
Scleroderma - Pipeline Insight, 2024
Description
Scleroderma - Pipeline Insight, 2024
DelveInsight’s, “Scleroderma - Pipeline Insight, 2024” report provides comprehensive insights about 45+ companies and 50+ pipeline drugs in Scleroderma pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
- Global coverage
Scleroderma: Overview
Scleroderma is a connective tissue disorder characterized primarily by the thickening and hardening of the skin. The combining form “sclero” means ""hard"" in Greek, and the word “dermis” means skin. There are two primary types of scleroderma: localized and systemic (also called systemic sclerosis). In localized scleroderma, the disease affects mainly the skin and may have an impact on the muscles and bones. In systemic scleroderma, there is an involvement of the internal organs, such as the digestive tract, heart, lungs, and kidneys, among others. The severity and outcome of scleroderma are variable. Three primary mechanisms contribute to the development of the scleroderma: vascular anomalies, excess fibrosis, and autoimmune phenomenon. Abnormal interactions between endothelial cells, fibroblasts, and lymphocytes (B and T) lead to microcirculatory vascular involvement. The endothelial cells produce large amounts of endothelin 1, causing vasoconstriction and fibroblast activation. Also, fibroblasts and activated endothelial cells produce reactive oxygen species that speed up vascular remodeling, leading to the obliteration of small vessels. Activated fibroblasts differentiate easily into myofibroblasts, which have increased collagen synthesis ability.
Scleroderma is diagnosed through a clinical evaluation that includes a thorough examination, medical history review, and physical tests like skin biopsy and blood tests to assess organ involvement Common diagnostic procedures include nailfold capillaroscopy, ANA test, pulmonary function tests, CT scans, EKGs, echocardiograms, X-rays, and motility studies. The diagnosis is often made by dermatologists or rheumatologists who specialize in skin and autoimmune disorders. Treatment for scleroderma focuses on managing symptoms and complications, involving medications to suppress the immune system, physical therapy, pain relief, skin care, and emotional support early intervention is crucial for effective treatment and improving quality of life in scleroderma patients.
Scleroderma treatment aims to manage symptoms and prevent complications since there is currently no cure for the condition. Treatment strategies are tailored to individual needs, considering factors like symptoms, type of scleroderma, age, and overall health. Common treatment approaches include pain relief using nonsteroidal anti-inflammatory medications or corticosteroids, managing skin itchiness with lotions and moisturizers, and slowing skin thickening with immune system-suppressing medications. Additionally, physical therapy helps maintain muscle strength, while medications control blood pressure, improve blood flow, and address specific symptoms like heartburn and Raynaud's phenomenon. Surgery may be necessary in cases where complications cannot be resolved with less invasive therapies. Regular monitoring and early intervention are key to improving quality of life for individuals with scleroderma.
""Scleroderma- Pipeline Insight, 2024"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Scleroderma pipeline landscape is provided which includes the disease overview and Scleroderma treatment guidelines. The assessment part of the report embraces, in depth Scleroderma commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Scleroderma collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Scleroderma R&D. The therapies under development are focused on novel approaches to treat/improve Scleroderma.
This segment of the Scleroderma report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Scleroderma Emerging Drugs
- Belimumab: GlaxoSmithKline
- FT011: Certa Therapeutics
- CM-101: Chemomab Therapeutics
Further product details are provided in the report……..
Scleroderma: Therapeutic Assessment
This segment of the report provides insights about the different Scleroderma drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in Scleroderma
- There are approx. 45+ key companies which are developing the therapies for Scleroderma. The companies which have their Scleroderma drug candidates in the most advanced stage, i.e. Phase III include, GlaxoSmithKline.
- Phases
- Late stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage product (Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Oral
- Intravenous
- Subcutaneous
- Parenteral
- Topical
- Molecule Type
- Recombinant fusion proteins
- Small molecule
- Monoclonal antibody
- Peptide
- Polymer
- Gene therapy
- Product Type
Scleroderma: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Scleroderma therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Scleroderma drugs.
Scleroderma Report Insights
- Scleroderma Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Scleroderma drugs?
- How many Scleroderma drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Scleroderma?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Scleroderma therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Scleroderma and their status?
- What are the key designations that have been granted to the emerging drugs?
- Genentech
- Maruho
- Mitsubishi Tanabe Pharma America
- GlaxoSmithKline
- Gesynta Pharma
- Certa Therapeutics
- ChemomAb
- Boehringer Ingelheim
- Bioray Laboratories
- Cabaletta Bio
- Vixarelimab
- Nemolizumab
- MT-7117
- Belimumab
- GS-248
- FT011
- CM-101
- Avenciguat
- BRL-301
- CABA 201
Table of Contents
180 Pages
- Introduction
- Executive Summary
- Scleroderma: Overview
- Introduction
- Causes
- Pathophysiology
- Signs and Symptoms
- Diagnosis
- Treatment
- Pipeline Therapeutics
- Comparative Analysis
- Therapeutic Assessment
- Assessment by Product Type
- Assessment by Stage and Product Type
- Assessment by Route of Administration
- Assessment by Stage and Route of Administration
- Assessment by Molecule Type
- Assessment by Stage and Molecule Type
- Scleroderma– DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Comparative Analysis
- Belimumab: GlaxoSmithKline
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- Comparative Analysis
- FT011: Certa Therapeutics
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- Comparative Analysis
- CM-101: Chemomab Therapeutics
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Preclinical and Discovery Stage Products
- Comparative Analysis
- Drug name: Company name
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Inactive Products
- Comparative Analysis
- Scleroderma Key Companies
- Scleroderma Key Products
- Scleroderma- Unmet Needs
- Scleroderma- Market Drivers and Barriers
- Scleroderma- Future Perspectives and Conclusion
- Scleroderma Analyst Views
- Scleroderma Key Companies
- Appendix
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