MIS Interbody Devices Market Size, Share, and Trends Analysis - Global - 2025-2031 - Includes: MIPLIF Market, MITLIF Market, and 2 more
Description
Global MIS Interbody Device Market Report, 2025 Edition
Executive Summary
The global minimally invasive spinal (MIS) interbody device market includes all devices used in fusion procedures performed through minimally invasive surgical approaches. In 2024, the lateral lumbar interbody fusion (LLIF) segment represented the largest share of the market. All subsegments are expected to continue growing over the forecast period, with minimally invasive posterior lumbar interbody fusion (MIPLIF) showing the fastest growth rate. Despite this, MIPLIF remains the smallest subsegment due to a decline in average selling prices (ASPs) resulting from heightened competition and price sensitivity.
The global MIS interbody device market continues to expand as technological innovation, surgeon training, and patient demand shift toward less invasive approaches. This report covers MIPLIF, minimally invasive transforaminal lumbar interbody fusion (MITLIF), LLIF, and oblique lateral interbody fusion (OLIF) procedures and devices. It quantifies unit sales, average selling prices, market values, growth rates, and company shares, while analyzing market drivers and limiters, technology trends, mergers and acquisitions (M&A), and leading company portfolios. Historical data are provided from 2021 to 2024, with forecasts to 2031.
Minimally invasive surgery continues to reshape spinal fusion by providing faster recovery, reduced muscle and tissue trauma, and improved cosmetic outcomes compared to open procedures. Surgeons and patients are increasingly opting for these procedures, making the MIS interbody device market one of the most dynamic segments in spinal implant technology.
Market Overview
Minimally invasive spinal (MIS) interbody fusion devices are designed to facilitate spinal fusion through smaller incisions and reduced soft tissue disruption. The goal is to stabilize the spine while minimizing postoperative pain, blood loss, and recovery time. The main procedural subsegments—MIPLIF, MITLIF, LLIF, and OLIF—represent different access points to the intervertebral space.
MIPLIF and MITLIF involve posterior and transforaminal approaches using smaller tubular retractors to reach the spine with minimal muscle damage.
LLIF and OLIF use lateral or oblique approaches to access the disc space through the psoas muscle or between the psoas and major vessels.
These techniques allow surgeons to perform spinal fusion with reduced disruption to surrounding tissues, often resulting in shorter hospital stays and quicker return to daily activities.
Market growth is fueled by an aging global population and increasing demand for procedures that minimize postoperative recovery times. MIS techniques are particularly attractive for elderly patients who face higher risks from open surgeries.
Over the forecast period, all procedural subsegments are expected to increase in value. The LLIF segment will continue to hold the largest share, while MIPLIF will expand fastest due to continued adoption in emerging markets and improved surgeon familiarity.
Market Drivers
Minimally Invasive Surgery
The strongest driver of the MIS interbody device market is the growing preference for minimally invasive techniques. Patients and surgeons are consistently choosing MIS approaches over traditional open fusion because of their clinical advantages, including smaller incisions, less blood loss, and reduced hospital stays.
MIS techniques minimize tissue damage, lower infection risks, and reduce complications. Improved outcomes and faster patient recovery times have made MIS fusion procedures a preferred option for suitable candidates. As awareness grows, this preference is expected to increase procedural volumes globally.
360° MIS Fusion
The development and clinical validation of 360° fusion techniques support the continued growth of MIS fusion procedures. In a 360° fusion, both anterior and posterior elements of the spinal column are fused, often using a combination of MIS techniques. For example, an XLIF® system may be used to place the interbody device laterally, while posterior fixation is achieved through percutaneous screws.
These comprehensive approaches have proven effective in providing superior stability, which strengthens clinical outcomes and further drives the market for MIS interbody devices.
Physician Education and Training
The expansion of training programs dedicated to minimally invasive spinal surgery is a key growth driver. The successful adoption of MIS techniques depends heavily on surgeon proficiency. As more surgeons are trained in retractor-based and percutaneous techniques, procedural adoption increases.
Manufacturers are heavily investing in surgeon education programs, workshops, and simulation-based training to accelerate the learning curve. Increased familiarity and skill among physicians directly contribute to procedural growth and greater device utilization worldwide.
Market Limiters
Motion Preservation Technologies
Because MIS interbody devices are part of the broader spinal fusion market, motion preservation devices pose a significant threat. These include facet arthroplasty, disc arthroplasty, and nucleus replacement technologies that allow motion at the treated spinal segment.
As more motion-preserving alternatives enter the market, growth of the total spinal fusion segment—including MIS fusion—is expected to slow. Although MIS fusion will likely continue to gain share within fusion procedures, the overall ceiling for growth may be limited by competition from non-fusion solutions.
Surgical Complexity
MIS fusion procedures are technically demanding and require specialized equipment and training. Retractor-based techniques, in particular, involve complex instrumentation and limited visualization, which can increase procedure times and learning curves.
Older surgeons who trained primarily in open surgery are often reluctant to transition to MIS approaches due to the required learning investment. In some regions, limited access to training programs further constrains adoption rates.
Import Prices and Reimbursement
In developing regions, exchange rate fluctuations and pricing pressures limit market accessibility. The strength of the U.S. dollar has made it difficult for hospitals in cost-sensitive regions to afford premium MIS technologies manufactured in North America and Europe.
Furthermore, reimbursement policies in several countries do not differentiate between MIS and open procedures, discouraging investment in higher-cost MIS equipment. Manufacturers have responded by lowering ASPs or offering financing models to stimulate adoption, but profitability challenges persist in lower-income markets.
Market Coverage and Data Scope
Quantitative Coverage
Market size, market shares, market forecasts, growth rates, units sold, and average selling prices.
Qualitative Coverage
Market growth trends, limiters, competitive analysis and SWOT for top competitors, M&A activity, company profiles, product portfolios, FDA approvals and recalls, and disruptive technologies.
Time Frame
Historical data: 2021–2024
Base year: 2024
Forecast period: 2025–2031
Data Sources
Primary interviews with spine surgeons and executives, regulatory and hospital purchasing data, import/export data, and iData Research’s proprietary MedTech database.
Markets Covered and Segmentation
Global MIS Interbody Device Market – Further Segmented Into:
Device Type:
Minimally Invasive Posterior Lumbar Interbody Fusion (MIPLIF)
Minimally Invasive Transforaminal Lumbar Interbody Fusion (MITLIF)
Lateral Lumbar Interbody Fusion (LLIF)
Oblique Lateral Interbody Fusion (OLIF)
Competitive Analysis
Globus Medical/NuVasive led the global MIS interbody device market in 2024. The company’s leadership was strengthened by its 2023 merger, which combined Globus Medical’s innovation in MIS technology with NuVasive’s strong procedural base in lateral fusion systems. The merged company held the largest market share in North America, Western Europe, and across the Rest of the World. Its broad product portfolio and training infrastructure have solidified its dominance.
Medtronic maintained the second-largest market share globally. Its presence in the LLIF segment is anchored by the Direct Lateral Interbody Fusion (DLIF®) system, which remains a key standard in lateral access procedures. Medtronic’s strong brand recognition and extensive distribution networks ensure its continued competitiveness in all regions.
DePuy Synthes, part of Johnson & Johnson MedTech, ranked third in the global MIS interbody device market in 2024. The company’s position is supported by its well-established spinal implant line and ongoing investments in research and development for MIS innovations. Future growth will depend heavily on its ability to launch differentiated, procedure-specific MIS solutions to compete with more specialized rivals.
Other notable competitors include Stryker, Zimmer Biomet, and SeaSpine, each active in specific subsegments of the MIS interbody market. Emerging regional players from Asia-Pacific are expected to exert price pressure in developing markets through cost-competitive offerings.
Technology and Practice Trends
Improved retractors and visualization systems continue to enhance safety and efficiency in MIS fusion procedures.
Expandable interbody cages are gaining traction, offering better endplate contact and restoration of disc height with minimal insertion trauma.
3D-printed titanium implants are being increasingly adopted for their porous structures that promote osseointegration.
Integration with surgical navigation and robotics is expanding, providing more accurate implant placement and shorter learning curves.
Single-position surgery—performing both interbody and posterior fixation without repositioning the patient—is becoming a major trend in LLIF and OLIF procedures, reducing operative time.
Regional training programs and virtual education platforms are helping expand procedural expertise, particularly in emerging markets.
Geography
This report provides global coverage across North America, Europe, Asia-Pacific, Latin America, the Middle East, and Africa.
Why This Report
Where are the largest and fastest-growing opportunities in the MIS interbody device market?
How do MIPLIF, MITLIF, LLIF, and OLIF differ in growth potential, pricing trends, and adoption rates?
What regional factors influence adoption and reimbursement for MIS fusion procedures?
Which companies hold the strongest product portfolios, and how are mergers reshaping competitive dynamics?
How are navigation, robotics, and imaging integration influencing future MIS device design?
What are the emerging technologies and materials that could disrupt traditional interbody fusion techniques?
How can suppliers align pricing, training, and regional expansion strategies to maximize growth through 2031?
The Global MIS Interbody Device Market Report from iData Research answers these questions with detailed data, forecasts, and competitive insights. Use it to identify growth opportunities, guide product strategy, and plan commercial expansion in one of the fastest-evolving segments of spinal care.
About iData Research
iData Research is a premium market intelligence firm headquartered in Canada with offices across North America and Europe.
Over the last 20 years, the company has specialized in device-level sizing, procedure models, pricing trends, and competitive share across MedTech.
Since 2005, iData has supported global OEMs, mid-market innovators, and investors with triangulated data based on units and ASPs, with country-level forecasts and analyst access across Europe, North America, Latin America, the Middle East, Africa, and APAC.
Reports are available with flexible licensing to fit commercial, strategy, and investment workflows
Executive Summary
The global minimally invasive spinal (MIS) interbody device market includes all devices used in fusion procedures performed through minimally invasive surgical approaches. In 2024, the lateral lumbar interbody fusion (LLIF) segment represented the largest share of the market. All subsegments are expected to continue growing over the forecast period, with minimally invasive posterior lumbar interbody fusion (MIPLIF) showing the fastest growth rate. Despite this, MIPLIF remains the smallest subsegment due to a decline in average selling prices (ASPs) resulting from heightened competition and price sensitivity.
The global MIS interbody device market continues to expand as technological innovation, surgeon training, and patient demand shift toward less invasive approaches. This report covers MIPLIF, minimally invasive transforaminal lumbar interbody fusion (MITLIF), LLIF, and oblique lateral interbody fusion (OLIF) procedures and devices. It quantifies unit sales, average selling prices, market values, growth rates, and company shares, while analyzing market drivers and limiters, technology trends, mergers and acquisitions (M&A), and leading company portfolios. Historical data are provided from 2021 to 2024, with forecasts to 2031.
Minimally invasive surgery continues to reshape spinal fusion by providing faster recovery, reduced muscle and tissue trauma, and improved cosmetic outcomes compared to open procedures. Surgeons and patients are increasingly opting for these procedures, making the MIS interbody device market one of the most dynamic segments in spinal implant technology.
Market Overview
Minimally invasive spinal (MIS) interbody fusion devices are designed to facilitate spinal fusion through smaller incisions and reduced soft tissue disruption. The goal is to stabilize the spine while minimizing postoperative pain, blood loss, and recovery time. The main procedural subsegments—MIPLIF, MITLIF, LLIF, and OLIF—represent different access points to the intervertebral space.
MIPLIF and MITLIF involve posterior and transforaminal approaches using smaller tubular retractors to reach the spine with minimal muscle damage.
LLIF and OLIF use lateral or oblique approaches to access the disc space through the psoas muscle or between the psoas and major vessels.
These techniques allow surgeons to perform spinal fusion with reduced disruption to surrounding tissues, often resulting in shorter hospital stays and quicker return to daily activities.
Market growth is fueled by an aging global population and increasing demand for procedures that minimize postoperative recovery times. MIS techniques are particularly attractive for elderly patients who face higher risks from open surgeries.
Over the forecast period, all procedural subsegments are expected to increase in value. The LLIF segment will continue to hold the largest share, while MIPLIF will expand fastest due to continued adoption in emerging markets and improved surgeon familiarity.
Market Drivers
Minimally Invasive Surgery
The strongest driver of the MIS interbody device market is the growing preference for minimally invasive techniques. Patients and surgeons are consistently choosing MIS approaches over traditional open fusion because of their clinical advantages, including smaller incisions, less blood loss, and reduced hospital stays.
MIS techniques minimize tissue damage, lower infection risks, and reduce complications. Improved outcomes and faster patient recovery times have made MIS fusion procedures a preferred option for suitable candidates. As awareness grows, this preference is expected to increase procedural volumes globally.
360° MIS Fusion
The development and clinical validation of 360° fusion techniques support the continued growth of MIS fusion procedures. In a 360° fusion, both anterior and posterior elements of the spinal column are fused, often using a combination of MIS techniques. For example, an XLIF® system may be used to place the interbody device laterally, while posterior fixation is achieved through percutaneous screws.
These comprehensive approaches have proven effective in providing superior stability, which strengthens clinical outcomes and further drives the market for MIS interbody devices.
Physician Education and Training
The expansion of training programs dedicated to minimally invasive spinal surgery is a key growth driver. The successful adoption of MIS techniques depends heavily on surgeon proficiency. As more surgeons are trained in retractor-based and percutaneous techniques, procedural adoption increases.
Manufacturers are heavily investing in surgeon education programs, workshops, and simulation-based training to accelerate the learning curve. Increased familiarity and skill among physicians directly contribute to procedural growth and greater device utilization worldwide.
Market Limiters
Motion Preservation Technologies
Because MIS interbody devices are part of the broader spinal fusion market, motion preservation devices pose a significant threat. These include facet arthroplasty, disc arthroplasty, and nucleus replacement technologies that allow motion at the treated spinal segment.
As more motion-preserving alternatives enter the market, growth of the total spinal fusion segment—including MIS fusion—is expected to slow. Although MIS fusion will likely continue to gain share within fusion procedures, the overall ceiling for growth may be limited by competition from non-fusion solutions.
Surgical Complexity
MIS fusion procedures are technically demanding and require specialized equipment and training. Retractor-based techniques, in particular, involve complex instrumentation and limited visualization, which can increase procedure times and learning curves.
Older surgeons who trained primarily in open surgery are often reluctant to transition to MIS approaches due to the required learning investment. In some regions, limited access to training programs further constrains adoption rates.
Import Prices and Reimbursement
In developing regions, exchange rate fluctuations and pricing pressures limit market accessibility. The strength of the U.S. dollar has made it difficult for hospitals in cost-sensitive regions to afford premium MIS technologies manufactured in North America and Europe.
Furthermore, reimbursement policies in several countries do not differentiate between MIS and open procedures, discouraging investment in higher-cost MIS equipment. Manufacturers have responded by lowering ASPs or offering financing models to stimulate adoption, but profitability challenges persist in lower-income markets.
Market Coverage and Data Scope
Quantitative Coverage
Market size, market shares, market forecasts, growth rates, units sold, and average selling prices.
Qualitative Coverage
Market growth trends, limiters, competitive analysis and SWOT for top competitors, M&A activity, company profiles, product portfolios, FDA approvals and recalls, and disruptive technologies.
Time Frame
Historical data: 2021–2024
Base year: 2024
Forecast period: 2025–2031
Data Sources
Primary interviews with spine surgeons and executives, regulatory and hospital purchasing data, import/export data, and iData Research’s proprietary MedTech database.
Markets Covered and Segmentation
Global MIS Interbody Device Market – Further Segmented Into:
Device Type:
Minimally Invasive Posterior Lumbar Interbody Fusion (MIPLIF)
Minimally Invasive Transforaminal Lumbar Interbody Fusion (MITLIF)
Lateral Lumbar Interbody Fusion (LLIF)
Oblique Lateral Interbody Fusion (OLIF)
Competitive Analysis
Globus Medical/NuVasive led the global MIS interbody device market in 2024. The company’s leadership was strengthened by its 2023 merger, which combined Globus Medical’s innovation in MIS technology with NuVasive’s strong procedural base in lateral fusion systems. The merged company held the largest market share in North America, Western Europe, and across the Rest of the World. Its broad product portfolio and training infrastructure have solidified its dominance.
Medtronic maintained the second-largest market share globally. Its presence in the LLIF segment is anchored by the Direct Lateral Interbody Fusion (DLIF®) system, which remains a key standard in lateral access procedures. Medtronic’s strong brand recognition and extensive distribution networks ensure its continued competitiveness in all regions.
DePuy Synthes, part of Johnson & Johnson MedTech, ranked third in the global MIS interbody device market in 2024. The company’s position is supported by its well-established spinal implant line and ongoing investments in research and development for MIS innovations. Future growth will depend heavily on its ability to launch differentiated, procedure-specific MIS solutions to compete with more specialized rivals.
Other notable competitors include Stryker, Zimmer Biomet, and SeaSpine, each active in specific subsegments of the MIS interbody market. Emerging regional players from Asia-Pacific are expected to exert price pressure in developing markets through cost-competitive offerings.
Technology and Practice Trends
Improved retractors and visualization systems continue to enhance safety and efficiency in MIS fusion procedures.
Expandable interbody cages are gaining traction, offering better endplate contact and restoration of disc height with minimal insertion trauma.
3D-printed titanium implants are being increasingly adopted for their porous structures that promote osseointegration.
Integration with surgical navigation and robotics is expanding, providing more accurate implant placement and shorter learning curves.
Single-position surgery—performing both interbody and posterior fixation without repositioning the patient—is becoming a major trend in LLIF and OLIF procedures, reducing operative time.
Regional training programs and virtual education platforms are helping expand procedural expertise, particularly in emerging markets.
Geography
This report provides global coverage across North America, Europe, Asia-Pacific, Latin America, the Middle East, and Africa.
Why This Report
Where are the largest and fastest-growing opportunities in the MIS interbody device market?
How do MIPLIF, MITLIF, LLIF, and OLIF differ in growth potential, pricing trends, and adoption rates?
What regional factors influence adoption and reimbursement for MIS fusion procedures?
Which companies hold the strongest product portfolios, and how are mergers reshaping competitive dynamics?
How are navigation, robotics, and imaging integration influencing future MIS device design?
What are the emerging technologies and materials that could disrupt traditional interbody fusion techniques?
How can suppliers align pricing, training, and regional expansion strategies to maximize growth through 2031?
The Global MIS Interbody Device Market Report from iData Research answers these questions with detailed data, forecasts, and competitive insights. Use it to identify growth opportunities, guide product strategy, and plan commercial expansion in one of the fastest-evolving segments of spinal care.
About iData Research
iData Research is a premium market intelligence firm headquartered in Canada with offices across North America and Europe.
Over the last 20 years, the company has specialized in device-level sizing, procedure models, pricing trends, and competitive share across MedTech.
Since 2005, iData has supported global OEMs, mid-market innovators, and investors with triangulated data based on units and ASPs, with country-level forecasts and analyst access across Europe, North America, Latin America, the Middle East, Africa, and APAC.
Reports are available with flexible licensing to fit commercial, strategy, and investment workflows
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