
Non-cystic fibrosis bronchiectasis - Pipeline Insight, 2024
Description
Non‐cystic fibrosis bronchiectasis - Pipeline Insight, 2024
DelveInsight’s, “Non‐cystic fibrosis bronchiectasis - Pipeline Insight, 2024” report provides comprehensive insights about 15+ companies and 15+ pipeline drugs in Non‐cystic fibrosis bronchiectasis pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Geography Covered
- Global coverage
Non‐cystic fibrosis bronchiectasis: Overview
Non–cystic fibrosis (non-CF) bronchiectasis (henceforth referred to as bronchiectasis) is a progressive respiratory disease characterized by a permanent dilation of bronchi, retention of mucus, and ciliary clearance impairment. Clinical features include chronic daily sputum, cough, shortness of breath, and recurrent respiratory infections, with consequent increased morbidity and worsened quality of life. One of the cornerstones in the management of bronchiectasis is the identification and treatment of underlying causes.
Cole's “vicious cycle” of infection, airway inflammation and lung damage is the most widely accepted mechanism for the development of NCFB. The cycle is triggered when the defense system of the lung is breached and mucociliary clearance is impaired. Potential causes of this breach include severe lower respiratory tract infections, gastric aspiration, and/or inhalation of toxic gases. Other inflammatory processes may be associated with local and systemic inflammation that leads to changes in the architecture of the bronchial airways. However, a clear trigger is not identified in up to 30%‐53% of patients. Regardless of the cause, when mucociliary clearance is impaired, mucous is retained in the airways. This in turn leads to microbial colonization or infection with a subsequent development of an inflammatory response. As the host fails to eliminate the persistent infection, airway inflammation becomes chronic. Both host inflammatory responses and microbial cytotoxins cause additional structural damage to the lung and further impair mucus clearance; thus, the vicious cycle persists. Some microorganisms, such as Pseudomonas aeruginosa, may form biofilms in the bronchial airways. Biofilms are thin layers that form on colonized surfaces and are typically comprised of bacteria and a matrix of an extracellular polymeric substance that includes polysaccharides, proteins, and DNA. This may facilitate the persistence of the “vicious cycle” of bronchiectasis because the biofilms protect bacteria from clearance by the host immune system and reduce the effects of antibiotics, further potentiating airway inflammation. Disruption of the biofilms by some antibiotics (i.e., macrolides) is thought to be one of the mechanisms by which chronic antibiotic therapy may improve outcomes in bronchiectasis.
""Non‐cystic fibrosis bronchiectasis- Pipeline Insight, 2024"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Non‐cystic fibrosis bronchiectasis pipeline landscape is provided which includes the disease overview and Non‐cystic fibrosis bronchiectasis treatment guidelines. The assessment part of the report embraces, in depth Non‐cystic fibrosis bronchiectasis commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Non‐cystic fibrosis bronchiectasis collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
Report Highlights
- The companies and academics are working to assess challenges and seek opportunities that could influence Non‐cystic fibrosis bronchiectasis R&D. The therapies under development are focused on novel approaches to treat/improve Non‐cystic fibrosis bronchiectasis.
This segment of the Non‐cystic fibrosis bronchiectasis report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Non‐cystic fibrosis bronchiectasis Emerging Drugs
- Brensocatib: Insmed Incorporated
Brensocatib may decrease the damaging effects of inflammatory diseases such as bronchiectasis by inhibiting DPP1 and its activation of NSPs. Insmed acquired the license for the treatment from AstraZeneca in 2016. Currently, the drug is in Phase III stage of its clinical trial evaluation for the treatment of Non‐cystic fibrosis bronchiectasis.
- HSK31858: Haisco Pharmaceutical Group Co., Ltd.
- CSL 787: CSL Behring
Further product details are provided in the report……..
Non‐cystic fibrosis bronchiectasis: Therapeutic Assessment
This segment of the report provides insights about the different Non‐cystic fibrosis bronchiectasis drugs segregated based on following parameters that define the scope of the report, such as:
- Major Players in Non‐cystic fibrosis bronchiectasis
- Phases
- Late stage products (Phase III)
- Mid-stage products (Phase II)
- Early-stage product (Phase I) along with the details of
- Pre-clinical and Discovery stage candidates
- Discontinued & Inactive candidates
- Route of Administration
- Intravenous
- Subcutaneous
- Oral
- Intramuscular
- Molecule Type
- Monoclonal antibody
- Small molecule
- Peptide
- Product Type
Non‐cystic fibrosis bronchiectasis: Pipeline Development Activities
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Non‐cystic fibrosis bronchiectasis therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Non‐cystic fibrosis bronchiectasis drugs.
Non‐cystic fibrosis bronchiectasis Report Insights
- Non‐cystic fibrosis bronchiectasis Pipeline Analysis
- Therapeutic Assessment
- Unmet Needs
- Impact of Drugs
- Pipeline Product Profiles
- Therapeutic Assessment
- Pipeline Assessment
- Inactive drugs assessment
- Unmet Needs
Current Treatment Scenario and Emerging Therapies:
- How many companies are developing Non‐cystic fibrosis bronchiectasis drugs?
- How many Non‐cystic fibrosis bronchiectasis drugs are developed by each company?
- How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Non‐cystic fibrosis bronchiectasis?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Non‐cystic fibrosis bronchiectasis therapeutics?
- What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Non‐cystic fibrosis bronchiectasis and their status?
- What are the key designations that have been granted to the emerging drugs?
- Zambon SpA
- Insmed Incorporated
- NovaBiotics
- Haisco Pharmaceutical Group
- Armata Pharmaceuticals
- Chiesi Farmaceutici
- CSL Behring
- Colistimethate sodium
- Brensocatib
- HSK31858
- CHF 6333
- CSL 787
- AP-PA02
- ARINA-1
Table of Contents
60 Pages
- Introduction
- Executive Summary
- Non‐cystic fibrosis bronchiectasis: Overview
- Causes
- Mechanism of Action
- Signs and Symptoms
- Diagnosis
- Disease Management
- Pipeline Therapeutics
- Comparative Analysis
- Therapeutic Assessment
- Assessment by Product Type
- Assessment by Stage and Product Type
- Assessment by Route of Administration
- Assessment by Stage and Route of Administration
- Assessment by Molecule Type
- Assessment by Stage and Molecule Type
- Non‐cystic fibrosis bronchiectasis– DelveInsight’s Analytical Perspective
- Late Stage Products (Phase III)
- Comparative Analysis
- Brensocatib: Insmed Incorporated
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Mid Stage Products (Phase II)
- Comparative Analysis
- HSK31858: Haisco Pharmaceutical Group Co., Ltd.
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Early Stage Products (Phase I)
- Comparative Analysis
- CSL 787: CSL Behring
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Preclinical and Discovery Stage Products
- Comparative Analysis
- Drug name: Company name
- Product Description
- Research and Development
- Product Development Activities
- Drug profiles in the detailed report…..
- Inactive Products
- Comparative Analysis
- Non‐cystic fibrosis bronchiectasis Key Companies
- Non‐cystic fibrosis bronchiectasis Key Products
- Non‐cystic fibrosis bronchiectasis- Unmet Needs
- Non‐cystic fibrosis bronchiectasis- Market Drivers and Barriers
- Non‐cystic fibrosis bronchiectasis- Future Perspectives and Conclusion
- Non‐cystic fibrosis bronchiectasis Analyst Views
- Non‐cystic fibrosis bronchiectasis Key Companies
- Appendix
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