
Treg Cell-Based Therapies - Pipeline Insight, 2025
Description
DelveInsight’s, “Treg Cell-Based Therapies - Pipeline Insight, 2025” report provides comprehensive insights about 51+ companies and 55+ pipeline drugs in Treg Cell-Based Therapies pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
Treg Cell-Based Therapies: Overview
Treg (regulatory T cell) cell-based therapies harness the immunosuppressive properties of regulatory T cells to treat a variety of conditions, including autoimmune diseases, inflammatory conditions, and transplant rejection. These therapies leverage the natural function of Tregs, which play a crucial role in maintaining immune homeostasis by suppressing excessive immune responses that can cause tissue damage and by preventing the development of autoimmunity. Tregs achieve this by modulating the activity of other immune cells, thereby maintaining a balanced immune environment essential for health.
Treg cells regulate the immune system through intricate mechanisms aimed at inhibiting the activation and proliferation of other immune cells, notably effector T cells. Their regulatory functions are executed via direct cell-to-cell contact and the secretion of various anti-inflammatory cytokines, including IL-10 and TGF-β. These processes collectively contribute to the maintenance of immune balance and suppression of excessive immune responses, crucial for preventing autoimmune reactions and promoting immune tolerance.
The combination approaches for regulatory T (Treg) cell adoptive cell transfer include the concomitant use of IL-2 receptor and signal transducer and activator of transcription 5 (STAT5) agonists, but other approaches may include debulking the intrinsic effector T cell responses (which are often associated with resistance to Treg cell-based therapies through the use of anti-T cell therapies including anti-thymocyte globulin.
Although Treg cell therapy has a clear immunologic rationale, there are many challenges at this early stage of its implementation and testing. The magnitude of ex vivo expansion of Treg cells can be highly variable depending on patient population and underlying diseases. There are also limited clinical-grade (Good Manufacturing Practice) reagents and instruments specifically designed for Treg cell manufacturing.
Treg therapies are being developed to treat various autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and type 1 diabetes, by restoring immune tolerance. Additionally, Treg therapies can prevent the immune system from attacking transplanted organs or tissues, reducing the need for long-term immunosuppressive drugs. Furthermore, Treg therapies may also be beneficial in inflammatory diseases such as inflammatory bowel disease and psoriasis, as they can mitigate chronic inflammation.
""Treg Cell-Based Therapies - Pipeline Insight, 2025"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Treg Cell-Based Therapies pipeline landscape is provided which includes the disease overview and Treg Cell-Based Therapies treatment guidelines. The assessment part of the report embraces, in depth Treg Cell-Based Therapies commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Treg Cell-Based Therapies collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
This segment of the Treg Cell-Based Therapies report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II/III, II, I, preclinical and discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Treg Cell-Based Therapies Emerging Drugs
Further product details are provided in the report……..
Treg Cell-Based Therapies: Therapeutic Assessment
This segment of the report provides insights about the different Treg Cell-Based Therapies drugs segregated based on following parameters that define the scope of the report, such as:
Treg Cell-Based Therapies: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Treg Cell-Based Therapies therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Treg Cell-Based Therapies drugs.
Treg Cell-Based Therapies Report Insights
Current Treatment Scenario and Emerging Therapies:
Please Note: It will take 4-5 business days to complete the report upon order confirmation.
Geography Covered
- Global coverage
Treg Cell-Based Therapies: Overview
Treg (regulatory T cell) cell-based therapies harness the immunosuppressive properties of regulatory T cells to treat a variety of conditions, including autoimmune diseases, inflammatory conditions, and transplant rejection. These therapies leverage the natural function of Tregs, which play a crucial role in maintaining immune homeostasis by suppressing excessive immune responses that can cause tissue damage and by preventing the development of autoimmunity. Tregs achieve this by modulating the activity of other immune cells, thereby maintaining a balanced immune environment essential for health.
Treg cells regulate the immune system through intricate mechanisms aimed at inhibiting the activation and proliferation of other immune cells, notably effector T cells. Their regulatory functions are executed via direct cell-to-cell contact and the secretion of various anti-inflammatory cytokines, including IL-10 and TGF-β. These processes collectively contribute to the maintenance of immune balance and suppression of excessive immune responses, crucial for preventing autoimmune reactions and promoting immune tolerance.
The combination approaches for regulatory T (Treg) cell adoptive cell transfer include the concomitant use of IL-2 receptor and signal transducer and activator of transcription 5 (STAT5) agonists, but other approaches may include debulking the intrinsic effector T cell responses (which are often associated with resistance to Treg cell-based therapies through the use of anti-T cell therapies including anti-thymocyte globulin.
Although Treg cell therapy has a clear immunologic rationale, there are many challenges at this early stage of its implementation and testing. The magnitude of ex vivo expansion of Treg cells can be highly variable depending on patient population and underlying diseases. There are also limited clinical-grade (Good Manufacturing Practice) reagents and instruments specifically designed for Treg cell manufacturing.
Treg therapies are being developed to treat various autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and type 1 diabetes, by restoring immune tolerance. Additionally, Treg therapies can prevent the immune system from attacking transplanted organs or tissues, reducing the need for long-term immunosuppressive drugs. Furthermore, Treg therapies may also be beneficial in inflammatory diseases such as inflammatory bowel disease and psoriasis, as they can mitigate chronic inflammation.
""Treg Cell-Based Therapies - Pipeline Insight, 2025"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Treg Cell-Based Therapies pipeline landscape is provided which includes the disease overview and Treg Cell-Based Therapies treatment guidelines. The assessment part of the report embraces, in depth Treg Cell-Based Therapies commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Treg Cell-Based Therapies collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Treg Cell-Based Therapies R&D. The therapies under development are focused on novel approaches to treat/improve Treg Cell-Based Therapies.
This segment of the Treg Cell-Based Therapies report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II/III, II, I, preclinical and discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Treg Cell-Based Therapies Emerging Drugs
- Orca-T: Orca Bio
- NKTR-358: Nektar Therapeutics
- QEL-001: Quell Therapeutics
- CUG-252: Cugene
Further product details are provided in the report……..
Treg Cell-Based Therapies: Therapeutic Assessment
This segment of the report provides insights about the different Treg Cell-Based Therapies drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in Treg Cell-Based Therapies
- Phases
- Late stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage product (Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Intravenous
- Subcutaneous
- Oral
- Intramuscular
- Molecule Type
- Monoclonal antibody
- Small molecule
- Peptide
- Product Type
Treg Cell-Based Therapies: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Treg Cell-Based Therapies therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Treg Cell-Based Therapies drugs.
Treg Cell-Based Therapies Report Insights
- Treg Cell-Based Therapies Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Treg Cell-Based Therapies drugs?
- How many Treg Cell-Based Therapies drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Treg Cell-Based Therapies?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Treg Cell-Based Therapies therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Treg Cell-Based Therapies and their status?
- What are the key designations that have been granted to the emerging drugs?
- Orca Bio
- Nektar Therapeutics
- Quell Therapeutics
- Cugene
- Sangamo Therapeutics
- Abata Therapeutics
- HCW Biologics
- GentiBio
- Tr1X
- PolTREG
- Cellenkos
- VT BIO
- Miltenyi Biotec GmbH
- KSQ Therapeutics
- TeraImmune
- Orca-T
- NKTR-358
- QEL-001
- CUG-252
- TX200
- ABA-101
- HCW9302
- GNTI-122
- TRX-103
- PTG-020
- CK-0804
- VT-301
- TR-004
- Research programme
- TI-620
Please Note: It will take 4-5 business days to complete the report upon order confirmation.
Table of Contents
180 Pages
- Introduction
- Executive Summary
- Treg Cell-Based Therapies: Overview
- Introduction
- Mechanism of action
- Challenges of Treg cell therapy
- Applications
- Pipeline Therapeutics
- Comparative Analysis
- Therapeutic Assessment
- Assessment by Product Type
- Assessment by Stage and Product Type
- Assessment by Route of Administration
- Assessment by Stage and Route of Administration
- Assessment by Molecule Type
- Assessment by Stage and Molecule Type
- Treg Cell-Based Therapies– DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Comparative Analysis
- Orca-T: Orca Bio
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- Comparative Analysis
- NKTR-358: Nektar Therapeutics
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- Comparative Analysis
- CUG-252: Cugene
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Preclinical and Discovery Stage Products
- Comparative Analysis
- Drug name: Company name
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Inactive Products
- Comparative Analysis
- Treg Cell-Based Therapies Key Companies
- Treg Cell-Based Therapies Key Products
- Treg Cell-Based Therapies- Unmet Needs
- Treg Cell-Based Therapies- Market Drivers and Barriers
- Treg Cell-Based Therapies- Future Perspectives and Conclusion
- Treg Cell-Based Therapies Analyst Views
- Treg Cell-Based Therapies Key Companies
- Appendix
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