Large Molecule Drug Substance CDMO Market Size, Share, Trends, Industry Analysis Report By Product (Biologics and Biosimilar), By Service, By Source, By End User, and By Region – Market Forecast, 2025–2034

The Large molecule drug substance CDMO market size is expected to reach USD 108.18 Billion by 2034, according to a new study by Polaris Market Research. The report “Large Molecule Drug Substance CDMO Market Share, Size, Trends, Industry Analysis Report: By Product (Biologics and Biosimilar), By Service, By Source, By End User, and By Region; Market Forecast, 2025–2034” gives a detailed insight into current market dynamics and provides analysis on future market growth.

Large molecule drug substance CDMO involves outsourcing biologics development and manufacturing, including monoclonal antibodies and biosimilars. It allows pharmaceutical companies to access specialized infrastructure, expertise, and regulatory support for efficient production.

The market growth is driven by rising global approvals of biologic drugs, expanding healthcare expenditure, increasing biologics share in total pharmaceutical spending, growing adoption of biosimilars, and rising investments in advanced bioprocessing technologies worldwide.

Large Molecule Drug Substance CDMO Market Report Highlights
Based on product, the biologics dominated due to high demand for monoclonal antibodies and complex proteins.
In terms of service, the contract manufacturing dominated owing to large-scale production requirements.
Based on source, the mammalian systems dominated for producing complex and high-quality biologics.
In terms of end user, the biopharmaceutical companies dominated due to extensive biologics pipelines and large-scale production needs.
North America held the largest share in 2024 due to established biopharma infrastructure and continuous biologic approvals.
Asia Pacific witnessed fast growth due to rising biologics manufacturing investments in China and India and supportive government initiatives.
A few global key market players include Thermo Fisher Scientific Inc., Eurofins Scientific SE, Wuxi Biologics, Samsung Biologics Co., Ltd., Catalent, Inc., AGC Biologics, Boehringer Ingelheim International GmbH, FUJIFILM Diosynth Biotechnologies, Lonza Group, Recipharm AB, Siegfried Holding AG, and Rentschler Biopharma SE.
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Polaris Market Research has segmented the market report on the basis of product, service, source, end user, and region:
By Product Outlook (Revenue, USD Billion, 2020–2034)

Biologics
Biosimilar
By Service Outlook (Revenue, USD Billion, 2020–2034)

Contract Manufacturing
Clinical
Commercial
Contract Development
Cell Line Development
Process Development
By Source Outlook (Revenue, USD Billion, 2020–2034)

Mammalian
Microbial
Others
By End User Outlook (Revenue, USD Billion, 2020–2034)

Biopharmaceutical Companies
Biotechnology Companies
Academic and Research Institutes
By Regional Outlook (Revenue, USD Billion, 2020–2034)

North America
US
Canada
Europe
Germany
France
UK
Italy
Spain
Netherlands
Russia
Rest of Europe
Asia Pacific
China
Japan
India
Malaysia
South Korea
Indonesia
Australia
Vietnam
Rest of Asia Pacific
Middle East & Africa
Saudi Arabia
UAE
Israel
South Africa
Rest of Middle East & Africa
Latin America
Mexico
Brazil
Argentina
Rest of Latin America Show more