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Global Monocyte Activation Test Market Size Study, by Product (MAT Kits, Reagents), by Source (PBMC Based, Cell Line Based), by Application (Drug Development, Vaccine Development, Medical Device Testing, Others), by End Use (Pharmaceutical Industry, Biote

Publisher Factview Research
Published Oct 03, 2025
Length 285 Pages
SKU # FAVR20464188

Description

The Global Monocyte Activation Test (MAT) Market was valued at approximately USD 593.299 million in 2024 and is anticipated to grow at a CAGR of 16.7% over the forecast period 2025-2034. The rising demand for safer pharmaceutical and biopharmaceutical products, coupled with the increased adoption of in-vitro alternatives to animal testing, is driving market growth. Regulatory agencies, including the FDA and European Pharmacopeia, have actively endorsed MAT, accelerating its market adoption. Additionally, the increasing awareness of ethical testing methods, along with ongoing advancements in MAT technology, is fostering industry expansion. The growing prevalence of chronic diseases and the rise in biologics development necessitate accurate pyrogen detection, further boosting market demand. Technological innovations, including luciferase-based assays and cryopreserved PBMC-based testing, are improving the reliability and efficiency of MAT, solidifying its presence in the industry.

The regulatory landscape is significantly influencing the MAT market, especially in Europe, where the European Pharmacopoeia Commission (EPC) has mandated the elimination of the Rabbit Pyrogen Test (RPT) by July 2025, transitioning to in-vitro testing methods such as MAT. This shift aligns with global sustainability goals and ensures the safety, efficacy, and quality of drugs, vaccines, and medical devices. Pharmaceutical and biotechnology companies are integrating MAT into quality control procedures as it provides more accurate human inflammatory response assessments compared to conventional methods. These factors have accelerated the adoption of MAT, reinforcing its position as the gold standard in pyrogen testing.

The MAT market is experiencing a technological evolution with the introduction of next-generation testing solutions. Innovations like Lonza Bioscience’s PyroCell MAT System, which employs cryopreserved PBMCs, are eliminating donor qualification challenges and enhancing assay efficiency. These advancements address lot-to-lot variability and reduce labor-intensive processes, ensuring on-demand testing for pharmaceuticals and biologics. Moreover, novel LumiMAT™ assays, leveraging luciferase-based reporter genes, have revolutionized high-sensitivity pyrogen detection, eliminating reliance on ELISA-based techniques. This transition towards automation and standardization is ensuring greater accuracy and repeatability in MAT applications across the pharmaceutical and biotechnology industries.

From a geographical perspective, North America dominates the market due to its strong pharmaceutical and biotechnology sectors, stringent regulatory guidelines, and widespread adoption of advanced in-vitro testing methodologies. Europe follows closely, propelled by regulatory mandates phasing out animal-based testing methods. Meanwhile, Asia-Pacific is expected to witness the fastest growth, with China, Japan, and India emerging as leading adopters due to the expansion of biopharmaceutical manufacturing and regulatory enhancements. The increasing global shift towards in-vitro, ethical, and sustainable testing methodologies continues to solidify MAT’s position as the preferred solution for pyrogen detection.

Major Market Players Included in This Report Are:
  • Lonza Group
  • Charles River Laboratories
  • Bio-Rad Laboratories
  • Merck KGaA
  • Seikagaku Corporation
  • Hyglos GmbH
  • Wako Chemicals USA
  • Thermo Fisher Scientific
  • MAT BioTech
  • Eurofins Scientific
  • Sanquin Reagents B.V.
  • FUJIFILM Wako Pure Chemical Corporation
  • Nelson Laboratories, LLC
  • GenScript Biotech Corporation
  • Sartorius AG
The Detailed Segments and Sub-Segments of the Market Are Explained Below:

By Product
  • MAT Kits
  • Reagents
By Source
  • PBMC Based
  • Cell Line Based
By Application
  • Drug Development
  • Vaccine Development
  • Medical Device Testing
  • Others
By End-Use
  • Pharmaceutical Industry
  • Biotechnology Industry
  • Medical Device Industry
  • Others
By Region:

North America
  • U.S.
  • Canada
Europe
  • UK
  • Germany
  • France
  • Spain
  • Italy
  • Rest of Europe
Asia Pacific
  • China
  • India
  • Japan
  • Australia
  • South Korea
  • Rest of Asia Pacific
Latin America
  • Brazil
  • Mexico
Middle East & Africa
  • Saudi Arabia
  • South Africa
  • Rest of MEA
Years Considered for the Study Are As Follows:
  • Historical Year: 2022
  • Base Year: 2024
  • Forecast Period: 2024 to 2034
Key Takeaways:
  • Market Estimates & Forecast for 10 Years (2022-2034)
  • Annualized Revenue and Regional Analysis for Each Market Segment
  • Geographical Landscape with Country-Level Analysis for Major Regions
  • Competitive Landscape with Key Market Players
  • Analysis of Key Business Strategies and Recommendations for Market Approach
  • Demand-Side and Supply-Side Market Analysis

Table of Contents

285 Pages
Chapter 1. Global Monocyte Activation Test Market Executive Summary
1.1. Global Monocyte Activation Test Market Size & Forecast (2024-2034)
1.2. Regional Summary
1.3. Segmental Summary
1.3.1. By Product
1.3.2. By Source
1.3.3. By Application
1.3.4. By End-Use
1.4. Key Trends
1.5. Recession Impact
1.6. Industry Metrics
1.7. Investment Analysis
1.8 .Investment Rationale
1.9. Analyst Recommendation & Conclusion
Chapter 2. Global Monocyte Activation Test Market Definition and Research Assumptions
2.1. Research Objective
2.2. Market Definition
2.3. Research Assumptions
2.3.1. Inclusion & Exclusion
2.3.2. Limitations
2.3.3. Supply Side Analysis
2.3.3.1. Availability
2.3.3.2. Infrastructure
2.3.3.3. Regulatory Environment
2.3.3.4. Market Competition
2.3.3.5. Economic Viability (Consumer’s Perspective)
2.3.4. Demand Side Analysis
2.3.4.1. Regulatory Frameworks
2.3.4.2. Technological Advancements
2.3.4.3. Environmental Considerations
2.3.4.4. Consumer Awareness & Acceptance
2.4. Estimation Methodology
2.5. Years Considered for the Study
2.6. Currency Conversion Rates
Chapter 3. Global Monocyte Activation Test Market Dynamics
3.1. Market Drivers
3.1.1. Growing Demand for In-Vitro Pyrogen Testing
3.1.2. Regulatory Mandates Favoring MAT Over Rabbit Pyrogen Testing (RPT)
3.1.3. Increasing R&D Investments in Biologics and Vaccines
3.2. Market Challenges
3.2.1. High Cost and Complexity of MAT Implementation
3.2.2. Limited Adoption in Developing Economies
3.3. Market Opportunities
3.3.1. Technological Advancements in MAT Assay Systems
3.3.2. Expansion of Regulatory Compliance Initiatives
Chapter 4. Global Monocyte Activation Test Market Industry Analysis
4.1. Porter’s 5 Force Model
4.1.1. Bargaining Power of Suppliers
4.1.2. Bargaining Power of Buyers
4.1.3. Threat of New Entrants
4.1.4. Threat of Substitutes
4.1.5. Competitive Rivalry
4.1.6. Futuristic Approach to Porter’s 5 Force Model
4.1.7. Porter’s 5 Force Impact Analysis
4.2. PESTEL Analysis
4.2.1. Political
4.2.2. Economical
4.2.3. Social
4.2.4. Technological
4.2.5. Environmental
4.2.6. Legal
4.3. Top Investment Opportunities
4.4. Top Winning Strategies
4.5. Disruptive Trends
4.6. Industry Expert Perspective
4.7. Analyst Recommendation & Conclusion
Chapter 5. Global Monocyte Activation Test Market Size & Forecasts by Product 2022-2032
5.1. Segment Dashboard
5.2. Global Monocyte Activation Test Market: Product Revenue Trend Analysis, 2022 & 2032 (USD Million)
5.2.1. MAT Kits
5.2.2. Reagents
Chapter 6. Global Monocyte Activation Test Market Size & Forecasts by Source 2022-2032
6.1. Segment Dashboard
6.2. Global Monocyte Activation Test Market: Source Revenue Trend Analysis, 2022 & 2032 (USD Million)
6.2.1. PBMC Based
6.2.2. Cell Line Based
Chapter 7. Global Monocyte Activation Test Market Size & Forecasts by Application 2022-2032
7.1. Segment Dashboard
7.2. Global Monocyte Activation Test Market: Application Revenue Trend Analysis, 2022 & 2032 (USD Million)
7.2.1. Drug Development
7.2.2. Vaccine Development
7.2.3. Medical Device Testing
7.2.4. Others
Chapter 8. Global Monocyte Activation Test Market Size & Forecasts by End-Use 2022-2032
8.1. Segment Dashboard
8.2. Global Monocyte Activation Test Market: End-Use Revenue Trend Analysis, 2022 & 2032 (USD Million)
8.2.1. Pharmaceutical Industry
8.2.2. Biotechnology Industry
8.2.3. Medical Device Industry
8.2.4. Others
Chapter 9. Global Monocyte Activation Test Market Size & Forecasts by Region 2022-2032
9.1. North America
9.1.1. U.S.
9.1.2. Canada
9.2. Europe
9.2.1. U.K.
9.2.2. Germany
9.2.3. France
9.2.4. Spain
9.2.5. Italy
9.2.6. Rest of Europe
9.3. Asia-Pacific
9.3.1. China
9.3.2. India
9.3.3. Japan
9.3.4. Australia
9.3.5. South Korea
9.3.6. Rest of Asia Pacific
9.4. Latin America
9.4.1. Brazil
9.4.2. Mexico
9.4.3. Rest of Latin America
9.5. Middle East & Africa
9.5.1. Saudi Arabia
9.5.2. South Africa
9.5.3. Rest of Middle East & Africa
Chapter 10. Competitive Intelligence
10.1. Key Company SWOT Analysis
10.1.1. Lonza Group
10.1.2. Charles River Laboratories
10.1.3. Bio-Rad Laboratories
10.2. Top Market Strategies
10.3. Company Profiles
10.3.1. Lonza Group
10.3.2. Charles River Laboratories
10.3.3. Bio-Rad Laboratories
10.3.4. Merck KGaA
10.3.5. Seikagaku Corporation
10.3.6. Hyglos GmbH
10.3.7. Wako Chemicals USA
10.3.8. Thermo Fisher Scientific
10.3.9. MAT BioTech
10.3.10. Eurofins Scientific
Chapter 11. Research Process
11.1. Research Process
11.1.1. Data Mining
11.1.2. Analysis
11.1.3. Market Estimation
11.1.4. Validation
11.1.5. Publishing
11.2. Research Attributes

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