Next-generation Sequencing Library Preparation

Global Next-generation Sequencing Library Preparation Market to Reach US$4.1 Billion by 2030

The global market for Next-generation Sequencing Library Preparation estimated at US$1.9 Billion in the year 2024, is expected to reach US$4.1 Billion by 2030, growing at a CAGR of 13.4% over the analysis period 2024-2030. Targeted Genome Sequencing, one of the segments analyzed in the report, is expected to record a 10.4% CAGR and reach US$1.4 Billion by the end of the analysis period. Growth in the Whole Genome Sequencing segment is estimated at 15.8% CAGR over the analysis period.

The U.S. Market is Estimated at US$503.5 Million While China is Forecast to Grow at 12.8% CAGR

The Next-generation Sequencing Library Preparation market in the U.S. is estimated at US$503.5 Million in the year 2024. China, the world`s second largest economy, is forecast to reach a projected market size of US$638.2 Million by the year 2030 trailing a CAGR of 12.8% over the analysis period 2024-2030. Among the other noteworthy geographic markets are Japan and Canada, each forecast to grow at a CAGR of 11.9% and 11.8% respectively over the analysis period. Within Europe, Germany is forecast to grow at approximately 10.1% CAGR.

Global Next-Generation Sequencing Library Preparation Market – Key Trends & Drivers Summarized

How Is Next-Generation Sequencing Library Preparation Advancing Genomic Research?

Next-generation sequencing (NGS) library preparation is a critical step in genomic analysis, enabling researchers to convert DNA and RNA samples into formats suitable for high-throughput sequencing. The preparation process involves fragmentation, adapter ligation, amplification, and quality control, ensuring accurate and efficient sequencing. NGS technology has revolutionized genetics, allowing for faster and more cost-effective analysis of genomes, transcriptomes, and epigenomes across various applications, including precision medicine, oncology, infectious disease research, and agricultural genomics. The increasing adoption of NGS in clinical diagnostics is driving demand for more streamlined, automation-friendly, and scalable library preparation kits that enhance efficiency and reproducibility. Additionally, advancements in single-cell sequencing and long-read sequencing are pushing the boundaries of genome analysis, necessitating improved library preparation methods tailored for complex samples. As researchers strive for higher sequencing accuracy, sensitivity, and throughput, library preparation technologies continue to evolve, playing a crucial role in advancing the field of genomics.

What Challenges Are Affecting the Adoption of NGS Library Preparation Technologies?

Despite its transformative potential, the NGS library preparation market faces several challenges that impact accessibility, efficiency, and cost-effectiveness. One of the primary concerns is the labor-intensive nature of traditional library preparation methods, which require skilled technicians, expensive reagents, and extensive sample handling. Variability in sample quality and preparation efficiency can lead to sequencing errors and reduced data reliability, necessitating robust quality control measures. Another major challenge is the high cost of library preparation kits, which can be prohibitive for smaller research institutions and clinical laboratories. Additionally, the complexity of handling diverse sample types, including low-input and degraded DNA, requires highly specialized protocols, increasing the need for customized solutions. Regulatory challenges and standardization issues further hinder clinical adoption, as laboratories must adhere to stringent compliance requirements for NGS-based diagnostics. Overcoming these challenges will require continued innovation in automation, reagent chemistry, and bioinformatics solutions to make NGS library preparation more efficient, cost-effective, and scalable for a wider range of applications.

How Are Innovations Driving the Future of NGS Library Preparation?

Technological advancements are significantly improving the efficiency and accuracy of NGS library preparation, addressing key challenges in sample processing and sequencing quality. One of the most impactful innovations is the automation of library preparation workflows, reducing hands-on time, minimizing human error, and increasing sample throughput. Robotic liquid handling systems and microfluidic platforms are streamlining the preparation process, making high-throughput sequencing more accessible to clinical and research laboratories. The development of transposase-based library preparation methods, such as Illumina’s Nextera technology, is simplifying DNA fragmentation and adapter insertion, reducing preparation time and reagent costs. Additionally, single-tube and direct RNA sequencing approaches are eliminating the need for complex workflows, improving efficiency in transcriptomics studies. Advances in molecular barcoding and unique molecular identifiers (UMIs) are enhancing sequencing accuracy by reducing PCR bias and detecting low-frequency variants. The integration of AI and machine learning in bioinformatics is also optimizing library preparation protocols by predicting optimal reagent conditions and improving data interpretation. As these innovations continue to evolve, the NGS library preparation market is poised for greater efficiency, scalability, and clinical adoption.

What Is Driving the Growth of the NGS Library Preparation Market?

The growth in the next-generation sequencing library preparation market is driven by several factors, including increasing demand for personalized medicine, expanding applications of NGS in disease research, and technological advancements in automation and reagent chemistry. The growing adoption of NGS-based diagnostics in oncology, infectious diseases, and rare genetic disorders is fueling demand for more efficient and cost-effective library preparation solutions. The rise of single-cell sequencing is also contributing to market growth, as researchers require specialized library preparation methods to analyze individual cells with high sensitivity. Additionally, the expansion of agricultural genomics, microbiome studies, and synthetic biology is further driving market demand, as these fields rely on high-throughput sequencing for genomic analysis. The push for standardization and regulatory approvals for clinical NGS applications is also shaping market trends, with manufacturers developing compliant library preparation kits that meet stringent diagnostic requirements. Investments in bioinformatics and cloud-based sequencing platforms are enhancing data management and accessibility, making NGS more widely available for diverse research and clinical applications. As advancements in sequencing technologies continue to lower costs and improve accuracy, the NGS library preparation market is expected to witness sustained growth, revolutionizing genomic research and precision medicine.

SCOPE OF STUDY:

The report analyzes the Next-generation Sequencing Library Preparation market in terms of units by the following Segments, and Geographic Regions/Countries:

Segments:
Sequencing Type (Targeted Genome Sequencing, Whole Genome Sequencing, Whole Exome Sequencing, Other Sequencing Types); Product Type (Library Preparation Reagents & Consumables, Library Preparation Instruments); Application (Drug & Biomarker Discovery Application, Disease Diagnostics Application, Cancer Diagnostics Application, Reproductive Health Diagnostics Application, Infectious Disease Diagnostics Application, Other Disease Diagnostic Applications); End-Use (Academic & Research Institutions End-Use, Pharma & Biotech Companies End-Use, Hospitals & Clinics End-Use, Other End-Uses)

Geographic Regions/Countries:
World; United States; Canada; Japan; China; Europe (France; Germany; Italy; United Kingdom; and Rest of Europe); Asia-Pacific; Rest of World.

Select Competitors (Total 48 Featured) -

• Agilent Technologies, Inc.
• Alida Biosciences, Inc.
• Beckman Coulter, Inc.
• Becton, Dickinson and Company (BD)
• Bio-Rad Laboratories, Inc.
• CD Genomics
• Claret Bioscience LLC
• F. Hoffmann-La Roche AG
• Fluidigm Corporation
• Hamilton Company
• Illumina, Inc.
• New England Biolabs Inc.
• Oxford Nanopore Technologies Ltd.
• Pacific Biosciences of California, Inc.
• PerkinElmer, Inc.
• QIAGEN N.V.
• Swift Biosciences Inc.
• Takara Bio Inc.
• Tecan Group Ltd.
• Thermo Fisher Scientific Inc.

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