Nasopharyngeal Cancer - Pipeline Insight, 2025

DelveInsight’s, “Nasopharyngeal Cancer - Pipeline Insight, 2025” report provides comprehensive insights about 25+ companies and 30+ pipeline drugs in Nasopharyngeal Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Nasopharyngeal Cancer: Understanding

Nasopharyngeal Cancer: Overview

Nasopharyngeal carcinoma (NPC), previously known as lymphoepithelioma, is an undifferentiated form of squamous cell carcinoma arising from the epithelium of the nasopharynx. It is the most common malignancy of the nasopharynx. Endemic to parts of Asia and Africa but found worldwide, the malignancy shows a variable rate of occurrence ranging from high incidence in the southern part of China (25 to 50 cases per 100,000) to a low rate in European populations (1 case per 100,000). Clinically, NPC presents with a variety of symptoms depending on the stage and spread of the disease. Early symptoms often include a painless lump in the neck due to lymph node involvement, nasal congestion, frequent nosebleeds, or hearing loss caused by Eustachian tube blockage. As the cancer progresses, more severe symptoms such as facial numbness, headaches, or difficulty swallowing may occur. Diagnosis typically involves a combination of physical examination, imaging studies like MRI or CT scans, and biopsy of the affected tissue.

Nasopharyngeal cancer is typically diagnosed when a person presents symptoms like a lump in the neck, stuffy nose, or other related signs. The diagnostic process involves a thorough medical history review, physical examination, and specific tests. These tests may include a nasendoscopy, imaging scans like MRI or CT scans, and a panendoscopy for a detailed examination under general anesthesia. Biopsies are commonly performed to confirm the presence of cancer cells. Additionally, blood tests, such as measuring Epstein-Barr virus DNA levels, and routine blood counts are conducted to assess overall health and aid in treatment decisions.

The main treatments for nasopharyngeal cancer (NPC) include radiation therapy, often combined with chemotherapy, known as concomitant chemoradiotherapy. Surgery is occasionally used, primarily to remove lymph nodes after chemoradiotherapy or to treat NPC that has recurred after initial treatment. Other treatment options may involve medications like chemotherapy and immunotherapy, which can be given intravenously or orally. For advanced stages of NPC, treatments may include chemotherapy with drugs like cisplatin and other medications like PD-1 inhibitors. Additionally, clinical trials are available for all stages of cancer, offering alternative treatment options. The choice of treatment depends on various factors such as the stage of cancer, overall health, and individual preferences.

""Nasopharyngeal Cancer- Pipeline Insight, 2025"" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Nasopharyngeal Cancer pipeline landscape is provided which includes the disease overview and Nasopharyngeal Cancer treatment guidelines. The assessment part of the report embraces, in depth Nasopharyngeal Cancer commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Nasopharyngeal Cancer collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence Nasopharyngeal Cancer R&D. The therapies under development are focused on novel approaches to treat/improve Nasopharyngeal Cancer.

Nasopharyngeal Cancer Emerging Drugs Chapters

This segment of the Nasopharyngeal Cancer report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Nasopharyngeal Cancer Emerging Drugs

• BL-B01D1: SystImmune

BL-B01D1 is a first-in-class bispecific antibody-drug conjugate (ADC) developed by SystImmune, targeting both EGFR and HER3, proteins that are highly expressed in most epithelial tumors. The tetravalent BL-B01D1 possesses two binding domains blocking each Growth Factor Receptor, which both drive cancer cell proliferation and survival. Inheriting the SI-B001 mechanisms of action, BL-B01D1 effectively blocks EGFR and HER3 signals to cancer cells, thereby reducing proliferation and survival signals. Upon antibody-mediated internalization, BL-B01D1 is trafficked to cancer cell lysosomes and liberates its therapeutic payload that induced genotoxic stress activating pathways leading to cancer cell death. Currently, the drug is in Phase III stage of its clinical trial for the treatment of nasopharyngeal Carcinoma.

• TAK-500: Takeda

TAK-500 is a first-in-class STING agonist immunostimulatory antibody drug conjugate (iADC) that delivers dazostinag to CCR2+ myeloid cells in the tumor microenvironment. By targeting the STING pathway and CCR2 expressing myeloid cells, TAK-500 may offer enhanced potency via improved PK and selective delivery. TAK-500 has three possible mechanisms of action: activation of IFN response, reprogramming of suppressive intratumoral CCR2+ myeloid cells, and blockade of suppressive tumor-associated macrophage recruitment. Currently, the drug is in Phase I/II stage of its clinical trial for the treatment of nasopharyngeal cancer.

• APG-5918: Ascentage Pharma

APG-5918 is under development for the treatment of beta-thalassemia, metastatic solid tumors or relapsed or refractory non-Hodgkin's Lymphoma, nasopharyngeal carcinoma, castration-resistant prostate cancer, B-cell non-Hodgkin lymphoma, IN1-negative malignant rhabdoid tumor, gastric cancer, ovarian clear cell carcinoma, mesothelioma, b cell lymphoma, sickle cell disease, diffuse large B cell lymphoma (DLBCL), SMARCB1-deficient malignant rhabdoid tumor,solid tumor, hematological tumor, anemia and unspecified indication. It is administered through oral route. It acts by targeting polycomb protein EED. Currently, the drug is in Phase I stage of clinical trial for the treatment of nasopharyngeal Carcinoma.

Further product details are provided in the report……..

Nasopharyngeal Cancer: Therapeutic Assessment

This segment of the report provides insights about the different Nasopharyngeal Cancer drugs segregated based on following parameters that define the scope of the report, such as:

• Major Players in Nasopharyngeal Cancer
• There are approx. 25+ key companies which are developing the therapies for Nasopharyngeal Cancer. The companies which have their Nasopharyngeal Cancer drug candidates in the most advanced stage, i.e. Phase III include, SystImmune.
• Phases

DelveInsight’s report covers around 30+ products under different phases of clinical development like

• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Nasopharyngeal Cancer pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Oral
• Intravenous
• Subcutaneous
• Parenteral
• Topical
• Molecule Type

Products have been categorized under various Molecule types such as

• Recombinant fusion proteins
• Small molecule
• Monoclonal antibody
• Peptide
• Polymer
• Gene therapy
• Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Nasopharyngeal Cancer: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Nasopharyngeal Cancer therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Nasopharyngeal Cancer drugs.

Nasopharyngeal Cancer Report Insights

• Nasopharyngeal Cancer Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Nasopharyngeal Cancer Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

• How many companies are developing Nasopharyngeal Cancer drugs?
• How many Nasopharyngeal Cancer drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Nasopharyngeal Cancer?
• What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Nasopharyngeal Cancer therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Nasopharyngeal Cancer and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• ProfoundBio
• Chia Tai Tianqing Pharmaceutical Group
• Takeda
• Shanghai Henlius Biotech
• Sichuan Baili Pharmaceutical
• Ascentage Pharma Group
• Akeso

Key Products

• PRO1160
• TQB2618
• TAK-500
• HLX07
• BL-B01D1
• APG-5918
• AK105

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