Biologics & Biosimilars Market Forecasts to 2032 – Global Analysis By Product Type (Biologics, Biosimilars), Therapeutic Area (Oncology, Ophthalmology, Autoimmune Disorders, Cardiovascular, Endocrinology, Infectious Diseases, Hematology, and Wound Healing
Description
According to Stratistics MRC, the Global Biologics & Biosimilars Market is accounted for $538.20 billion in 2025 and is expected to reach $1219.86 billion by 2032 growing at a CAGR of 12.4% during the forecast period. Biologics are innovative therapies produced using living cells or organisms, such as monoclonal antibodies, proteins, and vaccines, that target chronic and severe diseases. Biosimilars, created after biologics lose patent protection, are close replicas in terms of safety, efficacy, and quality, ensuring similar therapeutic effects. These cost-effective options expand patient access to critical treatments. Together, biologics and biosimilars enhance healthcare by advancing medical solutions, reducing treatment costs, and improving overall clinical outcomes.
Market Dynamics:
Driver:
Rising prevalence of chronic diseases
The increasing global burden of chronic illnesses such as cancer, diabetes, and autoimmune disorders is fuelling demand for biologics and biosimilars. Healthcare systems are prioritizing long-term treatment solutions that offer improved efficacy and reduced side effects. Biologics, with their targeted mechanisms, are becoming central to disease management strategies. As patient population’s age and diagnostic capabilities improve, the need for biologic therapies continues to rise. Biosimilars are gaining traction as cost-effective alternatives, especially in markets with strained healthcare budgets. This growing demand is accelerating innovation and investment across the biopharmaceutical landscape.
Restraint:
High development and manufacturing costs
Developing biologics and biosimilars involves complex processes, from cell line engineering to purification and validation. These high costs are compounded by stringent regulatory requirements and extended clinical trial timelines. Manufacturing facilities must meet rigorous quality standards, often requiring specialized infrastructure and skilled personnel. The need for cold chain logistics and contamination control further increases operational expenses. Smaller firms face barriers to entry, limiting competition and slowing market expansion. As a result, pricing remains a challenge, especially in emerging economies.
Opportunity:
Technological advancements in R&D and manufacturing
Advanced analytics and AI-driven modelling are enhancing drug discovery and reducing development timelines. Innovations in cell culture media and expression systems are improving yield and product consistency. Automation and digital twins are being adopted to optimize facility operations and reduce human error. These advancements are lowering costs and enabling scalable production of complex biologics. As technology matures, more players can enter the market with competitive biosimilar offerings.
Threat:
Intense competition and pricing pressure
Patent expirations are opening the door to multiple entrants, intensifying pricing battles. Regulatory pathways, while evolving, still pose hurdles that delay market access and increase compliance costs. Payers and healthcare providers are demanding lower prices, squeezing margins across the value chain. Brand loyalty and physician hesitancy toward biosimilars also impact adoption rates. Without differentiation and strategic positioning, companies risk losing market share in an increasingly commoditized landscape.
Covid-19 Impact
The pandemic disrupted clinical trials, supply chains, and manufacturing schedules for biologics and biosimilars. Lockdowns and resource reallocation toward vaccines and emergency treatments delayed non-COVID product launches. However, the crisis also highlighted the importance of biologics in managing infectious diseases and immune responses. Biopharma companies accelerated digital transformation, adopting remote monitoring and decentralized trial models. Governments and regulators introduced flexible frameworks to maintain continuity in drug development. Post-pandemic strategies now emphasize resilience, agility, and global collaboration in biologics manufacturing.
The biologics segment is expected to be the largest during the forecast period
The biologics segment is expected to account for the largest market share during the forecast period, its superior therapeutic outcomes and expanding indications. Monoclonal antibodies, recombinant proteins, and gene therapies are gaining widespread clinical acceptance. Increasing prevalence of complex diseases is driving demand for targeted biologic treatments. Regulatory approvals are accelerating, supported by robust clinical data and patient advocacy. Investment in biologics R&D continues to outpace other segments, reinforcing its market leadership. As biologics become more accessible, their share in global pharmaceutical spending is expected to rise steadily.
The biopharma companies segment is expected to have the highest CAGR during the forecast period
Over the forecast period, the biopharma companies segment is predicted to witness the highest growth rate, driven by aggressive innovation and pipeline expansion. These firms are leveraging advanced platforms for biologic synthesis, formulation, and delivery. Strategic collaborations and licensing agreements are enabling faster market entry and broader geographic reach. Biopharma players are also investing in biosimilar portfolios to capture post-patent opportunities. Their agility and focus on niche therapies position them well for sustained growth. As demand for personalized medicine increases, biopharma companies are leading the charge in biologics development.
Region with largest share:
During the forecast period, the Asia Pacific region is expected to hold the largest market share supported by rising healthcare expenditure and expanding patient populations. Countries like China, India, and South Korea are investing heavily in biologics infrastructure and regulatory modernization. Local manufacturers are scaling up production to meet domestic and export demand. Government initiatives are promoting biosimilar adoption to reduce treatment costs. Clinical trial activity is surging, with Asia Pacific emerging as a hub for biologics research. The region’s demographic and economic dynamics make it a key growth engine for the industry.
Region with highest CAGR:
Over the forecast period, the North America region is anticipated to exhibit the highest CAGR, furled by technological leadership and robust biopharma investment. The U.S. and Canada are advancing biologics innovation through academic-industry partnerships and federal funding. Regulatory agencies are streamlining approval pathways for biosimilars, encouraging market competition. Adoption of precision medicine and biologic therapies is accelerating across therapeutic areas. Digital health integration and AI-driven drug development are enhancing efficiency and outcomes.
Key players in the market
Some of the key players profiled in the Biologics & Biosimilars Market include Amgen, Sanofi, Pfizer, Eli Lilly, Novartis, Viatris, Biocon Biologics, AbbVie, Samsung Bioepis, Teva Pharmaceuticals, Celltrion, Fresenius Kabi, Roche, Boehringer Ingelheim, and Merck KGaA.
Key Developments:
In September 2025, Novartis AG has reached an agreement to purchase the New York-based firm, Tourmaline Bio Inc., in a deal valued at a staggering $1.4 billion. This move is aimed at reducing systemic inflammation, which is termed a major driver of cardiovascular disease. Novartis has been on the lookout for deals that would amplify its sales beyond 2025.
In August 2025, Sanofi announces the completion of its acquisition of Vigil Neuroscience, Inc. This acquisition strengthens Sanofi’s early-stage pipeline in neurology with VG-3927, a novel, oral, small-molecule TREM2 agonist, which will be evaluated in a phase 2 clinical study in patients with Alzheimer’s disease. In addition, the acquisition of Vigil’s preclinical pipeline will further strengthen Sanofi’s research in various neurodegenerative diseases.
Product Types Covered:
• Biologics
• Biosimilars
Therapeutic Areas Covered:
• Oncology
• Ophthalmology
• Autoimmune Disorders
• Cardiovascular
• Endocrinology
• Infectious Diseases
• Hematology
• Wound Healing & Regenerative Care
Manufacturing Sources Covered:
• Mammalian Cell Culture
• Yeast Expression Systems
• Bacterial Cell Culture
• Transgenic Models
Distribution Channels Covered:
• Hospital Pharmacies
• Specialty Clinics
• Retail Pharmacies
• Online Pharmacies
End Users Covered:
• Hospitals
• Diagnostic Labs
• Research Institutes
• Biopharma Companies
• Other End Users
Regions Covered:
• North America
US
Canada
Mexico
• Europe
Germany
UK
Italy
France
Spain
Rest of Europe
• Asia Pacific
Japan
China
India
Australia
New Zealand
South Korea
Rest of Asia Pacific
• South America
Argentina
Brazil
Chile
Rest of South America
• Middle East & Africa
Saudi Arabia
UAE
Qatar
South Africa
Rest of Middle East & Africa
What our report offers:
- Market share assessments for the regional and country-level segments
- Strategic recommendations for the new entrants
- Covers Market data for the years 2024, 2025, 2026, 2028, and 2032
- Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations)
- Strategic recommendations in key business segments based on the market estimations
- Competitive landscaping mapping the key common trends
- Company profiling with detailed strategies, financials, and recent developments
- Supply chain trends mapping the latest technological advancements
Market Dynamics:
Driver:
Rising prevalence of chronic diseases
The increasing global burden of chronic illnesses such as cancer, diabetes, and autoimmune disorders is fuelling demand for biologics and biosimilars. Healthcare systems are prioritizing long-term treatment solutions that offer improved efficacy and reduced side effects. Biologics, with their targeted mechanisms, are becoming central to disease management strategies. As patient population’s age and diagnostic capabilities improve, the need for biologic therapies continues to rise. Biosimilars are gaining traction as cost-effective alternatives, especially in markets with strained healthcare budgets. This growing demand is accelerating innovation and investment across the biopharmaceutical landscape.
Restraint:
High development and manufacturing costs
Developing biologics and biosimilars involves complex processes, from cell line engineering to purification and validation. These high costs are compounded by stringent regulatory requirements and extended clinical trial timelines. Manufacturing facilities must meet rigorous quality standards, often requiring specialized infrastructure and skilled personnel. The need for cold chain logistics and contamination control further increases operational expenses. Smaller firms face barriers to entry, limiting competition and slowing market expansion. As a result, pricing remains a challenge, especially in emerging economies.
Opportunity:
Technological advancements in R&D and manufacturing
Advanced analytics and AI-driven modelling are enhancing drug discovery and reducing development timelines. Innovations in cell culture media and expression systems are improving yield and product consistency. Automation and digital twins are being adopted to optimize facility operations and reduce human error. These advancements are lowering costs and enabling scalable production of complex biologics. As technology matures, more players can enter the market with competitive biosimilar offerings.
Threat:
Intense competition and pricing pressure
Patent expirations are opening the door to multiple entrants, intensifying pricing battles. Regulatory pathways, while evolving, still pose hurdles that delay market access and increase compliance costs. Payers and healthcare providers are demanding lower prices, squeezing margins across the value chain. Brand loyalty and physician hesitancy toward biosimilars also impact adoption rates. Without differentiation and strategic positioning, companies risk losing market share in an increasingly commoditized landscape.
Covid-19 Impact
The pandemic disrupted clinical trials, supply chains, and manufacturing schedules for biologics and biosimilars. Lockdowns and resource reallocation toward vaccines and emergency treatments delayed non-COVID product launches. However, the crisis also highlighted the importance of biologics in managing infectious diseases and immune responses. Biopharma companies accelerated digital transformation, adopting remote monitoring and decentralized trial models. Governments and regulators introduced flexible frameworks to maintain continuity in drug development. Post-pandemic strategies now emphasize resilience, agility, and global collaboration in biologics manufacturing.
The biologics segment is expected to be the largest during the forecast period
The biologics segment is expected to account for the largest market share during the forecast period, its superior therapeutic outcomes and expanding indications. Monoclonal antibodies, recombinant proteins, and gene therapies are gaining widespread clinical acceptance. Increasing prevalence of complex diseases is driving demand for targeted biologic treatments. Regulatory approvals are accelerating, supported by robust clinical data and patient advocacy. Investment in biologics R&D continues to outpace other segments, reinforcing its market leadership. As biologics become more accessible, their share in global pharmaceutical spending is expected to rise steadily.
The biopharma companies segment is expected to have the highest CAGR during the forecast period
Over the forecast period, the biopharma companies segment is predicted to witness the highest growth rate, driven by aggressive innovation and pipeline expansion. These firms are leveraging advanced platforms for biologic synthesis, formulation, and delivery. Strategic collaborations and licensing agreements are enabling faster market entry and broader geographic reach. Biopharma players are also investing in biosimilar portfolios to capture post-patent opportunities. Their agility and focus on niche therapies position them well for sustained growth. As demand for personalized medicine increases, biopharma companies are leading the charge in biologics development.
Region with largest share:
During the forecast period, the Asia Pacific region is expected to hold the largest market share supported by rising healthcare expenditure and expanding patient populations. Countries like China, India, and South Korea are investing heavily in biologics infrastructure and regulatory modernization. Local manufacturers are scaling up production to meet domestic and export demand. Government initiatives are promoting biosimilar adoption to reduce treatment costs. Clinical trial activity is surging, with Asia Pacific emerging as a hub for biologics research. The region’s demographic and economic dynamics make it a key growth engine for the industry.
Region with highest CAGR:
Over the forecast period, the North America region is anticipated to exhibit the highest CAGR, furled by technological leadership and robust biopharma investment. The U.S. and Canada are advancing biologics innovation through academic-industry partnerships and federal funding. Regulatory agencies are streamlining approval pathways for biosimilars, encouraging market competition. Adoption of precision medicine and biologic therapies is accelerating across therapeutic areas. Digital health integration and AI-driven drug development are enhancing efficiency and outcomes.
Key players in the market
Some of the key players profiled in the Biologics & Biosimilars Market include Amgen, Sanofi, Pfizer, Eli Lilly, Novartis, Viatris, Biocon Biologics, AbbVie, Samsung Bioepis, Teva Pharmaceuticals, Celltrion, Fresenius Kabi, Roche, Boehringer Ingelheim, and Merck KGaA.
Key Developments:
In September 2025, Novartis AG has reached an agreement to purchase the New York-based firm, Tourmaline Bio Inc., in a deal valued at a staggering $1.4 billion. This move is aimed at reducing systemic inflammation, which is termed a major driver of cardiovascular disease. Novartis has been on the lookout for deals that would amplify its sales beyond 2025.
In August 2025, Sanofi announces the completion of its acquisition of Vigil Neuroscience, Inc. This acquisition strengthens Sanofi’s early-stage pipeline in neurology with VG-3927, a novel, oral, small-molecule TREM2 agonist, which will be evaluated in a phase 2 clinical study in patients with Alzheimer’s disease. In addition, the acquisition of Vigil’s preclinical pipeline will further strengthen Sanofi’s research in various neurodegenerative diseases.
Product Types Covered:
• Biologics
• Biosimilars
Therapeutic Areas Covered:
• Oncology
• Ophthalmology
• Autoimmune Disorders
• Cardiovascular
• Endocrinology
• Infectious Diseases
• Hematology
• Wound Healing & Regenerative Care
Manufacturing Sources Covered:
• Mammalian Cell Culture
• Yeast Expression Systems
• Bacterial Cell Culture
• Transgenic Models
Distribution Channels Covered:
• Hospital Pharmacies
• Specialty Clinics
• Retail Pharmacies
• Online Pharmacies
End Users Covered:
• Hospitals
• Diagnostic Labs
• Research Institutes
• Biopharma Companies
• Other End Users
Regions Covered:
• North America
US
Canada
Mexico
• Europe
Germany
UK
Italy
France
Spain
Rest of Europe
• Asia Pacific
Japan
China
India
Australia
New Zealand
South Korea
Rest of Asia Pacific
• South America
Argentina
Brazil
Chile
Rest of South America
• Middle East & Africa
Saudi Arabia
UAE
Qatar
South Africa
Rest of Middle East & Africa
What our report offers:
- Market share assessments for the regional and country-level segments
- Strategic recommendations for the new entrants
- Covers Market data for the years 2024, 2025, 2026, 2028, and 2032
- Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations)
- Strategic recommendations in key business segments based on the market estimations
- Competitive landscaping mapping the key common trends
- Company profiling with detailed strategies, financials, and recent developments
- Supply chain trends mapping the latest technological advancements
Table of Contents
200 Pages
- 1 Executive Summary
- 2 Preface
- 2.1 Abstract
- 2.2 Stake Holders
- 2.3 Research Scope
- 2.4 Research Methodology
- 2.4.1 Data Mining
- 2.4.2 Data Analysis
- 2.4.3 Data Validation
- 2.4.4 Research Approach
- 2.5 Research Sources
- 2.5.1 Primary Research Sources
- 2.5.2 Secondary Research Sources
- 2.5.3 Assumptions
- 3 Market Trend Analysis
- 3.1 Introduction
- 3.2 Drivers
- 3.3 Restraints
- 3.4 Opportunities
- 3.5 Threats
- 3.6 Product Analysis
- 3.7 End User Analysis
- 3.8 Emerging Markets
- 3.9 Impact of Covid-19
- 4 Porters Five Force Analysis
- 4.1 Bargaining power of suppliers
- 4.2 Bargaining power of buyers
- 4.3 Threat of substitutes
- 4.4 Threat of new entrants
- 4.5 Competitive rivalry
- 5 Global Biologics & Biosimilars Market, By Product Type
- 5.1 Introduction
- 5.2 Biologics
- 5.2.1 Monoclonal Antibodies
- 5.2.2 Recombinant Proteins
- 5.2.3 Hormones
- 5.2.4 Vaccines
- 5.2.5 Cytokines & Interferons
- 5.2.6 Fusion Proteins
- 5.3 Biosimilars
- 5.3.1 Monoclonal Antibody Biosimilars
- 5.3.2 Low Molecular Weight Heparins
- 5.3.3 Recombinant Hormone Biosimilars
- 5.3.4 Immunomodulators
- 5.3.5 Anti-inflammatory Biosimilars
- 6 Global Biologics & Biosimilars Market, By Therapeutic Area
- 6.1 Introduction
- 6.2 Oncology
- 6.3 Ophthalmology
- 6.4 Autoimmune Disorders
- 6.5 Cardiovascular
- 6.6 Endocrinology
- 6.7 Infectious Diseases
- 6.8 Hematology
- 6.9 Wound Healing & Regenerative Care
- 7 Global Biologics & Biosimilars Market, By Manufacturing Source
- 7.1 Introduction
- 7.2 Mammalian Cell Culture
- 7.3 Yeast Expression Systems
- 7.4 Bacterial Cell Culture
- 7.5 Transgenic Models
- 8 Global Biologics & Biosimilars Market, By Distribution Channel
- 8.1 Introduction
- 8.2 Hospital Pharmacies
- 8.3 Specialty Clinics
- 8.4 Retail Pharmacies
- 8.5 Online Pharmacies
- 9 Global Biologics & Biosimilars Market, By End User
- 9.1 Introduction
- 9.2 Hospitals
- 9.3 Diagnostic Labs
- 9.4 Research Institutes
- 9.5 Biopharma Companies
- 9.6 Other End Users
- 10 Global Biologics & Biosimilars Market, By Geography
- 10.1 Introduction
- 10.2 North America
- 10.2.1 US
- 10.2.2 Canada
- 10.2.3 Mexico
- 10.3 Europe
- 10.3.1 Germany
- 10.3.2 UK
- 10.3.3 Italy
- 10.3.4 France
- 10.3.5 Spain
- 10.3.6 Rest of Europe
- 10.4 Asia Pacific
- 10.4.1 Japan
- 10.4.2 China
- 10.4.3 India
- 10.4.4 Australia
- 10.4.5 New Zealand
- 10.4.6 South Korea
- 10.4.7 Rest of Asia Pacific
- 10.5 South America
- 10.5.1 Argentina
- 10.5.2 Brazil
- 10.5.3 Chile
- 10.5.4 Rest of South America
- 10.6 Middle East & Africa
- 10.6.1 Saudi Arabia
- 10.6.2 UAE
- 10.6.3 Qatar
- 10.6.4 South Africa
- 10.6.5 Rest of Middle East & Africa
- 11 Key Developments
- 11.1 Agreements, Partnerships, Collaborations and Joint Ventures
- 11.2 Acquisitions & Mergers
- 11.3 New Product Launch
- 11.4 Expansions
- 11.5 Other Key Strategies
- 12 Company Profiling
- 12.1 Amgen
- 12.2 Sanofi
- 12.3 Pfizer
- 12.4 Eli Lilly
- 12.5 Novartis
- 12.6 Viatris
- 12.7 Biocon Biologics
- 12.8 AbbVie
- 12.9 Samsung Bioepis
- 12.10 Teva Pharmaceuticals
- 12.11 Celltrion
- 12.12 Fresenius Kabi
- 12.13 Roche
- 12.14 Boehringer Ingelheim
- 12.15 Merck KGaA
- List of Tables
- Table 1 Global Biologics & Biosimilars Market Outlook, By Region (2024-2032) ($MN)
- Table 2 Global Biologics & Biosimilars Market Outlook, By Product Type (2024-2032) ($MN)
- Table 3 Global Biologics & Biosimilars Market Outlook, By Biologics (2024-2032) ($MN)
- Table 4 Global Biologics & Biosimilars Market Outlook, By Monoclonal Antibodies (2024-2032) ($MN)
- Table 5 Global Biologics & Biosimilars Market Outlook, By Recombinant Proteins (2024-2032) ($MN)
- Table 6 Global Biologics & Biosimilars Market Outlook, By Hormones (2024-2032) ($MN)
- Table 7 Global Biologics & Biosimilars Market Outlook, By Vaccines (2024-2032) ($MN)
- Table 8 Global Biologics & Biosimilars Market Outlook, By Cytokines & Interferons (2024-2032) ($MN)
- Table 9 Global Biologics & Biosimilars Market Outlook, By Fusion Proteins (2024-2032) ($MN)
- Table 10 Global Biologics & Biosimilars Market Outlook, By Biosimilars (2024-2032) ($MN)
- Table 11 Global Biologics & Biosimilars Market Outlook, By Monoclonal Antibody Biosimilars (2024-2032) ($MN)
- Table 12 Global Biologics & Biosimilars Market Outlook, By Low Molecular Weight Heparins (2024-2032) ($MN)
- Table 13 Global Biologics & Biosimilars Market Outlook, By Recombinant Hormone Biosimilars (2024-2032) ($MN)
- Table 14 Global Biologics & Biosimilars Market Outlook, By Immunomodulators (2024-2032) ($MN)
- Table 15 Global Biologics & Biosimilars Market Outlook, By Anti-inflammatory Biosimilars (2024-2032) ($MN)
- Table 16 Global Biologics & Biosimilars Market Outlook, By Therapeutic Area (2024-2032) ($MN)
- Table 17 Global Biologics & Biosimilars Market Outlook, By Oncology (2024-2032) ($MN)
- Table 18 Global Biologics & Biosimilars Market Outlook, By Ophthalmology (2024-2032) ($MN)
- Table 19 Global Biologics & Biosimilars Market Outlook, By Autoimmune Disorders (2024-2032) ($MN)
- Table 20 Global Biologics & Biosimilars Market Outlook, By Cardiovascular (2024-2032) ($MN)
- Table 21 Global Biologics & Biosimilars Market Outlook, By Endocrinology (2024-2032) ($MN)
- Table 22 Global Biologics & Biosimilars Market Outlook, By Infectious Diseases (2024-2032) ($MN)
- Table 23 Global Biologics & Biosimilars Market Outlook, By Hematology (2024-2032) ($MN)
- Table 24 Global Biologics & Biosimilars Market Outlook, By Wound Healing & Regenerative Care (2024-2032) ($MN)
- Table 25 Global Biologics & Biosimilars Market Outlook, By Manufacturing Source (2024-2032) ($MN)
- Table 26 Global Biologics & Biosimilars Market Outlook, By Mammalian Cell Culture (2024-2032) ($MN)
- Table 27 Global Biologics & Biosimilars Market Outlook, By Yeast Expression Systems (2024-2032) ($MN)
- Table 28 Global Biologics & Biosimilars Market Outlook, By Bacterial Cell Culture (2024-2032) ($MN)
- Table 29 Global Biologics & Biosimilars Market Outlook, By Transgenic Models (2024-2032) ($MN)
- Table 30 Global Biologics & Biosimilars Market Outlook, By Distribution Channel (2024-2032) ($MN)
- Table 31 Global Biologics & Biosimilars Market Outlook, By Hospital Pharmacies (2024-2032) ($MN)
- Table 32 Global Biologics & Biosimilars Market Outlook, By Specialty Clinics (2024-2032) ($MN)
- Table 33 Global Biologics & Biosimilars Market Outlook, By Retail Pharmacies (2024-2032) ($MN)
- Table 34 Global Biologics & Biosimilars Market Outlook, By Online Pharmacies (2024-2032) ($MN)
- Table 35 Global Biologics & Biosimilars Market Outlook, By End User (2024-2032) ($MN)
- Table 36 Global Biologics & Biosimilars Market Outlook, By Hospitals (2024-2032) ($MN)
- Table 37 Global Biologics & Biosimilars Market Outlook, By Diagnostic Labs (2024-2032) ($MN)
- Table 38 Global Biologics & Biosimilars Market Outlook, By Research Institutes (2024-2032) ($MN)
- Table 39 Global Biologics & Biosimilars Market Outlook, By Biopharma Companies (2024-2032) ($MN)
- Table 40 Global Biologics & Biosimilars Market Outlook, By Other End Users (2024-2032) ($MN)
- Note: Tables for North America, Europe, APAC, South America, and Middle East & Africa Regions are also represented in the same manner as above.
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