
Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Description
Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Summary
According to the recently published report 'Leptin Receptor - Drugs In Development, 2022'; Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) pipeline Target constitutes close to 10 molecules.
Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) - Leptin receptor or LEP-R is a protein encoded by the LEPR gene. It acts as a receptor for hormone LEP/leptin. Upon binding it mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade. LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity.
The report 'Leptin Receptor - Drugs In Development, 2022' outlays comprehensive information on the Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II and Preclinical stages are 1, 1 and 8 respectively. Report covers products from therapy areas Metabolic Disorders, Oncology, Central Nervous System and Non Malignant Disorders which include indications Obesity, Lipodystrophy (Lipoatrophy), Triple-Negative Breast Cancer (TNBC), Acquired Generalized Lipodystrophy (Lawrence Syndrome), Alzheimer's Disease, Benign Tumor, Choroidal Neovascularization, Congenital Generalized Lipodystrophy (Berardinelli-Seip Syndrome), Insulin Resistance, Solid Tumor, Type 1 Diabetes (Juvenile Diabetes), Type 2 Diabetes and Unspecified Cancer.
Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
Scope
Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Summary
According to the recently published report 'Leptin Receptor - Drugs In Development, 2022'; Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) pipeline Target constitutes close to 10 molecules.
Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) - Leptin receptor or LEP-R is a protein encoded by the LEPR gene. It acts as a receptor for hormone LEP/leptin. Upon binding it mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade. LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity.
The report 'Leptin Receptor - Drugs In Development, 2022' outlays comprehensive information on the Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II and Preclinical stages are 1, 1 and 8 respectively. Report covers products from therapy areas Metabolic Disorders, Oncology, Central Nervous System and Non Malignant Disorders which include indications Obesity, Lipodystrophy (Lipoatrophy), Triple-Negative Breast Cancer (TNBC), Acquired Generalized Lipodystrophy (Lawrence Syndrome), Alzheimer's Disease, Benign Tumor, Choroidal Neovascularization, Congenital Generalized Lipodystrophy (Berardinelli-Seip Syndrome), Insulin Resistance, Solid Tumor, Type 1 Diabetes (Juvenile Diabetes), Type 2 Diabetes and Unspecified Cancer.
Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
Scope
- The report provides a snapshot of the global therapeutic landscape for Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR)
- The report reviews Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) targeted therapeutics and enlists all their major and minor projects
- The report assesses Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) targeted therapeutics
- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR)Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
Table of Contents
51 Pages
- Introduction
- Global Markets Direct Report Coverage
- Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) – Overview
- Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) – Therapeutics Development
- Products under Development by Stage of Development
- Products under Development by Therapy Area
- Products under Development by Indication
- Products under Development by Companies
- Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) – Therapeutics Assessment
- Assessment by Mechanism of Action
- Assessment by Route of Administration
- Assessment by Molecule Type
- Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) – Companies Involved in Therapeutics Development
- Aceragen Inc
- Amryt Pharma Plc
- Astellas Pharma Inc
- Cellivery Therapeutics Inc
- Jyant Technologies Inc
- NeuroNano Pharma Inc
- Neurotez Inc
- Regeneron Pharmaceuticals Inc
- XL-protein GmbH
- Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) – Drug Profiles
- ACG-401 – Drug Profile
- CV-08 – Drug Profile
- memtin – Drug Profile
- metreleptin – Drug Profile
- mibavademab – Drug Profile
- Peptide to Antagonize Leptin Receptor II for Triple Negative Breast Cancer – Drug Profile
- Peptides to Antagonize LEPR for Triple-Negative Breast Cancer – Drug Profile
- Recombinant Protein to Agonize Leptin Receptor for Obesity – Drug Profile
- VET-2L2 – Drug Profile
- XL-100 – Drug Profile
- Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) – Dormant Products
- Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) – Discontinued Products
- Leptin Receptor (HuB219 or OB Receptor or CD295 or LEPR) – Product Development Milestones
- Featured News & Press Releases
- Oct 17, 2022: Amryt receives reimbursement approval from the Dutch Ministry of Health for Myalepta (metreleptin)
- Mar 23, 2021: Amryt receives positive feedback from the FDA on the path forward for Myalept (metreleptin) indication in partial lipodystrophy
- Mar 22, 2021: Amryt receives reimbursement approval from the French Ministry of Social Affairs and Health for Myalepta (metreleptin)
- Jan 20, 2021: Amryt receives reimbursement approval from NICE for Myalepta (metreleptin) in England and Wales
- Aug 23, 2018: Novelion Therapeutics announces next phase of operational improvements
- Jul 31, 2018: Novelion Therapeutics Announces Marketing Authorization for MYALEPTA (metreleptin) in the European Union to Treat Generalized and Partial Lipodystrophy
- Jun 25, 2018: Novelion Therapeutics Announces Presentation of Positive Metreleptin Data at American Diabetes Association Scientific Sessions
- Jun 01, 2018: MYALEPTA (metreleptin) Receives Positive CHMP Opinion in Patients with Generalized and Partial Lipodystrophy
- Sep 15, 2017: Metreleptin and Lipodystrophy Data Presented at the International Meeting of Pediatric Endocrinology
- Jun 12, 2017: Novelion Therapeutics Announces Presentation of Metreleptin Data at American Diabetes Association
- May 05, 2017: Novelion Therapeutics Announces Presentation of Metreleptin Data at American Association of Clinical Endocrinology
- Apr 04, 2017: Metreleptin and Lipodystrophy Data Presented at the Annual Meeting of the Endocrine Society
- Mar 30, 2017: Novelion Therapeutics Subsidiary Announces New Data to be Presented at the Annual Meeting of the Endocrine Society
- Jan 23, 2017: Novelion Therapeutics Announces Acceptance of Marketing Authorization Application for Metreleptin by European Medicines Agency
- Dec 22, 2016: Novelion Therapeutics Subsidiary Files for European Approval for Metreleptin as a treatment for Generalized Lipodystrophy and a Subset of Patients with Partial Lipodystrophy
- Appendix
- Methodology
- Coverage
- Secondary Research
- Primary Research
- Expert Panel Validation
- Contact Us
- Disclaimer
- List of Tables
- Table 1: Number of Products under Development by Stage of Development, 2022
- Table 2: Number of Products under Development by Therapy Areas, 2022
- Table 3: Number of Products under Development by Indication, 2022
- Table 4: Number of Products under Development by Companies, 2022
- Table 5: Products under Development by Companies, 2022
- Table 6: Number of Products by Stage and Mechanism of Actions, 2022
- Table 7: Number of Products by Stage and Route of Administration, 2022
- Table 8: Number of Products by Stage and Molecule Type, 2022
- Table 9: Pipeline by Aceragen Inc, 2022
- Table 10: Pipeline by Amryt Pharma Plc, 2022
- Table 11: Pipeline by Astellas Pharma Inc, 2022
- Table 12: Pipeline by Cellivery Therapeutics Inc, 2022
- Table 13: Pipeline by Jyant Technologies Inc, 2022
- Table 14: Pipeline by NeuroNano Pharma Inc, 2022
- Table 15: Pipeline by Neurotez Inc, 2022
- Table 16: Pipeline by Regeneron Pharmaceuticals Inc, 2022
- Table 17: Pipeline by XL-protein GmbH, 2022
- Table 18: Dormant Projects, 2022
- Table 19: Discontinued Products, 2022
- List of Figures
- Figure 1: Number of Products under Development by Stage of Development, 2022
- Figure 2: Number of Products under Development by Therapy Areas, 2022
- Figure 3: Number of Products under Development by Top 10 Indications, 2022
- Figure 4: Number of Products by Mechanism of Actions, 2022
- Figure 5: Number of Products by Stage and Mechanism of Actions, 2022
- Figure 6: Number of Products byRoutes of Administration, 2022
- Figure 7: Number of Products by Stage and Routes of Administration, 2022
- Figure 8: Number of Products by Molecule Types, 2022
- Figure 9: Number of Products by Stage and Molecule Types, 2022
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