods Based on Electrophysiological Properties
- Size-based Methods
- IMMUNO-MEDIATED CAPTURE METHODS
- Magnetic Platforms
- Table Selected CTCs Magnetic Platforms Based on Cell Surface Markers
- Microfluidic Platforms
- Table Selected CTCs Immunomagnetic Microfluidics Platforms
- Conclusion
- Magnetic Platforms
- OPTICAL IDENTIFICATION AND ENUMERATION
- Bioview's Duet Cell Imaging System (Israel)
- CytoTrack's Optical Scanning Technology (Denmark)
- Epic Sciences (San Diego, California, USA)
- Ikonisys (New Haven, CT, USA)
- Table Selected CTCs Optical Identification Methods
- NUCLEIC ACID-BASED CTC DETECTION METHODS
- RNAscope (Advanced Cell Diagnostics, USA)
- Table Selected Nucleic Acid-based CTCs Detection Methods
- RNAscope (Advanced Cell Diagnostics, USA)
- CYTOMETRIC DETECTION AND ENUMERATION METHODS
- FASTcell Cytometer (SRI Biosciences, USA)
- On-chip Sort Cell Sorter (On-chip Biotechnologies, Japan)
- Table Comparison of Selected Cytometric CTCs Detection Methods
- OTHER CTCS ISOLATION AND DETECTION APPROACHES
- Virus Vectors Fluorescence
- Selectin-Mediated Capture
- Cell Adhesion Matrix
- Other Combination Negative Depletion/ Positive Selection Methods
- Rheology-based Methods
- In Vivo Detection Methods
- Table Selected CTCs In Vivo Detection Platforms
- Industry and Market Landscape
- INDUSTRY STRUCTURE
- Table Industry Structure - Selected Competitors and Marketed Products, 2014
- COMPETITIVE FACTORS
- PRODUCTS ANALYSIS
- CellSearch
- Table CellSearch System (IVD Use) Analysis, 2015
- AdnaTests
- Table AdnaTest (IVD Use) Analysis, 2015
- CellSearch
- SIGNIFICANT MARKET TRENDS
- Table Significant Trends in the CTCs Market, 2015
- Increasing Incorporation of CTCs Technologies in Clinical Trials to Accelerate Market Growth
- The Quest for Personalized Medicine to Spur the Use of CTCs in Research & Development
- Increasing Development of CTC-based Diagnostics Tests to Augment Market Revenues
- Increasing Global Incidence of Cancer and Life Expectancy to Increase Testing Volumes
- NOTABLE INDUSTRY EVENTS
- CTCs Enumeration by CellSearch Demonstrated Potential as Efficacy-Response Surrogate
- The Menarini Group Acquired Silicon Biosystems
- Cynvenio Biosystems Launched ClearID Breast Cancer Monitoring Test
- Vitatex Licenses Cell Adhesion Matrix Technology to Noble Life Sciences
- SWOG S0500 Clinical Trial Results Presented in December 2013
- Parsorter PS1 Launched to Market in Europe
- Clearbridge Biomedics Launched the ClearCell FX System for Capturing CTCs in Whole Blood Samples
- Fluxion Biosciences Launched Next Generation Sequencing Assay Kits for IsoFlux System
- Janssen Diagnostics and Asuragen Introduce NGS technology for CellSearch
- Biocept Collaborates with Rosetta Genomics to Evaluate CTCs' microRNA
- Biocept Launches Lung Cancer CTC Tests
- Parsortix Collaborates with EKF Diagnostics and Undisclosed Pharmaceutical Company to Develop "Liquid Biopsy" Applications
- ThermoFisher Scientific Enters into Distribution Agreement with Cynvenio Biosystems for LiquidBiopsy Platform
- QIAGEN Acquired AdnaGen's CTC's Technology
- TOTALMARKET REVENUES AND FORECAST
- Market Snapshot
- Total Market Forecast
- Table Global Revenues and Forecast for the CTCs Market ($ Millions) by Application, 2013-2015 and 2019
- Table Global Revenues for the CTCs Market by Geographic Region ($ Millions), 2013-2015 and 2019
- INDUSTRY STRUCTURE
- Company Profiles
- JANSSEN DIAGNOSTICS
- ADNAGEN AG (CURRENTLY QIAGENHANNOVER GMBH)
- ACOUSYS BIODEVICES, INC.
- ADVANCED CELL DIAGNOSTICS, INC.
- APOCELL, INC.
- BIOCEP LTD.
- BIOCEPT, INC.
- BIOFLUIDICA
- BIOVIEW LTD.
- CLEARBRIDGE BIOMEDICS PTE LTD
- CREATV MICROTECH, INC.
- CYNVENIO BIOSYSTEMS
- CYTOTRACK APS
- DENOVO SCIENCES INC.
- EPIC SCIENCES
- FLUIDIGM CORPORATION
- FLUXION BIOSCIENCES
- GILUPI GMBH
- ICELLATE MEDICAL AB
- IKONISYS, INC.
- IVDIAGNOSTICS, LLC
- MILTENYI BIOTEC GMBH
- ON-CHIP BIOTECHNOLOGIES
- ONCOLYS BIOPHARMA INC.
- PARSORTIX/ANGLE PLC
- QIAGEN N.V.
- RARECELLS DIAGNOSTICS
- RARECYTE, INC.
- SCREENCELL
- SILICON BIOSYSTEMS
- SRI BIOSCIENCES
- VITATEX INC.
- VORTEX BIOSCIENCES
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