Bone Metastasis Pipeline Analysis Report 2025
Description
When cancer cells move from their initial location to the bones, they impair the normal activity of bone cells. This process is known as bone metastasis. It may result in hypercalcemia, spinal cord compression, discomfort, and fractures. Common causes include lung, prostate, and breast cancers. There are two types, osteoblastic (excess bone production) and osteolytic (bone destruction). Imaging and blood tests are used for diagnosis. Medicine, radiation, and surgery are used for therapy. The bone metastasis pipeline analysis by Expert Market Research focuses on various treatment options for this disease.
Report Coverage
The Bone Metastasis Pipeline Analysis Report by Expert Market Research gives comprehensive insights into bone metastasis therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for Bone Metastasis therapeutics. The bone metastasis report assessment includes the analysis of over 15 pipeline drugs and 10+ companies. The bone metastasis pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials, including their adverse effects on patients suffering from the condition, and alignment with bone metastasis treatment guidelines to ensure optimal care practices.
The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to bone metastasis.
Bone Metastasis Pipeline Outlook
The pathophysiology of bone metastasis involves tumor cells colonizing bone marrow, disrupting bone homeostasis through interactions with osteoclasts (bone-resorbing cells) and osteoblasts (bone-forming cells). This leads to a "vicious cycle" in which tumors release growth factors (e.g., TGF-β, IGF-1) that fuel tumor growth, while tumors secrete cytokines (e.g., PTHrP, IL-11) that further activate osteoclasts. Metastases can be osteolytic (excessive resorption, common in breast cancer) or osteoblastic (excessive bone formation, typical in prostate cancer). The tumor cells may lie dormant in marrow niches before reactivating. Bisphosphonates or denosumab are used to inhibit bone destruction.
The goals of treating bone metastases include reducing symptoms, maintaining quality of life, and avoiding skeletal issues. Bisphosphonates (zoledronic acid) and denosumab are examples of systemic treatments that prevent bone deterioration, lowering the likelihood of fractures and their associated pain. Radiation therapy reduces pain and controls tumors by focusing on specific lesions. Fractures or imminent fractures (such as spinal cord compression) are stabilized by surgery. Strontium-89 and samarium-153 are examples of radiopharmaceuticals that target certain bone lesions with radiation. While physical therapy promotes mobility, underlying malignancies are treated with analgesics, chemotherapy, and hormone treatment. Treatment regimens are customized based on the patient's health, lesion location, and kind of cancer.
Bone Metastasis Epidemiology
About 68–75% of instances of advanced malignancies involve bone metastases, with breast, prostate, and lung cancers making up most of these cases. Bone metastases occur in around 70% of patients with advanced prostate or breast cancer. Each type of cancer has a different prevalence; lung cancer has the highest percentage upon diagnosis (18.05%). In 2008, about 280,000 people in the United States had bone metastases.
Bone Metastasis – Drug Pipeline Therapeutic Assessment
This section of the report covers the analysis of bone metastasis drug candidates based on several segmentations, including:
By Phase
The report covers phase I, phase II, phase III, phase IV, and early-phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis , phase II covers a major share of the total bone metastasis clinical trials.
Bone Metastasis – Pipeline Assessment Segmentation, By Drug Classes
The drug molecule categories covered under the bone metastasis pipeline analysis include small molecules, RNA-based therapies, peptides, biologics, and gene editing therapies. The bone metastasis report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for Bone Metastasis.
Capsid assembly modulators (CAMs) are emerging as promising agents in the bone metastasis pipeline. For example, HAP18, a small molecule assembly agonist, disrupts the HBV core protein dimer’s hydrogen bonding while stabilizing capsids. This dual action results in empty, defective capsids and impedes viral genome release, reducing the formation of new infectious particles.
Bone Metastasis Clinical Trials – Key Players
The EMR report for the bone metastasis pipeline analysis covers the profile of key companies involved in clinical trials and their drugs under development. Below is the list of a few players involved in bone metastasis clinical trials:
This section covers the detailed analysis of each drug under multiple phases, including phase I, phase II, phase III, phase IV, and emerging drugs for bone metastasis. It includes product description, trial ID, study type, drug class, mode of administration, and recruitment status of bone metastasis drug candidates.
Drug: Abemaciclib
Abemaciclib by Eli Lilly and Company is in Phase 2 of a clinical trial for treating bone metastases. The trial assesses its efficacy in combination with endocrine therapy, focusing on disease progression and overall survival. Abemaciclib is a CDK4/6 inhibitor used in breast cancer treatment, aiming to prevent cancer cell growth. The study is industry-funded and currently active.
Drug: Radium-223
Radium-223, developed by Bayer, is in Phase 1 of a clinical trial for treating bone metastases. The trial evaluates its safety and efficacy, particularly in combination with pembrolizumab, in patients with metastatic castration-resistant prostate cancer (mCRPC). Radium-223 is a radiopharmaceutical that targets bone metastases, delivering localized radiation to cancer cells while minimizing damage to surrounding tissue.
Key Questions Answered in the Bone Metastasis Pipeline Analysis Report
The Bone Metastasis Pipeline Analysis Report provides a strategic overview of the latest and future landscape of treatments for bone metastasis. It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into bone metastasis collaborations, regulatory environments, and potential growth opportunities.
Related Reports
Hepatitis B Virus (HBV) Infection Drug Pipeline Analysis Report
Bone Metastasis Epidemiology Forecast
Global Clinical Trials Market
Report Coverage
The Bone Metastasis Pipeline Analysis Report by Expert Market Research gives comprehensive insights into bone metastasis therapeutics currently undergoing clinical trials. It covers various aspects related to the details of each of these drugs under development for Bone Metastasis therapeutics. The bone metastasis report assessment includes the analysis of over 15 pipeline drugs and 10+ companies. The bone metastasis pipeline landscape will include an analysis based on efficacy and safety measure outcomes published for the trials, including their adverse effects on patients suffering from the condition, and alignment with bone metastasis treatment guidelines to ensure optimal care practices.
The assessment part will include a detailed analysis of each drug, drug class, clinical studies, phase type, drug type, route of administration, and ongoing product development activities related to bone metastasis.
Bone Metastasis Pipeline Outlook
The pathophysiology of bone metastasis involves tumor cells colonizing bone marrow, disrupting bone homeostasis through interactions with osteoclasts (bone-resorbing cells) and osteoblasts (bone-forming cells). This leads to a "vicious cycle" in which tumors release growth factors (e.g., TGF-β, IGF-1) that fuel tumor growth, while tumors secrete cytokines (e.g., PTHrP, IL-11) that further activate osteoclasts. Metastases can be osteolytic (excessive resorption, common in breast cancer) or osteoblastic (excessive bone formation, typical in prostate cancer). The tumor cells may lie dormant in marrow niches before reactivating. Bisphosphonates or denosumab are used to inhibit bone destruction.
The goals of treating bone metastases include reducing symptoms, maintaining quality of life, and avoiding skeletal issues. Bisphosphonates (zoledronic acid) and denosumab are examples of systemic treatments that prevent bone deterioration, lowering the likelihood of fractures and their associated pain. Radiation therapy reduces pain and controls tumors by focusing on specific lesions. Fractures or imminent fractures (such as spinal cord compression) are stabilized by surgery. Strontium-89 and samarium-153 are examples of radiopharmaceuticals that target certain bone lesions with radiation. While physical therapy promotes mobility, underlying malignancies are treated with analgesics, chemotherapy, and hormone treatment. Treatment regimens are customized based on the patient's health, lesion location, and kind of cancer.
Bone Metastasis Epidemiology
About 68–75% of instances of advanced malignancies involve bone metastases, with breast, prostate, and lung cancers making up most of these cases. Bone metastases occur in around 70% of patients with advanced prostate or breast cancer. Each type of cancer has a different prevalence; lung cancer has the highest percentage upon diagnosis (18.05%). In 2008, about 280,000 people in the United States had bone metastases.
Bone Metastasis – Drug Pipeline Therapeutic Assessment
This section of the report covers the analysis of bone metastasis drug candidates based on several segmentations, including:
By Phase
- Late-Stage Products (Phase 3 and Phase 4)
- Mid-Stage Products (Phase 2)
- Early-Stage Products (Phase I)
- Preclinical and Discovery Stage Products
- Antibody
- Antisense oligonucleotides
- Immunotherapy
- Monoclonal antibody
- Peptides
- Protein
- Recombinant protein
- Small molecule
- Stem Cell
- Vaccine
- Oral
- Parenteral
- Others
The report covers phase I, phase II, phase III, phase IV, and early-phase drugs. The coverage includes an in-depth analysis of each drug across these phases. According to EMR analysis , phase II covers a major share of the total bone metastasis clinical trials.
Bone Metastasis – Pipeline Assessment Segmentation, By Drug Classes
The drug molecule categories covered under the bone metastasis pipeline analysis include small molecules, RNA-based therapies, peptides, biologics, and gene editing therapies. The bone metastasis report provides a comparative analysis of the drug classes for each drug in various phases of clinical trials for Bone Metastasis.
Capsid assembly modulators (CAMs) are emerging as promising agents in the bone metastasis pipeline. For example, HAP18, a small molecule assembly agonist, disrupts the HBV core protein dimer’s hydrogen bonding while stabilizing capsids. This dual action results in empty, defective capsids and impedes viral genome release, reducing the formation of new infectious particles.
Bone Metastasis Clinical Trials – Key Players
The EMR report for the bone metastasis pipeline analysis covers the profile of key companies involved in clinical trials and their drugs under development. Below is the list of a few players involved in bone metastasis clinical trials:
- Eli Lilly and Company
- Bayer
- Actuate Therapeutics Inc.
- Fusion Pharmaceuticals Inc.
- Progenics Pharmaceuticals, Inc.
- iOnctura
This section covers the detailed analysis of each drug under multiple phases, including phase I, phase II, phase III, phase IV, and emerging drugs for bone metastasis. It includes product description, trial ID, study type, drug class, mode of administration, and recruitment status of bone metastasis drug candidates.
Drug: Abemaciclib
Abemaciclib by Eli Lilly and Company is in Phase 2 of a clinical trial for treating bone metastases. The trial assesses its efficacy in combination with endocrine therapy, focusing on disease progression and overall survival. Abemaciclib is a CDK4/6 inhibitor used in breast cancer treatment, aiming to prevent cancer cell growth. The study is industry-funded and currently active.
Drug: Radium-223
Radium-223, developed by Bayer, is in Phase 1 of a clinical trial for treating bone metastases. The trial evaluates its safety and efficacy, particularly in combination with pembrolizumab, in patients with metastatic castration-resistant prostate cancer (mCRPC). Radium-223 is a radiopharmaceutical that targets bone metastases, delivering localized radiation to cancer cells while minimizing damage to surrounding tissue.
Key Questions Answered in the Bone Metastasis Pipeline Analysis Report
- Which companies/institutions are leading the bone metastasis drug development?
- Which company is leading the bone metastasis pipeline development activities?
- What is the current bone metastasis commercial assessment?
- What are the opportunities and challenges present in the bone metastasis pipeline landscape?
- What is the efficacy and safety profile of bone metastasis pipeline drugs?
- Which company is conducting major trials for bone metastasis drugs?
- Which companies/institutions are involved in bone metastasis collaborations aimed at providing enhanced therapeutic alternatives for patients?
- What are the geographies covered for clinical trials in bone metastasis?
The Bone Metastasis Pipeline Analysis Report provides a strategic overview of the latest and future landscape of treatments for bone metastasis. It provides necessary information for making informed investment decisions along with research, development, and strategic planning efforts. The stakeholders will benefit from the essential insights into bone metastasis collaborations, regulatory environments, and potential growth opportunities.
Related Reports
Hepatitis B Virus (HBV) Infection Drug Pipeline Analysis Report
Bone Metastasis Epidemiology Forecast
Global Clinical Trials Market
Table of Contents
200 Pages
- 1 Preface
- 1.1 Introduction
- 1.2 Objectives of the Study
- 1.3 Research Methodology & Assumptions
- 2 Executive Summary
- 3 Overview of Bone Metastasis
- 3.1 Signs and Symptoms
- 3.2 Causes
- 3.3 Risk Factors
- 3.4 Diagnosis
- 3.5 Treatment
- 4 Patient Profile: Bone Metastasis
- 4.1 Patient Profile Overview
- 4.2 Patient Psychology and Emotional Impact Factors
- 4.3 Risk Assessment and Treatment Success Rate
- 5 Bone Metastasis: Epidemiology Snapshot
- 5.1 Bone Metastasis Incidence by Key Markets
- 5.2 Bone Metastasis – Patients Seeking Treatment in Key Markets
- 6 Bone Metastasis: Market Dynamics
- 6.1 Market Drivers and Constraints
- 6.2 SWOT Analysis
- 7 Bone Metastasis: Key Facts Covered
- 7.1 Top Countries Contributing to Clinical Trials in Asia-Pacific
- 7.2 Top Countries Contributing to Clinical Trials in Europe
- 7.3 Top Countries Contributing to Clinical Trials in North America
- 7.4 Top Countries Contributing to Clinical Trials in Other Regions
- 8 Bone Metastasis, Drug Pipeline Assessment
- 8.1 Assessment by Treatment Type
- 8.2 Assessment by Route of Administration
- 8.3 Assessment by Drug Class
- 9 EMR Drug Pipeline Comparative Analysis
- 9.1 List of Bone Metastasis Pipeline Drugs
- 9.1.1 By Company
- 9.1.2 By Phase
- 9.1.3 By Indication
- 9.1.4 By Trial Status
- 9.1.5 By Funder Type
- 9.2 EMR Attribute Scoring Analysis of Pipeline Drugs (Top Drugs)
- 10 Bone Metastasis Drug Pipeline - Late-Stage Products (Phase III and IV) (Top Drugs)
- 10.1 Comparative Analysis for Late-Stage Drugs
- 10.1.1 Study Type
- 10.1.2 Recruitment Status
- 10.1.3 Company
- 10.1.4 Funder Type
- 10.2 Product Level Analysis*
- 10.2.1 Drug: Radium-223 dichloride
- 10.2.1.1 Product Description
- 10.2.1.2 Trial ID
- 10.2.1.3 Sponsor Name
- 10.2.1.4 Study Type
- 10.2.1.5 Drug Class
- 10.2.1.6 Eligibility Criteria
- 10.2.1.7 Study Record Dates
- 10.2.1.7.1 First Submitted
- 10.2.1.7.2 First Posted
- 10.2.1.7.3 Last Update Posted
- 10.2.1.7.4 Last Verified
- 10.2.1.8 Indication
- 10.2.1.9 Study Design
- 10.2.1.10 Recruitment Status
- 10.2.1.11 Enrollment (Estimated)
- 10.2.1.12 Location Countries
- 10.2.1.13 Recent Results
- 10.2.2 Other Drugs
- 11 Bone Metastasis Drug Pipeline - Mid-Stage Products (Phase II) (Top Drugs)
- 11.1 Comparative Analysis for Mid-Stage Drugs
- 11.1.1 Study Type
- 11.1.2 Recruitment Status
- 11.1.3 Company
- 11.1.4 Funder Type
- 11.2 Product Level Analysis*
- 11.2.1 Drug: Abemaciclib
- 11.2.1.1 Product Description
- 11.2.1.2 Trial ID
- 11.2.1.3 Sponsor Name
- 11.2.1.4 Study Type
- 11.2.1.5 Drug Class
- 11.2.1.6 Eligibility Criteria
- 11.2.1.7 Study Record Dates
- 11.2.1.7.1 First Submitted
- 11.2.1.7.2 First Posted
- 11.2.1.7.3 Last Update Posted
- 11.2.1.7.4 Last Verified
- 11.2.1.8 Indication
- 11.2.1.9 Study Design
- 11.2.1.10 Recruitment Status
- 11.2.1.11 Enrollment (Estimated)
- 11.2.1.12 Location Countries
- 11.2.1.13 Recent Results
- 11.2.2 Drug: 9-ING-41
- 11.2.3 Other Drugs
- 12 Bone Metastasis Drug Pipeline - Early-Stage Products (Phase I) (Top Drugs)
- 12.1 Comparative Analysis for Early-Stage Drugs
- 12.1.1 Study Type
- 12.1.2 Recruitment Status
- 12.1.3 Company
- 12.1.4 Funder Type
- 12.2 Product Level Analysis*
- 12.2.1 Drug: Pembrolizumab
- 12.2.1.1 Product Description
- 12.2.1.2 Trial ID
- 12.2.1.3 Sponsor Name
- 12.2.1.4 Study Type
- 12.2.1.5 Drug Class
- 12.2.1.6 Eligibility Criteria
- 12.2.1.7 Study Record Dates
- 12.2.1.7.1 First Submitted
- 12.2.1.7.2 First Posted
- 12.2.1.7.3 Last Update Posted
- 12.2.1.7.4 Last Verified
- 12.2.1.8 Indication
- 12.2.1.9 Study Design
- 12.2.1.10 Recruitment Status
- 12.2.1.11 Enrollment (Estimated)
- 12.2.1.12 Location Countries
- 12.2.2 Drug: [225]-FPI-2059
- 12.2.3 Other Drugs
- 13 Bone Metastasis, Key Drug Pipeline Companies
- 13.1 Eli Lilly and Company
- 13.1.1 Company Snapshot
- 13.1.2 Pipeline Product Portfolio
- 13.1.3 Financial Analysis
- 13.1.4 Recent News and Developments
- 13.2 Bayer
- 13.2.1 Company Snapshot
- 13.2.2 Pipeline Product Portfolio
- 13.2.3 Financial Analysis
- 13.2.4 Recent News and Developments
- 13.3 Actuate Therapeutics Inc.
- 13.3.1 Company Snapshot
- 13.3.2 Pipeline Product Portfolio
- 13.3.3 Financial Analysis
- 13.3.4 Recent News and Developments
- 13.4 Fusion Pharmaceuticals Inc.
- 13.4.1 Company Snapshot
- 13.4.2 Pipeline Product Portfolio
- 13.4.3 Financial Analysis
- 13.4.4 Recent News and Developments
- 13.5 Progenics Pharmaceuticals, Inc.
- 13.5.1 Company Snapshot
- 13.5.2 Pipeline Product Portfolio
- 13.5.3 Financial Analysis
- 13.5.4 Recent News and Developments
- 13.6 iOnctura
- 13.6.1 Company Snapshot
- 13.6.2 Pipeline Product Portfolio
- 13.6.3 Financial Analysis
- 13.6.4 Recent News and Developments
- 14 Regulatory Framework for Drug Approval, By Region
- 15 Terminated or Suspended Pipeline Products
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