
Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) Development by Therapy Areas and Indications, Stages, MoA, RoA, Molecule Type and Key Players, 2022 Update
Description
Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) Development by Therapy Areas and Indications, Stages, MoA, RoA, Molecule Type and Key Players, 2022 Update
Summary
According to the recently published report 'Proto Oncogene Tyrosine Protein Kinase Src - Drugs In Development, 2022'; Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) pipeline Target constitutes close to 17 molecules. Out of which approximately 15 molecules are developed by companies and remaining by the universities/institutes.
Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) - Proto-oncogene tyrosine-protein kinase Src or proto-oncogene c-Src is a non-receptor tyrosine kinase protein that is encoded by the SRC gene. It participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. It plays a role in the activation of other protein tyrosine kinase (PTK) families. It plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1.
The report 'Proto Oncogene Tyrosine Protein Kinase Src - Drugs In Development, 2022' outlays comprehensive information on the Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical and Discovery stages are 2, 6, 1, 1, 3 and 2 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 1 and 1 molecules, respectively. Report covers products from therapy areas Oncology, Respiratory, Central Nervous System, Genetic Disorders, Infectious Disease and Musculoskeletal Disorders which include indications Non-Small Cell Lung Cancer, Solid Tumor, Colorectal Cancer, Idiopathic Pulmonary Fibrosis, Central Nervous System (CNS) Tumor, Glioblastoma Multiforme (GBM), Melanoma, Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Anaplastic Large Cell Lymphoma (ALCL), Angiosarcoma, Breast Cancer, Bronchiolitis Obliterans, Cervical Cancer, Chronic Myelocytic Leukemia (CML, Chronic Myeloid Leukemia), Coronavirus Disease 2019 (COVID-19) Pneumonia, Endometrial Cancer, Esophageal Cancer, Fibrodysplasia Ossificans Progressiva (Myositis Ossificans Progressiva), Friedreich Ataxia, Gallbladder Cancer, Gastric Cancer, Gastroesophageal (GE) Junction Carcinomas, Head And Neck Cancer, Hepatocellular Carcinoma, Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu Disease), Interstitial Lung Fibrosis, Lewy Body Dementia, Liver Cancer, Lung Cancer, Lymphangioleiomyomatosis, Malignant Pleural Mesothelioma, Medullary Thyroid Cancer, Metastatic Brain Tumor, Neuroendocrine Tumors, Non-Hodgkin Lymphoma, Pancreatic Cancer, Papillary Thyroid Cancer, Parkinson's Disease, Pneumoconiosis, Psychosis, Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia, Renal Cell Carcinoma, Salivary Gland Cancer, Soft Tissue Sarcoma, Thyroid Cancer, Triple-Negative Breast Cancer (TNBC), Unspecified Cancer and Uterine Cancer.
Note:Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
Scope
Summary
According to the recently published report 'Proto Oncogene Tyrosine Protein Kinase Src - Drugs In Development, 2022'; Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) pipeline Target constitutes close to 17 molecules. Out of which approximately 15 molecules are developed by companies and remaining by the universities/institutes.
Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) - Proto-oncogene tyrosine-protein kinase Src or proto-oncogene c-Src is a non-receptor tyrosine kinase protein that is encoded by the SRC gene. It participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. It plays a role in the activation of other protein tyrosine kinase (PTK) families. It plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1.
The report 'Proto Oncogene Tyrosine Protein Kinase Src - Drugs In Development, 2022' outlays comprehensive information on the Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical and Discovery stages are 2, 6, 1, 1, 3 and 2 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 1 and 1 molecules, respectively. Report covers products from therapy areas Oncology, Respiratory, Central Nervous System, Genetic Disorders, Infectious Disease and Musculoskeletal Disorders which include indications Non-Small Cell Lung Cancer, Solid Tumor, Colorectal Cancer, Idiopathic Pulmonary Fibrosis, Central Nervous System (CNS) Tumor, Glioblastoma Multiforme (GBM), Melanoma, Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Anaplastic Large Cell Lymphoma (ALCL), Angiosarcoma, Breast Cancer, Bronchiolitis Obliterans, Cervical Cancer, Chronic Myelocytic Leukemia (CML, Chronic Myeloid Leukemia), Coronavirus Disease 2019 (COVID-19) Pneumonia, Endometrial Cancer, Esophageal Cancer, Fibrodysplasia Ossificans Progressiva (Myositis Ossificans Progressiva), Friedreich Ataxia, Gallbladder Cancer, Gastric Cancer, Gastroesophageal (GE) Junction Carcinomas, Head And Neck Cancer, Hepatocellular Carcinoma, Hereditary Hemorrhagic Telangiectasia (Osler-Weber-Rendu Disease), Interstitial Lung Fibrosis, Lewy Body Dementia, Liver Cancer, Lung Cancer, Lymphangioleiomyomatosis, Malignant Pleural Mesothelioma, Medullary Thyroid Cancer, Metastatic Brain Tumor, Neuroendocrine Tumors, Non-Hodgkin Lymphoma, Pancreatic Cancer, Papillary Thyroid Cancer, Parkinson's Disease, Pneumoconiosis, Psychosis, Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia, Renal Cell Carcinoma, Salivary Gland Cancer, Soft Tissue Sarcoma, Thyroid Cancer, Triple-Negative Breast Cancer (TNBC), Unspecified Cancer and Uterine Cancer.
Note:Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
Scope
- The report provides a snapshot of the global therapeutic landscape for Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2)
- The report reviews Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) targeted therapeutics and enlists all their major and minor projects
- The report assesses Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) targeted therapeutics
- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
Companies Mentioned
Companies Mentioned
AbbVie Inc
AstraZeneca Plc
Avalyn Pharma Inc
Boehringer Ingelheim International GmbH
Chengdu Fanxi Biopharma Co Ltd
Fratagene Therapeutics Srl
KeifeRx LLC
Lead Discovery Center GmbH
Nanocopoeia LLC
Prous Institute for Biomedical Research SA
Taiwan Liposome Co Ltd
Turning Point Therapeutics Inc
Companies Mentioned
AbbVie Inc
AstraZeneca Plc
Avalyn Pharma Inc
Boehringer Ingelheim International GmbH
Chengdu Fanxi Biopharma Co Ltd
Fratagene Therapeutics Srl
KeifeRx LLC
Lead Discovery Center GmbH
Nanocopoeia LLC
Prous Institute for Biomedical Research SA
Taiwan Liposome Co Ltd
Turning Point Therapeutics Inc
Table of Contents
119 Pages
- Introduction
- Global Markets Direct Report Coverage
- Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) - Overview
- Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) - Therapeutics Development
- Products under Development by Stage of Development
- Products under Development by Therapy Area
- Products under Development by Indication
- Products under Development by Companies
- Products under Development by Universities/Institutes
- Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) - Therapeutics Assessment
- Assessment by Mechanism of Action
- Assessment by Route of Administration
- Assessment by Molecule Type
- Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) - Companies Involved in Therapeutics Development
- AbbVie Inc
- AstraZeneca Plc
- Avalyn Pharma Inc
- Boehringer Ingelheim International GmbH
- Chengdu Fanxi Biopharma Co Ltd
- Fratagene Therapeutics Srl
- KeifeRx LLC
- Lead Discovery Center GmbH
- Nanocopoeia LLC
- Prous Institute for Biomedical Research SA
- Taiwan Liposome Co Ltd
- Turning Point Therapeutics Inc
- Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) - Drug Profiles
- bosutinib - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- dasatinib - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Drugs to Inhibit SRC for Friedreich Ataxia - Drug Profile
- Product Description
- Mechanism Of Action
- FNX-006 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- ilorasertib - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- JRP-890 - Drug Profile
- Product Description
- Mechanism Of Action
- nintedanib - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- nintedanib - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Ofev - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- repotrectinib - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- saracatinib difumarate - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Si-306 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Small Molecule to Inhibit IGF1R and SRC for Non-Small Cell Lung Cancer - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Small Molecules to Inhibit SRC for Oncology - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- TPX-0022 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- TPX-0046 - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Vargatef - Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) - Dormant Products
- Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) - Discontinued Products
- Proto Oncogene Tyrosine Protein Kinase Src (Proto Oncogene c Src or pp60c src or SRC or EC 2.7.10.2) - Product Development Milestones
- Featured News & Press Releases
- Feb 17, 2022: Zai Lab announces breakthrough therapy designation granted for Repotrectinib in China
- Feb 15, 2022: Boehringer Ingelheim Canada and the pan-Canadian Pharmaceutical Alliance (pCPA) complete negotiations for OFEV (nintedanib) for PF-ILD
- Jan 20, 2022: Turning Point Therapeutics announces FDA clearance of investigational new drug (IND) application for combination of elzovantinib and aumolertinib in EGFR mutant met-amplified non-small cell lung Cancer
- Oct 23, 2021: Turning Point Therapeutics presents early clinical data for Repotrectinib from care study in pediatric and young adult patients at SIOP 2021 Virtual Congress
- Oct 13, 2021: Turning Point Therapeutics and EQRx announce clinical collaboration to evaluate elzovantinib in combination with aumolertinib in patients with EGFR mutant met-amplified advanced non-small cell lung cancer
- Oct 11, 2021: Turning Point Therapeutics to present early clinical data for repotrectinib from the CARE study in pediatric and young adult patients at SIOP 2021 Virtual Congress
- Oct 08, 2021: Turning Point Therapeutics presents TRIDENT-1 study clinical data for repotrectinib in NTRK+ advanced solid tumors in plenary session at 2021 AACR-NCI-EORTC Conference
- Oct 04, 2021: Turning Point Therapeutics granted Breakthrough Therapy Designation for Repotrectinib treatment in patients with NTRK-positive, TKI-pretreated advanced solid tumors
- Sep 30, 2021: Turning Point Therapeutics announces additional details for three data presentations at the 2021 AACR-NCI-EORTC conference
- Sep 08, 2021: Turning Point Therapeutics announces early clinical data for Repotrectinib in NTRK fusion-positive advanced solid tumors selected for late-breaker plenary presentation at 2021 AACR-NCI-EORTC conference
- Aug 16, 2021: Turning Point Therapeutics initiates TRIDENT-2 clinical study investigating Repotrectinib-Trametinib combination in KRAS G12D mutated advanced solid tumors
- Aug 11, 2021: Turning Point Therapeutics granted sixth regulatory designation for Repotrectinib
- Jun 17, 2021: Turning Point Therapeutics granted FDA Orphan Drug Designation for TPX-0022 in gastric cancer
- May 28, 2021: Zai Lab announces first patient treated in China in the registrational phase 2 TRIDENT-1 study of repotrectinib
- May 14, 2021: Study analysis available during ATS 2021 supports long-term treatment with Ofev in patients with systemic sclerosis-associated interstitial lung disease
- Appendix
- Methodology
- Coverage
- Secondary Research
- Primary Research
- Expert Panel Validation
- Contact Us
- Disclaimer
- List of Tables
- Number of Products under Development by Stage of Development, 2022
- Number of Products under Development by Therapy Areas, 2022
- Number of Products under Development by Indications, 2022
- Number of Products under Development by Indications, 2022 (Contd..1)
- Number of Products under Development by Indications, 2022 (Contd..2)
- Number of Products under Development by Companies, 2022
- Products under Development by Companies, 2022
- Products under Development by Companies, 2022 (Contd..1)
- Products under Development by Companies, 2022 (Contd..2)
- Products under Development by Companies, 2022 (Contd..3)
- Number of Products under Investigation by Universities/Institutes, 2022
- Products under Investigation by Universities/Institutes, 2022
- Number of Products by Stage and Mechanism of Actions, 2022
- Number of Products by Stage and Route of Administration, 2022
- Number of Products by Stage and Molecule Type, 2022
- Pipeline by AbbVie Inc, 2022
- Pipeline by AstraZeneca Plc, 2022
- Pipeline by Avalyn Pharma Inc, 2022
- Pipeline by Boehringer Ingelheim International GmbH, 2022
- Pipeline by Chengdu Fanxi Biopharma Co Ltd, 2022
- Pipeline by Fratagene Therapeutics Srl, 2022
- Pipeline by KeifeRx LLC, 2022
- Pipeline by Lead Discovery Center GmbH, 2022
- Pipeline by Nanocopoeia LLC, 2022
- Pipeline by Prous Institute for Biomedical Research SA, 2022
- Pipeline by Taiwan Liposome Co Ltd, 2022
- Pipeline by Turning Point Therapeutics Inc, 2022
- Dormant Products, 2022
- Dormant Products, 2022 (Contd..1)
- Dormant Products, 2022 (Contd..2)
- Dormant Products, 2022 (Contd..3)
- Discontinued Products, 2022
- List of Figures
- Number of Products under Development by Stage of Development, 2022
- Number of Products under Development by Therapy Areas, 2022
- Number of Products under Development by Top 10 Indications, 2022
- Number of Products by Stage and Mechanism of Actions, 2022
- Number of Products by Routes of Administration, 2022
- Number of Products by Stage and Routes of Administration, 2022
- Number of Products by Stage and Routes of Administration, 2022
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