Uremic Pruritus - Pipeline Insight, 2025
Description
DelveInsight’s, “Uremic Pruritus - Pipeline Insight, 2025” report provides comprehensive insights about 2+ companies and 2+ pipeline drugs in Uremic Pruritus pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
Uremic Pruritus: Overview
Uremic pruritus (UP), also known as chronic kidney disease-associated pruritus (CKD-aP), is a common and distressing condition affecting patients with advanced chronic kidney disease (CKD), especially those on dialysis. It manifests as persistent itching, typically without a clear dermatological cause, and can significantly reduce the quality of life. The exact mechanisms are not fully understood but are thought to involve systemic inflammation, metabolic imbalances, and the buildup of uremic toxins due to impaired kidney function.
The primary symptom of uremic pruritus is persistent, intense itching, which can occur across the body or be localized to areas like the back, face, or arms. The itching is often worse at night, disrupting sleep and leading to fatigue and reduced quality of life. Unlike other skin conditions, there are typically no visible skin changes initially, but chronic scratching can lead to secondary lesions, redness, and thickening of the skin. Uremic pruritus is often accompanied by symptoms of chronic kidney disease, such as dry skin, muscle cramps, and general discomfort, further complicating the patient's condition.
The diagnosis of uremic pruritus is primarily clinical, based on a patient's history of chronic kidney disease (CKD) and the presence of persistent itching without an identifiable dermatological cause. Physicians typically rule out other causes of pruritus, such as allergies, liver disease, or dermatological conditions, through physical exams, blood tests, and skin assessments. In patients with CKD, the diagnosis is often supported by symptoms like generalized or localized itching, particularly if it worsens at night. The treatment of uremic pruritus focuses on symptom management and improving quality of life, as there is no definitive cure. Treatment approaches include optimizing dialysis to reduce the buildup of uremic toxins and addressing metabolic imbalances, such as hyperparathyroidism. Topical therapies like emollients and moisturizers are used to alleviate dry skin, while antihistamines and gabapentinoids may help reduce itching. Systemic treatments, such as opioid receptor modulators (e.g., nalfurafine) and immunomodulatory drugs like corticosteroids, can also provide relief. Phototherapy, particularly narrowband ultraviolet B (UVB) therapy, has been shown to be effective for some patients.
""Uremic Pruritus- Pipeline Insight, 2025"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Uremic Pruritus pipeline landscape is provided which includes the disease overview and Uremic Pruritus treatment guidelines. The assessment part of the report embraces, in depth Uremic Pruritus commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Uremic Pruritus collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
This segment of the Uremic Pruritus report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Uremic Pruritus Emerging Drugs
Further product details are provided in the report……..
Uremic Pruritus: Therapeutic Assessment
This segment of the report provides insights about the different Uremic Pruritus drugs segregated based on following parameters that define the scope of the report, such as:
Uremic Pruritus: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Uremic Pruritus therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Uremic Pruritus drugs.
Uremic Pruritus Report Insights
Current Treatment Scenario and Emerging Therapies:
Geography Covered
- Global coverage
Uremic Pruritus: Overview
Uremic pruritus (UP), also known as chronic kidney disease-associated pruritus (CKD-aP), is a common and distressing condition affecting patients with advanced chronic kidney disease (CKD), especially those on dialysis. It manifests as persistent itching, typically without a clear dermatological cause, and can significantly reduce the quality of life. The exact mechanisms are not fully understood but are thought to involve systemic inflammation, metabolic imbalances, and the buildup of uremic toxins due to impaired kidney function.
The primary symptom of uremic pruritus is persistent, intense itching, which can occur across the body or be localized to areas like the back, face, or arms. The itching is often worse at night, disrupting sleep and leading to fatigue and reduced quality of life. Unlike other skin conditions, there are typically no visible skin changes initially, but chronic scratching can lead to secondary lesions, redness, and thickening of the skin. Uremic pruritus is often accompanied by symptoms of chronic kidney disease, such as dry skin, muscle cramps, and general discomfort, further complicating the patient's condition.
The diagnosis of uremic pruritus is primarily clinical, based on a patient's history of chronic kidney disease (CKD) and the presence of persistent itching without an identifiable dermatological cause. Physicians typically rule out other causes of pruritus, such as allergies, liver disease, or dermatological conditions, through physical exams, blood tests, and skin assessments. In patients with CKD, the diagnosis is often supported by symptoms like generalized or localized itching, particularly if it worsens at night. The treatment of uremic pruritus focuses on symptom management and improving quality of life, as there is no definitive cure. Treatment approaches include optimizing dialysis to reduce the buildup of uremic toxins and addressing metabolic imbalances, such as hyperparathyroidism. Topical therapies like emollients and moisturizers are used to alleviate dry skin, while antihistamines and gabapentinoids may help reduce itching. Systemic treatments, such as opioid receptor modulators (e.g., nalfurafine) and immunomodulatory drugs like corticosteroids, can also provide relief. Phototherapy, particularly narrowband ultraviolet B (UVB) therapy, has been shown to be effective for some patients.
""Uremic Pruritus- Pipeline Insight, 2025"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Uremic Pruritus pipeline landscape is provided which includes the disease overview and Uremic Pruritus treatment guidelines. The assessment part of the report embraces, in depth Uremic Pruritus commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Uremic Pruritus collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Uremic Pruritus R&D. The therapies under development are focused on novel approaches to treat/improve Uremic Pruritus.
This segment of the Uremic Pruritus report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Uremic Pruritus Emerging Drugs
- QLG2198: Qilu Pharmaceutical
Further product details are provided in the report……..
Uremic Pruritus: Therapeutic Assessment
This segment of the report provides insights about the different Uremic Pruritus drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in Uremic Pruritus
- There are approx. 2+ key companies which are developing the therapies for Uremic Pruritus. The companies which have their Uremic Pruritus drug candidates in the most advanced stage, i.e. Phase III include, Qilu Pharmaceutical.
- Phases
- Late stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage product (Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Oral
- Intravenous
- Subcutaneous
- Parenteral
- Topical
- Molecule Type
- Recombinant fusion proteins
- Small molecule
- Monoclonal antibody
- Peptide
- Polymer
- Gene therapy
- Product Type
Uremic Pruritus: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Uremic Pruritus therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Uremic Pruritus drugs.
Uremic Pruritus Report Insights
- Uremic Pruritus Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Uremic Pruritus drugs?
- How many Uremic Pruritus drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Uremic Pruritus?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Uremic Pruritus therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Uremic Pruritus and their status?
- What are the key designations that have been granted to the emerging drugs?
- Qilu Pharmaceutical
- QLG2198
Table of Contents
60 Pages
- Introduction
- Executive Summary
- Uremic Pruritus: Overview
- Introduction
- Causes
- Pathophysiology
- Signs and Symptoms
- Diagnosis
- Treatment
- Pipeline Therapeutics
- Comparative Analysis
- Therapeutic Assessment
- Assessment by Product Type
- Assessment by Stage and Product Type
- Assessment by Route of Administration
- Assessment by Stage and Route of Administration
- Assessment by Molecule Type
- Assessment by Stage and Molecule Type
- Uremic Pruritus– DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Comparative Analysis
- QLG2198: Qilu Pharmaceutical
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- Comparative Analysis
- Drug name: Company name
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- Comparative Analysis
- Drug name: Company name
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Preclinical and Discovery Stage Products
- Comparative Analysis
- Drug name: Company name
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Inactive Products
- Comparative Analysis
- Uremic Pruritus Key Companies
- Uremic Pruritus Key Products
- Uremic Pruritus- Unmet Needs
- Uremic Pruritus- Market Drivers and Barriers
- Uremic Pruritus- Future Perspectives and Conclusion
- Uremic Pruritus Analyst Views
- Uremic Pruritus Key Companies
- Appendix
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