
Toll Like Receptor 8 (CD288 or TLR8) Development by Therapy Areas and Indications, Stages, MoA, RoA, Molecule Type and Key Players, 2022 Update
Description
Toll Like Receptor 8 (CD288 or TLR8) Development by Therapy Areas and Indications, Stages, MoA, RoA, Molecule Type and Key Players, 2022 Update
Summary
According to the recently published report 'Toll Like Receptor 8 - Drugs In Development, 2022'; Toll Like Receptor 8 (CD288 or TLR8) pipeline Target constitutes close to 35 molecules. Out of which approximately 34 molecules are developed by companies and remaining by the universities/institutes.
Toll Like Receptor 8 (CD288 or TLR8) - Toll-like receptor 8 is a protein encoded by the TLR8 gene. It controls host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
The report 'Toll Like Receptor 8 - Drugs In Development, 2022' outlays comprehensive information on the Toll Like Receptor 8 (CD288 or TLR8) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Toll Like Receptor 8 (CD288 or TLR8) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Phase I, Preclinical and Discovery stages are 1, 11, 7, 12 and 3 respectively. Similarly, the universities portfolio in Discovery stages comprises 1 molecule, respectively.
Report covers products from therapy areas Oncology, Immunology, Infectious Disease and Musculoskeletal Disorders which include indications Solid Tumor, Colorectal Cancer, Head And Neck Cancer Squamous Cell Carcinoma, Systemic Lupus Erythematosus, Hepatitis B, Melanoma, Metastatic Melanoma, Non-Small Cell Lung Cancer, Triple-Negative Breast Cancer (TNBC), Bladder Cancer, Gastric Cancer, Autoimmune Disorders, Bile Duct Cancer (Cholangiocarcinoma), Breast Cancer, Cervical Cancer, Cutaneous Lupus Erythematosus, Fibrosis, Gastroesophageal (GE) Junction Carcinomas, Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer), Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer (HER2+ Breast Cancer), Merkel Cell Carcinoma, Metastatic Breast Cancer, Metastatic Colorectal Cancer, Nasopharyngeal Cancer, Non Muscle Invasive Bladder Cancer (NMIBC) (Superficial Bladder Cancer), Prostate Cancer, Renal Cell Carcinoma, Sarcomas, Soft Tissue Sarcoma, Squamous Cell Carcinoma, Transitional Cell Cancer (Urothelial Cell Cancer), Unspecified Cancer, Adenocarcinoma Of The Gastroesophageal Junction, Adenoid Cystic Carcinoma (ACC), Anal Cancer, Arthritis, Chondrosarcoma, Chronic Cutaneous Lupus Erythematosus (CCLE) / Discoid Lupus Erythematosus (DLE), Colon Cancer, Coronavirus Disease 2019 (COVID-19), Coronavirus Disease 2019 (COVID-19) Pneumonia, Cutaneous T-Cell Lymphoma, Endometrial Cancer, Esophageal Cancer, Ewing Sarcoma, Head And Neck Cancer, Hepatocellular Carcinoma, Hypopharyngeal Cancer, Inflammation, Kaposi Sarcoma, Laryngeal Cancer, Leiomyosarcoma, Leukemia, Medullary Thyroid Cancer, Metastatic Transitional (Urothelial) Tract Cancer, Mycosis Fungoides, Neuroendocrine Tumors, Oral Cavity (Mouth) Cancer, Oropharyngeal Cancer, Osteoarthritis, Osteosarcoma, Pancreatic Cancer, Penile Cancer, Pleomorphic Liposarcoma, Recurrent Head And Neck Cancer Squamous Cell Carcinoma, Rheumatoid Arthritis, Sicca Syndrome (Sjogren), Small-Cell Lung Cancer, Squamous Non-Small Cell Lung Cancer, Subacute Cutaneous Lupus Erythematosus (SCLE), Synovial Sarcoma, Systemic-Onset Juvenile Idiopathic Arthritis (Still Disease) and Transitional Cell Carcinoma (Urothelial Cell Carcinoma).
Note:Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
Scope
Summary
According to the recently published report 'Toll Like Receptor 8 - Drugs In Development, 2022'; Toll Like Receptor 8 (CD288 or TLR8) pipeline Target constitutes close to 35 molecules. Out of which approximately 34 molecules are developed by companies and remaining by the universities/institutes.
Toll Like Receptor 8 (CD288 or TLR8) - Toll-like receptor 8 is a protein encoded by the TLR8 gene. It controls host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
The report 'Toll Like Receptor 8 - Drugs In Development, 2022' outlays comprehensive information on the Toll Like Receptor 8 (CD288 or TLR8) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Toll Like Receptor 8 (CD288 or TLR8) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Phase I, Preclinical and Discovery stages are 1, 11, 7, 12 and 3 respectively. Similarly, the universities portfolio in Discovery stages comprises 1 molecule, respectively.
Report covers products from therapy areas Oncology, Immunology, Infectious Disease and Musculoskeletal Disorders which include indications Solid Tumor, Colorectal Cancer, Head And Neck Cancer Squamous Cell Carcinoma, Systemic Lupus Erythematosus, Hepatitis B, Melanoma, Metastatic Melanoma, Non-Small Cell Lung Cancer, Triple-Negative Breast Cancer (TNBC), Bladder Cancer, Gastric Cancer, Autoimmune Disorders, Bile Duct Cancer (Cholangiocarcinoma), Breast Cancer, Cervical Cancer, Cutaneous Lupus Erythematosus, Fibrosis, Gastroesophageal (GE) Junction Carcinomas, Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer (HER2- Breast Cancer), Human Epidermal Growth Factor Receptor 2 Positive Breast Cancer (HER2+ Breast Cancer), Merkel Cell Carcinoma, Metastatic Breast Cancer, Metastatic Colorectal Cancer, Nasopharyngeal Cancer, Non Muscle Invasive Bladder Cancer (NMIBC) (Superficial Bladder Cancer), Prostate Cancer, Renal Cell Carcinoma, Sarcomas, Soft Tissue Sarcoma, Squamous Cell Carcinoma, Transitional Cell Cancer (Urothelial Cell Cancer), Unspecified Cancer, Adenocarcinoma Of The Gastroesophageal Junction, Adenoid Cystic Carcinoma (ACC), Anal Cancer, Arthritis, Chondrosarcoma, Chronic Cutaneous Lupus Erythematosus (CCLE) / Discoid Lupus Erythematosus (DLE), Colon Cancer, Coronavirus Disease 2019 (COVID-19), Coronavirus Disease 2019 (COVID-19) Pneumonia, Cutaneous T-Cell Lymphoma, Endometrial Cancer, Esophageal Cancer, Ewing Sarcoma, Head And Neck Cancer, Hepatocellular Carcinoma, Hypopharyngeal Cancer, Inflammation, Kaposi Sarcoma, Laryngeal Cancer, Leiomyosarcoma, Leukemia, Medullary Thyroid Cancer, Metastatic Transitional (Urothelial) Tract Cancer, Mycosis Fungoides, Neuroendocrine Tumors, Oral Cavity (Mouth) Cancer, Oropharyngeal Cancer, Osteoarthritis, Osteosarcoma, Pancreatic Cancer, Penile Cancer, Pleomorphic Liposarcoma, Recurrent Head And Neck Cancer Squamous Cell Carcinoma, Rheumatoid Arthritis, Sicca Syndrome (Sjogren), Small-Cell Lung Cancer, Squamous Non-Small Cell Lung Cancer, Subacute Cutaneous Lupus Erythematosus (SCLE), Synovial Sarcoma, Systemic-Onset Juvenile Idiopathic Arthritis (Still Disease) and Transitional Cell Carcinoma (Urothelial Cell Carcinoma).
Note:Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
Scope
- The report provides a snapshot of the global therapeutic landscape for Toll Like Receptor 8 (CD288 or TLR8)
- The report reviews Toll Like Receptor 8 (CD288 or TLR8) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Toll Like Receptor 8 (CD288 or TLR8) targeted therapeutics and enlists all their major and minor projects
- The report assesses Toll Like Receptor 8 (CD288 or TLR8)) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Toll Like Receptor 8 (CD288 or TLR8) targeted therapeutics
- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Toll Like Receptor 8 (CD288 or TLR8)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Toll Like Receptor 8 (CD288 or TLR8) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
Companies Mentioned
Companies Mentioned
Altimmune Inc
Ambrx Biopharma Inc
Ascendis Pharma AS
Avidea Technologies Inc
Bolt Biotherapeutics Inc
Bristol-Myers Squibb Co
Curebiotech Inc
Curevac NV
Dynavax Technologies Corp
Eisai Co Ltd
Galderma SA
Gilead Sciences Inc
IngenoVax LLC
Janus Biotherapeutics Inc
Jiangsu Hengrui Medicine Co Ltd
Merck KGaA
Nektar Therapeutics
Novartis AG
Resolve Therapeutics LLC
Seven and Eight Biopharmaceuticals Corp
Seven and Eight Biopharmaceuticals Inc
Shanghai De Novo Pharmatech Co Ltd
Shanghai Zhimeng Biopharma Inc
Silverback Therapeutics Inc
UroGen Pharma Ltd
Vaccex Inc
Companies Mentioned
Altimmune Inc
Ambrx Biopharma Inc
Ascendis Pharma AS
Avidea Technologies Inc
Bolt Biotherapeutics Inc
Bristol-Myers Squibb Co
Curebiotech Inc
Curevac NV
Dynavax Technologies Corp
Eisai Co Ltd
Galderma SA
Gilead Sciences Inc
IngenoVax LLC
Janus Biotherapeutics Inc
Jiangsu Hengrui Medicine Co Ltd
Merck KGaA
Nektar Therapeutics
Novartis AG
Resolve Therapeutics LLC
Seven and Eight Biopharmaceuticals Corp
Seven and Eight Biopharmaceuticals Inc
Shanghai De Novo Pharmatech Co Ltd
Shanghai Zhimeng Biopharma Inc
Silverback Therapeutics Inc
UroGen Pharma Ltd
Vaccex Inc
Table of Contents
117 Pages
- Introduction
- Global Markets Direct Report Coverage
- Toll Like Receptor 8 (CD288 or TLR8) - Overview
- Toll Like Receptor 8 (CD288 or TLR8) - Therapeutics Development
- Products under Development by Stage of Development
- Products under Development by Therapy Area
- Products under Development by Indication
- Products under Development by Companies
- Products under Development by Universities/Institutes
- Toll Like Receptor 8 (CD288 or TLR8) - Therapeutics Assessment
- Assessment by Mechanism of Action
- Assessment by Route of Administration
- Assessment by Molecule Type
- Toll Like Receptor 8 (CD288 or TLR8) - Companies Involved in Therapeutics Development
- Altimmune Inc
- Ambrx Biopharma Inc
- Ascendis Pharma AS
- Avidea Technologies Inc
- Bolt Biotherapeutics Inc
- Bristol-Myers Squibb Co
- Curebiotech Inc
- Curevac NV
- Dynavax Technologies Corp
- Eisai Co Ltd
- Galderma SA
- Gilead Sciences Inc
- IngenoVax LLC
- Janus Biotherapeutics Inc
- Jiangsu Hengrui Medicine Co Ltd
- Merck KGaA
- Nektar Therapeutics
- Novartis AG
- Resolve Therapeutics LLC
- Seven and Eight Biopharmaceuticals Corp
- Seven and Eight Biopharmaceuticals Inc
- Shanghai De Novo Pharmatech Co Ltd
- Shanghai Zhimeng Biopharma Inc
- Silverback Therapeutics Inc
- UroGen Pharma Ltd
- Vaccex Inc
- Toll Like Receptor 8 (CD288 or TLR8) - Drug Profiles
- afimetoran - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- ALT-702 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- BDB-001 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- BDB-018 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- BDB-030 - Drug Profile
- Product Description
- Mechanism Of Action
- BDB-102 - Drug Profile
- Product Description
- Mechanism Of Action
- BDC-1001 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- CB06-036 - Drug Profile
- Product Description
- Mechanism Of Action
- CUCPT-8m - Drug Profile
- Product Description
- Mechanism Of Action
- CV-8102 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- DN-1508052 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Drugs to Agonize TLR8 for Fibrosis and Solid Tumors - Drug Profile
- Product Description
- Mechanism Of Action
- E-6742 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- enpatoran - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- HRS-9950 - Drug Profile
- Product Description
- Mechanism Of Action
- imiquimod - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- imiquimod + zalifrelimab - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- INGMM-1 - Drug Profile
- Product Description
- Mechanism Of Action
- JB-6121 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Monoclonal Antibody Conjugates to Agonize TLR 7 and 8 for Unspecified Cancer - Drug Profile
- Product Description
- Mechanism Of Action
- motolimod - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- NKTR-262 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- resiquimod - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- resiquimod - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- resiquimod SR - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- RSLV-132 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- SBT-6050 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- SBT-6290 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- SBT-8230 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- selgantolimod - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Small Molecule to Agonize TLR7 and TLR8 for Solid Tumors - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Small Molecule to Antagonize TLR7 and TLR8 for Autoimmune Disorders - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Small Molecules to Antagonize TLR8 for Rheumatoid Arthritis - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- SYN-001 - Drug Profile
- Product Description
- Mechanism Of Action
- VTX-1463 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Toll Like Receptor 8 (CD288 or TLR8) - Dormant Products
- Toll Like Receptor 8 (CD288 or TLR8) - Discontinued Products
- Toll Like Receptor 8 (CD288 or TLR8) - Product Development Milestones
- Featured News & Press Releases
- Jan 06, 2022: Bolt Biotherapeutics doses first patient with BDC-1001 in combination with OPDIVO (nivolumab) in ongoing phase 1/2 clinical trial for the Treatment of HER2-expressing solid tumors
- Dec 14, 2021: Ascendis Pharma virtual R&D program update highlights continued development across R&D pipeline
- Dec 07, 2021: Ascendis Pharma to host virtual R&D program update on December 14
- Dec 06, 2021: Bolt Biotherapeutics reports interim BDC-1001 phase 1/2 data demonstrating a safe and well-tolerated profile and emerging clinical activity at the ESMO Immuno-Oncology Congress 2021
- Dec 02, 2021: Bolt Biotherapeutics to present interim clinical data on BDC-1001 phase 1/2 clinical trial at ESMO Immuno-Oncology Congress 2021
- Nov 13, 2021: Seven and Eight Biopharma’s BDB001 in combination with an anti-PD-L1 mAb shows favorable safety and clinical responses in interim phase 1 data presented at the 2021 SITC Annual Meeting
- Nov 12, 2021: Silverback Therapeutics presents preclinical data for SBT8230 at AASLD The Liver Meeting 2021
- Nov 12, 2021: Silverback Therapeutics presents SBT6050-201 trial in progress poster at Society for Immunotherapy of Cancer's (SITC) 36th Annual Meeting
- Nov 10, 2021: CureVac presents promising data at SITC from Phase 1 study of oncology candidate CV8102 showing systemic immune response
- Nov 09, 2021: Ascendis Pharma presents new non-clinical data for TransCon TLR7/8 agonist oncology program at SITC 2021
- Sep 16, 2021: Silverback Therapeutics presents interim clinical results from the ongoing phase 1/1b study of SBT6050 alone or in combination with Pembrolizumab in patients with advanced or metastatic HER2-expressing solid tumors
- Sep 13, 2021: Silverback Therapeutics to present data from its phase 1/1b clinical trial of SBT6050 at the European Society for Medical Oncology (ESMO) 2021 Virtual Congress
- Sep 07, 2021: Seven and Eight Biopharmaceuticals announces the first patient treated in a phase 2 clinical trial of the TLR 7/8 dual agonist BDB001 in anti-PD-1 / anti-PD-L1 refractory solid tumors
- Jun 24, 2021: Resolve Therapeutics to start Phase II Trial of RSLV-132 for long Covid
- Jun 23, 2021: Seven and Eight Biopharmaceuticals announces the first patient treated in a first-in-human clinical trial of the TLR7/8 dual agonist BDB018 in advanced solid tumors
- Appendix
- Methodology
- Coverage
- Secondary Research
- Primary Research
- Expert Panel Validation
- Contact Us
- Disclaimer
- List of Tables
- Number of Products under Development by Stage of Development, 2022
- Number of Products under Development by Therapy Areas, 2022
- Number of Products under Development by Indications, 2022
- Number of Products under Development by Indications, 2022 (Contd..1)
- Number of Products under Development by Indications, 2022 (Contd..2)
- Number of Products under Development by Indications, 2022 (Contd..3)
- Number of Products under Development by Companies, 2022
- Products under Development by Companies, 2022
- Products under Development by Companies, 2022 (Contd..1)
- Products under Development by Companies, 2022 (Contd..2)
- Products under Development by Companies, 2022 (Contd..3)
- Products under Development by Companies, 2022 (Contd..4)
- Products under Development by Companies, 2022 (Contd..5)
- Products under Development by Companies, 2022 (Contd..6)
- Number of Products under Investigation by Universities/Institutes, 2022
- Products under Investigation by Universities/Institutes, 2022
- Number of Products by Stage and Mechanism of Actions, 2022
- Number of Products by Stage and Route of Administration, 2022
- Number of Products by Stage and Molecule Type, 2022
- Pipeline by Altimmune Inc, 2022
- Pipeline by Ambrx Biopharma Inc, 2022
- Pipeline by Ascendis Pharma AS, 2022
- Pipeline by Avidea Technologies Inc, 2022
- Pipeline by Bolt Biotherapeutics Inc, 2022
- Pipeline by Bristol-Myers Squibb Co, 2022
- Pipeline by Curebiotech Inc, 2022
- Pipeline by Curevac NV, 2022
- Pipeline by Dynavax Technologies Corp, 2022
- Pipeline by Eisai Co Ltd, 2022
- Pipeline by Galderma SA, 2022
- Pipeline by Gilead Sciences Inc, 2022
- Pipeline by IngenoVax LLC, 2022
- Pipeline by Janus Biotherapeutics Inc, 2022
- Pipeline by Jiangsu Hengrui Medicine Co Ltd, 2022
- Pipeline by Merck KGaA, 2022
- Pipeline by Nektar Therapeutics, 2022
- Pipeline by Novartis AG, 2022
- Pipeline by Resolve Therapeutics LLC, 2022
- Pipeline by Seven and Eight Biopharmaceuticals Corp, 2022
- Pipeline by Seven and Eight Biopharmaceuticals Inc, 2022
- Pipeline by Shanghai De Novo Pharmatech Co Ltd, 2022
- Pipeline by Shanghai Zhimeng Biopharma Inc, 2022
- Pipeline by Silverback Therapeutics Inc, 2022
- Pipeline by UroGen Pharma Ltd, 2022
- Pipeline by Vaccex Inc, 2022
- Dormant Products, 2022
- Dormant Products, 2022 (Contd..1)
- Dormant Products, 2022 (Contd..2)
- Discontinued Products, 2022
- List of Figures
- Number of Products under Development by Stage of Development, 2022
- Number of Products under Development by Therapy Areas, 2022
- Number of Products under Development by Top 10 Indications, 2022
- Number of Products by Mechanism of Actions, 2022
- Number of Products by Stage and Mechanism of Actions, 2022
- Number of Products by Routes of Administration, 2022
- Number of Products by Stage and Routes of Administration, 2022
- Number of Products by Molecule Types, 2022
- Number of Products by Stage and Molecule Types, 2022
Pricing
Currency Rates
Questions or Comments?
Our team has the ability to search within reports to verify it suits your needs. We can also help maximize your budget by finding sections of reports you can purchase.