Polycythemia - Pipeline Insight, 2025

DelveInsight’s, Polycythaemia - Pipeline Insight, 2025,” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Polycythaemia pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Polycythaemia Understanding

Polycythaemia: Overview

Polycythemia, also called erythrocytosis, refers to an increase in red blood cell mass, noted on laboratory evaluation as increased hemoglobin and hematocrit levels. Polycythemia vera is a subtype of polycythemia and is associated with the overproduction of all 3 cell lines. The clinical significance of erythrocytosis, due to any cause, is related to the associated risk of thrombotic events due to hyperviscosity of blood. Additionally, in cases of polycythemia vera, there is potential for progression to leukemia. This activity reviews the evaluation, treatment, and potential complications of polycythemia vera and highlights the role of the interprofessional team in identifying and treating this condition.

The clinical significance of erythrocytosis, due to any cause, lies in the associated risk of thrombotic events due to hyperviscosity of blood. Additionally, the potential for progression to leukemia in cases of polycythemia vera also warrants attention.

""Polycythaemia - Pipeline Insight, 2025"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Polycythaemia pipeline landscape is provided which includes the disease overview and Polycythaemia treatment guidelines. The assessment part of the report embraces, in depth Polycythaemia commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Polycythaemia collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence R&D Polycythaemia. The therapies under development are focused on novel approaches to treat/improve Polycythaemia.

This includes conducting a phase 2 study of its lead program bitopertin, an oral, clinical-stage GlyT1 inhibitor with potential to become the first disease-modifying treatment for erythropoietic Polycythaemias (EP), a family of rare and debilitating genetic disorders caused by dysregulated heme synthesis.

Polycythaemia Emerging Drugs

• Givinostat: Italfarmaco

Givinostat (ITF2357) is an orally bioavailable hydroxymate inhibitor of histone deacetylase (HDAC) with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Givinostat prohibits class I and class II HDACs, leading to an accumulation of highly acetylated histones, followed by the induction of chromatin remodelling and an altered pattern of gene expression.

• Bomedemstat: Imago BioSciences

Bomedemstat (IMG-7289) is a small molecule discovered by Imago BioSciences that hampers the lysine-specific demethylase 1 (LSD1 or KDM1A), which is an enzyme vital for the production and normal function of megakaryocytes and self-renewal of malignant hematopoietic stem or progenitor cells. In non-clinical studies, bomedemstat displayed robust in vivo efficacy as a single agent, and combination with other therapeutics across a range of myeloid malignancy models that include the myeloproliferative neoplasms comprising of myelofibrosis, essential thrombocythemia and Polycythemia Vera.

Further product details are provided in the report……..

Polycythaemia: Therapeutic Assessment

This segment of the report provides insights about the Polycythaemia drugs segregated based on following parameters that define the scope of the report, such as:

• Major Players in Polycythaemia

There are approx. 10+ key companies which are developing the therapies Polycythaemia. The companies which have their Polycythaemia drug candidates in the most advanced stage, i.e Phase III include, Protagonist Therapeutics.

• Phases

DelveInsight’s report covers around 10+ products under different phases of clinical development like

• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Polycythaemia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Oral
• Intravenous
• Subcutaneous
• Molecule Type

Products have been categorized under various Molecule types such as

• Small molecule
• Cell Therapy
• Peptides
• Polymer
• Small molecule
• Gene therapy
• Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Polycythaemia: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Polycythaemia therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Polycythaemia drugs.

Polycythaemia Report Insights

• Polycythaemia Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Polycythaemia Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

• How many companies are developing Polycythaemia drugs?
• How many Polycythaemia drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Polycythaemia?
• What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Polycythaemia therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Polycythaemia and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Protagonist Therapeutics
• Ionis Pharmaceuticals
• Perseus Proteomics
• Kartos Therapeutics
• Imago BioSciences
• Incyte Corporation
• Italfarmaco
• Lynk Pharmaceutical
• Promedior

Key Products

• Rusfertide
• Sapablursen
• PPMX T003
• Navtemadlin
• Bomedemstat
• Parsaclisib
• Givinostat
• LNK01002
• PRM-151

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