Nanobodies

Global Nanobodies Market to Reach US$1.5 Billion by 2030

The global market for Nanobodies estimated at US$561.0 Million in the year 2024, is expected to reach US$1.5 Billion by 2030, growing at a CAGR of 18.0% over the analysis period 2024-2030. Mono-Specific Type, one of the segments analyzed in the report, is expected to record a 19.5% CAGR and reach US$1.1 Billion by the end of the analysis period. Growth in the Multi-Specific Type segment is estimated at 14.8% CAGR over the analysis period.

The U.S. Market is Estimated at US$152.8 Million While China is Forecast to Grow at 24.0% CAGR

The Nanobodies market in the U.S. is estimated at US$152.8 Million in the year 2024. China, the world`s second largest economy, is forecast to reach a projected market size of US$342.4 Million by the year 2030 trailing a CAGR of 24.0% over the analysis period 2024-2030. Among the other noteworthy geographic markets are Japan and Canada, each forecast to grow at a CAGR of 13.2% and 16.4% respectively over the analysis period. Within Europe, Germany is forecast to grow at approximately 14.4% CAGR.

Global Nanobodies Market - Key Trends & Drivers Summarized

Why Are Nanobodies Gaining Momentum in Therapeutics and Diagnostics?

Nanobodies, also known as single-domain antibodies, are a unique class of antibody fragments derived from camelid species. Unlike conventional antibodies, nanobodies are small, stable, and can bind to hidden or difficult-to-reach epitopes. Their compact size allows better tissue penetration, rapid clearance from the bloodstream, and ease of manufacturing. These properties make them highly attractive for applications in oncology, autoimmune diseases, infectious disease treatment, and diagnostic imaging.

Their structural simplicity also enables rapid engineering into multi-specific formats or fusion proteins. Nanobodies can be delivered through non-traditional routes such as inhalation or topical application, offering alternatives to injectable biologics. With pharmaceutical developers increasingly seeking targeted, fast-acting, and cost-effective biologics, nanobodies are positioned as next-generation tools in both therapeutic development and in vivo diagnostics.

How Is Innovation in Design and Delivery Expanding Nanobody Potential?

Advances in protein engineering and phage display libraries are improving nanobody discovery and affinity optimization. Researchers can now generate synthetic nanobody libraries without direct reliance on camelid immunization, accelerating development timelines. Nanobodies are being designed for multivalent formats, which enhance binding strength or engage multiple targets simultaneously—especially relevant in cancer immunotherapy and viral neutralization.

In drug delivery, nanobodies are being fused with toxins, cytokines, or radionuclides to selectively target diseased cells. Their ability to be expressed in microbial systems like E. coli or yeast reduces production costs compared to full-length monoclonal antibodies. Nanobody-drug conjugates, nanobody-based CAR-T therapies, and bispecific formats are also under active development. These advances allow tailored delivery of therapeutic payloads while minimizing systemic exposure and immune-related toxicity.

Which Applications Are Driving Demand Across Research and Clinical Settings?

In diagnostics, nanobodies are widely used in biosensors, immunoassays, and molecular imaging tools. Their stability under extreme conditions makes them suitable for point-of-care testing and field-based detection systems. In imaging, nanobody-based PET tracers enable real-time visualization of tumors, inflammation, or infectious sites with higher resolution and faster clearance compared to conventional antibodies.

Therapeutically, nanobodies are being investigated for inflammatory conditions, cancers, neurodegenerative diseases, and viral infections including COVID-19. In oncology, nanobody-drug conjugates and immune checkpoint inhibitors are showing promise in early-phase clinical trials. In neurology, their ability to cross the blood-brain barrier is under evaluation for targeted delivery to amyloid plaques or misfolded proteins in diseases like Alzheimer’s and Parkinson’s. Veterinary medicine and agricultural biotechnology are also exploring nanobodies for disease control and detection.

Growth in the Nanobodies Market Is Driven by Several Factors…

Growth in the nanobodies market is driven by several factors. Rising demand for targeted biologics and precision diagnostics encourages development of compact and high-affinity binding molecules. Advances in synthetic biology and display technologies accelerate nanobody discovery and screening. Cost-effective microbial expression systems support scalable production. Expanding clinical pipeline and regulatory support for biologics enhance commercial viability. Increased investment in oncology, neurodegeneration, and infectious disease research creates new application opportunities. Partnerships between biotech firms, academic labs, and pharmaceutical companies further support product development, licensing, and market expansion.

SCOPE OF STUDY:

The report analyzes the Nanobodies market in terms of units by the following Segments, and Geographic Regions/Countries:

Segments:
Type (Mono-Specific Type, Multi-Specific Type); Application (Acquired Thrombotic Thrombocytopenic Purpura Application, Respiratory Syncytial Virus Infection Application, Rheumatoid Arthritis Application, Systemic Lupus Erythematosus Application, Oncology Application, Psoriasis Application, Bone Disorders Application, Other Applications); End-Use (Pharma & Biotech Companies End-Use, Research Laboratories End-Use, Other End-Uses)

Geographic Regions/Countries:
World; United States; Canada; Japan; China; Europe (France; Germany; Italy; United Kingdom; Spain; Russia; and Rest of Europe); Asia-Pacific (Australia; India; South Korea; and Rest of Asia-Pacific); Latin America (Argentina; Brazil; Mexico; and Rest of Latin America); Middle East (Iran; Israel; Saudi Arabia; United Arab Emirates; and Rest of Middle East); and Africa.

Select Competitors (Total 34 Featured) -

• AbCellera Biologics Inc.
• Abiocenter
• Alpaca Nanobodies Inc.
• Amgen Inc.
• BIOCYTOGEN Group
• Bio-Rad Laboratories
• Boehringer Ingelheim GmbH
• Capralogics Inc.
• Creative Biolabs
• Cusabio
• GenScript Biotech Corporation
• Merck KGaA
• Morphosys AG (Ablynx tech)
• NanoTag Biotechnologies GmbH
• Novartis AG
• Proteintech Group, Inc.
• PREGENE
• QVQ Holding BV
• Sanofi (Ablynx)
• Thermo Fisher Scientific
• Yiteng Pharmaceutical

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