Global Single Domain Antibody Services Market 2025 by Company, Regions, Type and Application, Forecast to 2031

According to our (Global Info Research) latest study, the global Single Domain Antibody Services market size was valued at US$ 1701 million in 2024 and is forecast to a readjusted size of USD 3407 million by 2031 with a CAGR of 10.5% during review period.

Single domain antibody services refer to the services offered by biotechnology companies or research institutions that specialize in the production, engineering, and characterization of single domain antibodies (sdAbs).

Single domain antibodies, also known as nanobodies, are antibody fragments derived from the variable regions of heavy-chain-only antibodies found in camelids (such as camels and llamas) and cartilaginous fish (such as sharks and rays). These sdAbs are smaller in size compared to conventional antibodies, consisting of a single monomeric antibody domain, and possess unique properties that make them attractive for various applications.

Single domain antibody services typically include the following:

1. Generation and production: Companies offer services for the generation of sdAbs through immunization of animals or by using synthetic libraries. This involves the extraction of peripheral blood lymphocytes or bone marrow cells from immunized animals, followed by isolation and cloning of sdAbs.

2. Engineering and optimization: Service providers offer antibody engineering services to optimize the properties of sdAbs, such as improving their affinity, stability, and solubility. This can be achieved through techniques like site-directed mutagenesis, affinity maturation, or humanization.

3. Antibody expression and purification: Companies provide services for the expression and purification of sdAbs using various expression systems, including bacterial, yeast, insect, or mammalian cell systems. Purification methods may include affinity chromatography, ion exchange chromatography, or size exclusion chromatography.

4. Characterization and validation: Single domain antibody services also involve the characterization and validation of sdAbs. This includes assessing their binding specificity, affinity, and functionality using techniques like ELISA, surface plasmon resonance (SPR), or flow cytometry. Companies may also offer services for epitope mapping, stability testing, or in vitro functional assays.

5. Conjugation and labeling: Some service providers offer conjugation or labeling services to attach sdAbs to various molecules or particles, such as enzymes, fluorophores, or nanoparticles. This enables the development of sdAb-based diagnostic or therapeutic agents.



This report is a detailed and comprehensive analysis for global Single Domain Antibody Services market. Both quantitative and qualitative analyses are presented by company, by region & country, by Type and by Application. As the market is constantly changing, this report explores the competition, supply and demand trends, as well as key factors that contribute to its changing demands across many markets. Company profiles and product examples of selected competitors, along with market share estimates of some of the selected leaders for the year 2025, are provided.

Key Features:

Global Single Domain Antibody Services market size and forecasts, in consumption value ($ Million), 2020-2031

Global Single Domain Antibody Services market size and forecasts by region and country, in consumption value ($ Million), 2020-2031

Global Single Domain Antibody Services market size and forecasts, by Type and by Application, in consumption value ($ Million), 2020-2031

Global Single Domain Antibody Services market shares of main players, in revenue ($ Million), 2020-2025

The Primary Objectives in This Report Are:

To determine the size of the total market opportunity of global and key countries

To assess the growth potential for Single Domain Antibody Services

To forecast future growth in each product and end-use market

To assess competitive factors affecting the marketplace

This report profiles key players in the global Single Domain Antibody Services market based on the following parameters - company overview, revenue, gross margin, product portfolio, geographical presence, and key developments. Key companies covered as a part of this study include Creative Biolabs, Abnova, ProteoGenix, Synbio Technologies, Abrev Biotechnology, NanoTag Biotechnologies, ProSci, GenScript ProBio, Abterra Bio, Bio-Techne, etc.

This report also provides key insights about market drivers, restraints, opportunities, new product launches or approvals.

Market segmentation

Single Domain Antibody Services market is split by Type and by Application. For the period 2020-2031, the growth among segments provides accurate calculations and forecasts for Consumption Value by Type and by Application. This analysis can help you expand your business by targeting qualified niche markets.

Market segment by Type
Single Domain Antibody Library Construction and Screening
Premade Single Domain Antibody Library Screening
Bispecific Single Domain Antibody Production
Anti-membrane protein sdAb Production
Anti-idiotypic sdAb Production
Anti-Albumin Single Domain Antibody Discovery Service
Single Domain Antibody Humanization
Single Domain Antibody Conjugation Services
Single Domain Antibody Stability Improvement Service
Other

Market segment by Application
Academic Research
Disease Diagnosis and Treatment
Biotechnology Development

Market segment by players, this report covers
Creative Biolabs
Abnova
ProteoGenix
Synbio Technologies
Abrev Biotechnology
NanoTag Biotechnologies
ProSci
GenScript ProBio
Abterra Bio
Bio-Techne
CliniSciences

Market segment by regions, regional analysis covers

North America (United States, Canada and Mexico)

Europe (Germany, France, UK, Russia, Italy and Rest of Europe)

Asia-Pacific (China, Japan, South Korea, India, Southeast Asia and Rest of Asia-Pacific)

South America (Brazil, Rest of South America)

Middle East & Africa (Turkey, Saudi Arabia, UAE, Rest of Middle East & Africa)

The content of the study subjects, includes a total of 13 chapters:

Chapter 1, to describe Single Domain Antibody Services product scope, market overview, market estimation caveats and base year.

Chapter 2, to profile the top players of Single Domain Antibody Services, with revenue, gross margin, and global market share of Single Domain Antibody Services from 2020 to 2025.

Chapter 3, the Single Domain Antibody Services competitive situation, revenue, and global market share of top players are analyzed emphatically by landscape contrast.

Chapter 4 and 5, to segment the market size by Type and by Application, with consumption value and growth rate by Type, by Application, from 2020 to 2031

Chapter 6, 7, 8, 9, and 10, to break the market size data at the country level, with revenue and market share for key countries in the world, from 2020 to 2025.and Single Domain Antibody Services market forecast, by regions, by Type and by Application, with consumption value, from 2026 to 2031.

Chapter 11, market dynamics, drivers, restraints, trends, Porters Five Forces analysis.

Chapter 12, the key raw materials and key suppliers, and industry chain of Single Domain Antibody Services.

Chapter 13, to describe Single Domain Antibody Services research findings and conclusion.