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Orthopedic Bone Graft Substitute Market Size, Share, and Trends Analysis - Global - 2025-2031 - MedCore - Includes: Allograft Market, Demineralized Bone Matrix Market, and 1 more

Published Jan 24, 2025
Length 135 Pages
SKU # IDR20814422

Description

Global Orthopedic Bone Graft Substitute Market Report, 2025 Edition

The global orthopedic bone graft substitute (BGS) market was valued at approximately 2.83 billion dollars in 2024. The market is expected to grow at a 4.1 percent CAGR to reach nearly 3.75 billion dollars by 2031. Growth is sustained by high unmet clinical needs in spine, trauma, oncology and large joint reconstruction, along with steady adoption of synthetic and demineralized bone matrix (DBM) products.

This edition covers allograft bone graft substitutes, DBM allograft BGS, and synthetic BGS across major anatomical indications. It includes device-level units, average selling prices, market values, procedure numbers, growth rates, and competitive shares. It also reviews recent mergers and acquisitions, technology shifts, pricing trends and key clinical factors shaping demand in bone grafting and reconstruction.

The report provides historical data to 2021 and forecasts to 2031. It includes qualitative analysis of market drivers, limiters, clinical workflow trends and supply constraints that influence short-term and long-term growth.

Market Overview

Orthopedic bone graft substitutes are used to support bone healing in procedures where native bone cannot regenerate adequately. They are used in spine surgery, non-union and fresh fracture trauma, large joint reconstruction, craniomaxillofacial reconstruction, oncology-related bone defects and foot and ankle reconstruction.

Market growth is influenced by several global demographic and clinical trends. The aging population continues to increase demand for procedures that rely on BGS products, such as spinal fusion, hip reconstruction and revision trauma surgery. The number of unit sales is expected to rise steadily worldwide, although growth is expected to be slower in well-developed healthcare markets that have mature access to biomaterials.

Lower-income regions are projected to show the strongest unit growth as access to orthopedic care expands and as synthetic BGS products become more affordable. Synthetic materials help improve accessibility because they are widely available, do not depend on donor availability, and eliminate the need for autograft harvesting.

Average selling prices continue to decline due to competition, procurement standardization and bundled pricing strategies. While volumes are increasing, declining ASPs limit the overall growth of the market. These pricing pressures are especially visible in countries where hospitals receive BGS materials at discounted rates or as part of broader implant contracts.

Across both high-income and developing regions, the clinical shift toward synthetic and DBM materials remains a strong influence on product adoption. Clinicians continue to seek materials that are easy to use, consistent in quality and associated with a low complication risk. As a result, synthetic products are gaining share from both allograft and autograft techniques.

Market Drivers

Clinical Efficacy and Expanding Applications

A major driver of the market is the clinical performance of non-allograft bone graft substitutes. DBM products offer strong osteoconductivity and are easy to shape, pack and hydrate. Their ability to support bone regeneration without the need for donor harvesting makes them appealing in spine, trauma and joint reconstruction procedures.

Synthetic bone graft substitutes provide reliable osteoconductive scaffolding and increasingly mimic natural bone properties. While they remain less osteoinductive than autograft materials, they offer consistency, predictable handling and reduced procedural complexity. They also avoid the variability associated with donor-derived tissue.

Low Risk of Complications

Synthetic materials carry a very low risk of disease transmission and immunogenic rejection. This is a significant advantage over allograft materials, particularly for patients who may be at higher risk of immune response or those with limited donor tissue matching options. Avoiding a separate autograft harvest procedure also reduces pain, surgical time and the potential for donor-site morbidity.

These benefits have contributed to a continued decline in autograft usage and supported stronger adoption of synthetic and DBM materials.

Growing Acceptance of Synthetic Bone Grafts

Synthetic bone graft substitutes are increasingly seen as a practical and accessible option for both surgeons and patients. Their affordability, supply stability and ease of availability make them attractive alternatives to allografts and DBMs. Manufacturers offer a wide range of formulations, such as granules, putties, strips and moldable matrices, which allows physicians to select products tailored to specific anatomical needs.

Globally, patients have become more informed about synthetic options and are more comfortable with biomaterial-based solutions. Combined with expanding distribution in emerging healthcare markets, synthetic products are positioned to maintain a strong growth trajectory.

Market Limiters

Product Bundling and Price Compression

Bundling strategies have lowered the selling prices of many synthetic BGS products. Companies increasingly provide complimentary graft materials when hospitals purchase their implant systems. This practice encourages volume adoption but reduces market-level ASPs, especially in regions with high contract penetration.

Allograft materials are also affected. In markets such as Italy, hospitals often receive allograft products for free as part of larger orthopedic procurement arrangements. This makes it harder for companies to maintain profitable price points and contributes to long-term pricing declines.

Constraints on Live Tissue Availability

Allograft supply depends on donor availability, tissue bank operations and logistics. Seasonal variation, fluctuations in donation rates, and funding limitations can all affect the reliability of supply. Tissue banks must manage screening, processing and storage requirements carefully, which adds cost and introduces potential bottlenecks.

When supply tightens, hospitals may shift toward synthetic or DBM products, but the limitations still affect overall market stability, especially for procedures where surgeons prefer allograft materials.

Pricing Pressure From New Entrants

New market participants often enter with significantly lower-priced products to gain share. While this creates more options for hospitals, it accelerates price erosion and raises the competitive pressure on established suppliers. As purchasers adjust to lower price expectations, achieving sustainable margins becomes more challenging.

This trend is especially strong in developing markets where cost sensitivity is high and procurement decisions emphasize affordability.

Market Coverage and Data Scope

Quantitative Coverage

Market size

Market shares

Market forecasts

Growth rates

Units sold

Average selling prices

Qualitative Coverage

Market growth trends

Market limiters

Competitive analysis and SWOT for top competitors

Mergers and acquisitions

Company profiles and product portfolios

FDA recalls

Disruptive technologies

Disease overviews and demand influencers

Time Frame

Historical data to 2021

Base year 2024

Forecasts to 2031

Data Sources

Primary interviews with industry leaders

Government and physician datasets

Regulatory data

Hospital private data

Import and export data

iData Research internal databases

Markets Covered and Segmentation

Allograft Bone Graft Substitute Market

Further Segmented Into:

Spine

Trauma

Oncology

Craniomaxillofacials

Large Joint Reconstruction

Foot Reconstructions

Demineralized Bone Matrix Market

Further Segmented Into:

Spine

Trauma

Oncology

Craniomaxillofacials

Large Joint Reconstruction

Foot Reconstructions

Synthetic Bone Graft Substitute Market

Further Segmented Into:

Spine

Trauma

Oncology

Craniomaxillofacials

Large Joint Reconstruction

Foot Reconstructions

Competitive Analysis

In 2024, Medtronic held the leading share of the global BGS market. The company leads the DBM market with its well-established Grafton product line, which was the first fiber-based DBM allograft BGS. Medtronic also has a strong position in the synthetic segment through its MASTERGRAFT portfolio, which includes granules, moldable putty, flexible strip formats and the MASTERGRAFT Matrix EXT.

Stryker held the second-leading market share. The company offers multiple product families, including Vitoss, ALLOMATRIX, FUSIONFLEX and PRO-STIM. These products are widely used across trauma, spine and joint reconstruction procedures.

DePuy Synthes ranked third in the global BGS market. Its key offerings include the DBX DBM product line and the chronOS synthetic BGS portfolio. These products support the company’s strong presence across spine and reconstructive orthopedic markets.

The competitive landscape also includes regional tissue banks, emerging synthetic manufacturers and specialty companies focused on bone regeneration. Price competition, innovation in carrier materials and improved osteoconductive formulations remain core areas of differentiation.

Technology and Practice Trends

Orthopedic surgeons continue to favor materials that deliver predictable handling, consistent quality and favorable healing outcomes. Several key trends are shaping clinical practice:

Shift toward synthetic formulations

Synthetic grafts continue to gain share due to supply reliability, reduced complication risk and broader availability. Companies are refining their materials to improve porosity, resorption rates and structural integrity.

Advancements in DBM carriers and consistency

Manufacturers are improving DBM handling and viscosity through better carriers and standardized processing techniques. Fiber-based DBM formulations remain popular for ease of use and graft containment.

Preference for minimally invasive solutions

As minimally invasive spine and trauma procedures expand, surgeons require products that are easy to deliver through small incisions and compatible with instrumentation.

Growth in oncology and reconstructive applications

Rising multimorbidity, aging populations and improved survival rates for cancer patients contribute to demand for BGS products in tumor-related bone defects.

Increasing emphasis on cost containment

Hospitals are consolidating procurement across implant systems, bone grafting materials and biologics. As a result, graft products are increasingly selected based on contracted pricing and product standardization.

Geography

This report provides global coverage across North America, Europe, Asia-Pacific, Latin America, the Middle East, and Africa.

Why This Report

Which BGS product category is positioned to grow the fastest over the forecast period, and what factors support this outlook?

How are declining ASPs affecting growth, and where are synthetic products gaining share from DBM and allograft materials?

What clinical, demographic and supply factors are driving procedure volumes in spine, trauma and oncology?

How do procurement strategies influence pricing, and what role does product bundling play in compressing ASPs?

What competitive strategies are leaders such as Medtronic, Stryker and DePuy Synthes using to maintain share?

How will donor availability constraints affect allograft growth, and where will synthetic products fill the gap?

What are the most important product features surgeons prioritize across synthetic, DBM and allograft options?

This report answers these questions through detailed category-level data, competitive analysis and procedure-based forecasting.

About iData Research

iData Research is a premium market intelligence firm headquartered in Canada with offices across North America and Europe.

Over the last 20 years, the company has specialized in device-level sizing, procedure models, pricing trends, and competitive share across MedTech.

Since 2005, iData has supported global OEMs, mid-market innovators, and investors with triangulated data based on units and ASPs, with country-level forecasts and analyst access across Europe, North America, Latin America, the Middle East, Africa, and APAC.

Reports are available with flexible licensing to fit commercial, strategy, and investment workflows

Table of Contents

135 Pages
Research Methodology
Step 1: Project Initiation & Team Selection
Step 2: Prepare Data Systems And Perform Secondary Research
Step 3: Preparation For Interviews & Questionnaire Design
Step 4: Performing Primary Research
Step 5: Research Analysis: Establishing Baseline Estimates
Step 6: Market Forecast And Analysis
Step 7: Identify Strategic Opportunities
Step 8: Final Review And Market Release
Step 9: Customer Feedback And Market Monitoring
Orthopedic Bone Graft Substitute Market
4.1 Executive Summary
4.1.1 Global Orthopedic Bone Graft Substitute Market Overview
4.1.2 Competitive Analysis
4.1.3 Procedure Segmentation
4.1.4 Market Segmentation
4.1.5 Regions Included
4.2 Introduction
4.3 Procedure Numbers
4.3.1 Total Orthopedic Bone Grafting Procedures
4.3.2 Allograft Procedures
4.3.3 Demineralized Bone Matrix Procedures
4.3.4 Synthetic Procedures
4.4 Market Overview
4.4.1 By Segment
4.4.2 By Region
4.5 Market Analysis And Forecast
4.5.1 Total Orthopedic Bone Graft Substitute Market
4.5.2 Allograft Bone Graft Substitute Market
4.5.3 Demineralized Bone Matrix Allograft Bone Graft Substitute Market
4.5.4 Synthetic Bone Graft Substitute Market
4.5.4.1 Synthetic Bone Graft Substitute Market By Generation Type
4.6 Unit Analysis
4.6.1 Allograft Bone Graft Substitute Unit Analysis
4.6.1.1 Allograft Bone Graft Substitute Units Sold By Indication
4.6.1.1.1 Spine Allograft Bone Graft Substitute Units Sold
4.6.1.1.2 Trauma Allograft Bone Graft Substitute Units Sold
4.6.1.1.3 Large Joint Reconstruction Allograft Bone Graft Substitute Units Sold
4.6.2 Demineralized Bone Matrix Allograft Bone Graft Substitute Unit Analysis
4.6.2.1 Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold By Indication
4.6.2.1.1 Spine Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold
4.6.2.1.2 Trauma Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold
4.6.2.1.3 Large Joint Reconstruction Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold
4.6.3 Synthetic Bone Graft Substitute Unit Analysis
4.6.3.1 Synthetic Bone Graft Substitute Units Sold By Indication
4.6.3.1.1 Spine Synthetic Bone Graft Substitute Units Sold
4.6.3.1.2 Trauma Synthetic Bone Graft Substitute Units Sold
4.6.3.1.3 Large Joint Reconstruction Synthetic Bone Graft Substitute Units Sold
4.7 Drivers And Limiters
4.7.1 Market Drivers
4.7.2 Market Limiters
4.8 Competitive Market Share Analysis
Abbreviations
Chart 4-1: Orthopedic Bone Graft Substitute Market, Global, 2024 & 2031
Chart 4-2: Orthopedic Bone Graft Substitute Procedures, Global, 2024
Chart 4-3: Orthopedic Bone Grafting Procedures by Segment, Global, 2021– 2031
Chart 4-4: Orthopedic Bone Graft Substitute Device Market by Segment, Global, 2021 – 2031
Chart 4-5: Orthopedic Bone Graft Substitute Device Market by Region, Global, 2021 – 2031
Chart 4-6: Leading Competitors, Orthopedic Bone Graft Substitute Market, Global, 2024
Figure 4-1: Orthopedic Bone Graft Substitute Regions Covered, Global (1 of 2)
Figure 4-2: Orthopedic Bone Graft Substitute Regions Covered, Global (2 of 2)
Figure 4-3: Orthopedic Bone Grafting Procedures by Segment, Global, 2021 – 2031
Figure 4-4: Orthopedic Bone Grafting Procedures by Region, Global, 2021 – 2031
Figure 4-5: Orthopedic Bone Grafting Procedures by Country, North America, 2021 – 2031
Figure 4-6: Orthopedic Bone Grafting Procedures by Country, Latin America, 2021 – 2031 (1 of 2)
Figure 4-7: Orthopedic Bone Grafting Procedures by Country, Latin America, 2021 – 2031 (2 of 2)
Figure 4-8: Orthopedic Bone Grafting Procedures by Country, Western Europe, 2021– 2031
Figure 4-9: Orthopedic Bone Grafting Procedures by Country, Central & Eastern Europe, 2021 – 2031 (1 of 2)
Figure 4-10: Orthopedic Bone Grafting Procedures by Country, Central & Eastern Europe, 2021 – 2031 (2 of 2)
Figure 4-11: Orthopedic Bone Grafting Procedures by Country, Middle East, 2021 – 2031
Figure 4-12: Orthopedic Bone Grafting Procedures by Country, Asia-Pacific, 2021– 2031 (1 of 3)
Figure 4-13: Orthopedic Bone Grafting Procedures by Country, Asia-Pacific, 2021 – 2031 (2 of 3)
Figure 4-14: Orthopedic Bone Grafting Procedures by Country, Asia-Pacific, 2021 – 2031 (3 of 3)
Figure 4-15: Orthopedic Bone Grafting Procedures by Country, Africa, 2021 – 2031
Figure 4-16: Allograft Procedures by Region, Global, 2021– 2031
Figure 4-17: Allograft Procedures by Country, North America, 2021– 2031
Figure 4-18: Allograft Procedures by Country, Latin America, 2021– 2031 (1 of 2)
Figure 4-19: Allograft Procedures by Country, Latin America, 2021– 2031 (2 of 2)
Figure 4-20: Allograft Procedures by Country, Western Europe, 2021 – 2031
Figure 4-21: Allograft Procedures by Country, Central & Eastern Europe, 2021 – 2031 (1 of 2)
Figure 4-22: Allograft Procedures by Country, Central & Eastern Europe, 2021 – 2031 (2 of 2)
Figure 4-23: Allograft Procedures by Country, Middle East, 2021– 2031
Figure 4-24: Allograft Procedures by Country, Asia-Pacific, 2021 – 2031 (1 of 3)
Figure 4-25: Allograft Procedures by Country, Asia-Pacific, 2021 – 2031 (2 of 3)
Figure 4-26: Allograft Procedures by Country, Asia-Pacific, 2021 – 2031 (3 of 3)
Figure 4-27: Allograft Procedures by Country, Africa, 2021– 2031
Figure 4-28: Demineralized Bone Matrix Procedures by Region, Global, 2021– 2031
Figure 4-29: Demineralized Bone Matrix Procedures by Country, North America, 2021– 2031
Figure 4-30: Demineralized Bone Matrix Procedures by Country, Latin America, 2021– 2031 (1 of 2)
Figure 4-31: Demineralized Bone Matrix Procedures by Country, Latin America, 2021– 2031 (2 of 2)
Figure 4-32: Demineralized Bone Matrix Procedures by Country, Western Europe, 2021 – 2031
Figure 4-33: Demineralized Bone Matrix Procedures by Country, Central & Eastern Europe, 2021 – 2031 (1 of 2)
Figure 4-34: Demineralized Bone Matrix Procedures by Country, Central & Eastern Europe, 2021 – 2031 (2 of 2)
Figure 4-35: Demineralized Bone Matrix Procedures by Country, Middle East, 2021 – 2031
Figure 4-36: Demineralized Bone Matrix Procedures by Country, Asia-Pacific, 2021– 2031 (1 of 3)
Figure 4-37: Demineralized Bone Matrix Procedures by Country, Asia-Pacific, 2021– 2031 (2 of 3)
Figure 4-38: Demineralized Bone Matrix Procedures by Country, Asia-Pacific, 2021 – 2031 (3 of 3)
Figure 4-39: Demineralized Bone Matrix Procedures by Country, Africa, 2021 – 2031
Figure 4-40: Synthetic Procedures by Region, Global, 2021 – 2031
Figure 4-41: Synthetic Procedures by Country, North America, 2021 – 2031
Figure 4-42: Synthetic Procedures by Country, Latin America, 2021 – 2031 (1 of 2)
Figure 4-43: Synthetic Procedures by Country, Latin America, 2021 – 2031 (2 of 2)
Figure 4-44: Synthetic Procedures by Country, Western Europe, 2021– 2031
Figure 4-45: Synthetic Procedures by Country, Central & Eastern Europe, 2021 – 2031 (1 of 2)
Figure 4-46: Synthetic Procedures by Country, Central & Eastern Europe, 2021 – 2031 (2 of 2)
Figure 4-47: Synthetic Procedures by Country, Middle East, 2021 – 2031
Figure 4-48: Synthetic Procedures by Country, Asia-Pacific, 2021 – 2031 (1 of 3)
Figure 4-49: Synthetic Procedures by Country, Asia-Pacific, 2021 – 2031 (2 of 3)
Figure 4-50: Synthetic Procedures by Country, Asia-Pacific, 2021 – 2031 (3 of 3)
Figure 4-51: Synthetic Procedures by Country, Africa, 2021 – 2031
Figure 4-52: Orthopedic Bone Graft Substitute Device Market by Segment, Global, 2021 – 2031 (US$M)
Figure 4-53: Orthopedic Bone Graft Substitute Device Market by Region, Global, 2021 – 2031 (US$M)
Figure 4-54: Orthopedic Bone Graft Substitute Market, Global, 2021 – 2031
Figure 4-55: Units Sold by Region, Orthopedic Bone Graft Substitute Market, Global, 2021 – 2031
Figure 4-56: Average Selling Price by Region, Orthopedic Bone Graft Substitute Market, Global, 2021– 2031 (US$)
Figure 4-57: Market Value by Region, Orthopedic Bone Graft Substitute Market, Global, 2021 – 2031 (US$M)
Figure 4-58: Allograft Bone Graft Substitute Market, Global, 2021 – 2031
Figure 4-59: Units Sold by Region, Allograft Bone Graft Substitute Market, Global, 2021 – 2031
Figure 4-60: Average Selling Price by Region, Allograft Bone Graft Substitute Market, Global, 2021 – 2031 (US$)
Figure 4-61: Market Value by Region, Allograft Bone Graft Substitute Market, Global, 2021 – 2031 (US$M)
Figure 4-62: Demineralized Bone Matrix Allograft Bone Graft Substitute Market, Global, 2021 – 2031
Figure 4-63: Units Sold by Region, Demineralized Bone Matrix Allograft Bone Graft Substitute Market, Global, 2021 – 2031
Figure 4-64: Average Selling Price by Region, Demineralized Bone Matrix Allograft Bone Graft Substitute Market, Global, 2021 – 2031 (US$)
Figure 4-65: Market Value by Region, Demineralized Bone Matrix Allograft Bone Graft Substitute Market, Global, 2021 – 2031 (US$M)
Figure 4-66: Synthetic Bone Graft Substitute Market, Global, 2021 – 2031
Figure 4-67: Units Sold by Region, Synthetic Bone Graft Substitute Market, Global, 2021 – 2031
Figure 4-68: Average Selling Price by Region, Synthetic Bone Graft Substitute Market, Global, 2021 – 2031 (US$)
Figure 4-69: Market Value by Region, Synthetic Bone Graft Substitute Market, Global, 2021 – 2031 (US$M)
Figure 4-70: Generation 1 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031
Figure 4-71: Units Sold by Region, Generation 1 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031
Figure 4-72: Average Selling Price by Region, Generation 1 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031 (US$)
Figure 4-73: Market Value by Region, Generation 1 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031 (US$M)
Figure 4-74: Generation 2 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031
Figure 4-75: Units Sold by Region, Generation 2 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031
Figure 4-76: Average Selling Price by Region, Generation 2 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031 (US$)
Figure 4-77: Market Value by Region, Generation 2 Synthetic Bone Graft Substitute Market, Global, 2021 – 2031 (US$M)
Figure 4-78: Allograft Bone Graft Substitute Units Sold by Indication, Global, 2021 – 2031
Figure 4-79: Spine Allograft Bone Graft Substitute Units Sold, Global, 2021 – 2031
Figure 4-80: Trauma Allograft Bone Graft Substitute Units Sold, Global, 2021 – 2031
Figure 4-81: Large Joint Reconstruction Allograft Bone Graft Substitute Units Sold, Global, 2021– 2031
Figure 4-82: Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold by Indication, Global, 2021 – 2031
Figure 4-83: Spine Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold, Global, 2021 – 2031
Figure 4-84: Trauma Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold, Global, 2021 – 2031
Figure 4-85: Large Joint Reconstruction Demineralized Bone Matrix Allograft Bone Graft Substitute Units Sold, Global, 2021 – 2031
Figure 4-86: Synthetic Bone Graft Substitute Units Sold by Indication, Global, 2021 – 2031
Figure 4-87: Spine Synthetic Bone Graft Substitute Units Sold, Global, 2021 – 2031
Figure 4-88: Trauma Synthetic Bone Graft Substitute Units Sold, Global, 2021 – 2031
Figure 4-89: Large Joint Reconstruction Synthetic Bone Graft Substitute Units Sold, Global, 2021 – 2031
Figure 4-90: Leading Competitors, Orthopedic Bone Graft Substitute Market, Global, 2024
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