
Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) Drugs in Development by Therapy Areas and Indications, Stages, MoA, RoA, Molecule Type and Key Players, 2022 Update
Description
Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) Drugs in Development by Therapy Areas and Indications, Stages, MoA, RoA, Molecule Type and Key Players, 2022 Update
Summary
According to the recently published report 'Aryl Hydrocarbon Receptor - Drugs In Development, 2022'; Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) pipeline Target constitutes close to 32 molecules. Out of which approximately 29 molecules are developed by companies and remaining by the universities/institutes.
Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) - Aryl hydrocarbon receptor is a protein encoded by the AHR gene. It mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. It involved in cell-cycle regulation. It plays an important role in the development and maturation of many tissues. It regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1.
The report 'Aryl Hydrocarbon Receptor - Drugs In Development, 2022' outlays comprehensive information on the Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Phase I, Preclinical and Discovery stages are 3, 2, 4, 17 and 3 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 2 and 1 molecules, respectively.
Report covers products from therapy areas Oncology, Immunology, Gastrointestinal, Dermatology, Central Nervous System, Infectious Disease, Metabolic Disorders, Ophthalmology and Respiratory which include indications Coronavirus Disease 2019 (COVID-19), Psoriasis, Solid Tumor, Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Atopic Dermatitis (Atopic Eczema), Chronic Myelocytic Leukemia (CML, Chronic Myeloid Leukemia), Colorectal Cancer, Head And Neck Cancer Squamous Cell Carcinoma, Inflammatory Bowel Disease, Multiple Sclerosis, Triple-Negative Breast Cancer (TNBC), Type 1 Diabetes (Juvenile Diabetes), Ulcerative Colitis, Unspecified Cancer, Unspecified Dermatological Disorders, Uveitis, Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Acute Respiratory Distress Syndrome, Alopecia, Androgen-Sensitive Prostate Cancer, B-Cell Non-Hodgkin Lymphoma, Bladder Cancer, Blepharitis, Burkitt Lymphoma, Celiac Disease, Colitis, Coronavirus Disease 2019 (COVID-19) Associated Acute Respiratory Distress Syndrome, Crohn's Disease (Regional Enteritis), Dengue Fever, Graft Versus Host Disease (GVHD), Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma), Keratoconjunctivitis Sicca (Dry Eye), Lupus Nephritis, Mantle Cell Lymphoma, Melanoma, Metastatic Hepatocellular Carcinoma (HCC), Metastatic Transitional (Urothelial) Tract Cancer, Multiple Myeloma (Kahler Disease), Myasthenia Gravis, Myelodysplastic Syndrome, Non-Small Cell Lung Cancer, Oral Cancer, Osteoarthritis Pain, Pancreatic Ductal Adenocarcinoma, Pemphigus, Plaque Psoriasis (Psoriasis Vulgaris), Rheumatoid Arthritis, Systemic Sclerosis (Scleroderma), T-Cell Lymphomas, Transitional Cell Cancer (Urothelial Cell Cancer), Vitiligo, Wet (Neovascular / Exudative) Macular Degeneration and Zika Virus Infections.
Note:Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
Scope
Summary
According to the recently published report 'Aryl Hydrocarbon Receptor - Drugs In Development, 2022'; Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) pipeline Target constitutes close to 32 molecules. Out of which approximately 29 molecules are developed by companies and remaining by the universities/institutes.
Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) - Aryl hydrocarbon receptor is a protein encoded by the AHR gene. It mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. It involved in cell-cycle regulation. It plays an important role in the development and maturation of many tissues. It regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1.
The report 'Aryl Hydrocarbon Receptor - Drugs In Development, 2022' outlays comprehensive information on the Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.
It also reviews key players involved in Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Phase I, Preclinical and Discovery stages are 3, 2, 4, 17 and 3 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 2 and 1 molecules, respectively.
Report covers products from therapy areas Oncology, Immunology, Gastrointestinal, Dermatology, Central Nervous System, Infectious Disease, Metabolic Disorders, Ophthalmology and Respiratory which include indications Coronavirus Disease 2019 (COVID-19), Psoriasis, Solid Tumor, Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Atopic Dermatitis (Atopic Eczema), Chronic Myelocytic Leukemia (CML, Chronic Myeloid Leukemia), Colorectal Cancer, Head And Neck Cancer Squamous Cell Carcinoma, Inflammatory Bowel Disease, Multiple Sclerosis, Triple-Negative Breast Cancer (TNBC), Type 1 Diabetes (Juvenile Diabetes), Ulcerative Colitis, Unspecified Cancer, Unspecified Dermatological Disorders, Uveitis, Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Acute Respiratory Distress Syndrome, Alopecia, Androgen-Sensitive Prostate Cancer, B-Cell Non-Hodgkin Lymphoma, Bladder Cancer, Blepharitis, Burkitt Lymphoma, Celiac Disease, Colitis, Coronavirus Disease 2019 (COVID-19) Associated Acute Respiratory Distress Syndrome, Crohn's Disease (Regional Enteritis), Dengue Fever, Graft Versus Host Disease (GVHD), Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma), Keratoconjunctivitis Sicca (Dry Eye), Lupus Nephritis, Mantle Cell Lymphoma, Melanoma, Metastatic Hepatocellular Carcinoma (HCC), Metastatic Transitional (Urothelial) Tract Cancer, Multiple Myeloma (Kahler Disease), Myasthenia Gravis, Myelodysplastic Syndrome, Non-Small Cell Lung Cancer, Oral Cancer, Osteoarthritis Pain, Pancreatic Ductal Adenocarcinoma, Pemphigus, Plaque Psoriasis (Psoriasis Vulgaris), Rheumatoid Arthritis, Systemic Sclerosis (Scleroderma), T-Cell Lymphomas, Transitional Cell Cancer (Urothelial Cell Cancer), Vitiligo, Wet (Neovascular / Exudative) Macular Degeneration and Zika Virus Infections.
Note:Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
Scope
- The report provides a snapshot of the global therapeutic landscape for Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR)
- The report reviews Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) targeted therapeutics and enlists all their major and minor projects
- The report assesses Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) targeted therapeutics
- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
Table of Contents
106 Pages
- Introduction
- Global Markets Direct Report Coverage
- Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) – Overview
- Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) – Therapeutics Development
- Products under Development by Stage of Development
- Products under Development by Therapy Area
- Products under Development by Indication
- Products under Development by Companies
- Products under Development by Universities/Institutes
- Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) – Therapeutics Assessment
- Assessment by Mechanism of Action
- Assessment by Route of Administration
- Assessment by Molecule Type
- Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) – Companies Involved in Therapeutics Development
- Actavalon Inc
- Active Biotech AB
- Ampio Pharmaceuticals Inc
- AnTolRx Inc
- Aqilion AB
- Artus Therapeutics Inc
- Aslan Pharmaceuticals Ltd
- Azora Therapeutics Australia Pty Ltd
- Bayer AG
- Dermavant Sciences Inc
- Hercules Pharmaceuticals BV
- Ikena Oncology Inc
- JAGUAHR Therapeutics Pte Ltd
- Magenta Therapeutics Inc
- Nogra Pharma Ltd
- Pfizer Inc
- Phenex Pharmaceuticals AG
- Shenogen Pharma Group Ltd
- Sol-Gel Technologies Ltd
- Welichem Biotech Inc
- Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) – Drug Profiles
- Ampion – Drug Profile
- AQ-312 – Drug Profile
- ARTX-28 – Drug Profile
- AT-177 – Drug Profile
- BAY-218 – Drug Profile
- BAY-2416964 – Drug Profile
- Celiac Disease – Drug Profile
- cinnabarinic acid – Drug Profile
- Dermatology – Drug Profile
- Drug to Agonize Aryl Hydrocarbon Receptor for Type 1 Diabetes – Drug Profile
- Drugs to Antagonize AHR for Oncology – Drug Profile
- HP-163 – Drug Profile
- IK-175 – Drug Profile
- Inflammatory Bowel Disease – Drug Profile
- JaguAhR – Drug Profile
- laquinimod sodium – Drug Profile
- Multiple Sclerosis – Drug Profile
- -Myasthenia Gravis – Drug Profile
- NPD-0614 – Drug Profile
- Psoriasis – Drug Profile
- Rheumatoid Arthritis – Drug Profile
- Small Molecule to Agonize AhR for Type 1 Diabetes and Graft Versus Host Disease – Drug Profile
- Small Molecules to Agonize AHR for Inflammatory Bowel Disease – Drug Profile
- Small Molecules to Agonize AHR for Psoriasis and Atopic Dermatitis – Drug Profile
- Small Molecules to Antagonize AHR for Coronavirus Disease 2019 (COVID-19) and Solid Tumor – Drug Profile
- Small Molecules to Antagonize AHR for Triple Negative Breast Cancer – Drug Profile
- Small Molecules to Antagonize Aryl Hydrocarbon Receptor for Oncology – Drug Profile
- Small Molecules to Antagonize Aryl Hydrocarbon Receptor for Pancreatic Ductal Adenocarcinoma – Drug Profile
- SNG-162 – Drug Profile
- spanlecortemlocel – Drug Profile
- tapinarof – Drug Profile
- Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) – Dormant Products
- Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) – Discontinued Products
- Aryl Hydrocarbon Receptor (Class E Basic Helix Loop Helix Protein 76 or bHLHe76 or AHR) – Product Development Milestones
- Featured News & Press Releases
- May 24, 2022: FDA approves Dermavant’s VTAMA (tapinarof) cream, 1% for the treatment of Plaque Psoriasis in Adults: first topical novel chemical entity launched for psoriasis in the U.S. in 25 Years
- May 16, 2022: Ampio independent committee to conduct investigation
- Apr 28, 2022: Ikena Oncology to present data on IK-175 at the American Society of Clinical Oncology (ASCO) 2022 Annual Meeting
- Apr 26, 2022: Active Biotech strengthens the patent protection for laquinimod in eye disorders
- Apr 20, 2022: Ampio provides regulatory update
- Mar 25, 2022: Dermavant showcases new long-term durability and tolerability data from phase 3 PSOARING 3 trial of tapinarof cream for adults with plaque psoriasis at the 2022 AAD annual meeting
- Mar 11, 2022: Dermavant to present new data from the phase 3 PSOARING 3 long-term extension trial of tapinarof cream for adults with plaque psoriasis at the 2022 American Academy of Dermatology Annual Meeting
- Mar 02, 2022: Ampio Pharmaceuticals releases positive phase 3 data analysis for Ampion targeting severe Osteoarthritis of the knee (OAK)
- Jan 15, 2022: Dermavant presents new patient satisfaction data from PSOARING 3 long term extension trial of tapinarof in adults with plaque psoriasis at the 2022 Winter Clinical Dermatology Conference
- Jan 07, 2022: Dermavant to present new data from phase 3 PSOARING program at the 2022 Winter Clinical Dermatology Conference
- Dec 10, 2021: Active Biotech: First subject dosed in phase I clinical study with eye-drop formulation of laquinimod
- Dec 09, 2021: Dermavant announces publication of PSOARING 1 & 2 pivotal studies of tapinarof in plaque psoriasis in The New England Journal of Medicine
- Nov 12, 2021: Ikena Oncology presents data at SITC 36th Annual Meeting describing the indication selection methodology, translational data, and trial in progress for IK-175
- Oct 01, 2021: Ikena Oncology to present a trial-in-progress update, translational data, and indication selection methodology for novel AHR Inhibition Program at the 2021 Society for Immunotherapy of Cancer (SITC) 36th Annual Meeting
- Appendix
- Methodology
- Coverage
- Secondary Research
- Primary Research
- Expert Panel Validation
- Contact Us
- Disclaimer
- List of Tables
- Table 1: Number of Products under Development by Stage of Development, 2022
- Table 2: Number of Products under Development by Therapy Areas, 2022
- Table 3: Number of Products under Development by Indications, 2022
- Table 4: Number of Products under Development by Indications, 2022 (Contd..1)
- Table 5: Number of Products under Development by Indications, 2022 (Contd..2)
- Table 6: Number of Products under Development by Companies, 2022
- Table 7: Products under Development by Companies, 2022
- Table 8: Products under Development by Companies, 2022 (Contd..1)
- Table 9: Products under Development by Companies, 2022 (Contd..2)
- Table 10: Products under Development by Companies, 2022 (Contd..3)
- Table 11: Number of Products under Investigation by Universities/Institutes, 2022
- Table 12: Products under Investigation by Universities/Institutes, 2022
- Table 13: Number of Products by Stage and Mechanism of Actions, 2022
- Table 14: Number of Products by Stage and Route of Administration, 2022
- Table 15: Number of Products by Stage and Molecule Type, 2022
- Table 16: Pipeline by Actavalon Inc, 2022
- Table 17: Pipeline by Active Biotech AB, 2022
- Table 18: Pipeline by Ampio Pharmaceuticals Inc, 2022
- Table 19: Pipeline by AnTolRx Inc, 2022
- Table 20: Pipeline by Aqilion AB, 2022
- Table 21: Pipeline by Artus Therapeutics Inc, 2022
- Table 22: Pipeline by Aslan Pharmaceuticals Ltd, 2022
- Table 23: Pipeline by Azora Therapeutics Australia Pty Ltd, 2022
- Table 24: Pipeline by Bayer AG, 2022
- Table 25: Pipeline by Dermavant Sciences Inc, 2022
- Table 26: Pipeline by Hercules Pharmaceuticals BV, 2022
- Table 27: Pipeline by Ikena Oncology Inc, 2022
- Table 28: Pipeline by JAGUAHR Therapeutics Pte Ltd, 2022
- Table 29: Pipeline by Magenta Therapeutics Inc, 2022
- Table 30: Pipeline by Nogra Pharma Ltd, 2022
- Table 31: Pipeline by Pfizer Inc, 2022
- Table 32: Pipeline by Phenex Pharmaceuticals AG, 2022
- Table 33: Pipeline by Shenogen Pharma Group Ltd, 2022
- Table 34: Pipeline by Sol-Gel Technologies Ltd, 2022
- Table 35: Pipeline by Welichem Biotech Inc, 2022
- Table 36: Dormant Products, 2022
- Table 37: Dormant Products, 2022 (Contd..1)
- Table 38: Discontinued Products, 2022
- List of Figures
- Figure 1: Number of Products under Development by Stage of Development, 2022
- Figure 2: Number of Products under Development by Therapy Areas, 2022
- Figure 3: Number of Products under Development by Top 10 Indications, 2022
- Figure 4: Number of Products by Mechanism of Actions, 2022
- Figure 5: Number of Products by Stage and Mechanism of Actions, 2022
- Figure 6: Number of Products by Routes of Administration, 2022
- Figure 7: Number of Products by Stage and Routes of Administration, 2022
- Figure 8: Number of Products by Molecule Types, 2022
- Figure 9: Number of Products by Stage and Molecule Types, 2022
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