U.S. Population Health Management Market Size, Share & Trends Analysis Report By Product (Software, Services), By Delivery Mode (On-Premise, Cloud-based), By End Use (Providers, Payers, Employer Groups), By Region, And Segment Forecasts, 2025 - 2033

U.S. Population Health Management Market Summary

The U.S. population health management market size was estimated at USD 36.04 billion in 2024 and is projected to reach USD 210.18 billion by 2033, growing at a CAGR of 21.70% from 2025 to 2033. The market growth is majorly driven by the rising demand for healthcare IT services and solutions that support value-based healthcare delivery, resulting in a transition from Fee-For-Service (FFS) to a Value-Based Payment (VBP) model.

Increasing healthcare expenditure, the rising need for value-based healthcare, and effective disease management across different care settings are expected to drive the growth of the U.S. population health management industry. More than 130 million people in the U.S. suffer from at least one chronic condition. For instance, according to the data published by the Centers for Disease Control and Prevention (CDC) in February 2024, an estimated 129 million people in the U.S. live with at least one major chronic disease.

Population health management solutions based on open Application Programming Interfaces (APIs) are helpful for the management of chronic conditions with high treatment costs, such as cardiac diseases, asthma, and diabetes. PHM solutions also help reduce the cost of care, improve patient outcomes. PHM software also enables better analysis of patient data to make informed decisions.

Moreover, the implementation of population health management (PHM) facilitates the identification of at-risk patients and enhances disease prevention and management, resulting in financial savings. The Centers for Medicare & Medicaid Services (CMS) has introduced the Value-Based Payment Modifier to promote the adoption of PHM systems. This modifier offers varying payment rates to physician groups based on the quality of care provided, rather than the cost of care incurred during their performance period.

In the U.S., providers, payers, and accountable care organizations promote PHM systems. Many providers and payers require upgrading and automating their healthcare management systems, which is anticipated to improve healthcare delivery and help departments collaborate. The providers mainly focus on chronic diseases, such as diabetes and cardiovascular disorders, which are generally responsible for significant healthcare costs. The rising prevalence of lifestyle disorders has increased the need for effective management of the disease burden on healthcare centers.

Furthermore, key players are engaged in strategic initiatives, such as the launch of new products, partnerships and collaborations, mergers and acquisition activities, etc., which contribute to market growth. For instance, in May 2025, Oracle, the Cleveland Clinic, and G42 announced a strategic partnership to develop an AI-based global healthcare platform. This platform will leverage AI, large-scale data analytics, and clinical expertise to deliver scalable, affordable care models, enhancing patient outcomes, precision medicine, and public health management across the U.S. and UAE.

U.S. Population Health Management Market Report Segmentation

This report forecasts revenue growth and provides an analysis of the latest trends in each of the sub-segments from 2021 to 2033. For this report, Grand View Research has segmented the U.S. population health management market report based on product, delivery mode, and end use:

• Product Outlook (Revenue, USD Million, 2021 - 2033)
• Software
• Services
• Delivery Mode Outlook (Revenue, USD Million, 2021 - 2033)
• On-Premise
• Cloud-based
• End Use Outlook (Revenue, USD Million, 2021 - 2033)
• Providers
• Payers
• Employer Groups

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