
Relapsing Refractory Multiple Myeloma- Pipeline Insight, 2024
Description
Relapsing Refractory Multiple Myeloma- Pipeline Insight, 2024
DelveInsight’s, “Relapsing Refractory Multiple Myeloma- Pipeline Insight, 2024” report provides comprehensive insights about 55+ companies and 60+ pipeline drugs in Relapsing Refractory Multiple Myeloma pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
- Global coverage
Relapsing Refractory Multiple Myeloma: Overview
Multiple myeloma (MM) is a hematologic disorder which is characterized by a proliferation of malignant, monoclonal plasma cells in the bone marrow (BM) and/or extramedullary sites. Relapsed refractory multiple myeloma (RRMM) occurs when an individual has treatment for multiple myeloma, but the cancer returns or does not respond to treatment. Refractory myeloma develops as a result of cancer cells making certain changes. The longer cancer cells live, grow, and divide, the more gene changes (mutations) they collect. Some of these mutations can help protect the cancer cells from being killed by medications. Additionally, myeloma cells cause bone marrow changes that make it easier for the cells to survive. By modifying their environment, the cells may be able to “hide” from cancer drugs and the immune system. As a result, myeloma becomes more difficult to treat. MM is essentially a stage in the spectrum of monoclonal gammopathy. It is thought to arise from a pre-malignant, asymptomatic phase of clonal plasma cell growth called monoclonal gammopathy of undetermined significance (MGUS). MGUS is defined as detecting monoclonal immunoglobulins in the blood or urine without evidence of end-organ damage. This is quite common and is known to be detectable in over 3% of persons above age 50. It appears that the cell of origin is a post-germinal center plasma cell. This is typically a benign condition, although as noted above, it has a risk of progression to MM of about 1% per year. Presenting Features Patients generally present with bone pain (60%), fatigue (30%), weight loss (25%), paresthesia (5%), and recurrent infections (particularly pneumonia and urinary tract infections) with streptococcus pneumonia, Hemophilus influenza and Escherichia coli being the most common causative agents. Examination may reveal fever (0.7%), hepatomegaly (4%), splenomegaly (1%) and lymphadenopathy (1%). Pulmonary and pleural involvement are rare except in advanced disease. Cardiac involvement is seen with accompanying amyloidosis. Extra-medullary plasmacytomas are seen in 7% upfront and up to 20% at relapse. Cord compression (caused by an extra-medullary plasmacytoma or bony fragments from vertebral fractures) is rare (5%). Peripheral neuropathy is also rare at initial presentation and suggests amyloidosis or POEMS syndrome. The NCCN guidelines recommend the following diagnostic studies: Complete blood count (CBC) with differential, platelet count BUN, creatinine, electrolytes, albumin, calcium levels, Serum LDH and beta-2 macroglobulin, Serum immunoglobulins, serum protein electrophoresis (SPEP), serum immunofixation electrophoresis (SIFE), 24-hour proteinuria, urine protein electrophoresis (UPEP), urine immunofixation electrophoresis (UIFE), Serum-free light chain (FLC) assay. New regimens which include the novel agents thalidomide, bortezomib and lenalidomide as single-agents or in combination with dexamethasone have shown significant activity in patients with relapsed MM and are generally well tolerated. These agents have set the stage for the development of next-generation immunomodulatory drugs (IMiDs) and proteasome inhibitors, i.e. pomalidomide and carfilzomib in relapsed and/or refractory disease.
""Relapsing Refractory Multiple Myeloma- Pipeline Insight, 2024"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Relapsing Refractory Multiple Myeloma pipeline landscape is provided which includes the disease overview and Relapsing Refractory Multiple Myeloma treatment guidelines. The assessment part of the report embraces, in depth Relapsing Refractory Multiple Myeloma commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Relapsing Refractory Multiple Myeloma collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Relapsing Refractory Multiple Myeloma R&D. The therapies under development are focused on novel approaches to treat/improve Relapsing Refractory Multiple Myeloma.
This segment of the Relapsing Refractory Multiple Myeloma report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Relapsing Refractory Multiple Myeloma Emerging Drugs
- Mezigdomide: Bristol-Myers Squibb
- Iopofosine: Cellectar Biosciences, Inc.
- ORIC-533: ORIC Pharmaceuticals
Further product details are provided in the report……..
Relapsing Refractory Multiple Myeloma: Therapeutic Assessment
This segment of the report provides insights about the different Relapsing Refractory Multiple Myeloma drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in Relapsing Refractory Multiple Myeloma
Phases
DelveInsight’s report covers around 60+ products under different phases of clinical development like
- Late stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage product (Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Intra-articular
- Intraocular
- Intrathecal
- Intravenous
- Ophthalmic
- Oral
- Parenteral
- Subcutaneous
- Topical
- Transdermal
- Molecule Type
- Oligonucleotide
- Peptide
- Small molecule
- Product Type
Relapsing Refractory Multiple Myeloma: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Relapsing Refractory Multiple Myeloma therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Relapsing Refractory Multiple Myeloma drugs.
Relapsing Refractory Multiple Myeloma Report Insights
- Relapsing Refractory Multiple Myeloma Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Relapsing Refractory Multiple Myeloma drugs?
- How many Relapsing Refractory Multiple Myeloma drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Relapsing Refractory Multiple Myeloma?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Relapsing Refractory Multiple Myeloma therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Relapsing Refractory Multiple Myeloma and their status?
- What are the key designations that have been granted to the emerging drugs?
- Bristol-Myers Squibb
- I-MAB Biopharma
- Pfizer
- Arcellx
- Gilead sciences
- Novartis
- Array Biopharma
- Hrain Biotechnology Co., Ltd.
- Cartesian Therapeutics
- Xencor
- Takeda
- Sorrento Therapeutics
- Heidelberg Pharma AG
- Ichnos Sciences
- Allogene Therapeutics
- Harpoon Therapeutics
- Cellectis
- Poseida Therapeutics
- Regeneron Pharmaceuticals
- ONK Theraputics
- TeneoOne
- iTeos Therapeutics
- Oricell Therapeutics
- Anaveon AG
- Luminary Therapeutics
- Seagen Inc.
- Trillium Therapeutics Inc.
- Virtuoso BINco, Inc.
- Seagen Inc.
- Trillium Therapeutics Inc.
- Mezigdomide
- felzartamab
- Elranatamab
- CART-ddBCMA
- Magrolimab
- PHE885
- Encorafenib
- Human BCMA Targeted T Cells Injection
- Marizomib
- Iopofosine
- Modakafusp Alfa
- STI-6129
- HDP 101
- ISB 1442
- ALLO-605
- TAK-981
- HPN217
- LAVA-051
- EMB-06
- REGN5459
- BGB-11417
- Descartes-25
- CID-103
- FT576
- KTX-1001
- OriCAR-017
- ANV419
- LMY-920
- SEA-BCMA
- TTI-622
Table of Contents
180 Pages
- Introduction
- Executive Summary
- Relapsing Refractory Multiple Myeloma: Overview
- Causes
- Mechanism of Action
- Signs and Symptoms
- Diagnosis
- Disease Management
- Pipeline Therapeutics
- Comparative Analysis
- Therapeutic Assessment
- Assessment by Product Type
- Assessment by Stage and Product Type
- Assessment by Route of Administration
- Assessment by Stage and Route of Administration
- Assessment by Molecule Type
- Assessment by Stage and Molecule Type
- Relapsing Refractory Multiple Myeloma– DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Comparative Analysis
- Mezigdomide: Bristol-Myers Squibb
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- Comparative Analysis
- Iopofosine: Cellectar Biosciences, Inc.
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- Comparative Analysis
- ORIC-533: ORIC Pharmaceuticals
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Preclinical and Discovery Stage Products
- Comparative Analysis
- Drug Name: Company Name
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Inactive Products
- Comparative Analysis
- Relapsing Refractory Multiple Myeloma Key Companies
- Relapsing Refractory Multiple Myeloma Key Products
- Relapsing Refractory Multiple Myeloma- Unmet Needs
- Relapsing Refractory Multiple Myeloma- Market Drivers and Barriers
- Relapsing Refractory Multiple Myeloma- Future Perspectives and Conclusion
- Relapsing Refractory Multiple Myeloma Analyst Views
- Relapsing Refractory Multiple Myeloma Key Companies
- Appendix
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