Mixed Mode Chromatography Resins

Global Mixed Mode Chromatography Resins Market to Reach US$203.7 Million by 2030

The global market for Mixed Mode Chromatography Resins estimated at US$146.9 Million in the year 2024, is expected to reach US$203.7 Million by 2030, growing at a CAGR of 5.6% over the analysis period 2024-2030. Ion Exchange - Hydrophobic, one of the segments analyzed in the report, is expected to record a 6.2% CAGR and reach US$107.8 Million by the end of the analysis period. Growth in the Hydroxyapatite segment is estimated at 5.2% CAGR over the analysis period.

The U.S. Market is Estimated at US$40.5 Million While China is Forecast to Grow at 5.3% CAGR

The Mixed Mode Chromatography Resins market in the U.S. is estimated at US$40.5 Million in the year 2024. China, the world`s second largest economy, is forecast to reach a projected market size of US$31.8 Million by the year 2030 trailing a CAGR of 5.3% over the analysis period 2024-2030. Among the other noteworthy geographic markets are Japan and Canada, each forecast to grow at a CAGR of 5.2% and 4.4% respectively over the analysis period. Within Europe, Germany is forecast to grow at approximately 4.4% CAGR.

Global Mixed Mode Chromatography Resins Market - Key Trends and Drivers Summarized

How Is Mixed Mode Chromatography Revolutionizing Biomolecule Separation?

Mixed mode chromatography resins are specialized materials used in the separation and purification of biomolecules, such as proteins, antibodies, and nucleic acids. These resins utilize a combination of different interaction modes, such as ion exchange, hydrophobic interaction, and affinity chromatography, to improve the efficiency and selectivity of the purification process. The adoption of mixed mode chromatography is gaining traction in the biopharmaceutical industry, where there is a growing need for high-purity and cost-effective separation techniques for complex biological products. The versatility of mixed mode chromatography resins makes them suitable for various applications, including the purification of monoclonal antibodies, recombinant proteins, and vaccine components. They are particularly valuable for purifying biomolecules that are challenging to separate using traditional single-mode chromatography techniques. The ability to achieve high resolution and selectivity in a single step can significantly reduce the number of purification steps required, thereby saving time and reducing costs.

What Innovations Are Shaping the Mixed Mode Chromatography Resins Market?

Several innovations are driving the development of mixed mode chromatography resins, including advances in resin design, enhanced ligand chemistry, and the incorporation of novel materials. Companies are focusing on developing resins that offer higher binding capacities and better selectivity for target molecules. The introduction of new ligands that can operate under a wider range of pH conditions and ionic strengths is expanding the applicability of mixed mode chromatography across different types of biomolecules. Automation and process control are also enhancing the adoption of mixed mode chromatography in industrial-scale purification. Automated chromatography systems can be programmed to optimize process parameters for specific resins, ensuring consistent and high-quality separations. The integration of continuous chromatography techniques, where mixed mode resins are used in continuous processing formats, is emerging as a trend in biomanufacturing, allowing for more efficient purification workflows.

How Do Market Segments Define the Growth of Mixed Mode Chromatography Resins?

Techniques include hydrophobic interaction, ion exchange, and multimodal chromatography, with multimodal chromatography being one of the most widely used due to its ability to combine different interaction mechanisms for improved selectivity. Applications encompass antibody purification, protein purification, and others, with antibody purification accounting for a significant market share due to the growing demand for monoclonal antibodies in therapeutic applications. End-users of mixed mode chromatography resins include biopharmaceutical companies, research institutions, and contract research organizations (CROs). Biopharmaceutical companies represent the largest end-user segment, driven by the need to improve purification processes and reduce manufacturing costs. Geographically, North America leads the market due to a strong presence of biopharmaceutical companies and advanced research infrastructure, while Asia-Pacific is experiencing rapid growth owing to increasing biopharmaceutical investments and research activities.

What Factors Are Driving the Growth in the Mixed Mode Chromatography Resins Market?

The growth in the mixed mode chromatography resins market is driven by several factors, including the increasing demand for biopharmaceuticals, the need for cost-effective purification techniques, and advancements in resin technology. As the biopharmaceutical industry expands, there is a growing need for high-purity separation techniques to produce therapeutic proteins, antibodies, and vaccines. The ability of mixed mode chromatography to simplify purification workflows and reduce the number of steps required is appealing to manufacturers looking to optimize production costs. Additionally, the development of novel resins with enhanced binding capacities and the integration of automation in chromatography processes are further propelling market growth.

SCOPE OF STUDY:

The report analyzes the Mixed Mode Chromatography Resins market in terms of units by the following Segments, and Geographic Regions/Countries:

Segments:
Technique (Ion Exchange - Hydrophobic, Hydroxyapatite, Other Techniques); Application (Polyclonal Antibodies, Non-Antibody Protein, Monoclonal Antibodies)

Geographic Regions/Countries:
World; United States; Canada; Japan; China; Europe (France; Germany; Italy; United Kingdom; and Rest of Europe); Asia-Pacific; Rest of World.

Select Competitors (Total 43 Featured) -

• Bio-Rad Laboratories
• Bio-Works Company Ltd.
• Danaher Corporation
• GE Healthcare Life Sciences
• JSR Micro Inc.
• Kaneka Corporation
• Knauer Gmbh
• Life Technology Corporation
• Merck
• Pall Corporation
• Purolite Corporation
• Sepragen Corporation
• Thermo Fisher Scientific
• Tosoh Corporation

TARIFF IMPACT FACTOR

Our new release incorporates impact of tariffs on geographical markets as we predict a shift in competitiveness of companies based on HQ country, manufacturing base, exports and imports (finished goods and OEM). This intricate and multifaceted market reality will impact competitors by artificially increasing the COGS, reducing profitability, reconfiguring supply chains, amongst other micro and macro market dynamics.

We are diligently following expert opinions of leading Chief Economists (14,949), Think Tanks (62), Trade & Industry bodies (171) worldwide, as they assess impact and address new market realities for their ecosystems. Experts and economists from every major country are tracked for their opinions on tariffs and how they will impact their countries.

We expect this chaos to play out over the next 2-3 months and a new world order is established with more clarity. We are tracking these developments on a real time basis.

As we release this report, U.S. Trade Representatives are pushing their counterparts in 183 countries for an early closure to bilateral tariff negotiations. Most of the major trading partners also have initiated trade agreements with other key trading nations, outside of those in the works with the United States. We are tracking such secondary fallouts as supply chains shift.

To our valued clients, we say, we have your back. We will present a simplified market reassessment by incorporating these changes!

APRIL 2025: NEGOTIATION PHASE

Our April release addresses the impact of tariffs on the overall global market and presents market adjustments by geography. Our trajectories are based on historic data and evolving market impacting factors.

JULY 2025 FINAL TARIFF RESET

Complimentary Update: Our clients will also receive a complimentary update in July after a final reset is announced between nations. The final updated version incorporates clearly defined Tariff Impact Analyses.

Reciprocal and Bilateral Trade & Tariff Impact Analyses:

USA
CHINA
MEXICO
CANADA
EU
JAPAN
INDIA
176 OTHER COUNTRIES.

Leading Economists - Our knowledge base tracks 14,949 economists including a select group of most influential Chief Economists of nations, think tanks, trade and industry bodies, big enterprises, and domain experts who are sharing views on the fallout of this unprecedented paradigm shift in the global econometric landscape. Most of our 16,491+ reports have incorporated this two-stage release schedule based on milestones.

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