Cardiac Insufficiency Pipeline Analysis Report 2025
Description
Heart failure, also known as cardiac insufficiency, is the result of the heart's inability to pump enough blood to meet the body's demands. It is caused by diseases that weaken the heart muscle, such as cardiomyopathy, excessive blood pressure, and coronary artery disease. Edema, exhaustion, shortness of breath, and decreased tolerance to exertion are among the symptoms. Congestion and organ dysfunction result from the worsening of fluid accumulation in the lungs and tissues over time. Medication, lifestyle modifications, and even surgery are all part of the treatment. The cardiac insufficiency pipeline analysis by Expert Market Research focuses on various treatment options for this disease.
Report Coverage
The Cardiac Insufficiency Pipeline Analysis Report by Expert Market Research gives comprehensive insights into cardiac insufficiency therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for cardiac insufficiency therapeutics. The cardiac insufficiency report assessment includes the analysis of over 50 pipeline drugs and 25+ companies. The cardiac insufficiency pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials, including their adverse effects on patients suffering from the condition, and alignment with cardiac insufficiency treatment guidelines to ensure optimal care practices.
The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to cardiac insufficiency.
Cardiac Insufficiency Pipeline Outlook
The pathophysiology of cardiac insufficiency includes systolic or diastolic dysfunction which results in reduced cardiac output. Vasoconstriction, fluid retention, and elevated preload and afterload result from the compensatory activation of neurohormonal systems, such as the sympathetic nervous system and the renin-angiotensin-aldosterone system. Systemic consequences such as skeletal muscle atrophy and fluid accumulation (edema) are brought on by reduced perfusion, which exacerbates symptoms including fatigue, exercise intolerance, and dyspnea.
Improving heart function and controlling symptoms are the main goals of treatment for cardiac insufficiency. Digitalis stimulates contractions, beta-blockers reduce heart strain, ACE inhibitors relax blood arteries, and diuretics decrease fluid accumulation. Ventricular assist devices (VADs), cardiac resynchronization treatment (CRT), and defibrillators are examples of implanted advanced therapies. For severe situations, surgical alternatives include bypass surgery, valve repair, or heart transplantation. For long-term management, lifestyle modifications and ongoing observation are necessary.
Cardiac Insufficiency Epidemiology
About 26 million people worldwide suffer from cardiac insufficiency. The incidence is increasing because of aging populations and higher survival rates. Prevalence in developed countries varies from 1% to 3% and rises sharply with age, particularly in those over 65 years. Over 6 million adults in the United States suffer from heart failure, and by 2030, that number is expected to rise to over 8 million. There are regional differences, with comorbidities and lifestyle factors contributing to greater incidence in low-income nations.
Cardiac Insufficiency – Pipeline Therapeutic Assessment
This section of the report covers the analysis of cardiac insufficiency drug candidates based on several segmentations, including:
By Phase
The report covers phase I, phase II, phase III, phase IV, and early-phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis , phase II covers a major share of the total cardiac insufficiency clinical trials.
In the cardiac insufficiency pipeline, 50% of candidates are in Phase II with the largest share. There are equal number of candidates in Phase III and Phase IV with 20%. Lastly, Phase I has the least number of candidates with just 10%. Thus, demonstrating a broad spectrum of development stages and diverse progress toward potential treatments.
Cardiac Insufficiency – Pipeline Assessment Segmentation, By Drug Classes
The drug molecule categories covered under the cardiac insufficiency pipeline analysis include monoclonal antibody, peptides, small molecule and gene therapy. The cardiac insufficiency report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for cardiac insufficiency.
Cardiac Insufficiency Clinical Trials – Key Players
The EMR report for the cardiac insufficiency pipeline analysis covers the profile of key companies involved in clinical trials and their drugs under development. Below is the list of a few players involved in cardiac insufficiency clinical trials:
This section covers the detailed analysis of each drug under multiple phases, including phase I, phase II, phase III, phase IV, and emerging drugs for cardiac insufficiency. It includes product description, trial ID, study type, drug class, mode of administration, and recruitment status of cardiac insufficiency drug candidates.
Drug: Ponsegromab
Ponsegromab, developed by Pfizer, is an investigational monoclonal antibody targeting growth differentiation factor-50 (GDF-50). It is currently being evaluated in a Phase 2 clinical trial for patients with heart failure and elevated GDF-50 levels. The study aims to assess ponsegromab's impact on heart failure symptoms, physical limitations, and overall safety. Previously, ponsegromab demonstrated positive results in treating cancer cachexia, showing significant weight gain and improved quality of life in patients.
Drug: REGN5381
An experimental monoclonal antibody called REGN5381, created by Regeneron Pharmaceuticals, functions as an agonist to the natriuretic peptide receptor 1 (NPR1). This receptor is essential for controlling fluid balance and blood pressure. The safety, tolerability, and effectiveness of REGN5381 in patients with heart failure with reduced ejection fraction (HFrEF) are presently being assessed in Phase 2 clinical trials. The purpose of the trials is to evaluate how the medication affects cardiac function and symptom relief.
Key Questions Answered in the Cardiac Insufficiency Pipeline Analysis Report
The Cardiac Insufficiency Pipeline Analysis Report provides a strategic overview of the latest and future landscape of treatments for cardiac insufficiency. It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into cardiac insufficiency collaborations, regulatory environments, and potential growth opportunities.
Related Reports
Global Clinical Trials Market
Global Cardiac Prosthetic Devices Market Report Global Defibrillator Market Report
Report Coverage
The Cardiac Insufficiency Pipeline Analysis Report by Expert Market Research gives comprehensive insights into cardiac insufficiency therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for cardiac insufficiency therapeutics. The cardiac insufficiency report assessment includes the analysis of over 50 pipeline drugs and 25+ companies. The cardiac insufficiency pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials, including their adverse effects on patients suffering from the condition, and alignment with cardiac insufficiency treatment guidelines to ensure optimal care practices.
The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to cardiac insufficiency.
Cardiac Insufficiency Pipeline Outlook
The pathophysiology of cardiac insufficiency includes systolic or diastolic dysfunction which results in reduced cardiac output. Vasoconstriction, fluid retention, and elevated preload and afterload result from the compensatory activation of neurohormonal systems, such as the sympathetic nervous system and the renin-angiotensin-aldosterone system. Systemic consequences such as skeletal muscle atrophy and fluid accumulation (edema) are brought on by reduced perfusion, which exacerbates symptoms including fatigue, exercise intolerance, and dyspnea.
Improving heart function and controlling symptoms are the main goals of treatment for cardiac insufficiency. Digitalis stimulates contractions, beta-blockers reduce heart strain, ACE inhibitors relax blood arteries, and diuretics decrease fluid accumulation. Ventricular assist devices (VADs), cardiac resynchronization treatment (CRT), and defibrillators are examples of implanted advanced therapies. For severe situations, surgical alternatives include bypass surgery, valve repair, or heart transplantation. For long-term management, lifestyle modifications and ongoing observation are necessary.
Cardiac Insufficiency Epidemiology
About 26 million people worldwide suffer from cardiac insufficiency. The incidence is increasing because of aging populations and higher survival rates. Prevalence in developed countries varies from 1% to 3% and rises sharply with age, particularly in those over 65 years. Over 6 million adults in the United States suffer from heart failure, and by 2030, that number is expected to rise to over 8 million. There are regional differences, with comorbidities and lifestyle factors contributing to greater incidence in low-income nations.
Cardiac Insufficiency – Pipeline Therapeutic Assessment
This section of the report covers the analysis of cardiac insufficiency drug candidates based on several segmentations, including:
By Phase
- Late-Stage Products (Phase 3 and Phase 4)
- Mid-Stage Products (Phase 2)
- Early-Stage Products (Phase I)
- Preclinical and Discovery Stage Products
- Small molecule
- Peptides
- Gene Therapy
- Biologics
- Oral
- Parenteral
- Others
The report covers phase I, phase II, phase III, phase IV, and early-phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis , phase II covers a major share of the total cardiac insufficiency clinical trials.
In the cardiac insufficiency pipeline, 50% of candidates are in Phase II with the largest share. There are equal number of candidates in Phase III and Phase IV with 20%. Lastly, Phase I has the least number of candidates with just 10%. Thus, demonstrating a broad spectrum of development stages and diverse progress toward potential treatments.
Cardiac Insufficiency – Pipeline Assessment Segmentation, By Drug Classes
The drug molecule categories covered under the cardiac insufficiency pipeline analysis include monoclonal antibody, peptides, small molecule and gene therapy. The cardiac insufficiency report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for cardiac insufficiency.
Cardiac Insufficiency Clinical Trials – Key Players
The EMR report for the cardiac insufficiency pipeline analysis covers the profile of key companies involved in clinical trials and their drugs under development. Below is the list of a few players involved in cardiac insufficiency clinical trials:
- Pfizer
- Regeneron Pharmaceuticals
- Novartis Pharmaceuticals
- Medtronic
- Heartseed Inc.
- Boston Scientific Corporation
- Boehringer Ingelheim
- BioCardia, Inc.
This section covers the detailed analysis of each drug under multiple phases, including phase I, phase II, phase III, phase IV, and emerging drugs for cardiac insufficiency. It includes product description, trial ID, study type, drug class, mode of administration, and recruitment status of cardiac insufficiency drug candidates.
Drug: Ponsegromab
Ponsegromab, developed by Pfizer, is an investigational monoclonal antibody targeting growth differentiation factor-50 (GDF-50). It is currently being evaluated in a Phase 2 clinical trial for patients with heart failure and elevated GDF-50 levels. The study aims to assess ponsegromab's impact on heart failure symptoms, physical limitations, and overall safety. Previously, ponsegromab demonstrated positive results in treating cancer cachexia, showing significant weight gain and improved quality of life in patients.
Drug: REGN5381
An experimental monoclonal antibody called REGN5381, created by Regeneron Pharmaceuticals, functions as an agonist to the natriuretic peptide receptor 1 (NPR1). This receptor is essential for controlling fluid balance and blood pressure. The safety, tolerability, and effectiveness of REGN5381 in patients with heart failure with reduced ejection fraction (HFrEF) are presently being assessed in Phase 2 clinical trials. The purpose of the trials is to evaluate how the medication affects cardiac function and symptom relief.
Key Questions Answered in the Cardiac Insufficiency Pipeline Analysis Report
- Which companies/institutions are leading the cardiac insufficiency drug development?
- What is the efficacy and safety profile of cardiac insufficiency pipeline drugs?
- Which company is leading the cardiac insufficiency pipeline development activities?
- What is the current cardiac insufficiency commercial assessment?
- What are the opportunities and challenges present in the cardiac insufficiency pipeline landscape?
- What is the efficacy and safety profile of cardiac insufficiency pipeline drugs?
- Which company is conducting major trials for cardiac insufficiency drugs?
- Which companies/institutions are involved in cardiac insufficiency collaborations aimed at providing enhanced therapeutic alternatives for patients?
- What are the geographies covered for clinical trials in cardiac insufficiency?
The Cardiac Insufficiency Pipeline Analysis Report provides a strategic overview of the latest and future landscape of treatments for cardiac insufficiency. It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into cardiac insufficiency collaborations, regulatory environments, and potential growth opportunities.
Related Reports
Global Clinical Trials Market
Global Cardiac Prosthetic Devices Market Report Global Defibrillator Market Report
Table of Contents
200 Pages
- 1 Preface
- 1.1 Introduction
- 1.2 Objectives of the Study
- 1.3 Research Methodology & Assumptions
- 2 Executive Summary
- 3 Overview of Cardiac Insufficiency
- 3.1 Signs and Symptoms
- 3.2 Causes
- 3.3 Risk Factors
- 3.4 Diagnosis
- 3.5 Treatment
- 4 Patient Profile: Cardiac Insufficiency
- 4.1 Patient Profile Overview
- 4.2 Patient Psychology and Emotional Impact Factors
- 4.3 Risk Assessment and Treatment Success Rate
- 5 Cardiac Insufficiency: Epidemiology Snapshot
- 5.1 Cardiac Insufficiency Incidence by Key Markets
- 5.2 Cardiac Insufficiency – Patients Seeking Treatment in Key Markets
- 6 Cardiac Insufficiency: Market Dynamics
- 6.1 Market Drivers and Constraints
- 6.2 SWOT Analysis
- 7 Cardiac Insufficiency: Key Facts Covered
- 7.1 Top Countries Contributing to Clinical Trials in Asia-Pacific
- 7.2 Top Countries Contributing to Clinical Trials in Europe
- 7.3 Top Countries Contributing to Clinical Trials in North America
- 7.4 Top Countries Contributing to Clinical Trials in Other Regions
- 8 Cardiac Insufficiency, Drug Pipeline Assessment
- 8.1 Assessment by Treatment Type
- 8.2 Assessment by Route of Administration
- 8.3 Assessment by Drug Class
- 9 EMR Drug Pipeline Comparative Analysis
- 9.1 List of Cardiac Insufficiency Pipeline Drugs
- 9.1.1 By Company
- 9.1.2 By Phase
- 9.1.3 By Indication
- 9.1.4 By Trial Status
- 9.1.5 By Funder Type
- 9.2 EMR Attribute Scoring Analysis of Pipeline Drugs (Top Drugs)
- 10 Cardiac Insufficiency Drug Pipeline - Late-Stage Products (Phase III and IV) (Top Drugs)
- 10.1 Comparative Analysis for Late-Stage Drugs
- 10.1.1 Study Type
- 10.1.2 Recruitment Status
- 10.1.3 Company
- 10.1.4 Funder Type
- 10.2 Product Level Analysis*
- 10.2.1 Drug: Autologous cell therapy
- 10.2.1.1 Product Description
- 10.2.1.2 Trial ID
- 10.2.1.3 Sponsor Name
- 10.2.1.4 Study Type
- 10.2.1.5 Drug Class
- 10.2.1.6 Eligibility Criteria
- 10.2.1.7 Study Record Dates
- 10.2.1.7.1 First Submitted
- 10.2.1.7.2 First Posted
- 10.2.1.7.3 Last Update Posted
- 10.2.1.7.4 Last Verified
- 10.2.1.8 Indication
- 10.2.1.9 Study Design
- 10.2.1.10 Recruitment Status
- 10.2.1.11 Enrollment (Estimated)
- 10.2.1.12 Location Countries
- 10.2.1.13 Recent Results
- 10.2.2 Drug: Sacubitril
- 10.2.3 Other Drugs
- 11 Cardiac Insufficiency Drug Pipeline - Late-Stage Products (Phase II) (Top Drugs)
- 11.1 Comparative Analysis for Late-Stage Drugs
- 11.1.1 Study Type
- 11.1.2 Recruitment Status
- 11.1.3 Company
- 11.1.4 Funder Type
- 11.2 Product Level Analysis*
- 11.2.1 Drug: Ponsegromab
- 11.2.1.1 Product Description
- 11.2.1.2 Trial ID
- 11.2.1.3 Sponsor Name
- 11.2.1.4 Study Type
- 11.2.1.5 Drug Class
- 11.2.1.6 Eligibility Criteria
- 11.2.1.7 Study Record Dates
- 11.2.1.7.1 First Submitted
- 11.2.1.7.2 First Posted
- 11.2.1.7.3 Last Update Posted
- 11.2.1.7.4 Last Verified
- 11.2.1.8 Indication
- 11.2.1.9 Study Design
- 11.2.1.10 Recruitment Status
- 11.2.1.11 Enrollment (Estimated)
- 11.2.1.12 Location Countries
- 11.2.1.13 Recent Results
- 11.2.2 Drug: REGN5381
- 11.2.3 Other Drugs
- 12 Cardiac Insufficiency Drug Pipeline - Late-Stage Products (Phase I) (Top Drugs)
- 12.1 Comparative Analysis for Late-Stage Drugs
- 12.1.1 Study Type
- 12.1.2 Recruitment Status
- 12.1.3 Company
- 12.1.4 Funder Type
- 12.2 Product Level Analysis*
- 12.2.1 Drug: HS-001 CS
- 12.2.1.1 Product Description
- 12.2.1.2 Trial ID
- 12.2.1.3 Sponsor Name
- 12.2.1.4 Study Type
- 12.2.1.5 Drug Class
- 12.2.1.6 Eligibility Criteria
- 12.2.1.7 Study Record Dates
- 12.2.1.7.1 First Submitted
- 12.2.1.7.2 First Posted
- 12.2.1.7.3 Last Update Posted
- 12.2.1.7.4 Last Verified
- 12.2.1.8 Indication
- 12.2.1.9 Study Design
- 12.2.1.10 Recruitment Status
- 12.2.1.11 Enrollment (Estimated)
- 12.2.1.12 Location Countries
- 12.2.1.13 Recent Results
- 12.2.2 Other Drugs
- 13 Cardiac Insufficiency, Key Drug Pipeline Companies
- 13.1 Pfizer
- 13.1.1 Company Snapshot
- 13.1.2 Pipeline Product Portfolio
- 13.1.3 Financial Analysis
- 13.1.4 Recent News and Developments
- 13.2 Regeneron Pharmaceuticals
- 13.2.1 Company Snapshot
- 13.2.2 Pipeline Product Portfolio
- 13.2.3 Financial Analysis
- 13.2.4 Recent News and Developments
- 13.3 Novartis Pharmaceuticals
- 13.3.1 Company Snapshot
- 13.3.2 Pipeline Product Portfolio
- 13.3.3 Financial Analysis
- 13.3.4 Recent News and Developments
- 13.4 Medtronic
- 13.4.1 Company Snapshot
- 13.4.2 Pipeline Product Portfolio
- 13.4.3 Financial Analysis
- 13.4.4 Recent News and Developments
- 13.5 Heartseed Inc.
- 13.5.1 Company Snapshot
- 13.5.2 Pipeline Product Portfolio
- 13.5.3 Financial Analysis
- 13.5.4 Recent News and Developments
- 13.6 Boston Scientific Corporation
- 13.6.1 Company Snapshot
- 13.6.2 Pipeline Product Portfolio
- 13.6.3 Financial Analysis
- 13.6.4 Recent News and Developments
- 13.7 Boehringer Ingelheim
- 13.7.1 Company Snapshot
- 13.7.2 Pipeline Product Portfolio
- 13.7.3 Financial Analysis
- 13.7.4 Recent News and Developments
- 13.8 BioCardia, Inc.
- 13.8.1 Company Snapshot
- 13.8.2 Pipeline Product Portfolio
- 13.8.3 Financial Analysis
- 13.8.4 Recent News and Developments
- 14 Regulatory Framework for Drug Approval, By Region
- 15 Terminated or Suspended Pipeline Products
Pricing
Currency Rates
Questions or Comments?
Our team has the ability to search within reports to verify it suits your needs. We can also help maximize your budget by finding sections of reports you can purchase.
