
Epstein-Barr Virus (HHV-4) Infections Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Description
Epstein-Barr Virus (HHV-4) Infections Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update
Summary
Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Epstein-Barr Virus (HHV-4) Infections - Drugs In Development, 2022, provides an overview of the Epstein-Barr Virus (HHV-4) Infections (Infectious Disease) pipeline landscape.
Epstein-Barr virus (EBV) or human herpes virus 4 virus is a member of the Herpesviridae family. It is one of the most common human viruses to cause cancer in humans and is associated with a wide range of human cancers originating from epithelial cells, lymphocytes and mesenchymal cells. It spreads most commonly through bodily fluids. It can also spread through blood and semen during sexual contact, blood transfusions, and organ transplantations. Symptoms of EBV infections include fatigue, fever, and inflamed throat, swollen lymph nodes in the neck, enlarged spleen, swollen liver and rash. Treatment includes over-the-counter pain and fever medications to get relief from the symptoms of the disease.
Report Highlights
Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Epstein-Barr Virus (HHV-4) Infections - Drugs In Development, 2022, provides comprehensive information on the therapeutics under development for Epstein-Barr Virus (HHV-4) Infections (Infectious Disease), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.
The Epstein-Barr Virus (HHV-4) Infections (Infectious Disease) pipeline guide also reviews of key players involved in therapeutic development for Epstein-Barr Virus (HHV-4) Infections and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Phase III, Phase II, Phase I, Preclinical, Discovery and Unknown stages are 1, 1, 6, 3, 18, 7 and 1 respectively. Similarly, the Universities portfolio in Phase III, Phase II, Phase I, Preclinical and Discovery stages comprises 2, 10, 9, 8 and 5 molecules, respectively.
Epstein-Barr Virus (HHV-4) Infections (Infectious Disease) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.
Note:Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
Scope
Summary
Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Epstein-Barr Virus (HHV-4) Infections - Drugs In Development, 2022, provides an overview of the Epstein-Barr Virus (HHV-4) Infections (Infectious Disease) pipeline landscape.
Epstein-Barr virus (EBV) or human herpes virus 4 virus is a member of the Herpesviridae family. It is one of the most common human viruses to cause cancer in humans and is associated with a wide range of human cancers originating from epithelial cells, lymphocytes and mesenchymal cells. It spreads most commonly through bodily fluids. It can also spread through blood and semen during sexual contact, blood transfusions, and organ transplantations. Symptoms of EBV infections include fatigue, fever, and inflamed throat, swollen lymph nodes in the neck, enlarged spleen, swollen liver and rash. Treatment includes over-the-counter pain and fever medications to get relief from the symptoms of the disease.
Report Highlights
Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Epstein-Barr Virus (HHV-4) Infections - Drugs In Development, 2022, provides comprehensive information on the therapeutics under development for Epstein-Barr Virus (HHV-4) Infections (Infectious Disease), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.
The Epstein-Barr Virus (HHV-4) Infections (Infectious Disease) pipeline guide also reviews of key players involved in therapeutic development for Epstein-Barr Virus (HHV-4) Infections and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Phase III, Phase II, Phase I, Preclinical, Discovery and Unknown stages are 1, 1, 6, 3, 18, 7 and 1 respectively. Similarly, the Universities portfolio in Phase III, Phase II, Phase I, Preclinical and Discovery stages comprises 2, 10, 9, 8 and 5 molecules, respectively.
Epstein-Barr Virus (HHV-4) Infections (Infectious Disease) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.
Note:Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
Scope
- The pipeline guide provides a snapshot of the global therapeutic landscape of Epstein-Barr Virus (HHV-4) Infections (Infectious Disease).
- The pipeline guide reviews pipeline therapeutics for Epstein-Barr Virus (HHV-4) Infections (Infectious Disease) by companies and universities/research institutes based on information derived from company and industry-specific sources.
- The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages.
- The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities.
- The pipeline guide reviews key companies involved in Epstein-Barr Virus (HHV-4) Infections (Infectious Disease) therapeutics and enlists all their major and minor projects.
- The pipeline guide evaluates Epstein-Barr Virus (HHV-4) Infections (Infectious Disease) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type.
- The pipeline guide encapsulates all the dormant and discontinued pipeline projects.
- The pipeline guide reviews latest news related to pipeline therapeutics for Epstein-Barr Virus (HHV-4) Infections (Infectious Disease)
- Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies.
- Recognize emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage.
- Find and recognize significant and varied types of therapeutics under development for Epstein-Barr Virus (HHV-4) Infections (Infectious Disease).
- Classify potential new clients or partners in the target demographic.
- Develop tactical initiatives by understanding the focus areas of leading companies.
- Plan mergers and acquisitions meritoriously by identifying key players and it’s most promising pipeline therapeutics.
- Formulate corrective measures for pipeline projects by understanding Epstein-Barr Virus (HHV-4) Infections (Infectious Disease) pipeline depth and focus of Indication therapeutics.
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
- Adjust the therapeutic portfolio by recognizing discontinued projects and understand from the know-how what drove them from pipeline.
Table of Contents
155 Pages
- Introduction
- Global Markets Direct Report Coverage
- Epstein–Barr Virus (HHV-4) Infections – Overview
- Epstein–Barr Virus (HHV-4) Infections – Therapeutics Development
- Pipeline Overview
- Pipeline by Companies
- Pipeline by Universities/Institutes
- Products under Development by Companies
- Products under Development by Universities/Institutes
- Epstein–Barr Virus (HHV-4) Infections – Therapeutics Assessment
- Assessment by Target
- Assessment by Mechanism of Action
- Assessment by Route of Administration
- Assessment by Molecule Type
- Epstein–Barr Virus (HHV-4) Infections – Companies Involved in Therapeutics Development
- Advenchen Laboratories LLC
- AlloVir Inc
- Atara Biotherapeutics Inc
- Boryung ViGenCell Inc
- Bristol-Myers Squibb Co
- China Immunotech Co Ltd
- Citranvi Biosciences LLC
- Codiak BioSciences Inc
- Elicio Therapeutics Inc
- Eutilex Co Ltd
- Galenbio Ltd
- Geneius Biotechnology Inc
- Genocea Biosciences Inc
- iCELL Biotechnology Co Ltd
- Immunotech Biopharm Ltd
- Incyte Corp
- Inmagene Biopharmaceuticals Ltd
- Innovent Biologics Inc
- Karyopharm Therapeutics Inc
- Lion TCR Pte Ltd
- ManysmarT Therapeutics Inc
- Moderna Inc
- Nanjing Iaso Biotherapeutics Co Ltd
- Omeros Corp
- OPKO Health Inc
- Oxford Vacmedix UK Ltd
- Replicate Bioscience Inc
- Savoy Pharmaceuticals Inc
- Shanghai YaKe Biotechnology Co Ltd
- Stemirna Therapeutics Ltd
- Viracta Therapeutics Inc
- Vironika LLC
- ViroStatics SRL
- Epstein–Barr Virus (HHV-4) Infections – Drug Profiles
- apatinib mesylate – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- ATA-190 – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Cellular Immunotherapy for EBV Associated Malignancies – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Cellular Immunotherapy for Epstein-Barr Viral Infections, Multiple Sclerosis and Systemic Lupus Erythematosus – Drug Profile
- Product Description
- Mechanism Of Action
- Cellular Immunotherapy for Epstein–Barr Virus (HHV-4) Infections – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Cellular Immunotherapy for Epstein–Barr Virus Infections and Nasopharyngeal Cancer – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Cellular Immunotherapy for Infectious Disease – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Cellular Immunotherapy for Infectious Diseases – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Cellular Immunotherapy for Refractory Epstein-Barr Virus Infection – Drug Profile
- Product Description
- Mechanism Of Action
- Cellular Immunotherapy for Unspecified Cancer and Viral Infections – Drug Profile
- Product Description
- Mechanism Of Action
- Cellular Immunotherapy for Viral Infections – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Cellular Immunotherapy to Target LMP-1 and LMP-2 for Epstein-Barr Virus Associated Cancers – Drug Profile
- Product Description
- Mechanism Of Action
- EBV vaccine – Drug Profile
- Product Description
- Mechanism Of Action
- EBViNT – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- ELI-006 – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Epstein-Barr Virus (HHV-4) vaccine – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Epstein-Barr virus (virus like particle) vaccine – Drug Profile
- Product Description
- Mechanism Of Action
- Epstein-Barr virus vaccine – Drug Profile
- Product Description
- Mechanism Of Action
- GEN-007 – Drug Profile
- Product Description
- Mechanism Of Action
- Gene Therapy 1 for Oncology – Drug Profile
- Product Description
- Mechanism Of Action
- Gene Therapy for Epstein–Barr Virus Associated Nasopharyngeal Cancer – Drug Profile
- Product Description
- Mechanism Of Action
- Gene Therapy for Epstein–Barr Virus Infections – Drug Profile
- Product Description
- Mechanism Of Action
- Gene Therapy for Viral Infections – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Gene Therapy for Viral Infections Post-HSCT – Drug Profile
- Product Description
- Mechanism Of Action
- Gene Therapy to Target Latent Membrane Protein-2 for Epstein-Barr Virus Associated Cancer – Drug Profile
- Product Description
- Mechanism Of Action
- Gene Therapy to Target LMP1 for Epstein-Barr Virus Associated Nasopharyngeal Cancer – Drug Profile
- Product Description
- Mechanism Of Action
- Gene Therapy to Target LMP1 for Epstein–Barr Virus (HHV-4) Infections and Oncology – Drug Profile
- Product Description
- Mechanism Of Action
- Gene Therapy to Target LMP2 for EBV Associated Nasopharyngeal Carcinoma – Drug Profile
- Product Description
- Mechanism Of Action
- GNSTEBV-001 – Drug Profile
- Product Description
- Mechanism Of Action
- IMG-025 – Drug Profile
- Product Description
- Mechanism Of Action
- ipilimumab + nivolumab – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Monoclonal Antibody to Target BARF-1 for Epstein-Barr Virus Infections and Oncology – Drug Profile
- Product Description
- Mechanism Of Action
- Monoclonal Antibody to Target LMP-1 for Epstein-Barr Virus Associated Cancer – Drug Profile
- Product Description
- Mechanism Of Action
- mRNA-1189 – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- mRNA-1195 – Drug Profile
- Product Description
- Mechanism Of Action
- MS-16EBV – Drug Profile
- Product Description
- Mechanism Of Action
- MVA vaccine – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- nanatinostat – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- OVM-400 – Drug Profile
- Product Description
- Mechanism Of Action
- posoleucel – Drug Profile
- Product Description
- Mechanism Of Action
- History of Events
- Protein for EBV Associated Cancer – Drug Profile
- Product Description
- Mechanism Of Action
- RBI-7000 – Drug Profile
- RD-128 – Drug Profile
- ruxolitinib phosphate – Drug Profile
- sintilimab – Drug Profile
- Small Molecule for Epstein-Barr Virus (HHV-4) Infections – Drug Profile
- Small Molecule to Activate ZTA for Epstein–Barr Virus (HHV-4) Infections – Drug Profile
- Small Molecule to Inhibit EBNA1 for Epstein-Barr Virus (EBV) Infections – Drug Profile
- Small Molecule to Inhibit GPR183 for Epstein-Barr Viral Infections and Osteoporosis – Drug Profile
- Small Molecules to Inhibit CDK4, CDK6 and CDK9 for EBV Infections – Drug Profile
- Small Molecules to Inhibit EBNA1 for Epstein-Barr Virus Infections – Drug Profile
- tabelecleucel – Drug Profile
- Vaccine for EBV Associated Nasopharyngeal Cancer and Hodgkin Lymphoma – Drug Profile
- Vaccines for Epstein-Barr Virus Associated Cancer – Drug Profile
- verdinexor – Drug Profile
- Viroprev – Drug Profile
- VK-2019 – Drug Profile
- VT-EBV-201 – Drug Profile
- YTE-001 – Drug Profile
- Epstein–Barr Virus (HHV-4) Infections – Dormant Projects
- Epstein–Barr Virus (HHV-4) Infections – Discontinued Products
- Epstein–Barr Virus (HHV-4) Infections – Product Development Milestones
- Featured News & Press Releases
- May 09, 2022: NIH commences Phase I trial of Epstein-Barr virus vaccine
- Apr 20, 2022: Key Opinion Leader webinar on nana-val for the treatment of advanced Epstein-Barr Virus-Positive solid tumors
- Apr 20, 2022: FDA Grants Regenerative Medicine Advanced Therapy (RMAT) Designation to AlloVir’s Posoleucel for Prevention of Multiple Life-Threatening Infections from Six Viruses in Allogeneic Hematopoietic Cell Transplant Patients
- Mar 22, 2022: AlloVir initiates global phase 3 registrational study of posoleucel for prevention of life-threatening viral infections from six common viruses in high-risk, allogeneic hematopoietic cell transplant patients
- Jan 31, 2022: Viracta Therapeutics announces first patient dosed in phase 1b/2 trial of Nana-val in patients with advanced Epstein-Barr virus-positive solid tumors
- Jan 06, 2022: Moderna doses first subject in Phase I EBV vaccine trial
- Dec 13, 2021: Atara Biotherapeutics announces positive results from pivotal phase 3 Trial (ALLELE) of Tab-cel at the 63rd American Society of Hematology (ASH) Annual Meeting
- Dec 13, 2021: Viracta Therapeutics announces final phase 1b/2 data showing promising and durable signal of efficacy for Nana-val in relapsed/refractory epstein-barr virus-positive lymphoma in an oral presentation at ASH 2021
- Nov 30, 2021: European Medicines Agency (EMA) validates Atara Biotherapeutics' marketing authorization application for Tabelecleucel for the treatment of Epstein-Barr virus-positive post-transplant lymphoproliferative disease
- Nov 29, 2021: Viracta Therapeutics announces orphan drug designation granted by FDA for its all-oral combination of nanatinostat and valganciclovir (Nana-val) for the treatment of Epstein Barr virus-positive diffuse large B-cell lymphoma
- Oct 06, 2021: Viracta Therapeutics initiates phase 1b/2 trial in Epstein-Barr Virus-Positive (EBV+) solid tumors
- Sep 27, 2021: European Medicines Agency grants Atara Biotherapeutics accelerated assessment of tab-cel for the treatment of Epstein-Barr virus positive post-transplant lymphoproliferative disease (PTLD)
- Jul 21, 2021: Viracta Therapeutics announces FDA clearance of IND application for phase 1b/2 trial in Epstein-barr virus-positive (EBV+) solid tumors
- Jul 01, 2021: Atara Biotherapeutics joins the rare disease company coalition alongside industry gamechangers
- Jun 07, 2021: Atara Biotherapeutics presents positive Tab-cel long-term overall survival data for epstein-barr virus-driven post-transplant lymphoproliferative disease after solid organ transplant at ATC 2021 Virtual Connect
- Appendix
- Methodology
- Coverage
- Secondary Research
- Primary Research
- Expert Panel Validation
- Contact Us
- Disclaimer
- List of Tables
- Table 1: Number of Products under Development for Epstein–Barr Virus (HHV-4) Infections, 2022
- Table 2: Number of Products under Development by Companies, 2022
- Table 3: Number of Products under Development by Companies, 2022 (Contd..1)
- Table 4: Number of Products under Development by Universities/Institutes, 2022
- Table 5: Number of Products under Development by Universities/Institutes, 2022 (Contd..1)
- Table 6: Products under Development by Companies, 2022
- Table 7: Products under Development by Companies, 2022 (Contd..1)
- Table 8: Products under Development by Universities/Institutes, 2022
- Table 9: Number of Products by Stage and Target, 2022
- Table 10: Number of Products by Stage and Mechanism of Action, 2022
- Table 11: Number of Products by Stage and Route of Administration, 2022
- Table 12: Number of Products by Stage and Molecule Type, 2022
- Table 13: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Advenchen Laboratories LLC, 2022
- Table 14: Epstein–Barr Virus (HHV-4) Infections – Pipeline by AlloVir Inc, 2022
- Table 15: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Atara Biotherapeutics Inc, 2022
- Table 16: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Boryung ViGenCell Inc, 2022
- Table 17: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Bristol-Myers Squibb Co, 2022
- Table 18: Epstein–Barr Virus (HHV-4) Infections – Pipeline by China Immunotech Co Ltd, 2022
- Table 19: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Citranvi Biosciences LLC, 2022
- Table 20: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Codiak BioSciences Inc, 2022
- Table 21: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Elicio Therapeutics Inc, 2022
- Table 22: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Eutilex Co Ltd, 2022
- Table 23: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Galenbio Ltd, 2022
- Table 24: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Geneius Biotechnology Inc, 2022
- Table 25: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Genocea Biosciences Inc, 2022
- Table 26: Epstein–Barr Virus (HHV-4) Infections – Pipeline by iCELL Biotechnology Co Ltd, 2022
- Table 27: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Immunotech Biopharm Ltd, 2022
- Table 28: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Incyte Corp, 2022
- Table 29: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Inmagene Biopharmaceuticals Ltd, 2022
- Table 30: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Innovent Biologics Inc, 2022
- Table 31: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Karyopharm Therapeutics Inc, 2022
- Table 32: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Lion TCR Pte Ltd, 2022
- Table 33: Epstein–Barr Virus (HHV-4) Infections – Pipeline by ManysmarT Therapeutics Inc, 2022
- Table 34: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Moderna Inc, 2022
- Table 35: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Nanjing Iaso Biotherapeutics Co Ltd, 2022
- Table 36: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Omeros Corp, 2022
- Table 37: Epstein–Barr Virus (HHV-4) Infections – Pipeline by OPKO Health Inc, 2022
- Table 38: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Oxford Vacmedix UK Ltd, 2022
- Table 39: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Replicate Bioscience Inc, 2022
- Table 40: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Savoy Pharmaceuticals Inc, 2022
- Table 41: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Shanghai YaKe Biotechnology Co Ltd, 2022
- Table 42: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Stemirna Therapeutics Ltd, 2022
- Table 43: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Viracta Therapeutics Inc, 2022
- Table 44: Epstein–Barr Virus (HHV-4) Infections – Pipeline by Vironika LLC, 2022
- Table 45: Epstein–Barr Virus (HHV-4) Infections – Pipeline by ViroStatics SRL, 2022
- Table 46: Epstein–Barr Virus (HHV-4) Infections – Dormant Projects, 2022
- Table 47: Epstein–Barr Virus (HHV-4) Infections – Dormant Projects, 2022 (Contd..1)
- Table 48: Epstein–Barr Virus (HHV-4) Infections – Discontinued Products, 2022
- List of Figures
- Figure 1: Number of Products under Development for Epstein–Barr Virus (HHV-4) Infections, 2022
- Figure 2: Number of Products under Development by Companies, 2022
- Figure 3: Number of Products under Development by Universities/Institutes, 2022
- Figure 4: Number of Products by Top 10 Targets, 2022
- Figure 5: Number of Products by Stage and Top 10 Targets, 2022
- Figure 6: Number of Products by Top 10 Mechanism of Actions, 2022
- Figure 7: Number of Products by Stage and Top 10 Mechanism of Actions, 2022
- Figure 8: Number of Products by Routes of Administration, 2022
- Figure 9: Number of Products by Stage and Routes of Administration, 2022
- Figure 10: Number of Products by Molecule Types, 2022
- Figure 11: Number of Products by Stage and Molecule Types, 2022
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