Optic neuritis is a potentially blinding condition that frequently appears as the initial sign of demyelinating disorders like multiple sclerosis. 15% to 20% of people with multiple sclerosis experience optic neuritis as their first inflammatory event, and almost half of all multiple sclerosis patients have at least one episode of optic neuritis throughout a 15-year span. The optic neuritis pipeline analysis by Expert Market Research focuses on various treatment options for this disease.
Report Coverage
The Optic Neuritis Pipeline Analysis Report by Expert Market Research gives comprehensive insights into optic neuritis therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for optic neuritis. The optic neuritis report assessment includes the analysis of over 25 pipeline drugs and 10+ companies. The optic neuritis pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials including their adverse effects on patients suffering from the condition, and alignment with optic neuritis treatment guidelines to ensure optimal care practices.
The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to optic neuritis.
Optic Neuritis Pipeline Outlook
Optic neuritis is an inflammatory disease that affects the optic nerve with symptoms like sudden vision loss, eye pain, and diminished color perception. It is frequently linked to autoimmune diseases like multiple sclerosis (MS). Clinical assessment, optical coherence tomography (OCT), visual acuity tests, and magnetic resonance imaging (MRI) are used in the diagnosis process to evaluate nerve damage and rule out underlying diseases. Immunosuppressive treatments such as rituximab or inebilizumab for recurring or MS-associated optic neuritis, plasma exchange for severe instances, and high-dose corticosteroids (IV methylprednisolone) to speed recovery are available as treatment options.
The field of treating optic neuritis is changing, with several interesting treatments being researched. In October 2022, the National Eye Institute was awarded with a USD 1.6 million grant to further develop TRE-515, an oral drug that targets inflammatory immune cells. Clinical trials are being conducted to see whether Oculis' OCS-05, a neuroprotective drug that inhibits Rho kinase, can help patients with optic neuritis avoid nerve damage and encourage repair. Furthermore, natalizumab (Antegren) is being investigated for its potential to prevent immune cell migration across the blood-brain barrier, which could reduce the frequency of relapses in multiple sclerosis-related optic neuritis. These advancements demonstrate the increased emphasis on cutting-edge therapies meant to enhance the prognosis of those with optic neuritis. Further, the rising focus on the development of optic neuritis emerging drugs and the advances in the understanding of the molecular pathogenesis of the disease are expected to support the pipeline expansion in the coming years.
Optic Neuritis Epidemiology
With an estimated yearly incidence of 1 to 5 cases per 100,000 people, optic neuritis incidence and prevalence varies throughout the world. As optic neuritis is frequently a presenting sign of multiple sclerosis, the frequency may be higher in populations where the demyelinating disease is more prevalent. With a female-to-male ratio of roughly 3:1, ocular neuritis affects women more frequently than males. Young adults, usually between the ages of 20 and 50, are the most affected with optic neuritis. 32 is the typical age at which it first appears.
Optic Neuritis – Pipeline Therapeutic Assessment
This section of the report covers the analysis of optic neuritis drug candidates based on several segmentations including:
By Phase
- Late-Stage Products (Phase 3 and Phase 4)
- Mid-Stage Products (Phase 2)
- Early-Stage Products (Phase I)
- Preclinical and Discovery Stage Products
- Recombinant Fusion Proteins
- Small Molecule
- Peptide
- Polymer
- Gene Therapy
- Others
- Oral
- Parenteral
- Subcutaneous
- Intravenous
- Topical
The report covers phase I, phase II, phase III, phase IV, and early phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis , phase III covers a major share of the total clinical trials, with a substantial number of optic neuritis drugs undergoing clinical development.
Optic Neuritis – Pipeline Assessment Segmentation, By Drug Classes
The drug molecule categories covered under optic neuritis pipeline analysis include recombinant fusion proteins, small molecules, biologics, peptides, and polymers, among others. The optic neuritis report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for optic neuritis.
Optic Neuritis Clinical Trials – Key Players
The EMR report for the optic neuritis drug pipeline covers the profile of key companies involved in clinical trials and their drugs under development. It provides a detailed optic neuritis therapeutic assessment, analyzing the competitive dynamics of the clinical trial landscape. Below is the list of a few players involved in optic neuritis clinical trials:
- Amgen
- Bio-Thera Solutions
- Alexion Pharmaceuticals, Inc.
- Hoffmann-La Roche
- Hansoh BioMedical R&D Company
This section covers the detailed analysis of each drug under multiple phases, including phase I, phase II, phase III, phase IV, and emerging drugs for optic neuritis. It includes product description, trial ID, study type, drug class, mode of administration, and recruitment status of optic neuritis drug candidates.
Drug: Inebilizumab
The Hansoh BioMedical R&D Company created the monoclonal antibody inebilizumab, which targets CD19 to reduce B cells. In China, it is authorized for the treatment of neuromyelitis optica spectrum disorders (NMOSD), an autoimmune condition that causes inflammation of the spinal cord and optic nerve.
Drug: Efgartigimod Alfa
Argenx's neonatal Fc receptor (FcRn) blocker, efgartigimod alfa, lowers immunoglobulin G (IgG) levels by preventing their recycling. It is authorized to treat the autoimmune neuromuscular disease known as generalized myasthenia gravis. The effectiveness of efgartigimod alfa in treating acute optic neuritis, an inflammatory disorder of the optic nerve, will be assessed in pilot Phase 2 clinical research.
Key Questions Answered in the Optic Neuritis – Pipeline Insight Report
- Which companies/institutions are leading the optic neuritis drug development?
- What is the efficacy and safety profile of optic neuritis pipeline drugs?
- Which company is leading the optic neuritis pipeline development activities?
- What is the current optic neuritis commercial assessment?
- What are the opportunities and challenges present in the optic neuritis pipeline landscape?
- Which company is conducting major trials for optic neuritis drugs?
- Which companies/institutions are involved in optic neuritis collaborations aimed at providing enhanced therapeutic alternatives for patients?
- What are the geographies covered for clinical trials in optic neuritis?
The Optic Neuritis Pipeline Analysis Report provides a strategic overview of the latest and future landscape of treatments for optic neuritis. It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into optic neuritis collaborations, regulatory environments, and potential growth opportunities.
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- 1 Preface
- 1.1 Introduction
- 1.2 Objectives of the Study
- 1.3 Research Methodology & Assumptions
- 2 Executive Summary
- 3 Overview of Optic Neuritis
- 3.1 Signs and Symptoms
- 3.2 Causes
- 3.3 Risk Factors
- 3.4 Types of Optic Neuritis
- 3.5 Diagnosis
- 3.6 Treatment
- 4 Patient Profile: Optic Neuritis
- 4.1 Patient Profile Overview
- 4.2 Patient Psychology and Emotional Impact Factors
- 4.3 Risk Assessment and Treatment Success Rate
- 5 Optic Neuritis: Epidemiology Snapshot
- 5.1 Optic Neuritis Incidence by Key Markets
- 5.2 Optic Neuritis – Patients Seeking Treatment in Key Markets
- 6 Optic Neuritis: Market Dynamics
- 6.1 Market Drivers and Constraints
- 6.2 SWOT Analysis
- 7 Optic Neuritis: Key Facts Covered
- 7.1 Top Countries Contributing to Clinical Trials in Asia-Pacific
- 7.2 Top Countries Contributing to Clinical Trials in Europe
- 7.3 Top Countries Contributing to Clinical Trials in North America
- 7.4 Top Countries Contributing to Clinical Trials in Other Regions
- 8 Optic Neuritis, Drug Pipeline Assessment
- 8.1 Assessment by Treatment Type
- 8.2 Assessment by Route of Administration
- 8.3 Assessment by Drug Class
- 9 EMR Drug Pipeline Comparative Analysis
- 9.1 List of Optic Neuritis Pipeline Drugs
- 9.1.1 By Company
- 9.1.2 By Phase
- 9.1.3 By Indication
- 9.1.4 By Trial Status
- 9.1.5 By Funder Type
- 9.2 EMR Attribute Scoring Analysis of Pipeline Drugs (Top Drugs)
- 10 Optic Neuritis Pipeline - Mid-Stage Products (Phase III & IV) (Top Drugs)
- 10.1 Comparative Analysis for Mid-Stage Drugs
- 10.1.1 Study Type
- 10.1.2 Recruitment Status
- 10.1.3 Company
- 10.1.4 Funder Type
- 10.2 Product Level Analysis*
- 10.2.1 Drug: Inebilizumab
- 10.2.1.1 Product Description
- 10.2.1.2 Trial ID
- 10.2.1.3 Sponsor Name
- 10.2.1.4 Study Type
- 10.2.1.5 Drug Class
- 10.2.1.6 Eligibility Criteria
- 10.2.1.7 Study Record Dates
- 10.2.1.7.1 First Submitted
- 10.2.1.7.2 First Posted
- 10.2.1.7.3 Last Update Posted
- 10.2.1.7.4 Last Verified
- 10.2.1.8 Indication
- 10.2.1.9 Study Design
- 10.2.1.10 Recruitment Status
- 10.2.1.11 Enrollment (Estimated)
- 10.2.1.12 Location Countries
- 10.2.1.13 Recent Results
- 10.2.2 Drug: Eculizumab
- 10.2.3 Drug: Satralizumab
- 10.2.4 Other Drugs
- 11 Optic Neuritis Pipeline - Mid-Stage Products (Phase II) (Top Drugs)
- 11.1 Comparative Analysis for Mid-Stage Drugs
- 11.1.1 Study Type
- 11.1.2 Recruitment Status
- 11.1.3 Company
- 11.1.4 Funder Type
- 11.2 Product Level Analysis*
- 11.2.1 Drug: Efgartigimod Alfa
- 11.2.1.1 Product Description
- 11.2.1.2 Trial ID
- 11.2.1.3 Sponsor Name
- 11.2.1.4 Study Type
- 11.2.1.5 Drug Class
- 11.2.1.6 Eligibility Criteria
- 11.2.1.7 Study Record Dates
- 11.2.1.7.1 First Submitted
- 11.2.1.7.2 First Posted
- 11.2.1.7.3 Last Update Posted
- 11.2.1.7.4 Last Verified
- 11.2.1.8 Indication
- 11.2.1.9 Study Design
- 11.2.1.10 Recruitment Status
- 11.2.1.11 Enrollment (Estimated)
- 11.2.1.12 Location Countries
- 11.2.1.13 Recent Results
- 11.2.2 Drug: B001
- 11.2.3 Other Drugs
- 12 Optic Neuritis Pipeline - Early-Stage Products (Phase I) (Top Drugs)
- 12.1 Comparative Analysis for Early-Stage Drugs
- 12.1.1 Study Type
- 12.1.2 Recruitment Status
- 12.1.3 Company
- 12.1.4 Funder Type
- 12.2 Product Level Analysis*
- 12.2.1 Biological: LCAR-AIO T cells
- 12.2.1.1 Product Description
- 12.2.1.2 Trial ID
- 12.2.1.3 Sponsor Name
- 12.2.1.4 Study Type
- 12.2.1.5 Drug Class
- 12.2.1.6 Eligibility Criteria
- 12.2.1.7 Study Record Dates
- 12.2.1.7.1 First Submitted
- 12.2.1.7.2 First Posted
- 12.2.1.7.3 Last Update Posted
- 12.2.1.7.4 Last Verified
- 12.2.1.8 Indication
- 12.2.1.9 Study Design
- 12.2.1.10 Recruitment Status
- 12.2.1.11 Enrollment (Estimated)
- 12.2.1.12 Location Countries
- 12.2.2 Drug: BAT4406F
- 12.2.3 Other Drugs
- 13 Optic Neuritis, Key Drug Pipeline Companies
- 13.1 Amgen
- 13.1.1 Company Snapshot
- 13.1.2 Pipeline Product Portfolio
- 13.1.3 Financial Analysis
- 13.1.4 Recent News and Developments
- 13.2 Bio-Thera Solutions
- 13.2.1 Company Snapshot
- 13.2.2 Pipeline Product Portfolio
- 13.2.3 Financial Analysis
- 13.2.4 Recent News and Developments
- 13.3 Alexion Pharmaceuticals, Inc.
- 13.3.1 Company Snapshot
- 13.3.2 Pipeline Product Portfolio
- 13.3.3 Financial Analysis
- 13.3.4 Recent News and Developments
- 13.4 Hoffmann-La Roche
- 13.4.1 Company Snapshot
- 13.4.2 Pipeline Product Portfolio
- 13.4.3 Financial Analysis
- 13.4.4 Recent News and Developments
- 13.5 Hansoh BioMedical R&D Company
- 13.5.1 Company Snapshot
- 13.5.2 Pipeline Product Portfolio
- 13.5.3 Financial Analysis
- 13.5.4 Recent News and Developments
- 14 Regulatory Framework for Drug Approval, By Region
- 15 Terminated or Suspended Pipeline Products
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