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Exocrine Pancreatic Insufficiency Treatment Market Report and Forecast 2025-2034

Published Jul 28, 2025
Length 350 Pages
SKU # EMAR20319919

Description

The exocrine pancreatic insufficiency treatment market was valued at USD 4.22 Billion in 2024, driven by the increasing cases of cystic fibrosis, which commonly develop EPI due to thickened secretions that obstruct the pancreatic ducts across the 8 major markets. The market is expected to grow at a CAGR of 8.27% during the forecast period of 2025-2034, with the values likely to reach USD 9.34 Billion by 2034.

Exocrine Pancreatic Insufficiency Treatment Market Overview

Exocrine pancreatic insufficiency (EPI) is a condition characterized by the inability of the pancreas to produce enough digestive enzymes to properly digest food. The treatment includes PERT, which involves taking pancreatic enzyme supplements with meals and snacks to replace the deficient enzymes. The enzyme supplements typically contain lipase, protease, and amylase to aid in the digestion of fats, proteins, and carbohydrates.

EPI is primarily caused by conditions that affect pancreatic function, such as chronic pancreatitis, cystic fibrosis , pancreatic cancer, and pancreatic surgery. The prevalence of these underlying conditions contributes to the growing demand for EPI treatment market.

The pharmaceutical companies are focusing on developing advanced formulations of pancreatic enzymes to improve stability, efficacy, and patient compliance. These innovations aim to optimize treatment outcomes and enhance patient satisfaction, which is expected to drive the market growth.

Exocrine Pancreatic Insufficiency Treatment Market Growth Drivers

Increasing Incidence and Prevalence of Underlying Conditions

Chronic pancreatitis is a significant cause of EPI, which is increasingly diagnosed due to rising cases linked to alcohol abuse, obesity, and other factors. This genetic condition affects pancreatic function, leading to EPI in a substantial number of patients. According to an article published by NCB I, chronic pancreatitis is the most common pancreatic disease associated with EPI.

Other conditions like pancreatic cancer and surgical interventions on the pancreas can impair its ability to produce digestive enzymes, necessitating EPI treatment. According to an article published by NCB I, pancreatic surgery alters digestive anatomy, the correct mixing of food, bile, and pancreatic enzymes and reduces the pancreatic volume. Different procedures are associated with different degrees of EPI. The growing number of individuals diagnosed with chronic pancreatitis directly expands the pool of patients at risk of developing EPI, thereby increasing the demand for its treatment market.

Technological Advancements in Treatment Options is Expected to Propel Exocrine Pancreatic Insufficiency Treatment Market Demand

The technological advancements in treatment options play a crucial role in driving the growth and development of the treatment market. The technological innovations enable the development of more effective formulations of pancreatic enzymes, including lipase, protease, and amylase. These formulations are designed to better mimic natural pancreatic enzyme activity, thereby improving digestion and nutrient absorption in patients with EPI. Pancreatic Enzyme Replacement Therapy (PERT) remains the mainstay of EPI treatment, with ongoing advancements in enzyme formulations, delivery systems, and dosing regimens to enhance efficacy and patient compliance.

The advancement in treatment includes other alternative therapies, exploration of adjunctive therapies, such as proton pump inhibitors (PPIs), dietary modifications, and nutritional supplements, provides additional treatment options tailored to patient needs. This innovation leads to increase in market demand.

Exocrine Pancreatic Insufficiency Treatment Market Trends

The market is witnessing several trends and developments to improve the current global scenario. Some of the notable trends are as follows:

Advancements in Enzyme Replacement Therapy

There is ongoing research and development aimed at enhancing the efficacy, stability, and bioavailability of pancreatic enzyme replacement therapy (PERT). The innovations include formulations with optimized enzyme ratios, enteric-coated tablets for improved delivery, and microencapsulation technologies to protect enzymes from degradation. These advancements are expected to drive the market growth.

Exploration of Novel Therapies

The ongoing research efforts are focused on exploring novel therapeutic approaches beyond traditional enzyme replacement, including enzyme enhancers, pancreatic duct clearance agents, and targeted therapies addressing underlying disease mechanisms.

Personalized Medicine Approach

The increasing use of genetic testing helps identify specific mutations (e.g., CFTR mutations in cystic fibrosis-related EPI) that influence treatment responses. This allows for personalized treatment plans tailored to individual genetic profiles, optimizing therapy effectiveness and patient outcomes. This is expected to drive market growth.

Exocrine Pancreatic Insufficiency Treatment Market Segmentation

“Exocrine Pancreatic Insufficiency Treatment Market Report and Forecast 2025-2034” offers a detailed analysis of the market based on the following segments:

Market Breakup by Treatment
  • Pancreatic Enzyme Replacement Therapy (PERT)
  • Nutritional Therapy (Dietary Supplements)
  • Others
Market Breakup by Indication
  • Abdominal Pain
  • Constipation
  • Diarrhea
  • Fatty Stools
  • Weight Loss
  • Others
Market Breakup by End User
  • Hospitals
  • Homecare
  • Specialty Centers
  • Others
Market Breakup by Region
  • United States
  • EU-4 and the United Kingdom
  
  • Germany

  •   
  • France

  •   
  • Italy

  •   
  • Spain

  •   
  • United Kingdom
    • Japan
    • India
    Exocrine Pancreatic Insufficiency Treatment Market Share

    Market Segmentation Based on Treatment is Anticipated to Witness Substantial Growth

    By treatment, the market is segmented into pancreatic enzyme replacement therapy (PERT), nutritional therapy (dietary supplements) and others. The pancreatic enzyme replacement therapy (PERT) segment is expected to dominate the market because it is the most recommended treatment. It helps in managing EPI symptoms by replacing the deficient pancreatic enzymes (lipase, protease, amylase) required for proper digestion of fats, proteins, and carbohydrates.

    Exocrine Pancreatic Insufficiency Treatment Market Analysis by Region

    Regionally, the market report offers an insight into the United States, EU-4 and the United Kingdom, Germany, France, Italy, Spain, United Kingdom, Japan, and India. The United States, having a robust healthcare infrastructure and a strong presence of prominent pharmaceutical companies, is estimated to hold a high market value. The robust research and development activities in pharmaceutical and biotechnology sectors, leading to continuous advancements in pancreatic enzyme replacement therapy (PERT) formulations, driving the regional demand.

    Germany holds a high exocrine pancreatic insufficiency treatment market value as the region boasts a well-developed healthcare system with robust diagnostic capabilities and access to specialized care, facilitating early detection and management of EPI.

    Additionally, Japan is expected to witness substantial market growth as the region has made significant progress in raising awareness among healthcare providers about gastrointestinal disorders, including EPI. This has led to improved diagnosis and management of the condition and thus driving the market demand.

    Leading Players in the Exocrine Pancreatic Insufficiency Treatment Market

    The key features of the market report include patent analysis, grants analysis, clinical trials analysis, fundings and investment analysis, and strategic initiatives by the leading key players. The major companies in the market are as follows:

    AbbVie Inc.

    AbbVie Inc., a prominent pharmaceutical company, has been involved in the treatment of exocrine pancreatic insufficiency (EPI) through its development and marketing of pancreatic enzyme replacement therapy (PERT) products.

    Johnson & Johnson Services, Inc.

    Johnson & Johnson Services, Inc., as a global pharmaceutical company focuses on several therapeutic areas such as pharmaceuticals, generics, eye care, and oncology, among others, including EPI.

    Other key players in the market include Nordmark Arzneimittel GmbH and Co. KG, Digestive Care, Inc., Cilian AG, Chiesi Farmaceutici S.p.A., Anthera Pharmaceuticals, Inc., and Aptalis Pharma Inc. among others.

    Key Questions Answered in the Exocrine Pancreatic Insufficiency Treatment Market Report
    • What was the exocrine pancreatic insufficiency treatment market value in 2023?
    • What is the exocrine pancreatic insufficiency treatment market forecast outlook for 2025-2034?
    • What are the regional markets covered in the EMR report?
    • What is market segmentation based on treatment?
    • What is market segmentation based on indication?
    • What is market segmentation based on end user?
    • What are the major factors aiding the exocrine pancreatic insufficiency treatment market demand?
    • How has the market performed so far and how is it anticipated to perform in the coming years?
    • What are the major trends influencing the market?
    • What are the market's major drivers, opportunities, and restraints?
    • Which regional market is expected to lead the market share in the forecast period?
    • Which country is expected to experience expedited growth during the forecast period?
    • How does the growing cases of chronic pancreatis affect the market landscape?
    • How does the clinical trials impact the market size?
    • Who are the key players involved in the exocrine pancreatic insufficiency treatment market?
    • What are the current unmet needs and challenges in the market?
    • How are partnerships, collaborations, mergers and acquisitions among the key market players shaping the market dynamics?
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    Table of Contents

    350 Pages
    1 Preface
    1.1 Objectives of the Study
    1.2 Key Assumptions
    1.3 Report Coverage – Key Segmentation and Scope
    1.4 Research Methodology
    2 Executive Summary
    3 Exocrine Pancreatic Insufficiency Treatment Market Overview – 8 Major Markets
    3.1 Exocrine Pancreatic Insufficiency Treatment Market Historical Value (2018-2024)
    3.2 Exocrine Pancreatic Insufficiency Treatment Market Forecast Value (2025-2034)
    4 Vendor Positioning Analysis
    4.1 Key Vendors
    4.2 Prospective Leaders
    4.3 Niche Leaders
    4.4 Disruptors
    5 Exocrine Pancreatic Insufficiency Treatment Overview
    5.1 Guidelines and Stages
    5.2 Pathophysiology
    5.3 Screening and Diagnosis
    5.4 Treatment Pathway
    6 Patient Profile
    6.1 Patient Profile Overview
    6.2 Patient Psychology and Emotional Impact Factors
    6.3 Risk Assessment and Treatment Success Rate
    7 Exocrine Pancreatic Insufficiency Treatment Epidemiology Scenario and Forecast – 8 Major Markets
    7.1 8MM Epidemiology Scenario Overview (2018-2034)
    7.1.1 Prevalence, by Country
    7.1.1.1 U.S.
    7.1.1.2 U.K.
    7.1.1.3 EU4
    7.1.1.4 India
    7.1.1.5 Japan
    7.1.2 Mortality, by Country
    7.1.2.1 U.S.
    7.1.2.2 U.K.
    7.1.2.3 EU4
    7.1.2.4 India
    7.1.2.5 Japan
    7.1.3 Treatment Seeking Rate, by Country
    7.1.3.1 U.S.
    7.1.3.2 U.K.
    7.1.3.3 EU4
    7.1.3.4 India
    7.1.3.5 Japan
    8 Exocrine Pancreatic Insufficiency Treatment Market Landscape – 8 Major Markets
    8.1 Exocrine Pancreatic Insufficiency Treatment: Developers Landscape
    8.1.1 Analysis by Year of Establishment
    8.1.2 Analysis by Company Size
    8.1.3 Analysis by Region
    8.2 Exocrine Pancreatic Insufficiency Treatment: Product Landscape
    8.2.1 Analysis by Treatment
    8.2.2 Analysis by Indication
    9 Exocrine Pancreatic Insufficiency Treatment Challenges and Unmet Needs
    9.1 Treatment Pathway Challenges
    9.2 Compliance and Drop-Out Analysis
    9.3 Awareness and Prevention Gaps
    10 Cost of Treatment
    11 Exocrine Pancreatic Insufficiency Treatment Market Dynamics
    11.1 Market Drivers and Constraints
    11.2 SWOT Analysis
    11.2.1 Strengths
    11.2.2 Weaknesses
    11.2.3 Opportunities
    11.2.4 Threats
    11.3 PESTEL Analysis
    11.3.1 Political
    11.3.2 Environmental
    11.3.3 Social
    11.3.4 Technological
    11.3.5 Ethical
    11.3.6 Legal
    11.4 Porter’s Five Forces Model
    11.4.1 Bargaining Power of Suppliers
    11.4.2 Bargaining Power of Buyers
    11.4.3 Threat of New Entrants
    11.4.4 Threat of Substitutes
    11.4.5 Degree of Rivalry
    11.5 Key Demand Indicators
    11.6 Key Price Indicators
    11.7 Industry Events, Initiatives, and Trends
    11.8 Value Chain Analysis
    12 Exocrine Pancreatic Insufficiency Treatment Market Segmentation (218-2034) - 8 Major Markets
    12.1 Exocrine Pancreatic Insufficiency Treatment Market (2018-2034) by Treatment
    12.1.1 Market Overview
    12.1.2 Pancreatic Enzyme Replacement Therapy (PERT)
    12.1.3 Nutritional Therapy (Dietary Supplements)
    12.1.4 Others
    12.2 Exocrine Pancreatic Insufficiency Treatment Market (2018-2034) by Indication
    12.2.1 Market Overview
    12.2.2 Abdominal Pain
    12.2.3 Constipation
    12.2.4 Diarrhea
    12.2.5 Fatty Stools
    12.2.6 Weight Loss
    12.2.7 Others
    12.3 Exocrine Pancreatic Insufficiency Treatment Market (2018-2034) by End User
    12.3.1 Market Overview
    12.3.2 Hospitals
    12.3.3 Homecare
    12.3.4 Specialty Centers
    12.3.5 Others
    12.4 Exocrine Pancreatic Insufficiency Treatment Market (2018-2034) by Region
    12.4.1 Market Overview
    12.4.2 United States
    12.4.3 EU-4 and the United Kingdom
    12.4.3.1 Germany
    12.4.3.2 France
    12.4.3.3 Italy
    12.4.3.4 Spain
    12.4.3.5 United Kingdom
    12.4.4 Japan
    12.4.5 India
    13 United States Exocrine Pancreatic Insufficiency Treatment Market (218-2034)
    13.1 United States Exocrine Pancreatic Insufficiency Treatment Market Historical Value (2018-2024)
    13.2 United States Exocrine Pancreatic Insufficiency Treatment Market Forecast Value (2025-2034)
    13.3 United States Exocrine Pancreatic Insufficiency Treatment Market (2018-2034) by Treatment
    13.3.1 Market Overview
    13.3.2 Pancreatic Enzyme Replacement Therapy (PERT)
    13.3.3 Nutritional Therapy (Dietary Supplements)
    13.3.4 Others
    13.4 United States Exocrine Pancreatic Insufficiency Treatment Market (2018-2034) by Indication
    13.4.1 Market Overview
    13.4.2 Abdominal Pain
    13.4.3 Constipation
    13.4.4 Diarrhea
    13.4.5 Fatty Stools
    13.4.6 Weight Loss
    13.4.7 Others
    14 EU-4 and United Kingdom Exocrine Pancreatic Insufficiency Treatment Market (218-2034)
    14.1 EU-4 and United Kingdom Exocrine Pancreatic Insufficiency Treatment Market Historical Value (2018-2024)
    14.2 EU-4 and United Kingdom Exocrine Pancreatic Insufficiency Treatment Market Forecast Value (2025-2034)
    14.3 EU-4 and United Kingdom Exocrine Pancreatic Insufficiency Treatment Market (2018-2034) by Treatment
    14.3.1 Market Overview
    14.3.2 Pancreatic Enzyme Replacement Therapy (PERT)
    14.3.3 Nutritional Therapy (Dietary Supplements)
    14.3.4 Others
    14.4 EU-4 and United Kingdom Exocrine Pancreatic Insufficiency Treatment Market (2018-2034) by Indication
    14.4.1 Market Overview
    14.4.2 Abdominal Pain
    14.4.3 Constipation
    14.4.4 Diarrhea
    14.4.5 Fatty Stools
    14.4.6 Weight Loss
    14.4.7 Others
    15 Japan Exocrine Pancreatic Insufficiency Treatment Market
    15.1 Japan Exocrine Pancreatic Insufficiency Treatment Market Historical Value (2018-2024)
    15.2 Japan Exocrine Pancreatic Insufficiency Treatment Market Forecast Value (2025-2034)
    15.3 Japan Exocrine Pancreatic Insufficiency Treatment Market (2018-2034) by Treatment
    15.3.1 Market Overview
    15.3.2 Pancreatic Enzyme Replacement Therapy (PERT)
    15.3.3 Nutritional Therapy (Dietary Supplements)
    15.3.4 Others
    15.4 Japan Exocrine Pancreatic Insufficiency Treatment Market (2018-2034) by Indication
    15.4.1 Market Overview
    15.4.2 Abdominal Pain
    15.4.3 Constipation
    15.4.4 Diarrhea
    15.4.5 Fatty Stools
    15.4.6 Weight Loss
    15.4.7 Others
    16 India Exocrine Pancreatic Insufficiency Treatment Market
    16.1 India Exocrine Pancreatic Insufficiency Treatment Market (2018-2034) Historical Value (2018-2024)
    16.2 India Exocrine Pancreatic Insufficiency Treatment Market (2018-2034) Forecast Value (2025-2034)
    16.3 India Exocrine Pancreatic Insufficiency Treatment Market (2018-2034) by Treatment
    16.3.1 Market Overview
    16.3.2 Pancreatic Enzyme Replacement Therapy (PERT)
    16.3.3 Nutritional Therapy (Dietary Supplements)
    16.3.4 Others
    16.4 India Exocrine Pancreatic Insufficiency Treatment Market (2018-2034) by Indication
    16.4.1 Market Overview
    16.4.2 Abdominal Pain
    16.4.3 Constipation
    16.4.4 Diarrhea
    16.4.5 Fatty Stools
    16.4.6 Weight Loss
    16.4.7 Others
    17 Regulatory Framework
    17.1 Regulatory Overview
    17.2 US FDA
    17.3 EU EMA
    17.4 Japan PMDA
    17.5 Others
    18 Patent Analysis
    18.1 Analysis by Type of Patent
    18.2 Analysis by Publication Year
    18.3 Analysis by Issuing Authority
    18.4 Analysis by Patent Age
    18.5 Analysis by CPC Analysis
    18.6 Analysis by Patent Valuation
    18.7 Analysis by Key Players
    19 Grants Analysis
    19.1 Analysis by Year
    19.2 Analysis by Amount Awarded
    19.3 Analysis by Issuing Authority
    19.4 Analysis by Grant Application
    19.5 Analysis by Funding Institute
    19.6 Analysis by NIH Departments
    19.7 Analysis by Recipient Organization
    20 Clinical Trials Analysis
    20.1 Analysis by Trial Registration Year
    20.2 Analysis by Trial Status
    20.3 Analysis by Trial Phase
    20.4 Analysis by Therapeutic Area
    20.5 Analysis by Geography
    21 Funding and Investment Analysis
    21.1 Analysis by Funding Instances
    21.2 Analysis by Type of Funding
    21.3 Analysis by Funding Amount
    21.4 Analysis by Leading Players
    21.5 Analysis by Leading Investors
    21.6 Analysis by Geography
    22 Strategic Initiatives
    22.1 Analysis by Partnership Instances
    22.2 Analysis by Type of Partnership and Collaborations
    22.3 Analysis by Joint Ventures
    22.4 Analysis by Leading Players
    22.5 Analysis by Region
    23 Supplier Landscape
    23.1 Market Share by Top 5 Companies
    23.2 AbbVie Inc.
    23.2.1 Financial Analysis
    23.2.2 Product Portfolio
    23.2.3 Demographic Reach and Achievements
    23.2.4 Mergers and Acquisitions
    23.2.5 Certifications
    23.3 Johnson & Johnson Services, Inc.
    23.3.1 Financial Analysis
    23.3.2 Product Portfolio
    23.3.3 Demographic Reach and Achievements
    23.3.4 Mergers and Acquisitions
    23.3.5 Certifications
    23.4 Chiesi Farmaceutici S.p.A.
    23.4.1 Financial Analysis
    23.4.2 Product Portfolio
    23.4.3 Demographic Reach and Achievements
    23.4.4 Mergers and Acquisitions
    23.4.5 Certifications
    23.5 Nordmark Arzneimittel GmbH and Co. KG
    23.5.1 Financial Analysis
    23.5.2 Product Portfolio
    23.5.3 Demographic Reach and Achievements
    23.5.4 Mergers and Acquisitions
    23.5.5 Certifications
    23.6 Digestive Care, Inc.
    23.6.1 Financial Analysis
    23.6.2 Product Portfolio
    23.6.3 Demographic Reach and Achievements
    23.6.4 Mergers and Acquisitions
    23.6.5 Certifications
    23.7 Cilian AG
    23.7.1 Financial Analysis
    23.7.2 Product Portfolio
    23.7.3 Demographic Reach and Achievements
    23.7.4 Mergers and Acquisitions
    23.7.5 Certifications
    23.8 Anthera Pharmaceuticals, Inc.
    23.8.1 Financial Analysis
    23.8.2 Product Portfolio
    23.8.3 Demographic Reach and Achievements
    23.8.4 Mergers and Acquisitions
    23.8.5 Certifications
    23.9 Aptalis Pharma Inc.
    23.9.1 Financial Analysis
    23.9.2 Product Portfolio
    23.9.3 Demographic Reach and Achievements
    23.9.4 Mergers and Acquisitions
    23.9.5 Certifications
    24 Exocrine Pancreatic Insufficiency Treatment Treatment Drugs - Distribution Model (Additional Insight)
    24.1 Overview
    24.2 Potential Distributors
    24.3 Key Parameters for Distribution Partner Assessment
    25 Key Opinion Leaders (KOL) Insights (Additional Insight)
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