
Wet Age-Related Macular Degeneration (Wet AMD) - Pipeline Insight, 2024
Description
Wet Age-Related Macular Degeneration (Wet AMD) - Pipeline Insight, 2024
DelveInsight’s, “Wet Age-Related Macular Degeneration (Wet AMD) - Pipeline Insight, 2024” report provides comprehensive insights about 70+ companies and 75+ pipeline drugs in Wet Age-Related Macular Degeneration (Wet AMD) pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
- Global coverage
Wet Age-Related Macular Degeneration (Wet AMD): Overview
Wet Age-Related Macular Degeneration (Wet AMD) is a significant form of age-related macular degeneration characterized by the growth of abnormal blood vessels beneath the retina. These vessels can leak fluid and blood, leading to scarring of the macula and rapid vision loss if left untreated. Wet AMD is a serious condition that affects a smaller percentage of individuals compared to the dry form but progresses more rapidly and can cause severe visual impairment. The key hallmark of Wet AMD is the development of pathologic choroidal neovascular membranes (CNVM) under the retina, which can result in central vision loss over a relatively short period. This form of AMD requires prompt diagnosis and treatment to prevent irreversible vision damage.
Age-Related Macular Degeneration (AMD) is a multifactorial disease influenced by various risk factors. These include older age, elevated total serum cholesterol, micronutrient deficiency, smoking, family history, hypertension, cardiovascular disease, and visible light exposure. Genetic predisposition is a significant factor, with at least 34 genetic loci and 52 gene variants associated with AMD. Inflammation is a key player in the pathogenesis of wet AMD, with polymorphisms of complement factor H being notable mutations linked to the disease. These mutations suggest the crucial role of complement activation in the development of wet AMD, highlighting the complex interplay of genetic and environmental factors in this vision-threatening condition.
Wet Age-Related Macular Degeneration (Wet AMD) presents with various symptoms that can significantly impact vision. Individuals with Wet AMD may experience gaps or dark spots in their vision, especially noticeable in the morning, along with fading colors. Objects may appear distorted or change shape, and straight lines can appear bent or wavy. Bright light may become uncomfortable, and adapting to changes in light environments may be challenging. Reading difficulties, disappearing words, and distorted perception of sizes and colors are common. Additionally, individuals may struggle with glare, have trouble seeing fine details clearly, and may notice objects appearing differently to each eye. In severe cases, visual hallucinations in the blind spot at the center of the field of vision can occur, a phenomenon known as Charles Bonnet syndrome. These symptoms highlight the complexity and impact of Wet AMD on visual function and quality of life.
The primary treatments for Wet Age-Related Macular Degeneration (Wet AMD) aim to slow disease progression and prevent further vision loss. Anti-VEGF (vascular endothelial growth factor) therapy, which involves injections of medications like aflibercept, bevacizumab, brolucizumab, or ranibizumab directly into the eye, is the most common and effective treatment. These drugs block the abnormal blood vessel growth and leakage that characterize Wet AMD. Nutritional supplements containing vitamins and minerals, such as the AREDS2 formula, may also help slow the progression of dry AMD and prevent Wet AMD in the other eye. In some cases, photodynamic therapy using a light-activated drug or laser surgery may be used to seal leaking blood vessels. Regular eye exams and prompt treatment are crucial to manage Wet AMD and preserve vision.
""Wet Age-Related Macular Degeneration (Wet AMD) - Pipeline Insight, 2024"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Wet Age-Related Macular Degeneration (Wet AMD) pipeline landscape is provided which includes the disease overview and Wet Age-Related Macular Degeneration (Wet AMD) treatment guidelines. The assessment part of the report embraces, in depth Wet Age-Related Macular Degeneration (Wet AMD) commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Wet Age-Related Macular Degeneration (Wet AMD) collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Wet Age-Related Macular Degeneration (Wet AMD) R&D. The therapies under development are focused on novel approaches to treat/improve Wet Age-Related Macular Degeneration (Wet AMD).
This segment of the Wet Age-Related Macular Degeneration (Wet AMD) report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II/III, II, I, preclinical and discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Wet Age-Related Macular Degeneration (Wet AMD) Emerging Drugs
- RGX-314: REGENXBIO
ATMOSPHERE, the first of two planned pivotal trials for the evaluation of subretinal delivery of RGX-314 in patients with wet AMD, is active and enrolling patients. In addition, the company is enrolling patients in AAVIATE, a Phase II trial for the treatment of wet AMD using suprachoroidal delivery of RGX-314. A Biologics License Application (BLA) is expected to be submitted to the United States Food and Drug Administration (FDA) in 2024 based on two pivotal trials, ASCENT and the ongoing ATMOSPHERE trial. ASCENT clinical trial conducted in partnership with AbbVie, is expected to enroll patients in the United States and Canada.
- 9MW 0211: Mabwell (Shanghai) Bioscience
- SYL1801: Sylentis
- OLX10212: OliX Pharmaceuticals
Further product details are provided in the report……..
Wet Age-Related Macular Degeneration (Wet AMD): Therapeutic Assessment
This segment of the report provides insights about the different Wet Age-Related Macular Degeneration (Wet AMD) drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in Wet Age-Related Macular Degeneration (Wet AMD)
- Phases
- Late stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage product (Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Intravenous
- Subcutaneous
- Oral
- Intramuscular
- Molecule Type
- Monoclonal antibody
- Small molecule
- Peptide
- Product Type
Wet Age-Related Macular Degeneration (Wet AMD): Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Wet Age-Related Macular Degeneration (Wet AMD) therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Wet Age-Related Macular Degeneration (Wet AMD) drugs.
Wet Age-Related Macular Degeneration (Wet AMD) Report Insights
- Wet Age-Related Macular Degeneration (Wet AMD) Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Wet Age-Related Macular Degeneration (Wet AMD) drugs?
- How many Wet Age-Related Macular Degeneration (Wet AMD) drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Wet Age-Related Macular Degeneration (Wet AMD)?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Wet Age-Related Macular Degeneration (Wet AMD) therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Wet Age-Related Macular Degeneration (Wet AMD) and their status?
- What are the key designations that have been granted to the emerging drugs?
- OliX Pharmaceuticals
- Frontera Therapeutics
- Kyowa Kirin
- Boehringer Ingelheim
- Clearside Biomedical
- PanOptica
- EyePoint Pharmaceuticals
- Unity Biotechnology
- AngioLab
- Kinarus Therapeutics
- Sylentis
- Mabwell (Shanghai) Bioscience
- Samsung Bioepis
- Sandoz
- Outlook Therapeutics
- Molecular Partners
- Sam Chun Dang Pharm
- TOT Biopharm
- OLX10212
- FT-003
- KHK4951
- BI 836880
- AXT107
- PAN-90806
- EYP-1901
- UBX1325
- ALS-L1023
- KIN001
- SYL1801
- 9MW 0211
- SB15
- SOK583A1
- ONS-5010
- Abicipar pegol
- SCD411
- TAB014
Table of Contents
240 Pages
- Introduction
- Executive Summary
- Wet Age-Related Macular Degeneration (Wet AMD): Overview
- Causes
- Etiology
- Signs and Symptoms
- Disease Treatment/Management
- Pipeline Therapeutics
- Comparative Analysis
- Therapeutic Assessment
- Assessment by Product Type
- Assessment by Stage and Product Type
- Assessment by Route of Administration
- Assessment by Stage and Route of Administration
- Assessment by Molecule Type
- Assessment by Stage and Molecule Type
- Wet Age-Related Macular Degeneration (Wet AMD)– DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Comparative Analysis
- RGX-314: REGENXBIO
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- Comparative Analysis
- SYL1801: Sylentis
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- Comparative Analysis
- OLX10212: OliX Pharmaceuticals
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Preclinical and Discovery Stage Products
- Comparative Analysis
- Drug name: Company name
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Inactive Products
- Comparative Analysis
- Wet Age-Related Macular Degeneration (Wet AMD) Key Companies
- Wet Age-Related Macular Degeneration (Wet AMD) Key Products
- Wet Age-Related Macular Degeneration (Wet AMD)- Unmet Needs
- Wet Age-Related Macular Degeneration (Wet AMD)- Market Drivers and Barriers
- Wet Age-Related Macular Degeneration (Wet AMD)- Future Perspectives and Conclusion
- Wet Age-Related Macular Degeneration (Wet AMD) Analyst Views
- Wet Age-Related Macular Degeneration (Wet AMD) Key Companies
- Appendix
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