Custom Oligo Synthesis Market Report: Trends, Forecast and Competitive Analysis to 2031

Custom Oligo Synthesis Market Trends and Forecast

The future of the global custom oligo synthesis market looks promising with opportunities in the biotech company and academic scientific research institution markets. The global custom oligo synthesis market is expected to grow with a CAGR of 7.2% from 2025 to 2031. The major drivers for this market are the rising demand for personalized medicine, the growing applications in diagnostics & therapeutics, and the increasing investments in research & development.

• Lucintel forecasts that, within the type category, modified primer synthesis is expected to witness higher growth over the forecast period.
• Within the application category, biotech company is expected to witness higher growth.
• In terms of region, APAC is expected to witness the highest growth over the forecast period.

Gain valuable insights for your business decisions with our comprehensive 150+ page report. Sample figures with some insights are shown below.

Emerging Trends in the Custom Oligo Synthesis Market

The custom oligo synthesis market is driven by fast-paced innovation and responsiveness to the changing needs of the life sciences research and therapeutic development communities.

• Progress in Long and Complex Oligo Synthesis: Increasingly, longer oligonucleotides with complex sequences are required for use in gene assembly and the synthesis of long non-coding RNAs (lncRNAs). Recent trends involve the creation of more efficient synthesis protocols and purification methods that increase the yield and quality of these difficult oligos, opening up their use in sophisticated research.
• Development of Novel Chemical Modifications: The ability to chemically modify oligos is crucial for enhancing their stability, targeting specific tissues, and improving their therapeutic efficacy. Emerging trends include the synthesis of oligos with novel modifications such as locked nucleic acids (LNAs), peptide nucleic acids (PNAs), and various conjugates (e.g., with lipids, peptides, or fluorophores) to broaden their applications in diagnostics and therapeutics.
• Greater Emphasis on Large-Scale Oligo Production for Therapeutics: The success of oligonucleotide-based drugs is generating high demand for large-scale, high-quality oligo production under rigorous regulatory conditions (GMP). Recent developments include the design of more cost-efficient and efficient large-scale synthesis and purification methodologies to address increasing clinical and commercial demands.
• Integration of High-Throughput Synthesis and Automation: In order to address the growing need for customized oligos for use in high-throughput screening and combinatorial chemistry, there is a move towards integrating automated synthesis platforms. Such platforms allow for parallel synthesis of hundreds of oligos with high efficiency and precision, minimizing turnaround times and expenses for researchers.
• Increased Demand for Specialty Oligos for Diagnostics and Gene Editing: Custom oligos are becoming more and more crucial in sophisticated diagnostic tests (e.g., PCR, FISH) and gene editing methods (e.g., CRISPR-Cas9). Current trends involve creating oligos with special modifications for greater sensitivity and specificity in diagnostics and better targeting and efficiency in gene editing platforms.

They are transforming the custom oligo synthesis market by making it possible to design more functional and complex oligos, allowing the scale-up of the production of therapeutic oligos, increasing synthesis efficiency by automating processes, and widening the usage areas of custom oligos in innovative diagnostics and gene editing tools.

Recent Developments in the Custom Oligo Synthesis Market

The custom oligo synthesis market is continually evolving to keep pace with the ever-increasing demands of biological research, diagnostics, and therapeutics.

• Advanced Synthesis Chemistry for Increased Yield and Purity: New advances in phosphonamidite chemistry and coupling methods have made it possible to achieve substantial gains in the yield and purity of oligos synthesized, especially for longer oligos and modified oligos. This translates into oligos of superior quality and minimizing the requirement for extensive purification.
• Widening Modification Options for Various Applications: The variety of available chemical modifications for tailor-made oligos has grown significantly. Novel modifications are being created to be more stable, be more easily taken into cells, facilitate conjugation to different molecules, and add specific functionalities for diagnostic and therapeutic use.
• Scalable and Cost-Effective Manufacturing Processes Development: In order to address the growing need for therapeutic oligonucleotides, much work is aimed at establishing scalable and cost-effective manufacturing processes that meet quality requirements. This involves solid-phase synthesis and downstream purification process innovations.
• Incorporation of Sophisticated Quality Control Measures: The quality and integrity of custom oligos are of utmost importance. New developments involve the adoption of more advanced analytical methods, including mass spectrometry and capillary electrophoresis, for stringent quality control at different steps in synthesis and purification.
• Specialist Oligo Synthesis Service Emergence: The industry is witnessing specialist vendors catering to specialist niches like highly modified oligo synthesis, long non-coding RNAs, or therapeutic-grade oligonucleotide synthesis. The specialized services support specific and technical demands of certain types of research or therapeutic application.

These advancements are affecting the custom oligo synthesis market by allowing the production of better quality and more effective oligos, making it easy to translate oligonucleotide-based therapeutics, guaranteeing the consistency of synthesized products, and offering specialist services for novel applications.

Strategic Growth Opportunities in the Custom Oligo Synthesis Market

There are many strategic opportunities for growth in the custom oligo synthesis market by serving oligonucleotide's diverse and growing applications in different industries.

• Therapeutic Oligonucleotides (ASOs, siRNAs, miRNAs): The emerging area of nucleic acid therapeutics is a very large growth opportunity. Extending and commercializing the manufacture of high-quality, modified oligos for antisense, RNAi, and microRNA-based therapies against a broad spectrum of disease conditions is a huge area of expansion.
• Molecular Diagnostics and Biomarker Discovery: Custom oligos play a significant role in PCR, qPCR, FISH, and other molecular diagnostic tests. The trend towards quicker and more precise diagnostics, such as liquid biopsies and point-of-care tests, offers growth potential for the creation of customized oligos to detect biomarkers.
• CRISPR-Cas9 Gene Editing Tools: Guide RNAs (gRNAs) that are customized to design are key elements of CRISPR-Cas9 gene editing tools. The rapidly expanding arena of gene editing in research, agriculture, and therapeutics is a big growth opportunity for the synthesis of quality gRNAs.
• Gene Assembly and Synthetic Biology: Custom oligos are the basic building blocks in synthetic biology for gene synthesis, DNA assembly, and the design of new biological systems. The rising field of synthetic biology provides a burgeoning need for long and complex custom oligos.
• Therapeutic and Diagnostic Aptamers: Therapeutic and diagnostic aptamers, short single-stranded DNA or RNA oligonucleotides with the ability to bind to target molecules, are on the verge of becoming promising therapeutic and diagnostic tools. Synthesis and development of tailored aptamers with high specificity and affinity are a strategic growth opportunity.

These strategic growth opportunities underscore the central role of custom oligo synthesis in driving cutting-edge research and the creation of innovative diagnostics and therapeutics in a wide range of sectors of the life sciences industry.

Custom Oligo Synthesis Market Driver and Challenges

The custom oligo synthesis market is propelled by the inherent demand for synthetic DNA and RNA across a broad spectrum of biological uses, but it also has some limitations and intricacies.

The factors responsible for driving the custom oligo synthesis market include:

1. Genomics and Molecular Biology: The ongoing development in genome comprehension and molecular mechanisms drives the requirement for custom oligos as pivotal tools for exploration, diagnostics, and therapeutics aimed at targeting specific genetic sequences.

2. Increasing Nucleic Acid Therapeutics Need: The high success rate of oligonucleotide-based treatments is a main driver, creating a need for large amounts of high-quality custom oligos containing specific modifications in order to elicit therapeutic function and stability.

3. Expanding Molecular Diagnostic Market: Requiring sensitive as well as specific diagnostic tests to detect infectious pathogens, genetic ailments, and tumors, the molecular diagnostics market fosters the utilization of custom oligos as probes and primers in numerous methods of detection.

4. Gene Editing Technologies Advances: The speedy use of gene editing technologies such as CRISPR-Cas9 has brought enormous demand for design custom guide RNAs, the most important players in targeted genome editing.

5. Biotechnology and Pharmaceutical R&D Spending Growth: The increasing biotechnology and pharmaceutical R&D expenditures around the world directly correspond to a greater need for custom oligo synthesis service and products.

Challenges in the custom oligo synthesis market are:

1. Oligonucleotide Synthesis of Long and Extended Sequences: The synthesis of longer oligos with high purity and fidelity is still a technically demanding task and can result in lower yields and higher costs.

2. Specialized Modifications Cost: Several advanced applications need oligos with specific chemical modifications, which greatly enhance the cost of synthesis.

3. Scalability and Manufacture Complexities for Therapeutics: Large-scale manufacture of therapeutic oligonucleotides to achieve clinical and commercial demand involves overcoming considerable technical and regulatory challenges.

In short, the custom oligo synthesis market is highly influenced by genomics progress, the success of nucleic acid drugs, the growth of molecular diagnostics, advances in gene editing, and growing R&D spending. Nonetheless, difficulties in synthesizing long and complicated oligos, modification costs, and the complexity of large-scale production must be overcome for further growth and development in the sector.

List of Custom Oligo Synthesis Companies

Companies in the market compete on the basis of product quality offered. Major players in this market focus on expanding their manufacturing facilities, R&D investments, infrastructural development, and leverage integration opportunities across the value chain. With these strategies custom oligo synthesis companies cater increasing demand, ensure competitive effectiveness, develop innovative products & technologies, reduce production costs, and expand their customer base. Some of the custom oligo synthesis companies profiled in this report include-

• Thermo Fisher Scientific
• Merck
• Azenta Life Sciences
• BBI Life Sciences
• TriLink BioTechnologies
• Aurigene Pharmaceutical Services
• Integrated DNA Technologies
• Cusabio
• Macrogen
• Synbio Technologies

Custom Oligo Synthesis Market by Segment

The study includes a forecast for the global custom oligo synthesis market by type, application, and region.

Custom Oligo Synthesis Market by Type [Value from 2019 to 2031]:

• Common Primer Synthesis
• Modified Primer Synthesis

Custom Oligo Synthesis Market by Application [Value from 2019 to 2031]:

• Biotech Company
• Academic Scientific Research Institution
• Others

Custom Oligo Synthesis Market by Region [Value from 2019 to 2031]:

• North America
• Europe
• Asia Pacific
• The Rest of the World

Country Wise Outlook for the Custom Oligo Synthesis Market

Current trends in the custom oligo synthesis market are characterized by ongoing innovation in synthesis technologies, variations, and applications. Growth in the market for custom oligonucleotides is driven by advances in genomics, molecular diagnostics, and the emerging area of nucleic acid therapeutics. Specific areas of interest are enhancing oligo synthesis efficiency for longer and more complicated oligos, creating new chemical modifications to achieve better stability and function, and scaling up oligo production to clinical and commercial levels. Demand is also driven by the growth in demand for high-quality, affordable oligos for research, diagnostics, and therapeutics in different parts of the world.

• United States: The US continues to be a key market for custom oligo synthesis, fueled by high research activities in pharmaceuticals and biotechnology. Recent advances include the increase in services for large-scale oligo production for therapeutic use, improvement in high-throughput synthesis platforms, and the creation of advanced modifications for RNA interference (RNAi) and antisense oligonucleotides (ASOs). Quality control and regulatory compliance for clinical-grade oligos are also a major focus.
• China: Chinas market for custom oligo synthesis is seeing some explosive growth, driven by huge investments in life sciences research and a growing biopharmaceutical sector. Recent trends include the mounting capability of local oligo synthesis suppliers, the creation of economical synthesis techniques, and an increasing emphasis on modifications pertinent to regional research interests, e.g., those for diagnostic uses and gene editing tools such as CRISPR.
• Germany: Germany is well placed in the custom oligo synthesis market, backed by its solid academic research base and mature biotech sector. Recent advances include progress in oligo modifications for enhanced in vivo stability and targeted delivery, and the creation of specialized oligos for diagnostic assays and basic research. High-quality synthesis and collaboration between academic and commercial providers are emphasized.
• India: India's custom oligo synthesis business is expanding progressively, fueled by rising research in pharmaceuticals, biotechnology, and diagnostics. Recent trends are the entry of local oligo synthesis service providers providing a variety of modifications and scales. The market is price-conscious, emphasizing cost-effective options for academic research and early drug discovery.
• Japan: Japan's oligo synthesis custom market is distinguished by high emphasis on precision and quality, fueling its high-level research in genomics and molecular biology. Recent trends are the creation of specialized oligo modifications for therapeutics and diagnostics, especially for applications in such fields as RNA medicine. Preference is given to established high-quality oligo synthesis suppliers and focus on reproducibility and reliability.

Features of the Global Custom Oligo Synthesis Market

Market Size Estimates: Custom oligo synthesis market size estimation in terms of value ($B).

Trend and Forecast Analysis: Market trends (2019 to 2024) and forecast (2025 to 2031) by various segments and regions.

Segmentation Analysis: Custom oligo synthesis market size by type, application, and region in terms of value ($B).

Regional Analysis: Custom oligo synthesis market breakdown by North America, Europe, Asia Pacific, and Rest of the World.

Growth Opportunities: Analysis of growth opportunities in different type, application, and regions for the custom oligo synthesis market.

Strategic Analysis: This includes M&A, new product development, and competitive landscape of the custom oligo synthesis market.

Analysis of competitive intensity of the industry based on Porter’s Five Forces model.

This report answers following 11 key questions:

Q.1. What are some of the most promising, high-growth opportunities for the custom oligo synthesis market by type (common primer synthesis and modified primer synthesis), application (biotech company, academic scientific research institution, and others), and region (North America, Europe, Asia Pacific, and the Rest of the World)?

Q.2. Which segments will grow at a faster pace and why?

Q.3. Which region will grow at a faster pace and why?

Q.4. What are the key factors affecting market dynamics? What are the key challenges and business risks in this market?

Q.5. What are the business risks and competitive threats in this market?

Q.6. What are the emerging trends in this market and the reasons behind them?

Q.7. What are some of the changing demands of customers in the market?

Q.8. What are the new developments in the market? Which companies are leading these developments?

Q.9. Who are the major players in this market? What strategic initiatives are key players pursuing for business growth?

Q.10. What are some of the competing products in this market and how big of a threat do they pose for loss of market share by material or product substitution?

Q.11. What M&A activity has occurred in the last 5 years and what has its impact been on the industry?

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