Pneumococcal disease is a bacterial infection which is brought on by Streptococcus pneumoniae. It affects the brain, blood, lungs, and other organs. It can result in severe infections like sepsis, pneumonia, and meningitis, particularly in young children, the elderly, and those with impaired immune systems. The condition spreads via respiratory droplets and can worsen quickly, leading to serious consequences like neurological damage or respiratory failure. Fever, coughing, dyspnea, stiff neck, and disorientation are the first signs. The life-threatening nature of pneumococcal illness highlights the importance of early detection and prophylactic immunization.
Report Coverage
The Pneumococcal Disease Drug Pipeline Insight Report by Expert Market Research gives comprehensive insights into pneumococcal disease therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for pneumococcal disease. The pneumococcal disease report assessment includes the analysis of over 25 pipeline drugs and 10+ companies. The pneumococcal disease pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials including their adverse effects on patients suffering from the condition, and alignment with pneumococcal disease treatment guidelines to ensure optimal care practices.
The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to pneumococcal disease.
Pneumococcal Disease Drug Pipeline Outlook
Streptococcus pneumoniae colonizing the nasopharynx, frequently without any symptoms, is the first step in the pathophysiology of pneumococcal illness. The bacteria infiltrates sterile places when human immunity deteriorates, leading to sepsis, meningitis, or pneumonia. Toxins like pneumolysin harm epithelial cells, rupturing the blood-brain and lung barriers, while the pathogen's polysaccharide capsule inhibits phagocytosis. Tissue damage and systemic problems result from the immune response's induction of inflammation, neutrophil infiltration, and cytokine release. Early detection and vaccination are essential for prevention because severe cases might cause neurological deficits, septic shock, or respiratory failure.
Since vaccines effectively prevent pneumococcal disease rather than only managing its symptoms, they are the recommended treatment for this illness. The immune system is stimulated by pneumococcal conjugate vaccines (PCVs) and pneumococcal polysaccharide vaccines (PPSVs) to produce long-term defence against Streptococcus pneumoniae. Vaccines are the gold standard for disease control because, unlike gene therapy or peptides, they reduce antibiotic resistance by reducing bacterial infections, avoid serious consequences like pneumonia and meningitis, and reduce disease incidence. Further, the rising focus on the development of pneumococcal disease emerging drugs and the advances in the understanding of the molecular pathogenesis of the disease are expected to support the pipeline expansion in the coming years.
Pneumococcal Disease Epidemiology
Pneumococcal disease continues to be a major global health concern, especially for the elderly and small children. According to the WHO estimates, an estimated 1 million children under five pass away from the disease each year. In individuals 65 years of age and older, the incidence of invasive pneumococcal disease (IPD) rises with age, reaching 6930 cases per 100,000. IPD incidence has been significantly decreasing by vaccination programs, although inequalities still exist, with higher rates seen in at-risk groups and during particular times, like the COVID-19 pandemic, when general illness rates momentarily decreased.
Pneumococcal Disease – Drug Pipeline Therapeutic Assessment
This section of the report covers the analysis of pneumococcal disease drug candidates based on several segmentations including:
By Phase
- Late-Stage Products (Phase 3 and Phase 4)
- Mid-Stage Products (Phase 2)
- Early-Stage Products (Phase I)
- Preclinical and Discovery Stage Products
- Gene Therapy
- Peptides
- Vaccines
- Others
- Oral
- Parenteral
- Others
The report covers phase I, phase II, phase III, phase IV, and early phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis , phase III covers a major share of the total clinical trials, with a substantial number of pneumococcal disease drugs undergoing clinical development.
Pneumococcal Disease – Pipeline Assessment Segmentation, By Drug Classes
The drug molecule categories covered under the pneumococcal disease pipeline analysis include small molecules, biologics, peptides, and immunotherapies, among others. The pneumococcal disease report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for pneumococcal disease.
Pneumococcal Disease Clinical Trials Therapeutic Assessment – Competitive Dynamics
The EMR report for the pneumococcal disease drug pipeline covers the profile of key companies involved in clinical trials and their drugs under development. It provides a detailed pneumococcal disease therapeutic assessment, analyzing the competitive dynamics of the clinical trial landscape. Below is the list of a few players involved in pneumococcal disease clinical trials:
- Merck Sharp & Dohme LLC
- Pfizer
- Walvax Biotechnology Co., Ltd.
- Fosun Adgenvax Biopharmaceutical Co., Ltd.
- Starmab biologics（Shanghai）Co., Ltd.
- GlaxoSmithKline
- Vaxcyte, Inc.
- Matrivax Research and Development Corporation
Major drugs currently in the drug pipeline are as follows:
Drug: V116
Sponsored by Merck Sharp & Dohme LLC, the objective of this multicenter clinical trial is to investigate the efficacy and safety of V116. The study is under Phase III clinical development.
Drug: AFX3772
GlaxoSmithKline is conducting a study aimed at examining the efficacy of the investigational drug AFX3772 for the treatment of pneumococcal disease. The study is under Phase II clinical development.
Reasons To Buy This Report
The pneumococcal disease drug Report provides a strategic overview of the latest and future landscape of treatments for pneumococcal disease. it provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into market trends, regulatory environments, and potential growth opportunities within pneumococcal disease pipeline insights.
Key Questions Answered in the Pneumococcal Disease – Pipeline Insight Report
- What is the current landscape of pneumococcal disease pipeline drugs?
- Which companies/institutions are developing pneumococcal disease emerging drugs?
- How many phase II drugs are currently present in pneumococcal disease pipeline drugs?
- Which company is leading the pneumococcal disease pipeline development activities?
- What is the current pneumococcal disease therapeutic assessment?
- What are the opportunities and challenges present in the pneumococcal disease drug pipeline landscape?
- What is the efficacy and safety profile of pneumococcal disease pipeline drugs?
- Which companies/institutions are involved in pneumococcal disease collaborations aimed at providing enhanced therapeutic alternatives for patients?
- What are the geographies covered for clinical trials in pneumococcal disease?
Pneumococcal Infections Drug Pipeline Analysis Report
Global Clinical Trials Market
- 1 Preface
- 1.1 Introduction
- 1.2 Objectives of the Study
- 1.3 Research Methodology & Assumptions
- 2 Executive Summary
- 3 Overview of Pneumococcal Disease
- 3.1 Signs and Symptoms
- 3.2 Causes
- 3.3 Risk Factors
- 3.4 Types of Pneumococcal Disease
- 3.5 Diagnosis
- 3.6 Treatment
- 4 Patient Profile: Pneumococcal Disease
- 4.1 Patient Profile Overview
- 4.2 Patient Psychology and Emotional Impact Factors
- 4.3 Risk Assessment and Treatment Success Rate
- 5 Pneumococcal Disease: Epidemiology Snapshot
- 5.1 Pneumococcal Disease Incidence by Key Markets
- 5.2 Pneumococcal Disease – Patients Seeking Treatment in Key Markets
- 6 Pneumococcal Disease: Market Dynamics
- 6.1 Market Drivers and Constraints
- 6.2 SWOT Analysis
- 7 Pneumococcal Disease: Key Facts Covered
- 7.1 Top Countries Contributing to Clinical Trials in Asia-Pacific
- 7.2 Top Countries Contributing to Clinical Trials in Europe
- 7.3 Top Countries Contributing to Clinical Trials in North America
- 7.4 Top Countries Contributing to Clinical Trials in Other Regions
- 8 Pneumococcal Disease, Drug Pipeline Assessment
- 8.1 Assessment by Treatment Type
- 8.2 Assessment by Route of Administration
- 8.3 Assessment by Drug Class
- 9 EMR Drug Pipeline Comparative Analysis
- 9.1 List of Pneumococcal Disease Pipeline Drugs
- 9.1.1 By Company
- 9.1.2 By Phase
- 9.1.3 By Indication
- 9.1.4 By Trial Status
- 9.1.5 By Funder Type
- 9.2 EMR Attribute Scoring Analysis of Pipeline Drugs (Top Drugs)
- 10 Pneumococcal Disease Drug Pipeline - Late-Stage Products (Phase III and IV) (Top Drugs)
- 10.1 Comparative Analysis for Late-Stage Drugs
- 10.1.1 Study Type
- 10.1.2 Recruitment Status
- 10.1.3 Company
- 10.1.4 Funder Type
- 10.2 Product Level Analysis*
- 10.2.1 Drug: V116
- 10.2.1.1 Product Description
- 10.2.1.2 Trial ID
- 10.2.1.3 Sponsor Name
- 10.2.1.4 Study Type
- 10.2.1.5 Drug Class
- 10.2.1.6 Eligibility Criteria
- 10.2.1.7 Study Record Dates
- 10.2.1.7.1 First Submitted
- 10.2.1.7.2 First Posted
- 10.2.1.7.3 Last Update Posted
- 10.2.1.7.4 Last Verified
- 10.2.1.8 Indication
- 10.2.1.9 Study Design
- 10.2.1.10 Recruitment Status
- 10.2.1.11 Enrollment (Estimated)
- 10.2.1.12 Location Countries
- 10.2.1.13 Recent Results
- 10.2.2 Drugs: 20vPnC
- 10.2.3 Other Drugs
- 11 Pneumococcal Disease Drug Pipeline - Mid-Stage Products (Phase II) (Top Drugs)
- 11.1 Comparative Analysis for Mid-Stage Drugs
- 11.1.1 Study Type
- 11.1.2 Recruitment Status
- 11.1.3 Company
- 11.1.4 Funder Type
- 11.2 Product Level Analysis*
- 11.2.1 Drug: AFX3772
- 11.2.1.1 Product Description
- 11.2.1.2 Trial ID
- 11.2.1.3 Sponsor Name
- 11.2.1.4 Study Type
- 11.2.1.5 Drug Class
- 11.2.1.6 Eligibility Criteria
- 11.2.1.7 Study Record Dates
- 11.2.1.7.1 First Submitted
- 11.2.1.7.2 First Posted
- 11.2.1.7.3 Last Update Posted
- 11.2.1.7.4 Last Verified
- 11.2.1.8 Indication
- 11.2.1.9 Study Design
- 11.2.1.10 Recruitment Status
- 11.2.1.11 Enrollment (Estimated)
- 11.2.1.12 Location Countries
- 11.2.1.13 Recent Results
- 11.2.2 Drug: VAX-24
- 11.2.3 Other Drugs
- 12 Pneumococcal Disease Drug Pipeline - Early-Stage Products (Phase I) (Top Drugs)
- 12.1 Comparative Analysis for Early-Stage Drugs
- 12.1.1 Study Type
- 12.1.2 Recruitment Status
- 12.1.3 Company
- 12.1.4 Funder Type
- 12.2 Product Level Analysis*
- 12.2.1 Drug: XJ103
- 12.2.1.1 Product Description
- 12.2.1.2 Trial ID
- 12.2.1.3 Sponsor Name
- 12.2.1.4 Study Type
- 12.2.1.5 Drug Class
- 12.2.1.6 Eligibility Criteria
- 12.2.1.7 Study Record Dates
- 12.2.1.7.1 First Submitted
- 12.2.1.7.2 First Posted
- 12.2.1.7.3 Last Update Posted
- 12.2.1.7.4 Last Verified
- 12.2.1.8 Indication
- 12.2.1.9 Study Design
- 12.2.1.10 Recruitment Status
- 12.2.1.11 Enrollment (Estimated)
- 12.2.1.12 Location Countries
- 12.2.2 Drugs: MVX01
- 12.2.3 Other Drugs
- 13 Pneumococcal Disease, Key Drug Pipeline Companies
- 13.1 Merck Sharp & Dohme LLC
- 13.1.1 Company Snapshot
- 13.1.2 Pipeline Product Portfolio
- 13.1.3 Financial Analysis
- 13.1.4 Recent News and Developments
- 13.2 Pfizer
- 13.2.1 Company Snapshot
- 13.2.2 Pipeline Product Portfolio
- 13.2.3 Financial Analysis
- 13.2.4 Recent News and Developments
- 13.3 Walvax Biotechnology Co., Ltd.
- 13.3.1 Company Snapshot
- 13.3.2 Pipeline Product Portfolio
- 13.3.3 Financial Analysis
- 13.3.4 Recent News and Developments
- 13.4 GlaxoSmithKline
- 13.4.1 Company Snapshot
- 13.4.2 Pipeline Product Portfolio
- 13.4.3 Financial Analysis
- 13.4.4 Recent News and Developments
- 13.5 Fosun Adgenvax Biopharmaceutical Co., Ltd.
- 13.5.1 Company Snapshot
- 13.5.2 Pipeline Product Portfolio
- 13.5.3 Financial Analysis
- 13.5.4 Recent News and Developments
- 13.6 Starmab biologics (Shanghai) Co., Ltd.
- 13.6.1 Company Snapshot
- 13.6.2 Pipeline Product Portfolio
- 13.6.3 Financial Analysis
- 13.6.4 Recent News and Developments
- 13.7 Vaxcyte, Inc.
- 13.7.1 Company Snapshot
- 13.7.2 Pipeline Product Portfolio
- 13.7.3 Financial Analysis
- 13.7.4 Recent News and Developments
- 13.8 Matrivax Research and Development Corporation
- 13.8.1 Company Snapshot
- 13.8.2 Pipeline Product Portfolio
- 13.8.3 Financial Analysis
- 13.8.4 Recent News and Developments
- 14 Regulatory Framework for Drug Approval, By Region
- 15 Terminated or Suspended Pipeline Products
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